LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Geoffrey P. Dobson"
  2. AU="Hyland, Andrew"
  3. AU="Helio Garcia Leite"
  4. AU="Chang, Yi-Yao"
  5. AU="Ren, Xiangzhong"
  6. AU="Ha, Van Thi Cam"
  7. AU="Zheng, Jinhong"
  8. AU="Tomatis-Souverbielle, Cristiana"
  9. AU="Al-Jumaily, Adel A"
  10. AU="Marallo, Carmine"
  11. AU="Alshammari, Afraj"
  12. AU="Min, Dong-Joon"
  13. AU=Fattorini Daniele AU=Fattorini Daniele
  14. AU="Lou, L X"
  15. AU="Yadollah Haji-Heydari"
  16. AU="Placidi, A"
  17. AU="Olivé, Claudia"
  18. AU="Türk, Y"
  19. AU="Brosnan, Hannah"
  20. AU="Hardy, Rowan S"
  21. AU="Demirci, Yılmaz Mehmet"
  22. AU="Dlugosz, Andrzej A"

Suchergebnis

Treffer 1 - 8 von insgesamt 8

Suchoptionen

  1. Artikel ; Online: Wired to Doubt

    Geoffrey P. Dobson

    Frontiers in Medicine, Vol

    Why People Fear Vaccines and Climate Change and Mistrust Science

    2022  Band 8

    Abstract: We all want to be right in our thinking. Vaccine hesitancy and global warming denial share much in common: (1) both are threats to personal, community and global health, (2) action is contingent on co-operation and social policy, and (3) public support ... ...

    Abstract We all want to be right in our thinking. Vaccine hesitancy and global warming denial share much in common: (1) both are threats to personal, community and global health, (2) action is contingent on co-operation and social policy, and (3) public support relies on trust in science. The irony is, however, as the science has become more convincing, public opinion has become more divided. A number of early polls showed that ~70% of people supported COVID-19 vaccine use and global warming, ~20% adopted a wait-and-see approach, and ~10% were staunch objectors. Although these percentages are approximate, what factors are responsible for the differences in engagement, doubt and distrust? How can we reduce the consensus gap? One approach is to return to grass roots and provide a brief history of the issues, understand the difference between fact and opinion, truth and falsehood, the problem of certainty, and how scientific consensus is reached. To doubt is a healthy response to new information, and it too has a scientific basis. Doubt and distrust reside in that region of the brain called the dorsolateral prefrontal cortex, which is responsible for suppressing unwanted representations. Bridging the consensus gap requires shifting human thinking patterns from doubt to belief, and belief to action. Education and improved public messaging are key, and social media providers require urgent oversight or regulation to remove false and harmful/dangerous content from our digital lives. Delays to vaccinate and failure to reduce greenhouse gases will dramatically change the way we live. The new norm may be more deadly COVID variants, strained healthcare systems, extreme weather patterns, diminished food supply, delays in goods and services, damage to world's economies and widespread global instability.
    Schlagwörter science ; truth ; climate change ; social media ; education ; coronavirus ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 306
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

  2. Artikel ; Online: Science and the War on Truth and Coronavirus

    Geoffrey P. Dobson

    Frontiers in Medicine, Vol

    2020  Band 7

    Schlagwörter science ; coronavirus ; truth ; university ; society ; funding ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2020-09-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

  3. Artikel ; Online: Immune dysfunction following severe trauma

    Geoffrey P. Dobson / Jodie L. Morris / Hayley L. Letson

    Frontiers in Medicine, Vol

    A systems failure from the central nervous system to mitochondria

    2022  Band 9

    Abstract: When a traumatic injury exceeds the body’s internal tolerances, the innate immune and inflammatory systems are rapidly activated, and if not contained early, increase morbidity and mortality. Early deaths after hospital admission are mostly from central ... ...

