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  1. Article ; Online: Staring us in the face: resumption of CPAP therapy.

    Joosten, Simon A / Genta, Pedro R

    The European respiratory journal

    2024  Volume 63, Issue 2

    MeSH term(s) Humans ; Mental Disorders ; Positive-Pressure Respiration ; France
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02213-2023
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
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    Zs.MO 292: Show issues

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  2. Article ; Online: Task Accomplished: Promising Effects of a New Topical Potassium Channel Antagonist in OSA.

    Genta, Pedro R / Taranto-Montemurro, Luigi

    Chest

    2023  Volume 163, Issue 4, Page(s) 749–750

    MeSH term(s) Humans ; Potassium Channels ; Sleep Apnea, Obstructive/drug therapy ; Potassium Channels, Tandem Pore Domain
    Chemical Substances Potassium Channels ; Potassium Channels, Tandem Pore Domain
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  3. Article ; Online: Sleep apnea and atrial fibrillation: the spell of Groundhog Day.

    Lorenzi-Filho, Geraldo / Genta, Pedro R

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2022  Volume 18, Issue 5, Page(s) 1223–1224

    MeSH term(s) Atrial Fibrillation/complications ; Humans ; Risk Factors ; Sleep Apnea Syndromes/complications ; Sleep Apnea Syndromes/diagnosis
    Language English
    Publishing date 2022-03-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.9984
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  4. Article ; Online: Clinical Decision-making for Continuous Positive Airway Pressure Mask Selection.

    Lima de Andrade Xavier, Jeane / Fernandes, Mariana Delgado / Lorenzi-Filho, Geraldo / Genta, Pedro R

    Sleep medicine clinics

    2022  Volume 17, Issue 4, Page(s) 569–576

    Abstract: Continuous positive airway pressure is the gold standard treatment for obstructive sleep apnea. Different interfaces with distinct characteristics, advantages, and disadvantages are available, which may influence long-term adherence. Oronasal masks have ... ...

    Abstract Continuous positive airway pressure is the gold standard treatment for obstructive sleep apnea. Different interfaces with distinct characteristics, advantages, and disadvantages are available, which may influence long-term adherence. Oronasal masks have been increasingly used. However, recent evidence suggest that nasal masks are more effective when continuous positive airway pressure is used to treat obstructive sleep apnea. The main objective of this review is to describe the basis for the selection of the interface for the treatment of obstructive sleep apnea with continuous positive airway pressure.
    MeSH term(s) Humans ; Continuous Positive Airway Pressure ; Sleep Apnea, Obstructive/therapy ; Masks ; Clinical Decision-Making
    Language English
    Publishing date 2022-10-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1556-4088
    ISSN (online) 1556-4088
    DOI 10.1016/j.jsmc.2022.07.011
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  5. Article ; Online: Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA).

    Yanagimori, Marcela / Fernandes, Mariana D / Garcia, Michelle L / Scudeller, Paula G / Carvalho, Carlos R R / Edwards, Bradley / Lorenzi-Filho, Geraldo / Genta, Pedro R

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 7638

    Abstract: Insomnia and obstructive sleep apnea (OSA) are common sleep disorders and frequently coexist (COMISA). Arousals from sleep may be a common link explaining the frequent comorbidity of both disorders. Respiratory arousal threshold (AT) is a physiologic ... ...

    Abstract Insomnia and obstructive sleep apnea (OSA) are common sleep disorders and frequently coexist (COMISA). Arousals from sleep may be a common link explaining the frequent comorbidity of both disorders. Respiratory arousal threshold (AT) is a physiologic measurement of the level of respiratory effort to trigger an arousal from sleep. The impact of COMISA on AT is not known. We hypothesized that a low AT is more common among COMISA than among patients with OSA without insomnia. Participants referred for OSA diagnosis underwent a type 3 sleep study and answered the insomnia severity index (ISI) questionnaire and the Epworth sleepiness scale. Participants with an ISI score ≥ 15 were defined as having insomnia. Sleep apnea was defined as an apnea hypopnea index (AHI) ≥ 15 events/h. Low AT was determined using a previously validated score based on 3 polysomnography variables (AHI, nadir SpO
    MeSH term(s) Male ; Humans ; Middle Aged ; Aged ; Sleep Initiation and Maintenance Disorders/complications ; Sleep Initiation and Maintenance Disorders/epidemiology ; Sleep Apnea Syndromes/complications ; Sleep Apnea Syndromes/epidemiology ; Comorbidity ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/diagnosis ; Arousal
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-34002-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Obstructive Sleep Apnea Is a Distinct Physiological Endotype in Individuals with Comorbid Insomnia and Sleep Apnea.

