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Article: Transcarotid stenting of extracranial carotid artery aneurysm with covered stents and flow reversal.

Zaidi, S Taha / George, Mitchell J / Cambiaghi, Tommaso / Saqib, Naveed / Miles, Daniel / Wang, Shihuan / Harlin, Stuart

Journal of vascular surgery cases and innovative techniques

2023 Volume 9, Issue 4, Page(s) 101347

Abstract: Introduction: An extracranial carotid artery aneurysm (ECAA) is a rare pathology comprising <1% of all arterial aneurysms. The etiology includes trauma, previous surgery, radiation, and infection. Treatment of ECAAs has evolved from open repair to ... ...

Abstract	Introduction: An extracranial carotid artery aneurysm (ECAA) is a rare pathology comprising <1% of all arterial aneurysms. The etiology includes trauma, previous surgery, radiation, and infection. Treatment of ECAAs has evolved from open repair to endovascular repair with stenting. Reports of endovascular repair describe the transfemoral approach; however, little more than case reports are available describing the transcarotid approach for ECAAs. In this study, we describe a cohort of patients who safely underwent transcarotid repair of ECAAs. Methods: We performed a retrospective medical record review of all cases of transcarotid stenting using covered stents for a carotid aneurysm within 11 different hospitals within the Memorial Hermann Health System from December 2019 through December 2022. Technical success is defined as coverage of the aneurysm with no endoleak. We report the patient demographics, clinical presentation, intraoperative metrics, and outcomes. Results: Seven patients underwent transcarotid covered stent placement using flow reversal for neurologic protection. Their average age was 65 years, and four of the seven patients were men. Three patients presented with pain, two with transient ischemic attack, one with stroke, and one with a pulsatile mass. Technical success was 100%. All the patients were treated with transcarotid stenting, and the average aneurysm size was 13 mm. The average operative time was 69 minutes, and the flow reversal time was 9 minutes. No postoperative stroke, myocardial infarction, or death occurred. The average length of hospital stay was 2.7 days. Conclusions: A transcarotid approach for endovascular treatment of ECAAs was safe for this cohort of patients, with no postoperative death, stroke, or myocardial infarction. Also, the technical success was 100%.
Language	English
Publishing date	2023-10-10
Publishing country	United States
Document type	Journal Article
ISSN	2468-4287
ISSN	2468-4287
DOI	10.1016/j.jvscit.2023.101347
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Article ; Online: Design and Development of a Clot Burst Pressure Device to Investigate Resuscitation Strategies.

Mankame, Atharwa R / Schriner, Jacob B / Skibber, Max A / George, Mitchell J / Cardenas, Jessica C / Cox, Charles S / Gill, Brijesh S

The Journal of surgical research

2023 Volume 291, Page(s) 646–652

Abstract: Introduction: A reduction in clot strength is a hallmark feature of trauma-induced coagulopathy. A better understanding of clot integrity can optimize resuscitation strategies. We designed a device to gauge clot strength by pressurizing fluids over a ... ...

Abstract	Introduction: A reduction in clot strength is a hallmark feature of trauma-induced coagulopathy. A better understanding of clot integrity can optimize resuscitation strategies. We designed a device to gauge clot strength by pressurizing fluids over a formed clot and measuring the pressure needed to dislodge the clot. We hypothesized that this device could distinguish between clots formed in hypocoagulable and hypercoagulable states by observing differences in the clot burst pressure. Methods: Whole blood from healthy volunteers was collected into sodium citrate tubes and was treated with heparin or fibrinogen to generate clots in a hypocoagulable or hypercoagulable state, respectively. Small bore holes were drilled into polystyrene plates, and recalcified blood was pipetted into the holes. Plates were incubated at 37°C for 30 min to form clots. A pressure cap with an inlet for fluid from a syringe pump and an outlet leading to a measurement column was secured in the wells with a watertight seal. Results: Clot burst pressure was normalized to individual baseline values to account for inherent differences in clot strength. The 1.0 g/L and 2.0 g/L fibrinogen groups were 1.65 ± 0.07 (P = 0.0078) and 2.26 ± 0.16 (P = 0.0078) times as strong as baseline, respectively. The 0.10, 0.15, or 0.20 USP units/mL groups were 0.388 ± 0.07 (P = 0.125), 0.31 ± 0.07 (P = 0.125), 0.21 ± 0.07 (P = 0.125) times as strong as baseline, respectively. Data were analyzed using Wilcoxon matched pairs signed rank testing. Conclusions: This device tests clot strength using burst pressure, an easily interpreted clinical parameter not measured in existing devices. Future work can test blood from trauma patients to better understand trauma pathophysiology.
MeSH term(s)	Humans ; Thrombosis/diagnosis ; Thrombosis/etiology ; Blood Coagulation Disorders ; Blood Coagulation/physiology ; Hemostatics ; Fibrinogen ; Thrombelastography ; Resuscitation
Chemical Substances	Hemostatics ; Fibrinogen (9001-32-5)
Language	English
Publishing date	2023-08-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2023.07.016
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Article ; Online: PLATELET FUNCTION IN TRAUMA: IS CURRENT TECHNOLOGY IN FUNCTION TESTING MISSING THE MARK IN INJURED PATIENTS?