    Abstract When a traumatic injury exceeds the body’s internal tolerances, the innate immune and inflammatory systems are rapidly activated, and if not contained early, increase morbidity and mortality. Early deaths after hospital admission are mostly from central nervous system (CNS) trauma, hemorrhage and circulatory collapse (30%), and later deaths from hyperinflammation, immunosuppression, infection, sepsis, acute respiratory distress, and multiple organ failure (20%). The molecular drivers of secondary injury include damage associated molecular patterns (DAMPs), pathogen associated molecular patterns (PAMPs) and other immune-modifying agents that activate the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic stress response. Despite a number of drugs targeting specific anti-inflammatory and immune pathways showing promise in animal models, the majority have failed to translate. Reasons for failure include difficulty to replicate the heterogeneity of humans, poorly designed trials, inappropriate use of specific pathogen-free (SPF) animals, ignoring sex-specific differences, and the flawed practice of single-nodal targeting. Systems interconnectedness is a major overlooked factor. We argue that if the CNS is protected early after major trauma and control of cardiovascular function is maintained, the endothelial-glycocalyx will be protected, sufficient oxygen will be delivered, mitochondrial energetics will be maintained, inflammation will be resolved and immune dysfunction will be minimized. The current challenge is to develop new systems-based drugs that target the CNS coupling of whole-body function.
    Schlagwörter trauma ; hemorrhage ; immune ; inflammation ; mitochondria ; system ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-08-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: Adenosine, Lidocaine and Magnesium (ALM) therapy modulates early sex-specific inflammatory and immune responses following experimental anterior cruciate ligament rupture and reconstruction

    Jodie L. Morris / Peter C. McEwen / Hayley L. Letson / Geoffrey P. Dobson

    Translational Medicine Communications, Vol 8, Iss 1, Pp 1-

    2023  Band 17

    Abstract: Abstract Background Early dysregulation of local and systemic inflammatory and immune responses is implicated in the pathogenesis of fibrotic and degenerative complications after anterior cruciate ligament reconstruction (ACLR) surgery. In other surgical ...

    Abstract Abstract Background Early dysregulation of local and systemic inflammatory and immune responses is implicated in the pathogenesis of fibrotic and degenerative complications after anterior cruciate ligament reconstruction (ACLR) surgery. In other surgical trauma models, ALM therapy has been shown to blunt inflammation, leading to a more permissive healing environment in injured tissues. The purpose of this study was to evaluate sex-specific effects of surgery and perioperative ALM therapy on leukocyte mobilization and activation, and systemic and joint tissue inflammation in a rat model of ACL rupture and reconstruction. Methods Adult male and female Sprague–Dawley rats were randomly divided into ALM (male, n = 15; female, n = 14) or Saline control (male, n = 13; female, n = 14) treatment groups. Three days after non-invasive ACL rupture, ACLR surgery was performed on the injured knee. Animals received a 1 h perioperative IV ALM or saline drip, and a 0.1 ml IA bolus of ALM or saline, and were monitored to 120 h postoperative. Hematology, leukocyte immunophenotyping, plasma and synovial inflammatory mediator concentrations, and joint tissue histopathology and gene expression of inflammatory markers were assessed. Results Following ACLR surgery, plasma concentrations of inflammatory cytokines IL-6, TNF-α and IL-1β peaked later and at a higher magnitude in females compared to males, with ALM dampening this systemic inflammatory response. At 1 h postoperative, ALM boosted circulating B cell numbers in males and females, and decreased neutrophil activation in females. By 72 h, numbers of circulating T cells with immunoregulatory potential were increased in all ALM-treated animals compared to Saline controls, and corresponded to a significant reduction in synovial TNF-α concentrations within the operated knees. Sex-specific treatment differences were found in inflammatory and immune profiles in the synovial fluid and joint tissues. Inflammatory cell infiltration and gene expression of markers of inflammation (Nfκb, ...
    Schlagwörter Anterior cruciate ligament ; ACL rupture ; ACL reconstruction ; Sex differences ; Inflammation ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2023-07-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

  5. Artikel ; Online: ALM Therapy Promotes Functional and Histologic Regeneration of Traumatized Peripheral Skeletal Muscle

    Nina Sarah Hoeger / Thomas Mittlmeier / Brigitte Vollmar / Ioannis Stratos / Geoffrey P. Dobson / Robert Rotter

    Biology, Vol 12, Iss 870, p

    2023  Band 870

    Abstract: Skeletal muscle trauma is a common injury with a range of severity. Adenosine, lidocaine and Mg 2+ (ALM) is a protective solution and improves tissue perfusion and coagulopathy. Male Wistar rats were anesthetized and subjected to standardized skeletal ... ...

