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  1. Article ; Online: Retraction Note: Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis.

    Nigam, Nidhi / George, Jasmine / Srivastava, Smita / Roy, Preeti / Bhui, Kulpreet / Singh, Madhulika / Shukla, Yogeshwer

    Cancer chemotherapy and pharmacology

    2023  Volume 93, Issue 3, Page(s) 269

    Language English
    Publishing date 2023-11-13
    Publishing country Germany
    Document type Retraction of Publication
    ZDB-ID 6820-2
    ISSN 1432-0843 ; 0344-5704 ; 0943-9404
    ISSN (online) 1432-0843
    ISSN 0344-5704 ; 0943-9404
    DOI 10.1007/s00280-023-04614-8
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  2. Article ; Online: Retraction Note: Chemopreventive Potential of Resveratrol in Mouse Skin Tumors Through Regulation of Mitochondrial and PI3K/AKT Signaling Pathways.

    Roy, Preeti / Kalra, Neetu / Prasad, Sahdeo / George, Jasmine / Shukla, Yogeshwer

    Pharmaceutical research

    2021  Volume 38, Issue 2, Page(s) 375

    Language English
    Publishing date 2021-02-03
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 843063-9
    ISSN 1573-904X ; 0724-8741 ; 0739-0742
    ISSN (online) 1573-904X
    ISSN 0724-8741 ; 0739-0742
    DOI 10.1007/s11095-020-02973-y
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  3. Article ; Online: Optimized proximity ligation assay (PLA) for detection of RNA-protein complex interactions in cell lines.

    George, Jasmine / Mittal, Sonam / Kadamberi, Ishaque P / Pradeep, Sunila / Chaluvally-Raghavan, Pradeep

    STAR protocols

    2022  Volume 3, Issue 2, Page(s) 101340

    Abstract: Conventional proximity ligation assay (PLA) suffers from target specificity issues that curtail their accuracy on interpreting proximal interactions in cell biology. Here, we present a reliable and sensitive approach by including a fluorochrome-labeled ... ...

    Abstract Conventional proximity ligation assay (PLA) suffers from target specificity issues that curtail their accuracy on interpreting proximal interactions in cell biology. Here, we present a reliable and sensitive approach by including a fluorochrome-labeled mRNA fragment along with biotin-labeled RNA probe and a target-specific antibody, which were used to generate proximal ligation signals through linear connectors in intact cells. This protocol will be particularly useful for studying the proximal interactions between RNA binding proteins (RBPs) and their target mRNAs in cells. For complete details on the use and execution of this protocol, please refer to George et al. (2021).
    MeSH term(s) Antibodies/metabolism ; Biophysical Phenomena ; Cell Line ; RNA, Messenger/genetics ; RNA-Binding Proteins/genetics
    Chemical Substances Antibodies ; RNA, Messenger ; RNA-Binding Proteins
    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101340
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  4. Article ; Online: Editorial Expression of Concern for: Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis.

    Nigam, Nidhi / George, Jasmine / Srivastava, Smita / Roy, Preeti / Bhui, Kulpreet / Singh, Madhulika / Shukla, Yogeshwer

    Cancer chemotherapy and pharmacology

    2022  Volume 89, Issue 6, Page(s) 841

    Language English
    Publishing date 2022-04-03
    Publishing country Germany
    Document type Journal Article ; Expression of Concern
    ZDB-ID 6820-2
    ISSN 1432-0843 ; 0344-5704 ; 0943-9404
    ISSN (online) 1432-0843
    ISSN 0344-5704 ; 0943-9404
    DOI 10.1007/s00280-022-04426-2
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    Zs.A 1420: Show issues Location:
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  5. Article ; Online: Mitochondrial Sirtuins in Cancer: Emerging Roles and Therapeutic Potential.

    George, Jasmine / Ahmad, Nihal

    Cancer research

    2016  Volume 76, Issue 9, Page(s) 2500–2506

    Abstract: The past few decades have witnessed a furious attention of scientific community toward identifying novel molecular factors and targets that could be exploited for drug development for cancer management. One such factor is the sirtuin (SIRT) family of ... ...

