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Article: Incidence of young-onset dementia in Italy: The Brescia register study.

Alzheimer's & dementia (Amsterdam, Netherlands)

2024 Volume 16, Issue 1, Page(s) e12544

Abstract: Introduction: The goal of the present work was to assess the incidence of dementia with onset before the age of 65 years (i.e., young-onset dementia [YOD]) and define the frequencies of young-onset Alzheimer's disease (AD), frontotemporal lobar ... ...

Abstract	Introduction: The goal of the present work was to assess the incidence of dementia with onset before the age of 65 years (i.e., young-onset dementia [YOD]) and define the frequencies of young-onset Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), and dementia with Lewy bodies (DLB) in the general population. Methods: The study was conducted from January 1, 2019 to December 31, 2019 in Brescia province (population: 1,268,455). During the study period, all new YOD cases (incident YOD) were counted, and all patients' records reviewed. The incidence was standardized to the Italian general population in 2019. Results: A total of 29 YOD patients were diagnosed. The age-sex standardized incidence rate was 4.58 (95% confidence interval, 3.07-6.58) per 100,000 person-years. No difference in incidence rate between YOD due to AD or FTLD ( Discussion: Presenting neurodegenerative YOD phenotypes encompasses both AD and FTLD. Improved knowledge on YOD epidemiology is essential to adequately plan and organize health services.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832898-X
ISSN	2352-8729
ISSN	2352-8729
DOI	10.1002/dad2.12544
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Article: Classification and Quantification of Physical Therapy Interventions across Multiple Neurological Disorders: An Italian Multicenter Network.

Bowman, Thomas / Mestanza Mattos, Fabiola Giovanna / Salvalaggio, Silvia / Marazzini, Francesca / Allera Longo, Cristina / Bocini, Serena / Gennuso, Michele / Materazzi, Francesco Giuseppe / Pelosin, Elisa / Putzolu, Martina / Russo, Rita / Turolla, Andrea / Mezzarobba, Susanna / Cattaneo, Davide

Journal of clinical medicine

2023 Volume 12, Issue 20

Abstract: Despite their relevance in neurorehabilitation, physical therapy (PT) goals and interventions are poorly described, compromising a proper understanding of PT effectiveness in everyday clinical practice. Thus, this paper aims to describe the prevalence of ...

Abstract	Despite their relevance in neurorehabilitation, physical therapy (PT) goals and interventions are poorly described, compromising a proper understanding of PT effectiveness in everyday clinical practice. Thus, this paper aims to describe the prevalence of PT goals and interventions in people with neurological disorders, along with the participants' clinical features, setting characteristics of the clinical units involved, and PT impact on outcome measures. A multicenter longitudinal observational study involving hospitals and rehabilitation centers across Italy has been conducted. We recruited people with stroke (
Language	English
Publishing date	2023-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12206483
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Article ; Online: Genetic and epigenetic disease modifiers in an Italian

Ratti, Antonia / Peverelli, Silvia / D'Adda, Elisabetta / Colombrita, Claudia / Gennuso, Michele / Prelle, Alessandro / Silani, Vincenzo

Amyotrophic lateral sclerosis & frontotemporal degeneration

2021 Volume 23, Issue 3-4, Page(s) 292–298

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Amyotrophic Lateral Sclerosis/genetics ; C9orf72 Protein/genetics ; DNA Repeat Expansion/genetics ; Epigenesis, Genetic/genetics ; Frontotemporal Dementia/genetics ; Humans ; Parkinson Disease/genetics ; Phenotype
Chemical Substances	C9orf72 Protein ; C9orf72 protein, human
Language	English
Publishing date	2021-08-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2705049-X
ISSN	2167-9223 ; 2167-8421
ISSN (online)	2167-9223
ISSN	2167-8421
DOI	10.1080/21678421.2021.1962355
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Article: Design and Operation of the Lombardy Parkinson's Disease Network.

Albanese, Alberto / Di Fonzo, Alessio / Fetoni, Vincenza / Franzini, Angelo / Gennuso, Michele / Molini, Graziella / Pacchetti, Claudio / Priori, Alberto / Riboldazzi, Giulio / Volonté, Maria Antonietta / Calandrella, Daniela

Frontiers in neurology

2020 Volume 11, Page(s) 573

Abstract: Background: ...

Abstract	Background:
Keywords	covid19
Language	English
Publishing date	2020-06-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2020.00573
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Article: Rhabdomyolysis in hyponatremia and paraneoplastic syndrome of inappropriate antidiuresis.