Schriner, Jacob B / George, Mitchell J / Cardenas, Jessica C / Olson, Scott D / Mankiewicz, Kimberly A / Cox, Charles S / Gill, Brijesh S / Wade, Charles E

Shock (Augusta, Ga.)

2022 Volume 58, Issue 1, Page(s) 1–13

Abstract: Abstract: Platelets are subcellular anucleate components of blood primarily responsible for initiating and maintaining hemostasis. After injury to a blood vessel, platelets can be activated via several pathways, resulting in changed shape, adherence to ... ...

Abstract	Abstract: Platelets are subcellular anucleate components of blood primarily responsible for initiating and maintaining hemostasis. After injury to a blood vessel, platelets can be activated via several pathways, resulting in changed shape, adherence to the injury site, aggregation to form a plug, degranulation to initiate activation in other nearby platelets, and acceleration of thrombin formation to convert fibrinogen to fibrin before contracting to strengthen the clot. Platelet function assays use agonists to induce and measure one or more of these processes to identify alterations in platelet function that increase the likelihood of bleeding or thrombotic events. In severe trauma, these assays have revealed that platelet dysfunction is strongly associated with poor clinical outcomes. However, to date, the mechanism(s) causing clinically significant platelet dysfunction remain poorly understood. We review the pros, cons, and evidence for use of many of the popular assays in trauma, discuss limitations of their use in this patient population, and present approaches that can be taken to develop improved functional assays capable of elucidating mechanisms of trauma-induced platelet dysfunction. Platelet dysfunction in trauma has been associated with need for transfusions and mortality; however, most of the current platelet function assays were not designed for evaluating trauma patients, and there are limited data regarding their use in this population. New or improved functional assays will help define the mechanisms by which platelet dysfunction occurs, as well as help optimize future treatment.
MeSH term(s)	Blood Platelets/metabolism ; Fibrin/metabolism ; Hemostasis/physiology ; Humans ; Platelet Aggregation ; Platelet Function Tests/methods ; Thrombosis ; Wounds and Injuries/metabolism
Chemical Substances	Fibrin (9001-31-4)
Language	English
Publishing date	2022-07-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/SHK.0000000000001948
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Zs.A 3985: Show issues

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Article ; Online: Adverse events are not increased with trainee participation in transcarotid revascularization.

Husman, Regina / Tanaka, Akiko / Saqib, Naveed U / Mirza, Aleem / George, Mitchell J / Keyhani, Arash / Keyhani, Kourosh / Wang, S Keisin

Vascular

2022 , Page(s) 17085381221140158

Abstract: Objective: To determine whether a vascular surgery trainee's participation in transcarotid revascularization (TCAR), a new technology, affects patient safety and outcomes.: Design: Retrospective, institutional review of our carotid database was ... ...

Abstract	Objective: To determine whether a vascular surgery trainee's participation in transcarotid revascularization (TCAR), a new technology, affects patient safety and outcomes. Design: Retrospective, institutional review of our carotid database was performed. Patients who underwent TCAR were stratified based on whether a vascular trainee was present during the procedure. Relevant demographics, comorbidities, anatomical indication, perioperative courses, and adverse events in the postoperative period were captured for statistical analysis. Setting: Data were obtained from affiliated Memorial Hermann Hospitals in Houston, Texas. Participants: All patients who underwent TCAR from September 2017 to January 2022 were included. Results: Of 486 patients who underwent TCAR, 173 (35.6%) were performed in the presence of a trainee, and 313 (64.4%) were performed without a trainee. Subjects in the trainee cohort had more challenging anatomy, defined as a higher rate of carotid bifurcation above C2, restenotic disease, previous ipsilateral neck dissection, and neck radiation. The trainee cohort had higher rates of estimated blood loss (61.1 ± 66 vs. 35.5 ± 39 mL, Conclusion: Vascular surgery trainee's involvement during TCAR did not increase adverse outcomes, such as stroke and death, in the perioperative period. The results presented herein should encourage other teaching institutions to provide surgical trainees with supervised, hands-on experience during TCAR.
Language	English
Publishing date	2022-11-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2137151-9
ISSN	1708-539X ; 1708-5381
ISSN (online)	1708-539X
ISSN	1708-5381
DOI	10.1177/17085381221140158
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Zs.A 4277: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 590: Show issues

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Article ; Online: 3D printing in aortic endovascular therapies.

George, Mitchell J / Dias-Neto, Marina / Ramos Tenorio, Emanuel / Skibber, Max A / Morris, Jonathan M / Oderich, Gustavo S

The Journal of cardiovascular surgery

2022 Volume 63, Issue 5, Page(s) 597–605

Abstract: Endovascular treatment of aortic disease, including aneurysm or dissection, is expanding at a rapid pace. Often, the specific patient anatomy in these cases is complex. Additive manufacturing, also known as three-dimensional (3D) printing, is especially ... ...

