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  1. Book ; Online: Biological Activities of Plant Food Components: Implications in Human Health

    Gentile, Carla

    2021  

    Keywords Research & information: general ; resveratrol ; bioactivities ; anticancer ; anti-obesity ; antidiabetes ; molecular mechanisms ; durum wheat bread ; Portulaca oleracea L. ; essential fatty acids ; omega-6/omega-3 ratio ; antioxidants ; Bangladesh ; vegetables ; polyphenols ; amylase ; glucosidase ; renin ; angiotensin-converting enzyme ; lipase ; mass spectrometry ; yeast ; antioxidant ; cytotoxicity ; bioavailability ; viability ; Punica granatum ; hydrolysable tannins ; flavonoids ; Ultra High Performance Liquid Chromatography-Orbitrap-Mass Spectrometry ; tempura ; deep-fried product ; barley ; buckwheat ; Job's tears ; antioxidant capacity ; oil deterioration ; polyphenol ; oxidative stress ; necroptosis ; plant extract ; secondary metabolite ; γH2AX ; copper ; African food spices ; GC-MS (gas chromatography mass spectrometry) ; antimicrobial ; antibiofilm ; violacein inhibition ; swarming inhibition ; swimming inhibition ; anticholinesterase ; antiurease ; antityrosinase ; sensory analysis ; mineral content ; proanthocyanidins ; carotenoids ; antioxidant activity ; FRAP ; DPPH ; ABTS ; CAA ; n/a
    Size 1 electronic resource (168 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021291227
    ISBN 9783036525310 ; 3036525319
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Biological Activities of Plant Food Components: Implications in Human Health.

    Gentile, Carla

    Foods (Basel, Switzerland)

    2021  Volume 10, Issue 2

    Abstract: Scientific data and epidemiological evidence collected over the last fifty years have shown that nutrition plays a decisive role in human health [ ... ]. ...

    Abstract Scientific data and epidemiological evidence collected over the last fifty years have shown that nutrition plays a decisive role in human health [...].
    Language English
    Publishing date 2021-02-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10020456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mucilage-Based and Calcium Ascorbate Edible Coatings Improve Postharvest Quality and Storability of Minimally Processed Cactus Pear Fruit Stored under Passive Atmosphere

    Liguori, G. / Greco, Giuseppe / Gaglio, Raimondo / Settanni, Luca / Gentile, Carla / Inglese, Paolo

    Horticulturae. 2022 Dec. 21, v. 9, no. 1

    2022  

    Abstract: The minimally processed fruit and vegetable industry showed rapid growth worldwide, primarily due to the increasing consumer need for ready-to-eat fresh products characterized by high nutritional, sensory and healthy value. The postharvest life of peeled ...

    Abstract The minimally processed fruit and vegetable industry showed rapid growth worldwide, primarily due to the increasing consumer need for ready-to-eat fresh products characterized by high nutritional, sensory and healthy value. The postharvest life of peeled cactus pear fruits is relatively short, due to the processing operations that affect fruit integrity and cause metabolic disfunctions, as well as pulp browning, microbial growth, loss of firmness, off-flavor development, and nutraceutical value loss. In this study, we investigated the effects of mucilage-based (OFI) and calcium ascorbate edible coating on minimally processed cactus pear summer-ripening fruit, cold stored under passive atmosphere. The effect of the edible coating on the postharvest life, quality attributes, and nutraceutical value of fruit was evaluated by colors, total soluble solids content, carbohydrates; titratable acidity, ascorbic acid, betalains, DPPH, visual quality, and sensorial analysis. Our data showed a significant effect of mucilage-based and calcium ascorbate-based coating on preserving quality, nutritional value, sensorial parameters, and improving postharvest life of minimally processed cactus pear fruits; OFI had the most effective barrier effect. Furthermore, both coating treatments did not negatively affect the natural taste of minimally processed cactus pear fruits, which is an important aspect regarding the use of edible coatings when taste modification is undesirable.
    Keywords betalains ; cactus pears ; calcium ; calcium ascorbate ; cold ; dietary supplements ; firmness ; fruits ; microbial growth ; nutritive value ; off flavors ; pulp ; ready-to-eat foods ; sensory evaluation ; shelf life ; taste ; titratable acidity ; vegetable industry
    Language English
    Dates of publication 2022-1221
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2813983-5
    ISSN 2311-7524
    ISSN 2311-7524
    DOI 10.3390/horticulturae9010015
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Phytochemical profile and antioxidant properties of the edible and non-edible portions of black sapote (Diospyros digyna Jacq.)