    Abstract Skeletal muscle trauma is a common injury with a range of severity. Adenosine, lidocaine and Mg 2+ (ALM) is a protective solution and improves tissue perfusion and coagulopathy. Male Wistar rats were anesthetized and subjected to standardized skeletal muscle trauma of the left soleus muscle with the protection of the neurovascular structures. Seventy animals were randomly assigned to saline control or ALM. Immediately after trauma, a bolus of ALM solution was applied intravenously, followed by a one-hour infusion. After 1, 4, 7, 14 and 42 days, the biomechanical regenerative capacity was examined using incomplete tetanic force and tetany, and immunohistochemistry was used to examine for proliferation and apoptosis characteristics. Biomechanical force development showed a significant increase following ALM therapy for incomplete tetanic force and tetany on days 4 and 7. In addition, the histological evaluation showed a significant increase in proliferative BrdU-positive cells with ALM therapy on days 1 and 14. Ki67 histology also detected significantly more proliferative cells on days 1, 4, 7, 14 and 42 in ALM-treated animals. Furthermore, a simultaneous decrease in the number of apoptotic cells was observed using the TUNEL method. ALM solution showed significant superiority in biomechanical force development and also a significant positive effect on cell proliferation in traumatized skeletal muscle tissue and reduced apoptosis.
    Schlagwörter muscle regeneration ; apoptosis ; ALM solution ; muscle crush injury ; muscle contraction force ; proliferation ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

  6. Artikel ; Online: Female rats have a different healing phenotype than males after anterior cruciate ligament rupture with no intervention

    Jodie L. Morris / Hayley L. Letson / Erik Biros / Peter C. McEwen / Geoffrey P. Dobson

    Frontiers in Medicine, Vol

    2022  Band 9

    Abstract: Little is known on the sex-specific healing responses after an anterior cruciate ligament (ACL) rupture. To address this, we compared male and female Sprague-Dawley rats following non-surgical ACL rupture. Hematology, inflammation, joint swelling, range ... ...

    Abstract Little is known on the sex-specific healing responses after an anterior cruciate ligament (ACL) rupture. To address this, we compared male and female Sprague-Dawley rats following non-surgical ACL rupture. Hematology, inflammation, joint swelling, range of motion, and pain-sensitivity were analyzed at various times over 31-days. Healing was assessed by histopathology and gene expression changes in the ACL remnant and adjacent joint tissues. In the first few days, males and females showed similar functional responses after rupture, despite contrasting hematology and systemic inflammatory profiles. Sex-specific differences were found in inflammatory, immune and angiogenic potential in the synovial fluid. Histopathology and increased collagen and fibronectin gene expression revealed significant tissue remodeling in both sexes. In the ACL remnant, however, Acta2 gene expression (α-SMA production) was 4-fold higher in males, with no change in females, indicating increased fibroblast-to-myofibroblast transition with higher contractile elements (stiffness) in males. Females had 80% lower Pparg expression, which further suggests reduced cellular differentiation potential in females than males. Sex differences were also apparent in the infrapatellar fat pad and articular cartilage. We conclude females and males showed different patterns of healing post-ACL rupture over 31-days, which may impact timing of reconstruction surgery, and possibly clinical outcome.
    Schlagwörter anterior cruciate ligament ; ACL rupture ; sex differences ; inflammation ; healing ; tissue remodeling ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 590 ; 610
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

  7. Artikel ; Online: Conventional and Specific-Pathogen Free Rats Respond Differently to Anesthesia and Surgical Trauma

    Hayley L. Letson / Jodie Morris / Erik Biros / Geoffrey P. Dobson

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Band 8

    Abstract: Abstract Specific-pathogen free (SPF) animals were introduced in the 1960s to minimize disease and infection as variables in biomedical research. Our aim was to examine differences in physiological response in rat colonies bred and housed in a ... ...

