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Article ; Online: Gut Microbiota Association with Diverticular Disease Pathogenesis and Progression: A Systematic Review.

Reitano, Elisa / Francone, Elisa / Bona, Elisa / Follenzi, Antonia / Gentilli, Sergio

2022 Volume 68, Issue 3, Page(s) 913–921

Abstract: Introduction: Growing evidence supports the role of the intestinal microbiome in the development of different intestinal and extraintestinal diseases. Diverticular disease (DD) is one of the most common disorders in western countries. In the last years, ...

Abstract	Introduction: Growing evidence supports the role of the intestinal microbiome in the development of different intestinal and extraintestinal diseases. Diverticular disease (DD) is one of the most common disorders in western countries. In the last years, different articles have suggested a possible role of the intestinal microbiome in DD pathogenesis and in the development of acute diverticulitis (AD). This systematic review aimed to clarify the current knowledge on the role of the intestinal microbiome in colonic diverticulitis in different stages according to the 2009 PRISMA guidelines. Materials and methods: Two independent reviewers searched the literature in a systematic manner through online databases, including Medline, Scopus, Embase, Cochrane Oral Health Group Specialized Register, ProQuest Dissertations and Theses Database, and Google Scholar. Patients with any stage of disease were included. The Newcastle-Ottawa scale for case-control and cohort studies was used for the quality assessment of the selected articles. Results: Overall, nine studies were included in the review. Only one article was focused on patients with AD, while all other articles only considered patients with DD without acute inflammation signs. Enterobacteriaceae seems to be the microbiota most associated with the disease, followed by Bifidobacteria. Conclusions: All the included studies showed great heterogeneity in population characteristics and sampling methods. Therefore, given the high prevalence of colonic diverticulitis in the general population, further studies are needed to clarify the role of the intestinal microbiome, paving the way to new target therapies with important social implications.
MeSH term(s)	Humans ; Diverticulitis, Colonic ; Gastrointestinal Microbiome ; Diverticular Diseases/etiology ; Diverticulitis/epidemiology ; Intestines
Language	English
Publishing date	2022-07-07
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-022-07600-x
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Article ; Online: Colorectal surgery in elderly patients: our experience with DaVinci Xi® System.

Oldani, A / Bellora, P / Monni, M / Amato, B / Gentilli, S

Aging clinical and experimental research

2017 Volume 29, Issue Suppl 1, Page(s) 91–99

Abstract: Background: Robotic technology for colorectal surgery was introduced by Weber in 2002 to improve the benefits of the minimally invasive surgery already offered by the laparoscopic approach.: Aims: To evaluate the feasibility and the efficacy of the ... ...

Abstract	Background: Robotic technology for colorectal surgery was introduced by Weber in 2002 to improve the benefits of the minimally invasive surgery already offered by the laparoscopic approach. Aims: To evaluate the feasibility and the efficacy of the application of robotic surgery in elderly patients affected by colorectal diseases. Methods: We reported the outcomes obtained during our first 50 colorectal robotic surgical performances with DaVinci Xi® System, and we compared the results assessed for patients younger or older than 70 years. Results: We examined 28 patients younger and 22 older than 70 years who underwent colorectal robotic surgery in our institution from September 2014 to June 2016. We performed 15 right colectomies, 20 left colectomies, 15 rectal resections. Mean ASA score was significantly higher in the Elderly Group. No statistically significant differences have been revealed in terms of post-operative morbidity, hospital stay, first diet intake, first flatus canalization and oncological outcome. Discussion: According to the prolonged operative time, robotic technology was initially reserved to young patients with good performance status in order to avoid systemic failures in elderly patients suffering from pre-existent comorbidities. Otherwise, once robotic approach safety and benefits in terms of better systemic outcomes were demonstrated, it started to be performed in elderly patients with satisfactory outcomes. Conclusion: Our experience revealed that robotic surgical approach is safe, feasible and offers many systemic benefits in elderly patients also with high ASA score. Age alone has not to be considered as exclusion criteria for robotic approach.
MeSH term(s)	Aged ; Colectomy/adverse effects ; Colectomy/methods ; Colorectal Neoplasms/surgery ; Feasibility Studies ; Female ; Humans ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Length of Stay ; Male ; Operative Time ; Outcome and Process Assessment (Health Care) ; Risk Adjustment ; Robotic Surgical Procedures/adverse effects ; Robotic Surgical Procedures/instrumentation ; Robotic Surgical Procedures/methods
Language	English
Publishing date	2017-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-016-0670-y
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Article ; Online: MicroRNAs differential expression profile in metastatic colorectal cancer: A pilot study with literature review.