    Mannino, Giuseppe / Serio, Graziella / Bertea, Cinzia Margherita / Chiarelli, Roberto / Lauria, Antonino / Gentile, Carla

    Food chemistry. 2022 June 30, v. 380

    2022  

    Abstract: This study evaluated the phytochemical profile and antioxidative properties of the edible and non-edible portions of black sapote. The phytochemical analysis highlighted the presence of several bioactive compounds, differently distributed among peel, ... ...

    Abstract This study evaluated the phytochemical profile and antioxidative properties of the edible and non-edible portions of black sapote. The phytochemical analysis highlighted the presence of several bioactive compounds, differently distributed among peel, pulp and seeds. In particular, the peel resulted rich of flavan-3-ols and proanthocyanidins, whereas seeds contained high amount of organic acids, including ferulic, citric and sinapic acids. Concerning functional properties, both edible and non-edible portions showed a significant prevention of lipid peroxidation in a cell-based model. Moreover, the results suggested that the antioxidant protection involved both redox active properties and gene expression modulation. Concerning redox active properties, peel extracts showed an antioxidant activity 7/12-fold higher than the edible portion, while seed extracts were more active in increasing catalase gene expression. The obtained results confirmed that black sapote is a good source of antioxidant phytochemicals and its non-edible portions have a great potential in the production of functional foods and supplements.
    Keywords Diospyros digyna ; antioxidant activity ; antioxidants ; catalase ; chemical constituents of plants ; flavanols ; food chemistry ; gene expression ; lipid peroxidation ; models ; proanthocyanidins ; pulp
    Language English
    Dates of publication 2022-0630
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2022.132137
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  5. Article ; Online: Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet.

    Caradonna, Fabio / Consiglio, Ornella / Luparello, Claudio / Gentile, Carla

    Nutrients

    2020  Volume 12, Issue 6

    Abstract: The Mediterranean Diet (MD), UNESCO Intangible Cultural Heritage of Humanity, has become a scientific topic of high interest due to its health benefits. The aim of this review is to pick up selected studies that report nutrigenomic or nutrigenetic data ... ...

    Abstract The Mediterranean Diet (MD), UNESCO Intangible Cultural Heritage of Humanity, has become a scientific topic of high interest due to its health benefits. The aim of this review is to pick up selected studies that report nutrigenomic or nutrigenetic data and recapitulate some of the biochemical/genomic/genetic aspects involved in the positive health effects of the MD. These include (i) the antioxidative potential of its constituents with protective effects against several diseases; (ii) the epigenetic and epigenomic effects exerted by food components, such as Indacaxanthin, Sulforaphane, and 3-Hydroxytyrosol among others, and their involvement in the modulation of miRNA expression; (iii) the existence of predisposing or protective human genotypes due to allelic diversities and the impact of the MD on disease risk. A part of the review is dedicated to the nutrigenomic effects of the main cooking methods used in the MD and also to a comparative analysis of the nutrigenomic properties of the MD and other diet regimens and non-MD-related aliments. Taking all the data into account, the traditional MD emerges as a diet with a high antioxidant and nutrigenomic modulation power, which is an example of the "Environment-Livings-Environment" relationship and an excellent patchwork of interconnected biological actions working toward human health.
    MeSH term(s) Antioxidants/analysis ; Antioxidants/pharmacology ; Diet, Healthy ; Diet, Mediterranean ; Eating/physiology ; Epigenomics ; Female ; Food Analysis ; Gene Expression/drug effects ; Health Status ; Humans ; Isothiocyanates/analysis ; Isothiocyanates/pharmacology ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Nutrigenomics ; Phenylethyl Alcohol/analogs & derivatives ; Phenylethyl Alcohol/analysis ; Phenylethyl Alcohol/pharmacology ; Xanthine/analysis ; Xanthine/pharmacology
    Chemical Substances Antioxidants ; Isothiocyanates ; MicroRNAs ; 3,4-dihydroxyphenylethanol (10597-60-1) ; Xanthine (1AVZ07U9S7) ; sulforaphane (GA49J4310U) ; Phenylethyl Alcohol (ML9LGA7468)
    Language English
    Publishing date 2020-06-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12061748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: In Silico Insights into the SARS CoV-2 Main Protease Suggest NADH Endogenous Defences in the Control of the Pandemic Coronavirus Infection.

