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  1. Article ; Online: A bumpy road ahead for genetic biocontainment.

    George, Dalton R / Danciu, Mark / Davenport, Peter W / Lakin, Matthew R / Chappell, James / Frow, Emma K

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 650

    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44531-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Articulating 'free, prior and informed consent' (FPIC) for engineered gene drives.

    George, Dalton R / Kuiken, Todd / Delborne, Jason A

    Proceedings. Biological sciences

    2019  Volume 286, Issue 1917, Page(s) 20191484

    Abstract: Recent statements by United Nations bodies point to free, prior and informed consent (FPIC) as a potential requirement in the development of engineered gene drive applications. As a concept developed in the context of protecting Indigenous rights to self- ...

    Abstract Recent statements by United Nations bodies point to free, prior and informed consent (FPIC) as a potential requirement in the development of engineered gene drive applications. As a concept developed in the context of protecting Indigenous rights to self-determination in land development scenarios, FPIC would need to be extended to apply to the context of ecological editing. Without an explicit framework of application, FPIC could be interpreted as a narrowly framed process of community consultation focused on the social implications of technology, and award little formal or advisory power in decision-making to Indigenous peoples and local communities. In this paper, we argue for an articulation of FPIC that attends to issues of transparency, iterative community-scale consent, and shared power through co-development among Indigenous peoples, local communities, researchers and technology developers. In realizing a comprehensive FPIC process, researchers and developers have an opportunity to incorporate enhanced participation and social guidance mechanisms into the design, development and implementation of engineered gene drive applications.
    MeSH term(s) Gene Drive Technology ; Humans ; Indigenous Peoples
    Language English
    Publishing date 2019-12-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2019.1484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Lessons for a SECURE Future: Evaluating Diversity in Crop Biotechnology Across Regulatory Regimes.

    George, Dalton R / Hornstein, Eli D / Clower, Carrie A / Coomber, Allison L / Dillard, DeShae / Mugwanya, Nassib / Pezzini, Daniela T / Rozowski, Casey

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 886765

    Abstract: Regulation of next-generation crops in the United States under the newly implemented "SECURE" rule promises to diversify innovation in agricultural biotechnology. Specifically, SECURE promises to expand the number of products eligible for regulatory ... ...

    Abstract Regulation of next-generation crops in the United States under the newly implemented "SECURE" rule promises to diversify innovation in agricultural biotechnology. Specifically, SECURE promises to expand the number of products eligible for regulatory exemption, which proponents theorize will increase the variety of traits, genes, organisms, and developers involved in developing crop biotechnology. However, few data-driven studies have looked back at the history of crop biotechnology to understand how specific regulatory pathways have affected diversity in crop biotechnology and how those patterns might change over time. In this article, we draw upon 30 years of regulatory submission data to 1) understand historical diversification trends across the landscape and history of past crop biotechnology regulatory pathways and 2) forecast how the new SECURE regulations might affect future diversification trends. Our goal is to apply an empirical approach to exploring the relationship between regulation and diversity in crop biotechnology and provide a basis for future data-driven analysis of regulatory outcomes. Based on our analysis, we suggest that diversity in crop biotechnology does not follow a single trajectory dictated by the shifts in regulation, and outcomes of SECURE might be more varied and restrictive despite the revamped exemption categories. In addition, the concept of confidential business information and its relationship to past and future biotechnology regulation is reviewed in light of our analysis.
    Language English
    Publishing date 2022-05-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.886765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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