D'Adda, Elisabetta / Paletta, Rosina / Brusaferri, Fabio / Cagnana, Antonio / Teresa Ferrò, Maria / Gennuso, Michele / Ghione, Isabella / Saponara, Riccardo / Prelle, Alessandro

Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology

2015 Volume 34, Issue 2-3, Page(s) 139–140

Abstract: We report a 26-year-old woman admitted to our hospital for generalized tonic seizure. Laboratory investigations revealed severe hyponatremia possibly triggered by vomiting and diarrhea. 24 hours after correction of hyponatremia she developed diffuse ... ...

Abstract	We report a 26-year-old woman admitted to our hospital for generalized tonic seizure. Laboratory investigations revealed severe hyponatremia possibly triggered by vomiting and diarrhea. 24 hours after correction of hyponatremia she developed diffuse myalgias and marked hyperCKemia. Syndrome of inappropriate antidiuresis (SIAD) was suspected as cause of hyponatremia. Abnormal vaginal bleeding prompts gynecological evaluation and a small-cell carcinoma of uterine cervix was detected.
MeSH term(s)	Adult ; Diagnosis, Differential ; Female ; Humans ; Hyponatremia/diagnosis ; Hyponatremia/therapy ; Inappropriate ADH Syndrome/diagnosis ; Inappropriate ADH Syndrome/therapy ; Paraneoplastic Syndromes/diagnosis ; Rhabdomyolysis/diagnosis ; Rhabdomyolysis/therapy ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/therapy
Language	English
Publishing date	2015-12
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	2102328-1
ISSN	1128-2460
ISSN	1128-2460
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Article ; Online: Clinical Presentation and Outcomes of Severe Acute Respiratory Syndrome Coronavirus 2-Related Encephalitis: The ENCOVID Multicenter Study.

Pilotto, Andrea / Masciocchi, Stefano / Volonghi, Irene / Crabbio, Massimo / Magni, Eugenio / De Giuli, Valeria / Caprioli, Francesca / Rifino, Nicola / Sessa, Maria / Gennuso, Michele / Cotelli, Maria Sofia / Turla, Marinella / Balducci, Ubaldo / Mariotto, Sara / Ferrari, Sergio / Ciccone, Alfonso / Fiacco, Fabrizio / Imarisio, Alberto / Risi, Barbara /

Benussi, Alberto / Premi, Enrico / Focà, Emanuele / Caccuri, Francesca / Leonardi, Matilde / Gasparotti, Roberto / Castelli, Francesco / Zanusso, Gianluigi / Pezzini, Alessandro / Padovani, Alessandro

The Journal of infectious diseases

2020 Volume 223, Issue 1, Page(s) 28–37

Abstract: Background: Several preclinical and clinical investigations have argued for nervous system involvement in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Some sparse case reports have described various forms of encephalitis in ... ...

Abstract	Background: Several preclinical and clinical investigations have argued for nervous system involvement in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Some sparse case reports have described various forms of encephalitis in coronavirus disease 2019 (COVID-19) disease, but very few data have focused on clinical presentations, clinical course, response to treatment, and outcomes. Methods: The SARS-CoV-2 related encephalopaties (ENCOVID) multicenter study included patients with encephalitis with full infectious screening, cerebrospinal fluid (CSF), electroencephalography (EEG), and magnetic resonance imaging (MRI) data and confirmed SARS-CoV-2 infection recruited from 13 centers in northern Italy. Clinical presentation and laboratory markers, severity of COVID-19 disease, response to treatment, and outcomes were recorded. Results: Twenty-five cases of encephalitis positive for SARS-CoV-2 infection were included. CSF showed hyperproteinorrachia and/or pleocytosis in 68% of cases whereas SARS-CoV-2 RNA by reverse-transcription polymerase chain reaction resulted negative. Based on MRI, cases were classified as acute demyelinating encephalomyelitis (ADEM; n = 3), limbic encephalitis (LE; n = 2), encephalitis with normal imaging (n = 13), and encephalitis with MRI alterations (n = 7). ADEM and LE cases showed a delayed onset compared to the other encephalitis cases (P = .001) and were associated with previous, more severe COVID-19 respiratory involvement. Patients with MRI alterations exhibited worse response to treatment and final outcomes compared to those with other encephalitis. Conclusions: SARS-CoV-2 infection is associated with a wide spectrum of encephalitis characterized by different clinical presentation, response to treatment, and outcomes.
MeSH term(s)	Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/therapy ; Electroencephalography ; Encephalitis/classification ; Encephalitis/diagnosis ; Encephalitis/virology ; Female ; Humans ; Italy ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Middle Aged
Keywords	covid19
Language	English
Publishing date	2020-10-09
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiaa609
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Article ; Online: The clinical spectrum of encephalitis in COVID-19 disease: the ENCOVID multicentre study