Francone, Elisa / Gentilli, Sergio / Santori, Gregorio / Stabilini, Cesare / Fornaro, Rosario / Frascio, Marco

Surgical oncology

2021 Volume 37, Page(s) 101524

Abstract: Background and objectives: Colorectal cancer is still one of the leading causes of cancer-related deaths worldwide and specific tools to improve disease assessment and treatment response are advocated. The aim of this study was to analyze miRNAs ... ...

Abstract	Background and objectives: Colorectal cancer is still one of the leading causes of cancer-related deaths worldwide and specific tools to improve disease assessment and treatment response are advocated. The aim of this study was to analyze miRNAs expression in metastatic and non-metastatic colorectal cancer, in order to identify reliable biomarkers suitable for prognosis, treatment and patient's monitoring. Material and methods: Among 25 patients (mean age 71 ± 12 years; Female/Male: 12/13) submitted to laparoscopic colorectal resection between August 2017 and February 2019, miRNAs were extracted from fresh frozen tissues of solid tumors. Gene expression's analysis arising from microarray technology was performed. Results: Pathological evaluation identified 15 metastatic patients (8 presenting with stage III and 7 with stage IV cancers) and 10 non-metastatic patients (4 presenting with stage I and 6 stage II cancers). Bioinformatic analysis of solid biopsies revealed 16 miRNAs (11 upregulated and 5 downregulated) differently expressed between metastatic and non-metastatic groups, with three miRNAs (miR-7515, miR-7109-5p and miR-6831-5p) never linked to colorectal cancer before. Conclusions: Our study showed an association between miRNAs and metastatic colorectal cancer, suggesting their potential role as biomarkers for tumor management, if confirmed by further studies.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Female ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; Neoplasm Metastasis/genetics ; Neoplasm Metastasis/pathology ; Pilot Projects ; Prospective Studies
Chemical Substances	Biomarkers, Tumor ; MicroRNAs
Language	English
Publishing date	2021-01-31
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1107810-8
ISSN	1879-3320 ; 0960-7404
ISSN (online)	1879-3320
ISSN	0960-7404
DOI	10.1016/j.suronc.2021.101524
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Article: A rare case of Calot's triangle paraganglioma

Oldani, A. / Boldorini, R. / Spina, P. / Gentilli, S.

European surgery

2017 Volume 49, Issue 5, Page(s) 244

Language	English ; German
Document type	Article
ZDB-ID	2073941-2
ISSN	1682-8631 ; 1682-1769
Database	Current Contents Medicine

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Article: Butyrate Inhibits Colorectal Cancer Cell Proliferation through Autophagy Degradation of β-Catenin Regardless of

Garavaglia, Beatrice / Vallino, Letizia / Ferraresi, Alessandra / Esposito, Andrea / Salwa, Amreen / Vidoni, Chiara / Gentilli, Sergio / Isidoro, Ciro

Biomedicines

2022 Volume 10, Issue 5

Abstract: Colorectal cancer (CRC) pathogenesis is mainly driven by alterations in WNT signaling, which results in altered transcriptional activity of β-Catenin. Mutations ... ...

Abstract	Colorectal cancer (CRC) pathogenesis is mainly driven by alterations in WNT signaling, which results in altered transcriptional activity of β-Catenin. Mutations in
Language	English
Publishing date	2022-05-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10051131
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Article: Thin metallic thread in the gastrointestinal tract: an uncommon complication after coil embolization of a visceral pseudoaneurysm.

Paladini, A / Guzzardi, G / Stanca, C / Del Sette, B / Tettoni, S / Negroni, D / Cernigliaro, M / Galbiati, A / Spinetta, M / Gentilli, S / Carriero, A

Journal of biological regulators and homeostatic agents

2020 Volume 34, Issue 5, Page(s) 1955–1957

MeSH term(s)	Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aneurysm, False/therapy ; Embolization, Therapeutic/adverse effects ; Gastrointestinal Tract ; Humans ; Stents
Language	English
Publishing date	2020-11-26
Publishing country	Italy
Document type	Letter
ZDB-ID	639196-5
ISSN	1724-6083 ; 0393-974X
ISSN (online)	1724-6083
ISSN	0393-974X
DOI	10.23812/20-315-L
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Article ; Online: Learning curve for laparoscopic cholecystectomy has not been defined: A systematic review.

Reitano, Elisa / de'Angelis, Nicola / Schembari, Elena / Carrà, Maria Clotilde / Francone, Elisa / Gentilli, Sergio / La Greca, Gaetano

ANZ journal of surgery

2021 Volume 91, Issue 9, Page(s) E554–E560

Abstract: Background: Laparoscopic cholecystectomy is one of the most performed surgeries worldwide but its learning curve is still unclear.: Methods: A systematic review was conducted according to the 2009 Preferred Reporting Items for Systematic Reviews and ... ...

Abstract	Background: Laparoscopic cholecystectomy is one of the most performed surgeries worldwide but its learning curve is still unclear. Methods: A systematic review was conducted according to the 2009 Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Two independent reviewers searched the literature in a systematic manner through online databases, including Medline, Scopus, Embase, and Google Scholar. Human studies investigating the learning curve of laparoscopic cholecystectomy were included. The Newcastle-Ottawa scale for cohort studies and the GRADE scale were used for the quality assessment of the selected articles. Results: Nine cohort studies published between 1991 and 2020 were included. All studies showed a great heterogeneity among the considered variables. Seven articles (77.7%) assessed intraoperative variables only, without considering patient's characteristics, operator's experience, and grade of gallbladder inflammation. Only five articles (55%) provided a precise cut-off value to see proficiency in the learning curve, ranging from 13 to 200 laparoscopic cholecystectomies. Conclusions: The lack of clear guidelines when evaluating the learning curve in surgery, probably contributed to the divergent data and heterogeneous results among the studies. The development of guidelines for the investigation and reporting of a surgical learning curve would be helpful to obtain more objective and reliable data especially for common operation such as laparoscopic cholecystectomy.
MeSH term(s)	Cholecystectomy, Laparoscopic ; Humans ; Learning Curve
Language	English
Publishing date	2021-06-28
Publishing country	Australia
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2050749-5
ISSN	1445-2197 ; 1445-1433 ; 0004-8682
ISSN (online)	1445-2197
ISSN	1445-1433 ; 0004-8682
DOI	10.1111/ans.17021
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Article ; Online: Ultrastructural analysis of different-made staplers' staples.

Gentilli, S / Portigliotti, L / Surico, D / Milanesio, M / Gatti, G

Techniques in coloproctology

2013 Volume 17, Issue 6, Page(s) 683–685

MeSH term(s)	Microscopy, Electron, Scanning ; Sutures
Language	English
Publishing date	2013-12
Publishing country	Italy
Document type	Comparative Study ; Journal Article
ZDB-ID	2083309-X
ISSN	1128-045X ; 1123-6337
ISSN (online)	1128-045X
ISSN	1123-6337
DOI	10.1007/s10151-012-0941-3
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Article ; Online: Ileal endometriosis and Crohn's disease: an unusual association causing acute bowel obstruction.

Oldani, Alberto / Monni, Manuela / Gentilli, Sergio

Annali italiani di chirurgia

2016 Volume 87, Issue ePub

Abstract: Aim: Endometriosis is a commun health disorder in women, which is defined as the presence of bowel endometrial-like tissue outside the uterus. Bowel endometriosis occurs in approximately10% pf all cases, with ileal localization as a very rare clinical ... ...