    Abstract Abstract Specific-pathogen free (SPF) animals were introduced in the 1960s to minimize disease and infection as variables in biomedical research. Our aim was to examine differences in physiological response in rat colonies bred and housed in a conventional versus SPF facility, and implications for research. Sprague-Dawley rats were anesthetized and catheterized for blood and pressure monitoring, and electrocardiogram (ECG) leads implanted. Hematology was assessed, and coagulation profile using rotational thromboelastometry. Health screening was outsourced to Cerberus Sciences. SPF rats had significantly lower pulse pressure (38% decrease), arrhythmias and prolonged QTc (27% increase) compared to conventional rats. No arrhythmias were found in conventional rats. SPF rats had significantly higher white cell, monocyte, neutrophil and lymphocyte counts, and were hyperfibrinolytic, indicated by EXTEM maximum lysis >15%. Independent assessment revealed similar pathogen exclusion between colonies, with the exception of Proteus in SPF animals. Returning to a conventional facility restored normal host physiology. We conclude that SPF animals displayed an abnormal hemodynamic, hematological and hemostatic phenotype in response to anesthesia and surgery, and provide a number of recommendations to help standardize research outcomes and translation.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

  8. Artikel ; Online: Intra-articular Adenosine, Lidocaine and Magnesium (ALM) solution decreases postoperative joint fibrosis in an experimental knee implant model

    Jodie L. Morris / Hayley L. Letson / Peter McEwen / Erik Biros / Constantin Dlaska / Kaushik Hazratwala / Matthew Wilkinson / Geoffrey P. Dobson

    Translational Medicine Communications, Vol 6, Iss 1, Pp 1-

    2021  Band 13

    Abstract: Abstract Background There is currently no drug therapy to prevent arthrofibrosis following knee surgery. We aimed to determine if the anti-ischemic and anti-inflammatory drug adenosine, lidocaine and Mg2+ (ALM), reduces surgery-related arthrofibrosis in ... ...

    Abstract Abstract Background There is currently no drug therapy to prevent arthrofibrosis following knee surgery. We aimed to determine if the anti-ischemic and anti-inflammatory drug adenosine, lidocaine and Mg2+ (ALM), reduces surgery-related arthrofibrosis in a rat model of knee implant surgery. Methods Male Sprague-Dawley rats (n = 24) were randomly divided into ALM or saline groups. The right knee of each animal was implanted with custom titanium (femur) and polyethylene (tibia) implants, and the left knee served as a non-operated control. An intra-articular ALM or saline bolus (0.1 ml) was administered at the end of surgery, and animals monitored for 4 weeks. Fibrotic changes were assessed by macroscopic examination, histopathology, and expression of key inflammatory and fibrotic markers in the joint capsule and infrapatellar fat pad (IFP). Results Knee swelling was evident in both groups at 4 weeks. However, range of motion was 2-fold higher in the ALM-treated knees, and differences in macroscopic pathology indicated improved healing, compared to the control group. Histologically, ALM treatment also led to significantly decreased synovitis and fibrotic pathology in the joint capsule and IFP compared to saline controls. RNA and protein expression profiles of pro-fibrotic mediators (α-SMA, TGF-β1, FGF1, PDGFA) were also significantly lower in knees from ALM-treated animals. In addition, the expression of inflammatory mediators was lower in plasma (IL-1β, IL-10) and joint tissue (NFκB, IL-1β, IL-12), 4 weeks after surgery. Conclusion We show that intra-articular administration of a single ALM bolus significantly decreased fibrotic pathology and synovitis in an experimental model of knee implant surgery, by blunting inflammation and modulating essential genes of fibrosis. ALM has the therapeutic potential for translation into humans undergoing knee replacement surgery.
    Schlagwörter Total knee arthroplasty ; Stiffness ; Arthrofibrosis ; Inflammation ; Medicine ; R
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang