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Article ; Online: Technical note: The use of a silicone prosthesis for the closure of a tracheoesophageal fistula.

Holmes, Matthew J V / George, Ajith

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

2022 Volume 47, Issue 3, Page(s) 483–485

MeSH term(s)	Humans ; Laryngectomy ; Larynx, Artificial ; Prosthesis Implantation ; Silicones ; Tracheoesophageal Fistula/surgery
Chemical Substances	Silicones
Language	English
Publishing date	2022-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2205891-6
ISSN	1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
ISSN (online)	1749-4486
ISSN	1749-4478 ; 0307-7772 ; 1365-2273
DOI	10.1111/coa.13916
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Article ; Online: A novel remote assessment pathway to streamline the management of two-week-wait suspected head and neck cancer referrals: a prospective analysis of 660 patients.

Metcalfe, Christopher / Oh, Soo / Glazzard, Nina / Ross, Elizabeth / George, Ajith

The Journal of laryngology and otology

2024 Volume 138, Issue 6, Page(s) 667–671

Abstract: Objective: This study analyses outcomes for 660 patients managed via a novel telescopic pathway for suspected head and neck cancer referrals.: Method: Data were collected prospectively between January 2021 and December 2022, capturing all two-week- ... ...

Abstract	Objective: This study analyses outcomes for 660 patients managed via a novel telescopic pathway for suspected head and neck cancer referrals. Method: Data were collected prospectively between January 2021 and December 2022, capturing all two-week-wait referrals triaged as low risk and managed via a nurse-led clinic for nasendoscopic examination and consultant-led remote assessment. Results: In total, 660 patients were included. There were six head and neck cancers diagnosed, giving a conversion rate of 0.9 per cent. Mean (standard deviation) time to informing the patient whether they did or did not have cancer (28-day faster diagnosis standard) was 28.6 days (20.2), with no significant difference observed in patients imaged prior to review ( Conclusion: Low-risk head and neck cancer referrals can be safely managed in a nurse-led clinic for recorded examination with asynchronous consultant-led management. Further work is required to ensure adherence to the new faster diagnosis standard.
MeSH term(s)	Humans ; Head and Neck Neoplasms/therapy ; Head and Neck Neoplasms/diagnosis ; Referral and Consultation/statistics & numerical data ; Prospective Studies ; Male ; Female ; Middle Aged ; Time Factors ; Waiting Lists ; Aged ; Triage/methods ; Adult ; Remote Consultation/methods
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S002221512400015X
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Article: Copper alumina @ poly (aniline-co-indole) nanocomposites: synthesis, characterization, electrical properties and gas sensing applications

Sankar, S. / George, Ajith / Ramesan, M. T.

RSC advances. 2022 June 14, v. 12, no. 27

2022

Abstract: Poly(aniline-co-indole)/copper alumina (PANI-co-PIN/Cu–Al₂O₃) with excellent AC conductivity, dielectric properties, and ammonia gas detecting capabilities were synthesised via in situ chemical oxidative polymerization. The presence of Cu–O bonding ... ...

Abstract	Poly(aniline-co-indole)/copper alumina (PANI-co-PIN/Cu–Al₂O₃) with excellent AC conductivity, dielectric properties, and ammonia gas detecting capabilities were synthesised via in situ chemical oxidative polymerization. The presence of Cu–O bonding vibrations and shift of some characteristic peaks in the Fourier transform infrared spectroscopy (FT-IR) revealed the successful encapsulation of Cu–Al₂O₃ nanoparticles in the copolymer. The XRD studies showed the crystalline peaks of Cu–Al₂O₃ in the PANI-co-PIN nanocomposites. The high-resolution transmission electron microscopy (HR-TEM) images confirmed the reinforcement of the inorganic moiety in the copolymer. The results from thermogravimetric analysis (TGA) showed that the inclusion of Cu–Al₂O₃ in the copolymer matrix greatly increases the thermal stability of PANI-co-PIN. The alternate current (AC) conductivity and dielectric properties of nanocomposites were higher than pure PANI-co-PIN. The improved electrical properties of nanocomposites were due to strong contact between the copolymer and metal oxide surfaces. The gas sensing properties of synthesized copolymer nanocomposites showed excellent sensitivity and response towards ammonia gas at room temperature. The PANI-co-PIN/5 wt% Cu–Al₂O₃ nanocomposite has the best gas sensing characteristics. The higher AC conductivity, dielectric properties and gas sensing characteristics of PANI-co-PIN/Cu–Al₂O₃ might be used to develop electrochemical sensing devices.
Keywords	Fourier transform infrared spectroscopy ; aluminum oxide ; ambient temperature ; ammonia ; composite polymers ; electrochemistry ; encapsulation ; moieties ; nanocomposites ; polymerization ; thermal stability ; thermogravimetry ; transmission electron microscopy
Language	English
Dates of publication	2022-0614
Size	p. 17637-17644.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/d2ra02213c
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Copper alumina @ poly (aniline-

Sankar, S / George, Ajith / Ramesan, M T

RSC advances

2022 Volume 12, Issue 27, Page(s) 17637–17644

Abstract: Poly(aniline-co-indole)/copper alumina (PANI- ...

