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  1. Book: Functional visual behavior

    Gentile, Michele

    a therapist's guide to evaluation and treatment options

    1997  

    Author's details Michele Gentile, ed
    Language English
    Size XX, 551 S. : Ill.
    Publisher American Occupational Therapist Organisation
    Publishing place Bethesda, Md
    Publishing country United States
    Document type Book
    HBZ-ID HT012830764
    ISBN 1-56900-071-9 ; 978-1-56900-071-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 A 5837 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Eukaryotic-driven directed evolution of Cas9 nucleases.

    Ruta, Giulia Vittoria / Ciciani, Matteo / Kheir, Eyemen / Gentile, Michele Domenico / Amistadi, Simone / Casini, Antonio / Cereseto, Anna

    Genome biology

    2024  Volume 25, Issue 1, Page(s) 79

    Abstract: Background: Further advancement of genome editing highly depends on the development of tools with higher compatibility with eukaryotes. A multitude of described Cas9s have great potential but require optimization for genome editing purposes. Among these, ...

    Abstract Background: Further advancement of genome editing highly depends on the development of tools with higher compatibility with eukaryotes. A multitude of described Cas9s have great potential but require optimization for genome editing purposes. Among these, the Cas9 from Campylobacter jejuni, CjCas9, has a favorable small size, facilitating delivery in mammalian cells. Nonetheless, its full exploitation is limited by its poor editing activity.
    Results: Here, we develop a Eukaryotic Platform to Improve Cas Activity (EPICA) to steer weakly active Cas9 nucleases into highly active enzymes by directed evolution. The EPICA platform is obtained by coupling Cas nuclease activity with yeast auxotrophic selection followed by mammalian cell selection through a sensitive reporter system. EPICA is validated with CjCas9, generating an enhanced variant, UltraCjCas9, following directed evolution rounds. UltraCjCas9 is up to 12-fold more active in mammalian endogenous genomic loci, while preserving high genome-wide specificity.
    Conclusions: We report a eukaryotic pipeline allowing enhancement of Cas9 systems, setting the ground to unlock the multitude of RNA-guided nucleases existing in nature.
    MeSH term(s) Animals ; CRISPR-Cas Systems ; Gene Editing ; Genome ; Mammals/genetics
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1474-760X
    ISSN (online) 1474-760X
    ISSN 1474-760X
    DOI 10.1186/s13059-024-03215-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Micropulse Laser Trabeculoplasty with 577 nm Wavelength at 1500 or 1000 mW for Primary Open-Angle Glaucoma: A Pilot Study.

    Verdina, Tommaso / Gironi, Matteo / Battaglia, Bruno / Gentile, Michele / Chester, Johanna / Kaleci, Shaniko / Scatigna, Gianluca / Mastropasqua, Rodolfo / Cavallini, Gian Maria

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: ... ...

    Abstract Aim
    Language English
    Publishing date 2023-04-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13040982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book: Functional visual behavior

    Gentile, Michele

    a therapist's guide to evaluation and treatment options

    1997  

    Author's details Michele Gentile, editor
    MeSH term(s) Vision Disorders/rehabilitation ; Visual Perception ; Occupational Therapy
    Language English
    Size xx, 551 p. :, ill.
    Publisher American Occupational Therapy Association
    Publishing place Bethesda, MD
    Document type Book
    ISBN 9781569000717 ; 1569000719
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Book ; Online: AI-based Data Preparation and Data Analytics in Healthcare

    Maranghi, Marianna / Anagnostopoulos, Aris / Cannistraci, Irene / Chatzigiannakis, Ioannis / Croce, Federico / Di Teodoro, Giulia / Gentile, Michele / Grani, Giorgio / Lenzerini, Maurizio / Leonardi, Stefano / Mastropietro, Andrea / Palagi, Laura / Pappa, Massimiliano / Rosati, Riccardo / Valentini, Riccardo / Velardi, Paola

    The Case of Diabetes

    2022  

    Abstract: The Associazione Medici Diabetologi (AMD) collects and manages one of the largest worldwide-available collections of diabetic patient records, also known as the AMD database. This paper presents the initial results of an ongoing project whose focus is ... ...

    Abstract The Associazione Medici Diabetologi (AMD) collects and manages one of the largest worldwide-available collections of diabetic patient records, also known as the AMD database. This paper presents the initial results of an ongoing project whose focus is the application of Artificial Intelligence and Machine Learning techniques for conceptualizing, cleaning, and analyzing such an important and valuable dataset, with the goal of providing predictive insights to better support diabetologists in their diagnostic and therapeutic choices.

    Comment: The work has been presented at the conference Ital-IA 2022 (https://www.ital-ia2022.it/)
    Keywords Computer Science - Machine Learning ; Computer Science - Databases
    Publishing date 2022-06-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Book: Il Regesto del Codice Pelavicino

    Lupo Gentile, Michele

    (Atti della Società ligure di storia patria ; 44)

    1912  

    Author's details con 2 facs. e note ill. del Prof. Michele Lupo Gentile
    Series title Atti della Società ligure di storia patria ; 44
    Language Italian
    Size XII, 734 S, 4"(8")
    Publisher Soc
    Publishing place Genova
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  7. Book: Gli Annales Pisani

    Maragone, Bernardo / Carducci, Giosue / Lupo Gentile, Michele Lupo / Muratori, Lodovico Antonio

    (Rerum Italicarum scriptores ; : raccolta degli storici italiani dal cinquecento al millecinquecento / ordinata da L. A. Muratori ; T. 6, Pt. 2)

    1936  

    Title variant Chronicon Pisanum seu fragmentum auctoris incerti ; Chronicon aliud breve Pisanum incerti auctoris ab anno MCI usque ad annum MCCLXVIII ; Gesta triumphalia per Pisanos facta de captione Hierusalem et civitatis Maioricarum et aliarum civitatum et de triumpho habito contra Ianuenses
    Author's details di Bernardo Maragone. A cura di Michele Lupo Gentile. Seguono in Appendice: 1. Gesta triumphalia per Pisanos facta de captione Hierusalem et civitatis Maioricarum et aliarum civitatum et de triumpho habito contra Ianuenses. 2. Chronicon Pisanum seu fragmentum auctoris incerti. 3. Chronicon aliud breve Pisanum incerti auctoris ab anno MCI usque ad annum MCCLXVIII
    Series title Rerum Italicarum scriptores
    : raccolta degli storici italiani dal cinquecento al millecinquecento / ordinata da L. A. Muratori ; T. 6, Pt. 2
    Language Latin ; Italian
    Size XX, 223 S, 2 Abb
    Edition Nuova ed. riv., ampliata e corr. con la dir. di Giosue Carducci ...
    Publisher Zanichelli
    Publishing place Bologna
    Document type Book
    Note Erscheinungsbeginn: 1930
    Database Former special subject collection: coastal and deep sea fishing

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