    Martorana, Annamaria / Gentile, Carla / Lauria, Antonino

    Viruses

    2020  Volume 12, Issue 8

    Abstract: COVID-19 is a pandemic health emergency faced by the entire world. The clinical treatment of the severe acute respiratory syndrome (SARS) CoV-2 is currently based on the experimental administration of HIV antiviral drugs, such as lopinavir, ritonavir, ... ...

    Abstract COVID-19 is a pandemic health emergency faced by the entire world. The clinical treatment of the severe acute respiratory syndrome (SARS) CoV-2 is currently based on the experimental administration of HIV antiviral drugs, such as lopinavir, ritonavir, and remdesivir (a nucleotide analogue used for Ebola infection). This work proposes a repurposing process using a database containing approximately 8000 known drugs in synergy structure- and ligand-based studies by means of the molecular docking and descriptor-based protocol. The proposed in silico findings identified new potential SARS CoV-2 main protease (M
    MeSH term(s) Aging/metabolism ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Betacoronavirus/drug effects ; Betacoronavirus/enzymology ; Binding Sites ; Computer Simulation ; Coronavirus Infections/drug therapy ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Cysteine Endopeptidases/chemistry ; DNA Damage ; Drug Repositioning ; HIV Protease Inhibitors/chemistry ; HIV Protease Inhibitors/pharmacology ; Humans ; Models, Molecular ; Molecular Docking Simulation ; NAD/metabolism ; Oxidation-Reduction ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; Protease Inhibitors/chemistry ; Protease Inhibitors/pharmacology ; Viral Nonstructural Proteins/antagonists & inhibitors ; Viral Nonstructural Proteins/chemistry
    Chemical Substances Antiviral Agents ; HIV Protease Inhibitors ; Protease Inhibitors ; Viral Nonstructural Proteins ; NAD (0U46U6E8UK) ; 3C-like proteinase, Coronavirus (EC 3.4.22.-) ; Cysteine Endopeptidases (EC 3.4.22.-)
    Keywords covid19
    Language English
    Publishing date 2020-07-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12080805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: In Silico Insights into the SARS CoV-2 Main Protease Suggest NADH Endogenous Defences in the Control of the Pandemic Coronavirus Infection

    Martorana, Annamaria / Gentile, Carla / Lauria, Antonino

    Viruses. 2020 July 26, v. 12, no. 8

    2020  

    Abstract: COVID-19 is a pandemic health emergency faced by the entire world. The clinical treatment of the severe acute respiratory syndrome (SARS) CoV-2 is currently based on the experimental administration of HIV antiviral drugs, such as lopinavir, ritonavir, ... ...

    Abstract COVID-19 is a pandemic health emergency faced by the entire world. The clinical treatment of the severe acute respiratory syndrome (SARS) CoV-2 is currently based on the experimental administration of HIV antiviral drugs, such as lopinavir, ritonavir, and remdesivir (a nucleotide analogue used for Ebola infection). This work proposes a repurposing process using a database containing approximately 8000 known drugs in synergy structure- and ligand-based studies by means of the molecular docking and descriptor-based protocol. The proposed in silico findings identified new potential SARS CoV-2 main protease (Mᴾᴿᴼ) inhibitors that fit in the catalytic binding site of SARS CoV-2 Mᴾᴿᴼ. Several selected structures are NAD-like derivatives, suggesting a relevant role of these molecules in the modulation of SARS CoV-2 infection in conditions of cell chronic oxidative stress. Increased catabolism of NAD(H) during protein ribosylation in the DNA damage repair process may explain the greater susceptibility of the elderly population to the acute respiratory symptoms of COVID-19. The molecular modelling studies proposed herein agree with this hypothesis.
    Keywords COVID-19 infection ; DNA repair ; Human immunodeficiency virus ; NAD (coenzyme) ; antiviral agents ; binding sites ; catalytic activity ; computer simulation ; databases ; elderly ; metabolism ; molecular models ; oxidative stress ; pandemic ; proteinases
    Language English
    Dates of publication 2020-0726
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12080805
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet

    Caradonna, Fabio / Consiglio, Ornella / Luparello, Claudio / Gentile, Carla

    Nutrients. 2020 June 11, v. 12, no. 6

    2020  

    Abstract: The Mediterranean Diet (MD), UNESCO Intangible Cultural Heritage of Humanity, has become a scientific topic of high interest due to its health benefits. The aim of this review is to pick up selected studies that report nutrigenomic or nutrigenetic data ... ...

    Abstract The Mediterranean Diet (MD), UNESCO Intangible Cultural Heritage of Humanity, has become a scientific topic of high interest due to its health benefits. The aim of this review is to pick up selected studies that report nutrigenomic or nutrigenetic data and recapitulate some of the biochemical/genomic/genetic aspects involved in the positive health effects of the MD. These include (i) the antioxidative potential of its constituents with protective effects against several diseases; (ii) the epigenetic and epigenomic effects exerted by food components, such as Indacaxanthin, Sulforaphane, and 3-Hydroxytyrosol among others, and their involvement in the modulation of miRNA expression; (iii) the existence of predisposing or protective human genotypes due to allelic diversities and the impact of the MD on disease risk. A part of the review is dedicated to the nutrigenomic effects of the main cooking methods used in the MD and also to a comparative analysis of the nutrigenomic properties of the MD and other diet regimens and non-MD-related aliments. Taking all the data into account, the traditional MD emerges as a diet with a high antioxidant and nutrigenomic modulation power, which is an example of the “Environment-Livings-Environment” relationship and an excellent patchwork of interconnected biological actions working toward human health.
    Keywords Mediterranean diet ; United Nations Educational, Scientific and Cultural Organization ; antioxidant activity ; antioxidants ; cultural heritage ; epigenetics ; epigenome ; genomics ; human health ; humans ; microRNA ; nutrigenomics ; risk ; sulforaphane
    Language English
    Dates of publication 2020-0611
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12061748
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Phytochemical profile and antioxidant properties of the edible and non-edible portions of black sapote (Diospyros digyna Jacq.).

    Mannino, Giuseppe / Serio, Graziella / Bertea, Cinzia Margherita / Chiarelli, Roberto / Lauria, Antonino / Gentile, Carla

    Food chemistry

    2022  Volume 380, Page(s) 132137

    Abstract: This study evaluated the phytochemical profile and antioxidative properties of the edible and non-edible portions of black sapote. The phytochemical analysis highlighted the presence of several bioactive compounds, differently distributed among peel, ... ...

    Abstract This study evaluated the phytochemical profile and antioxidative properties of the edible and non-edible portions of black sapote. The phytochemical analysis highlighted the presence of several bioactive compounds, differently distributed among peel, pulp and seeds. In particular, the peel resulted rich of flavan-3-ols and proanthocyanidins, whereas seeds contained high amount of organic acids, including ferulic, citric and sinapic acids. Concerning functional properties, both edible and non-edible portions showed a significant prevention of lipid peroxidation in a cell-based model. Moreover, the results suggested that the antioxidant protection involved both redox active properties and gene expression modulation. Concerning redox active properties, peel extracts showed an antioxidant activity 7/12-fold higher than the edible portion, while seed extracts were more active in increasing catalase gene expression. The obtained results confirmed that black sapote is a good source of antioxidant phytochemicals and its non-edible portions have a great potential in the production of functional foods and supplements.
    MeSH term(s) Antioxidants ; Diospyros ; Phytochemicals ; Plant Extracts ; Polyphenols
    Chemical Substances Antioxidants ; Phytochemicals ; Plant Extracts ; Polyphenols
    Language English
    Publishing date 2022-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2022.132137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  10. Article: Biological Activity and Metabolomics of

    Mannino, Giuseppe / Serio, Graziella / Gaglio, Raimondo / Maffei, Massimo E / Settanni, Luca / Di Stefano, Vita / Gentile, Carla

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: Griffonia ... ...

    Abstract Griffonia simplicifolia
    Language English
    Publishing date 2023-09-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12091709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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