Abstract	Poly(aniline-co-indole)/copper alumina (PANI-
Language	English
Publishing date	2022-06-14
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra02213c
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Article ; Online: Recent Advances in Fuel-Driven Molecular Switches and Machines.

Benny, Renitta / Sahoo, Diptiprava / George, Ajith / De, Soumen

ChemistryOpen

2022 Volume 11, Issue 9, Page(s) e202200128

Abstract: The molecular switches and machines arena has entered a new phase in which molecular machines operate under out-of-equilibrium conditions using appropriate fuel. Unlike the equilibrium version, the dissipative off-equilibrium machines necessitate only ... ...

Abstract	The molecular switches and machines arena has entered a new phase in which molecular machines operate under out-of-equilibrium conditions using appropriate fuel. Unlike the equilibrium version, the dissipative off-equilibrium machines necessitate only one stimulus input to complete each cycle and decrease chemical waste. Such a modus operandi would set significant steps towards mimicking the natural machines and may offer a platform for advancing new applications by providing temporal control. This review summarises the recent progress and blueprint of autonomous fuel-driven off-equilibrium molecular switches and machines.
Language	English
Publishing date	2022-09-12
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2655605-4
ISSN	2191-1363 ; 2191-1363
ISSN (online)	2191-1363
ISSN	2191-1363
DOI	10.1002/open.202200128
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Article ; Online: Using post-operative trend in C-reactive protein to predict fistula in neopharyngeal repairs following laryngectomy and pharyngectomy surgery in fifty-five patients.

Halliday, Edwin / George, Ajith

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

2020 Volume 46, Issue 1, Page(s) 119–122

MeSH term(s)	Aged ; Aged, 80 and over ; C-Reactive Protein/metabolism ; Cutaneous Fistula/blood ; Cutaneous Fistula/diagnosis ; Cutaneous Fistula/etiology ; Female ; Humans ; Laryngectomy/adverse effects ; Male ; Middle Aged ; Nasopharynx/surgery ; Pharyngectomy/adverse effects ; Postoperative Complications/blood ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Predictive Value of Tests ; ROC Curve ; Respiratory Tract Fistula/blood ; Respiratory Tract Fistula/etiology ; Respiratory Tract Fistula/metabolism ; Retrospective Studies ; Risk Factors
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2020-09-22
Publishing country	England
Document type	Letter
ZDB-ID	2205891-6
ISSN	1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
ISSN (online)	1749-4486
ISSN	1749-4478 ; 0307-7772 ; 1365-2273
DOI	10.1111/coa.13645
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Zs.A 1309: Show issues

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Article ; Online: A Novel Approach to Identifying the Spinal Accessory Nerve in Surgical Neck Dissection.

Eastwood, Michael James / George, Ajith Paulose

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2018 Volume 159, Issue 2, Page(s) 300–302

Abstract: Intraoperative identification of the spinal accessory nerve (SAN) is key in reducing nerve injury. This study aims to explore the surgical anatomy of the SAN and 2 landmarks for its identification-the sternocleidomastoid branch of the occipital artery ( ... ...

Abstract	Intraoperative identification of the spinal accessory nerve (SAN) is key in reducing nerve injury. This study aims to explore the surgical anatomy of the SAN and 2 landmarks for its identification-the sternocleidomastoid branch of the occipital artery (SBOA) and superior sternocleidomastoid tendon (SST)-to propose a novel method of identifying the SAN during surgical neck dissections. Twelve cadavers underwent bilateral level II-V neck dissection identifying the SAN, SBOA, and SST. Variation was documented and distance between landmarks and the SAN measured. The most common arrangement had the SST most superficially followed by the SBOA and then the SAN. The SAN was 3.63 ± 4.02 mm from the artery and 2.31 ± 1.72 mm from the tendon. A triangle-bordered by the tendon laterally, artery medially, and digastric muscle superiorly-contained the SAN in 95.8% of cases. This relationship translated into a reliable technique to identify the SAN intraoperatively, which has been used successfully in practice.
MeSH term(s)	Accessory Nerve/anatomy & histology ; Anatomic Landmarks ; Cadaver ; Humans ; Neck Dissection/methods ; Neck Muscles/innervation
Language	English
Publishing date	2018-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1177/0194599818766057
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Ul II Zs.83/a: Show issues

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Article: Telescopic otology referrals: Evaluation of feasibility and acceptability.

Cottrell, Elizabeth / George, Ajith / Coulson, Chris / Chambers, Ruth

Laryngoscope investigative otolaryngology

2020 Volume 5, Issue 2, Page(s) 221–227

Abstract: Objective: A remote telemedical otology referral and advice service was introduced to interested general practices. General practitioners (GPs) were given a new device, "endoscope-i" that combines an optimized smartphone high definition video app with ... ...

Abstract	Objective: A remote telemedical otology referral and advice service was introduced to interested general practices. General practitioners (GPs) were given a new device, "endoscope-i" that combines an optimized smartphone high definition video app with an otoendoscope. They were specifically trained to examine and capture images of patients' eardrums, which were sent electronically with a summary of clinical information and an in-app hearing testing (if required), for specialist advice to two ear, nose, and throat (ENT) consultants. We describe the findings from an evaluation of the first 6 months of this service to establish the feasibility and acceptability of an otology telemedical referral and advice service. Methods: The new service was advertised to GP practices in Northern Staffordshire. All interested GPs were provided with training and equipment to deliver the remote referral service. Data were collected from GPs at baseline, informal feedback in response to referral outcomes and end of service feedback. Referral data were collected routinely during the service delivery. Results: Fifteen GP leads from 15 practices received training and equipment. One quickly lost the equipment. Of the remaining 14 practices, eight sent a total of 53 remote referrals using this technology over 6 months. The most common reason for referral was an uncertainty of what could be seen in or around the eardrum. The primary barrier for implementation was lack of wireless internet connections within practices. GPs reported that they used this technology to share examination findings with patients. Conclusions: GPs were positive about the technology, from initial engagement with training and after advice were given. Some GPs expanded the role of the technology to a consultation aid. Referral volume was manageable. Commissioners should consider tariffs structures for such services; empirical cost-effectiveness and workload-impact evaluation would inform this.
Language	English
Publishing date	2020-03-03
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.367
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Article ; Online: Safe nasendoscopy assisted procedure in the post-COVID-19 pandemic era.

George, Ajith / Prince, Mark / Coulson, Chris

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

2020 Volume 45, Issue 5, Page(s) 844–846

MeSH term(s)	Aerosols ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Endoscopy/instrumentation ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Masks ; SARS-CoV-2
Chemical Substances	Aerosols
Keywords	covid19
Language	English
Publishing date	2020-06-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2205891-6
ISSN	1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
ISSN (online)	1749-4486
ISSN	1749-4478 ; 0307-7772 ; 1365-2273
DOI	10.1111/coa.13591
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Article: Introduction of a novel telescopic pathway to streamline 2-week-wait suspected head and neck cancer referrals and improve efficiency: A prospective service evaluation.

Metcalfe, Christopher / Dogan, Mehmet / Glazzard, Nina / Ross, Elizabeth / George, Ajith

Laryngoscope investigative otolaryngology

2021 Volume 7, Issue 1, Page(s) 117–124

Abstract: Objectives: This study summarizes the introduction of a novel telescopic pathway, which streamlines 2-week-wait suspected head and neck cancer referrals to our unit, describes the logistics of the pathway, and analyzes referral numbers and outcomes. We ... ...

Abstract	Objectives: This study summarizes the introduction of a novel telescopic pathway, which streamlines 2-week-wait suspected head and neck cancer referrals to our unit, describes the logistics of the pathway, and analyzes referral numbers and outcomes. We also discuss wider issues surrounding remote assessment in head and neck cancer. Methods: Data were collected prospectively between January and May 2021, capturing all 2-week-wait referrals to our unit following the introduction of a telescopic pathway which utilized a nurse-led clinic for nasendoscopic examination of selected patients and consultant-led remote assessment using store and forward technology. Information on referral numbers, waiting times and outcomes was recorded. Results: Three hundred and forty (185 high risk, 155 low risk) patients entered the telescopic pathway with the remaining 74 patients seen on the conventional standard of care pathway. Cancer conversion rates were 17%, <1%, and 5.4% for the high-risk telescopic, low-risk telescopic and standard of care pathways respectively. No patients discharged from the telescopic pathway were re-referred within 3 months. Review capacity for endoscopic examination was higher per consultant on the telescopic pathway versus the standard of care ( Conclusion: A combination of risk stratification and asynchronous telescopic assessment shows promise for the management of suspected head and neck cancer referrals. Potential benefits include consultant-led care for all patients and enhanced documentation. Digital communication with patients may also assist with adherence to the new NHS 28-day diagnostic standard for cancer referrals. Ongoing data collection is required to assess how the pathway functions over a longer period. Level of evidence: 2c.
Language	English
Publishing date	2021-12-28
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.721
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