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  1. AU="Gentaro Ikeda"
  2. AU="Pan, Zhihong"
  3. AU="Favre, Romain"
  4. AU="Silkov, Antonina"
  5. AU="Giulio M. Pasinetti"
  6. AU="Ivan Arano"
  7. AU="Fujii, Denise Nami"
  8. AU="Marquer, L"
  9. AU="Rosa, Giuseppe La"
  10. AU="Honari, Niloofar"
  11. AU="Grant, Patrick A"
  12. AU="Hojski, Aljaz"
  13. AU="SUN Chuanrui"
  14. AU="Holt, Liam J"
  15. AU="Matthew Bell"
  16. AU="Cheng, Pu"
  17. AU="D'Souza, Jill N"
  18. AU="Terrone, Sophie"
  19. AU="Esmaily, Hadi"
  20. AU="Al-Ani, Gada"
  21. AU="Denys, Damiaan A J P"
  22. AU="Irigoin, Victoria"
  23. AU="Kim, Joo-Yun"
  24. AU="Albu, Simona Elena"
  25. AU="Monalisa Feliciano Figueiredo"
  26. AU="Zhao, Houhua"
  27. AU="Kern, Bastian Johannes"
  28. AU="Antonio Vitobello"
  29. AU="Paulus Rahardjo"
  30. AU="Geier, Martina"
  31. AU="Kwon, Tae-Hwan"
  32. AU="Christos Barboutis, "
  33. AU="Fayaz, U"
  34. AU="Ba, Yabo"
  35. AU="Stevens, Valerie A"
  36. AU="Kahouli, Sophia"
  37. AU="Sun, Chuanrui"
  38. AU="Carrera, Carlo Giovanni"
  39. AU="Secrieru, Oana Manuela"
  40. AU="Wang, Lanzhong"

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  1. Artikel ; Online: Spinning-enabled wireless amphibious origami millirobot

    Qiji Ze / Shuai Wu / Jize Dai / Sophie Leanza / Gentaro Ikeda / Phillip C. Yang / Gianluca Iaccarino / Ruike Renee Zhao

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Band 9

    Abstract: Wireless millirobots are promising as minimally invasive biomedical devices. Here, the authors design a magnetically actuated amphibious millirobot that integrates spinning-enabled locomotion, targeted drug delivery, and cargo transportation by utilizing ...

    Abstract Wireless millirobots are promising as minimally invasive biomedical devices. Here, the authors design a magnetically actuated amphibious millirobot that integrates spinning-enabled locomotion, targeted drug delivery, and cargo transportation by utilizing geometrical features and folding/unfolding capability of the Kresling origami.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury

    Arihide Okahara / Jun-ichiro Koga / Tetsuya Matoba / Masaki Fujiwara / Masaki Tokutome / Gentaro Ikeda / Kaku Nakano / Masaki Tachibana / Tetsuro Ago / Takanari Kitazono / Hiroyuki Tsutsui / Kensuke Egashira

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Band 14

    Abstract: Abstract Ischemia–reperfusion injury impairs the efficacy of reperfusion therapy after ischemic stroke. Cyclophilin D (CypD)-mediated openings of mitochondrial permeability transition pore (mPTP) and subsequent monocyte-mediated inflammation are ... ...

    Abstract Abstract Ischemia–reperfusion injury impairs the efficacy of reperfusion therapy after ischemic stroke. Cyclophilin D (CypD)-mediated openings of mitochondrial permeability transition pore (mPTP) and subsequent monocyte-mediated inflammation are considered as major mechanisms of reperfusion injury. However, no medical therapies are currently available. Therefore, we have tested a hypothesis that simultaneous targeting of mPTP and inflammation confers substantial neuroprotection after cerebral ischemia–reperfusion. To address this point, we prepared CypD knockout mice, C–C chemokine receptor 2 (CCR2) knockout mice and CypD/CCR2 double knockout mice. These mice were subjected to 60 min transient cerebral ischemia by occluding middle cerebral arteries. Neurological deficits evaluated 3 days after reperfusion were significantly attenuated in CypD/CCR2 double knockout mice as compared to wild-type mice and other single knockout mice. Then, we have prepared polymeric nanoparticles containing cyclosporine A (CsA-NPs) and pitavastatin (Pitava-NPs), targeting mPTP opening and inflammation, respectively. Simultaneous administration of CsA-NP and Pitava-NP at the time of reperfusion also decreased infarct size and attenuated neurological deficits as compared to control nanoparticles and single administration of CsA-NPs or Pitava-NPs. These results indicate that simultaneous targeting of the mPTP opening and monocyte-mediated inflammation could be a novel strategy for better neurological outcomes in patients with ischemic stroke.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2020-09-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: A New Therapeutic Modality for Acute Myocardial Infarction

    Kazuhiro Nagaoka / Tetsuya Matoba / Yajing Mao / Yasuhiro Nakano / Gentaro Ikeda / Shizuka Egusa / Masaki Tokutome / Ryoji Nagahama / Kaku Nakano / Kenji Sunagawa / Kensuke Egashira

    PLoS ONE, Vol 10, Iss 7, p e

    Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model.

    2015  Band 0132451

    Abstract: There is an unmet need to develop an innovative cardioprotective modality for acute myocardial infarction (AMI), for which the effectiveness of interventional reperfusion therapy is hampered by myocardial ischemia-reperfusion (IR) injury. Pretreatment ... ...

    Abstract There is an unmet need to develop an innovative cardioprotective modality for acute myocardial infarction (AMI), for which the effectiveness of interventional reperfusion therapy is hampered by myocardial ischemia-reperfusion (IR) injury. Pretreatment with statins before ischemia is shown to reduce MI size in animals. However, no benefit was found in animals and patients with AMI when administered at the time of reperfusion, suggesting insufficient drug targeting into the IR myocardium. Here we tested the hypothesis that nanoparticle-mediated targeting of pitavastatin protects the heart from IR injury.In a rat IR model, poly(lactic acid/glycolic acid) (PLGA) nanoparticle incorporating FITC accumulated in the IR myocardium through enhanced vascular permeability, and in CD11b-positive leukocytes in the IR myocardium and peripheral blood after intravenous treatment. Intravenous treatment with PLGA nanoparticle containing pitavastatin (Pitavastatin-NP, 1 mg/kg) at reperfusion reduced MI size after 24 hours and ameliorated left ventricular dysfunction 4-week after reperfusion; by contrast, pitavastatin alone (as high as 10 mg/kg) showed no therapeutic effects. The therapeutic effects of Pitavastatin-NP were blunted by a PI3K inhibitor wortmannin, but not by a mitochondrial permeability transition pore inhibitor cyclosporine A. Pitavastatin-NP induced phosphorylation of Akt and GSK3β, and inhibited inflammation and cardiomyocyte apoptosis in the IR myocardium.Nanoparticle-mediated targeting of pitavastatin induced cardioprotection from IR injury by activation of PI3K/Akt pathway and inhibition of inflammation and cardiomyocyte death in this model. This strategy can be developed as an innovative cardioprotective modality that may advance currently unsatisfactory reperfusion therapy for AMI.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2015-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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