Pilotto, Andrea / Masciocchi, Stefano / Volonghi, Irene / del Zotto, Elisabetta / Magni, Eugenio / De Giuli, Valeria / Caprioli, Francesca / Rifino, Nicola / Sessa, Maria / Gennuso, Michele / Cotelli, Maria Sofia / Turla, Marinella / Balducci, Ubaldo / Mariotto, Sara / Ferrari, Sergio / Ciccone, Alfonso / Fiacco, Fabrizio / Imarisio, Alberto / Risi, Barbara /

Benussi, Alberto / Foca', Emanuele / Caccuri, Francesca / Leonardi, Matilde / Gasparotti, Roberto / Castelli, Francesco / Zanusso, Gianluigi / Pezzini, Alessandro / Padovani, Alessandro

medRxiv

Abstract: Background: Several preclinical and clinical investigations have argued for nervous system involvement in SARS-CoV-2 infection. Some sparse case reports have described various forms of encephalitis in COVID-19 disease, but very few data have focused on ... ...

Abstract	Background: Several preclinical and clinical investigations have argued for nervous system involvement in SARS-CoV-2 infection. Some sparse case reports have described various forms of encephalitis in COVID-19 disease, but very few data have focused on clinical presentations, clinical course, response to treatment and outcomes yet. Objective: to describe the clinical phenotype, laboratory and neuroimaging findings of encephalitis associated with SARS-CoV-2 infection, their relationship with respiratory function and inflammatory parameters and their clinical course and response to treatment. Design: The ENCOVID multicentre study was carried out in 13 centres in northern Italy between February 20th and May 31st, 2020. Only patients with altered mental status and at least two supportive criteria for encephalitis with full infectious screening, CSF, EEG, MRI data and a confirmed diagnosis of SARS-CoV-2 infection were included. Clinical presentation and laboratory markers, severity of COVID-19 disease, response to treatment and outcomes were recorded. Results: Out of 45 cases screened, twenty-five cases of encephalitis positive for SARS-CoV-2 infection with full available data were included. The most common symptoms at onset were delirium (68%), aphasia/dysarthria (24%) and seizures (24%). CSF showed hyperproteinorrachia and/or pleocytosis in 68% of cases whereas SARS-CoV-2 RNA by RT-PCR resulted negative. Based on MRI, cases were classified as ADEM (n=3), limbic encephalitis (LE, n=2), encephalitis with normal imaging (n=13) and encephalitis with MRI alterations (n=7). ADEM and LE cases showed a delayed onset compared to the other encephalitis (p=0.001) and were associated with previous more severe COVID-19 respiratory involvement. Patients with MRI alterations exhibited worse response to treatment and final outcomes compared to other encephalitis. Conclusions and relevance: We found a wide clinical spectrum of encephalitis associated with COVID19 infection, underlying different pathophysiological mechanisms. Response to treatment and final outcome strongly depended on specific CNS-manifestations.
Keywords	covid19
Language	English
Publishing date	2020-06-20
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.06.19.20133991
Database	COVID19

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Article: Clinical presentation and outcomes of SARS-CoV-2 related encephalitis: the ENCOVID multicentre study

J. infect. dis

Abstract: BACKGROUND: Several preclinical and clinical investigations have argued for nervous system involvement in SARS-CoV-2 infection. Some sparse case reports have described various forms of encephalitis in COVID-19 disease, but very few data have focused on ... ...

Abstract	BACKGROUND: Several preclinical and clinical investigations have argued for nervous system involvement in SARS-CoV-2 infection. Some sparse case reports have described various forms of encephalitis in COVID-19 disease, but very few data have focused on clinical presentations, clinical course, response to treatment and outcomes. METHODS: The ENCOVID multicentre study included patients with encephalitis with full infectious screening, CSF, EEG, MRI data and confirmed SARS-CoV-2 infection recruited from 13 centres in northern Italy. Clinical presentation and laboratory markers, severity of COVID-19 disease, response to treatment and outcomes were recorded. RESULTS: twenty-five cases of encephalitis positive for SARS-CoV-2 infection were included. CSF showed hyperproteinorrachia and/or pleocytosis in 68% of cases whereas SARS-CoV-2 RNA by RT-PCR resulted negative. Based on MRI, cases were classified as ADEM (n=3), limbic encephalitis (LE, n=2), encephalitis with normal imaging (n=13) and encephalitis with MRI alterations (n=7). ADEM and LE cases showed a delayed onset compared to the other encephalitis (p=0.001) and were associated with previous more severe COVID-19 respiratory involvement. Patients with MRI alterations exhibited worse response to treatment and final outcomes compared to other encephalitis. CONCLUSIONS: SARS-CoV-2 infection is associated with a wide spectrum of encephalitis characterized by different clinical presentation, response to treatment and outcomes.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #799739
Database	COVID19

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Article ; Online: Clinical presentation and outcomes of SARS-CoV-2 related encephalitis

the ENCOVID multicentre study

2020

Abstract: Several preclinical and clinical investigations have argued for nervous system involvement in SARS-CoV-2 infection. Some sparse case reports have described various forms of encephalitis in COVID-19 disease, but very few data have focused on clinical ... ...