    Abstract The past few decades have witnessed a furious attention of scientific community toward identifying novel molecular factors and targets that could be exploited for drug development for cancer management. One such factor is the sirtuin (SIRT) family of nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylases. The role of SIRTs in cancer is extremely complex, with dichotomous functions depending on cell contexts. Mammalian SIRTs (SIRT1-7) differ in their cellular localization and biologic functions. Among these, SIRT -3, -4, and -5 are located in the mitochondria and are being carefully investigated. These mitochondrial SIRTs (mtSIRT) regulate multiple cellular and physiologic processes, including cell cycle, gene expression, cell viability, stress response, metabolism, and energy homeostasis. Recent research suggests that mtSIRTs influence tumors by regulating the metabolic state of the cell. Although the research on the role of mtSIRTs in cancer is still in its infancy, studies have suggested tumor suppressor as well as tumor promoter roles for them. This review is focused on discussing up-to-date information about the roles and functional relevance of mtSIRTs (SIRT -3, -4, -5) in cancers. We have also provided a critical discussion and our perspective on their dual roles, as tumor promoter versus tumor suppressor, in cancer. Cancer Res; 76(9); 2500-6. ©2016 AACR.
    MeSH term(s) Animals ; Humans ; Mitochondria/metabolism ; Neoplasms/metabolism ; Sirtuins/metabolism
    Chemical Substances Sirtuins (EC 3.5.1.-)
    Language English
    Publishing date 2016--01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-15-2733
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  6. Article: Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma.

    Singh, Chandra K / George, Jasmine / Chhabra, Gagan / Nihal, Minakshi / Chang, Hao / Ahmad, Nihal

    Frontiers in oncology

    2021  Volume 11, Page(s) 676077

    Abstract: The mitochondrial sirtuin SIRT3 plays key roles in cellular metabolism and energy production, which makes it an obvious target for the management of cancer, including melanoma. Previously, we have demonstrated that SIRT3 was constitutively upregulated in ...

    Abstract The mitochondrial sirtuin SIRT3 plays key roles in cellular metabolism and energy production, which makes it an obvious target for the management of cancer, including melanoma. Previously, we have demonstrated that SIRT3 was constitutively upregulated in human melanoma and its inhibition resulted in anti-proliferative effects
    Language English
    Publishing date 2021-04-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.676077
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  7. Article ; Online: Tim-1 Deficiency Aggravates High-Fat Diet-Induced Steatohepatitis in Mice.

    George, Jasmine / Zhang, Yuanyuan / Sloan, Jacob / Sims, Joya M / Imig, John D / Zhao, Xueying

    Frontiers in immunology

    2021  Volume 12, Page(s) 747794

    Abstract: Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) is commonly associated with obesity and characterized by excessive lipid accumulation and liver inflammation. The T cell immunoglobulin and mucin domain 1 (Tim-1), also known ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) is commonly associated with obesity and characterized by excessive lipid accumulation and liver inflammation. The T cell immunoglobulin and mucin domain 1 (Tim-1), also known as hepatitis A virus cellular receptor 1 (Havcr-1) and kidney injury molecule 1 (Kim-1), has been shown to affect innate immunity-driven proinflammatory cascade in liver ischemia-reperfusion injury. However, its contribution to obesity-related NAFLD/NASH remains unknown. Thus, this study was designed to evaluate the role of Tim-1 in obesity-related liver inflammation and injury in wild-type (WT) and Tim-1-deficient (Tim-1
    MeSH term(s) Animals ; Diet, High-Fat/adverse effects ; Hepatitis A Virus Cellular Receptor 1/deficiency ; Hepatitis A Virus Cellular Receptor 1/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/immunology ; Non-alcoholic Fatty Liver Disease/pathology
    Chemical Substances Havcr1 protein, mouse ; Hepatitis A Virus Cellular Receptor 1
    Language English
    Publishing date 2021-10-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.747794
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  8. Article ; Online: 4'-Bromo-resveratrol, a dual Sirtuin-1 and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming.

    George, Jasmine / Nihal, Minakshi / Singh, Chandra K / Ahmad, Nihal

    Molecular carcinogenesis

    2019  Volume 58, Issue 10, Page(s) 1876–1885

    Abstract: Sirtuin-1 and -3 (SIRT1 and SIRT3) are important nicotinamide adenine dinucleotide ( ... ...