Abstract	Aim: Endometriosis is a commun health disorder in women, which is defined as the presence of bowel endometrial-like tissue outside the uterus. Bowel endometriosis occurs in approximately10% pf all cases, with ileal localization as a very rare clinical intestinal occlusion:acute intestinal obstruction is possible presentation of this disease. We report a case of a patient with known history of Crohn's treated with ileal resection for acute intestinal occlusion;histology showed the coexistence of IBD and endometriosis in the intestinal wall. Case report: A 35 years old female patient, with previous diagnosis of Crohn's disease confirmed by endoscopic biopsies, was admitted to our Institutions because oc acute intestinal obstruction. She previously suffered of dysmenorrhea and pelvic pain during menstration. A contrast enhanced CT abdominal scan was performed with evidence of diffuse small bowel fluid distension and thickening of terminal iileum wall, compatible with ilea stenosis in acute Crohn disease. Results: The patient underwent laparoscopic resection of distal ileus. Definitive histological examination showed ileal wall with multiple endometriosis foci and chronic follicular flogosis. Conclusion: The case that we have described shows a rare co-existence of the two clinical entitle (Crohn's disease and ileal deep endometriosis), histologically demonstrated, with acute presentation as intestinal obstruction, susseflully treated with laparoscopic ileal resection KEY WORDS Bowel obstruction, Crohn's disease, Endometriosis.
MeSH term(s)	Adult ; Crohn Disease/complications ; Diagnosis, Differential ; Endometriosis/complications ; Endometriosis/diagnosis ; Endometriosis/surgery ; Female ; Humans ; Ileum/surgery ; Intestinal Obstruction/diagnosis ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Laparoscopy ; Treatment Outcome
Language	English
Publishing date	2016-03-23
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
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Article ; Online: Genistein improves viability, proliferation and mitochondrial function of cardiomyoblasts cultured in physiologic and peroxidative conditions.

Farruggio, Serena / Raina, Giulia / Cocomazzi, Grazia / Librasi, Carlotta / Mary, David / Gentilli, Sergio / Grossini, Elena

International journal of molecular medicine

2019 Volume 44, Issue 6, Page(s) 2298–2310

Abstract: Phytoestrogens exert protective effects on the cardiovascular system through mechanisms that have yet to be clearly demonstrated. The aim of this study was to evaluate the protective effects exerted by genistein on cardiomyoblasts (H9C2) against ... ...

Abstract	Phytoestrogens exert protective effects on the cardiovascular system through mechanisms that have yet to be clearly demonstrated. The aim of this study was to evaluate the protective effects exerted by genistein on cardiomyoblasts (H9C2) against oxidative stress, nitric oxide (NO) release, viability, proliferation/migration and mitochondrial function. H9C2 cultured in physiological or peroxidative conditions, were treated with genistein in the absence or presence of estrogen receptors (ERs), G protein‑coupled‑estrogenic‑receptors (GPER), Akt, extracellular‑signal‑regulated kinases 1/2 (ERK1/2) and p38 mitogen activated protein kinase (p38MAPK) blockers. Cell viability, proliferation, migration, mitochondrial membrane potential, mitochondrial oxygen consumption and oxidant/antioxidant system, were measured by specific assays. Western blot assay was used for the analysis of NO synthase (NOS) subtypes' and expression and activation of various kinases. In all experiments 17β‑estradiol was used for comparison. The results showed that phytoestrogens and estrogens can increase cell viability, proliferation/migration and improve mitochondrial membrane potential and oxygen consumption of H9C2. Furthermore, NO release was modulated by genistein and 17β‑estradiol. These effects were reduced or abolished by the pre‑treatment with ERs, GPER, Akt, ERK1/2 and p38MAPK blockers. Finally, a reduction of reactive oxygen species production and an increase of glutathione content was found in response to the two agents. In H9C2 cultured in physiological conditions, genistein induced endothelial NOS‑dependent NO production through the involvement of estrogenic receptors and by the modulation of intracellular signalling related to Akt, ERK1/2, and p38MAPK. Moreover, estrogens and phytoestrogens protected H9C2 against oxidative stress by reducing inducible NOS expression and through the modulation of the antioxidant system and mitochondrial functioning.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Gene Expression Regulation/drug effects ; Genistein/pharmacology ; MAP Kinase Signaling System/genetics ; Mitochondria/drug effects ; Myoblasts, Cardiac/drug effects ; Nitric Oxide Synthase/genetics ; Oxidative Stress/drug effects ; Rats ; Reactive Oxygen Species/metabolism ; Receptors, Estrogen/genetics ; Receptors, G-Protein-Coupled/genetics ; Signal Transduction/drug effects
Chemical Substances	Gper1 protein, rat ; Reactive Oxygen Species ; Receptors, Estrogen ; Receptors, G-Protein-Coupled ; Genistein (DH2M523P0H) ; Nitric Oxide Synthase (EC 1.14.13.39)
Language	English
Publishing date	2019-10-03
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1444428-8
ISSN	1791-244X ; 1107-3756
ISSN (online)	1791-244X
ISSN	1107-3756
DOI	10.3892/ijmm.2019.4365
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