Abstract	Several preclinical and clinical investigations have argued for nervous system involvement in SARS-CoV-2 infection. Some sparse case reports have described various forms of encephalitis in COVID-19 disease, but very few data have focused on clinical presentations, clinical course, response to treatment and outcomes.
Keywords	ADEM ; COVID-19 ; Encephalitis ; SARS-CoV-2 ; neuroinflammation ; covid19
Language	English
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly.

Cattaneo, Annamaria / Cattane, Nadia / Galluzzi, Samantha / Provasi, Stefania / Lopizzo, Nicola / Festari, Cristina / Ferrari, Clarissa / Guerra, Ugo Paolo / Paghera, Barbara / Muscio, Cristina / Bianchetti, Angelo / Volta, Giorgio Dalla / Turla, Marinella / Cotelli, Maria Sofia / Gennuso, Michele / Prelle, Alessandro / Zanetti, Orazio / Lussignoli, Giulia / Mirabile, Dario /

Bellandi, Daniele / Gentile, Simona / Belotti, Gloria / Villani, Daniele / Harach, Taoufiq / Bolmont, Tristan / Padovani, Alessandro / Boccardi, Marina / Frisoni, Giovanni B

Neurobiology of aging

2017 Volume 49, Page(s) 60–68

Abstract: The pathway leading from amyloid-β deposition to cognitive impairment is believed to be a cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid buildup in sporadic nongenetic cases of AD is still unknown. AD brains ... ...

Abstract	The pathway leading from amyloid-β deposition to cognitive impairment is believed to be a cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid buildup in sporadic nongenetic cases of AD is still unknown. AD brains feature an inflammatory reaction around amyloid plaques, and a specific subset of the gut microbiota (GMB) may promote brain inflammation. We investigated the possible role of the GMB in AD pathogenesis by studying the association of brain amyloidosis with (1) GMB taxa with pro- and anti-inflammatory activity; and (2) peripheral inflammation in cognitively impaired patients. We measured the stool abundance of selected bacterial GMB taxa (Escherichia/Shigella, Pseudomonas aeruginosa, Eubacterium rectale, Eubacterium hallii, Faecalibacterium prausnitzii, and Bacteroides fragilis) and the blood expression levels of cytokines (pro-inflammatory cytokines: CXCL2, CXCL10, interleukin [IL]-1β, IL-6, IL-18, IL-8, inflammasome complex (NLRP3), tumor necrosis factor-alpha [TNF-α]; anti-inflammatory cytokines: IL-4, IL-10, IL-13) in cognitively impaired patients with (n = 40, Amy+) and with no brain amyloidosis (n = 33, Amy-) and also in a group of controls (n = 10, no brain amyloidosis and no cognitive impairment). Amy+ patients showed higher levels of pro-inflammatory cytokines (IL-6, CXCL2, NLRP3, and IL-1β) compared with both controls and with Amy- patients. A reduction of the anti-inflammatory cytokine IL-10 was observed in Amy+ versus Amy-. Amy+ showed lower abundance of E. rectale and higher abundance of Escherichia/Shigella compared with both healthy controls (fold change, FC = -9.6, p < 0.001 and FC = +12.8, p < 0.001, respectively) and to Amy- (FC = -7.7, p < 0.001 and FC = +7.4, p = 0.003). A positive correlation was observed between pro-inflammatory cytokines IL-1β, NLRP3, and CXCL2 with abundance of the inflammatory bacteria taxon Escherichia/Shigella (rho = 0.60, p < 0.001; rho = 0.57, p < 0.001; and rho = 0.30, p = 0.007, respectively) and a negative correlation with the anti-inflammatory E. rectale (rho = -0.48, p < 0.001; rho = -0.25, p = 0.024; rho = -0.49, p < 0.001). Our data indicate that an increase in the abundance of a pro-inflammatory GMB taxon, Escherichia/Shigella, and a reduction in the abundance of an anti-inflammatory taxon, E. rectale, are possibly associated with a peripheral inflammatory state in patients with cognitive impairment and brain amyloidosis. A possible causal relation between GMB-related inflammation and amyloidosis deserves further investigation.
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2016.08.019
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