    Brooker, Elliot J / Landry, Shane A / Thomson, Luke D J / Hamilton, Garun S / Genta, Pedro R / Drummond, Sean P A / Edwards, Bradley A

    Annals of the American Thoracic Society

    2023  Volume 20, Issue 10, Page(s) 1508–1515

    Abstract: Rationale: ...

    Abstract Rationale:
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202304-350OC
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    Zs.A 5828: Show issues Location:
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  7. Article ; Online: Response.

    Schorr, Fabiola / Genta, Pedro R

    Chest

    2016  Volume 149, Issue 6, Page(s) 1588–1589

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2016.04.003
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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  8. Article ; Online: Sealing the Leak: A Step Forward in Improving CPAP Adherence.

    Genta, Pedro R / Lorenzi-Filho, Geraldo

    Chest

    2018  Volume 153, Issue 4, Page(s) 774–775

    MeSH term(s) Continuous Positive Airway Pressure ; Humans ; Sleep Apnea, Obstructive
    Language English
    Publishing date 2018-04-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2017.10.023
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    Zs.MO 349: Show issues

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  9. Article ; Online: Reply to Jaffuel and Borel: If Oral Breathing Does Not Determine Mask Choice for Continuous Positive Airway Pressure Delivery, What Does?

    Xavier, Jeane Lima de Andrade / Madeiro Leite Viana Weaver, Fernanda / Pinheiro, George Lago / Sousa Fernandes, Paulo Henrique / Genta, Pedro R / Lorenzi-Filho, Geraldo

    American journal of respiratory and critical care medicine

    2022  Volume 205, Issue 11, Page(s) 1364–1365

    MeSH term(s) Continuous Positive Airway Pressure ; Humans ; Polysomnography ; Respiration ; Sleep Apnea, Obstructive/therapy
    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202201-0080LE
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  10. Article ; Online: Discriminating the severity of pharyngeal collapsibility in men using anthropometric and polysomnographic indices.

    Genta, Pedro R / Schorr, Fabiola / Edwards, Bradley A / Wellman, Andrew / Lorenzi-Filho, Geraldo

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2020  Volume 16, Issue 9, Page(s) 1531–1537

    Abstract: Study objectives: Although obstructive sleep apnea results from the combination of different pathophysiologic mechanisms, the degree of anatomical compromise remains the main responsible factor. The passive pharyngeal critical closing pressure (Pcrit) ... ...

    Abstract Study objectives: Although obstructive sleep apnea results from the combination of different pathophysiologic mechanisms, the degree of anatomical compromise remains the main responsible factor. The passive pharyngeal critical closing pressure (Pcrit) is a technique used to assess the collapsibility of the upper airway and is often used as a surrogate measure of this anatomical compromise. Patients with a low Pcrit (ie, less collapsible airway) are potential candidates for non-continuous positive airway pressure therapies. However, Pcrit determination is a technically complex method not available in clinical practice. We hypothesized that the discrimination between low and high Pcrit can be estimated from simple anthropometric and polysomnographic indices.
    Methods: Men with and without obstructive sleep apnea underwent Pcrit determination and full polysomnography. Receiver operating characteristics analysis was performed to select the best cutoff of each variable to predict a high Pcrit (Pcrit ≥ 2.5 cmH₂O). Multiple logistic regression analysis was performed to create a clinical score to predict a high Pcrit.
    Results: We studied 81 men, 48 ± 13 years of age, with an apnea-hypopnea index of 32 [14-60], range 1-96 events/h), and Pcrit of -0.7 ± 3.1 (range, -9.1 to +7.2 cmH₂O). A high and low Pcrit could be accurately identified by polysomnographic and anthropometric indices. A score to discriminate Pcrit showed good performance (area under the curve = 0.96; 95% confidence interval, 0.91-1.00) and included waist circumference, non-rapid eye movement obstructive apnea index/apnea-hypopnea index, mean obstructive apnea duration, and rapid eye movement apnea-hypopnea index.
    Conclusions: A low Pcrit (less collapsible) can be estimated from a simple clinical score. This approach may identify candidates more likely to respond to non-continuous positive airway pressure therapies for obstructive sleep apnea.
    MeSH term(s) Humans ; Male ; Pharynx ; Polysomnography ; Pressure ; Sleep Apnea, Obstructive/diagnosis ; Sleep, REM
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.8600
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