Article ; Online: The role of mitophagy in the development of chronic kidney disease.
2024 Volume 12, Page(s) e17260
Abstract: Chronic kidney disease (CKD) represents a significant global health concern, with renal fibrosis emerging as a prevalent and ultimate manifestation of this condition. The absence of targeted therapies presents an ongoing and substantial challenge. ... ...
| Abstract | Chronic kidney disease (CKD) represents a significant global health concern, with renal fibrosis emerging as a prevalent and ultimate manifestation of this condition. The absence of targeted therapies presents an ongoing and substantial challenge. Accumulating evidence suggests that the integrity and functionality of mitochondria within renal tubular epithelial cells (RTECs) often become compromised during CKD development, playing a pivotal role in the progression of renal fibrosis. Mitophagy, a specific form of autophagy, assumes responsibility for eliminating damaged mitochondria to uphold mitochondrial equilibrium. Dysregulated mitophagy not only correlates with disrupted mitochondrial dynamics but also contributes to the advancement of renal fibrosis in CKD. While numerous studies have examined mitochondrial metabolism, ROS (reactive oxygen species) production, inflammation, and apoptosis in kidney diseases, the precise pathogenic mechanisms underlying mitophagy in CKD remain elusive. The exact mechanisms through which modulating mitophagy mitigates renal fibrosis, as well as its influence on CKD progression and prognosis, have not undergone systematic investigation. The role of mitophagy in AKI has been relatively clear, but the role of mitophagy in CKD is still rare. This article presents a comprehensive review of the current state of research on regulating mitophagy as a potential treatment for CKD. The objective is to provide fresh perspectives, viable strategies, and practical insights into CKD therapy, thereby contributing to the enhancement of human living conditions and patient well-being. |
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| MeSH term(s) | Animals ; Humans ; Disease Progression ; Fibrosis/pathology ; Fibrosis/metabolism ; Kidney Tubules/pathology ; Kidney Tubules/metabolism ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitophagy ; Reactive Oxygen Species/metabolism ; Renal Insufficiency, Chronic/pathology ; Renal Insufficiency, Chronic/metabolism |
| Language | English |
| Publishing date | 2024-04-25 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 2703241-3 |
| ISSN | 2167-8359 ; 2167-8359 |
| ISSN (online) | 2167-8359 |
| ISSN | 2167-8359 |
| DOI | 10.7717/peerj.17260 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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