    Abstract Sirtuin-1 and -3 (SIRT1 and SIRT3) are important nicotinamide adenine dinucleotide (NAD
    MeSH term(s) Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cellular Reprogramming/drug effects ; Cellular Reprogramming/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Lactic Acid/metabolism ; Melanoma/drug therapy ; Melanoma/genetics ; Melanoma/pathology ; Mitochondria/drug effects ; Mitochondria/genetics ; Resorcinols/pharmacology ; Sirtuin 1/antagonists & inhibitors ; Sirtuin 1/genetics ; Sirtuin 3/antagonists & inhibitors ; Sirtuin 3/genetics ; Stilbenes/pharmacology
    Chemical Substances 5-(2-(4-bromophenyl)vinyl)-1,3-benzenediol ; Resorcinols ; Stilbenes ; Lactic Acid (33X04XA5AT) ; SIRT1 protein, human (EC 3.5.1.-) ; SIRT3 protein, human (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-) ; Sirtuin 3 (EC 3.5.1.-)
    Language English
    Publishing date 2019-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1004029-8
    ISSN 1098-2744 ; 0899-1987
    ISSN (online) 1098-2744
    ISSN 0899-1987
    DOI 10.1002/mc.23080
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    Zs.A 2664: Show issues Location:
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  9. Article ; Online: Correction to: Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors.

    Roy, Preeti / George, Jasmine / Srivastava, Smita / Tyagi, Shilpa / Shukla, Yogeshwer

    Investigational new drugs

    2019  Volume 37, Issue 6, Page(s) 1310–1311

    Abstract: The authors regret to inform that there were unknowing errors in figures. The corrected images are given below. These figures are not affecting the results and conclusion of the manuscript. Hence, the text in original paper remains unchanged. ...

    Abstract The authors regret to inform that there were unknowing errors in figures. The corrected images are given below. These figures are not affecting the results and conclusion of the manuscript. Hence, the text in original paper remains unchanged.
    Language English
    Publishing date 2019-08-07
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 604895-x
    ISSN 1573-0646 ; 0167-6997
    ISSN (online) 1573-0646
    ISSN 0167-6997
    DOI 10.1007/s10637-019-00841-0
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  10. Article: Saturated fatty acids bound to albumin enhance osteopontin expression and cleavage in renal proximal tubular cells.

    Cobbs, Alyssa / Ballou, Kristopher / Chen, Xiaoming / George, Jasmine / Zhao, Xueying

    International journal of physiology, pathophysiology and pharmacology

    2018  Volume 10, Issue 1, Page(s) 29–38

    Abstract: Osteopontin (OPN) is one of the proinflammatory cytokines upregulated in the kidneys of diabetic animals and patients with nephropathy. An increase in urinary albumin and albumin-bound fatty acids (FA) presents a proinflammatory environment to the ... ...

    Abstract Osteopontin (OPN) is one of the proinflammatory cytokines upregulated in the kidneys of diabetic animals and patients with nephropathy. An increase in urinary albumin and albumin-bound fatty acids (FA) presents a proinflammatory environment to the proximal tubules in proteinuric kidney diseases including diabetic nephropathy. This study was designed to examine if FA overload could stimulate OPN expression and cleavage in renal tubule epithelial cells. OPN gene and protein expression was examined in the kidney of Zucker diabetic (ZD) rats and cultured proximal tubular cells exposed to either bovine serum albumin (BSA) or BSA conjugated with palmitic acid (PA), the most abundant saturated plasma FA. Real-time PCR analysis confirmed an upregulation of renal cortical OPN gene correlated with albuminuria and nephropathy progression in ZD rats at the age of 7-20 weeks. Immunofluorescence staining of kidney sections revealed a massive induction of OPN protein in albumin-overloaded proximal tubules of ZD rats. A significant increase in both intact and cleaved OPN proteins was further demonstrated in the diabetic kidney and urine samples, which was attenuated by antiproteinuric treatment with losartan, an angiotensin II receptor blocker. When exposed to fatty acid-free BSA, NRK-52E cells exhibited an increase in protein levels of full-length and cleaved OPN. Moreover, the increase in OPN fragments was greatly enhanced in the presence of PA (250-500 µM). Together, our results support a stimulatory effect of albumin and conjugated FA on OPN expression and cleavage in renal tubule epithelial cells. Thus, besides lowering albuminuria/proteinuria, mitigating circulating FAs may be an effective intervention for preventing and slowing down the progression of nephropathy associated with obesity and type 2 diabetes.
    Language English
    Publishing date 2018-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2478821-1
    ISSN 1944-8171
    ISSN 1944-8171
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