Abstract	Endovascular treatment of aortic disease, including aneurysm or dissection, is expanding at a rapid pace. Often, the specific patient anatomy in these cases is complex. Additive manufacturing, also known as three-dimensional (3D) printing, is especially useful in the treatment of aortic disease, due to its ability to manufacture physical models of complex patient anatomy. Compared to other surgical procedures, endovascular aortic repair can readily exploit the advantages of 3D printing with regard to operative planning and preoperative training. To date, there have been numerous uses of 3D printing in the treatment of aortic pathology as an adjunct in presurgical planning and as a basis for training modules for fellows and residents. In this review, we summarize the current uses of 3D printing in the endovascular management of aortic disease. We also review the process of producing these models, the limitations of their applications, and future directions of 3D printing in this field.
MeSH term(s)	Aortic Diseases ; Endovascular Procedures/adverse effects ; Humans ; Printing, Three-Dimensional ; Vascular Surgical Procedures
Language	English
Publishing date	2022-07-13
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	80143-4
ISSN	1827-191X ; 0021-9509
ISSN (online)	1827-191X
ISSN	0021-9509
DOI	10.23736/S0021-9509.22.12407-9
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Zs.A 469: Show issues

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Article ; Online: Dual Institutional Experience with Transcarotid Artery Revascularization.

George, Mitchell J / Husman, Regina / Dakour-Aridi, Hanaa / Tanaka, Akiko / Madison, Mackenzie / Motaganahalli, Raghu / Leckie, Katherin / Wang, S Keisin

Vascular and endovascular surgery

2022 Volume 57, Issue 1, Page(s) 35–40

Abstract: Introduction: Transcarotid artery revascularization (TCAR) is a hybrid open and endovascular technique to treat carotid stenosis. The purpose of this study is to present a large cohort of patients who underwent TCAR at 2 high-volume TCAR health systems.! ...

Abstract	Introduction: Transcarotid artery revascularization (TCAR) is a hybrid open and endovascular technique to treat carotid stenosis. The purpose of this study is to present a large cohort of patients who underwent TCAR at 2 high-volume TCAR health systems. Methods: This study was a retrospective chart review of all instances of TCAR within the Memorial Hermann Health System and Indiana University Health, from December 2015-January 2022, using the ENROUTE Neuroprotection Device (Silk Road Medical, Sunnyvale, CA). We report patient demographics, intraoperative metrics, 30-day results and long-term results. Results: In all, 750 patients underwent TCAR in the designated time period. Average patient age was 73 years, with 68% being male. Overall, 53.9% of patients had coronary artery disease, 45.4% had diabetes, and 36.9% were symptomatic. Technical success was achieved in 98.8% of patients with conversion to open endarterectomy in 1.1%. Average reverse flow time was 9.1 minutes with length of stay greater than 1 day 38%. Ipsilateral stroke rate within 30 days was 2.3% and long-term cumulative stroke rate was 3.0%. Death within 30 days occurred in 1.2% of patients and in 5.9% over long-term follow up. In all, 1% of patients required reintervention. Conclusions: TCAR is a safe and effective treatment modality for carotid artery stenotic disease. Its outcomes are similar to historical results associated with carotid endarterectomy, long considered the gold standard.
MeSH term(s)	Humans ; Male ; Aged ; Female ; Retrospective Studies ; Treatment Outcome ; Risk Factors ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/surgery ; Endovascular Procedures ; Carotid Artery Diseases/surgery ; Stroke/etiology ; Arteries ; Stents
Language	English
Publishing date	2022-09-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2076272-0
ISSN	1938-9116 ; 1538-5744
ISSN (online)	1938-9116
ISSN	1538-5744
DOI	10.1177/15385744221127846
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Zs.A 622: Show issues

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Article ; Online: Predictors of 30-Day Stroke and Death After Transcarotid Revascularization.

Leckie, Katherin / Tanaka, Akiko / Dakour-Aridi, Hanaa / Motaganahalli, Raghu L / George, Mitchell J / Keyhani, Arash / Keyhani, Kourosh / Wang, S Keisin

The Journal of surgical research

2022 Volume 283, Page(s) 146–151

Abstract: Introduction: Much of the previous robust analyses of the results associated with transcarotid revascularization (TCAR) derives from industry-sponsored trials or the Vascular Quality Initiative (VQI). This investigation was performed to identify ... ...

Abstract	Introduction: Much of the previous robust analyses of the results associated with transcarotid revascularization (TCAR) derives from industry-sponsored trials or the Vascular Quality Initiative (VQI). This investigation was performed to identify preoperative predictors of 30-day stroke and death using institutional databases. Methods: A retrospective analysis was performed of carotid revascularization databases created at two high-volume TCAR centers and maintained independently of the VQI carotid module between December 2015 and December 2021. The primary outcome of interest was a composite of perioperative (30-day) stroke and death. Univariate regression analyses, followed by multivariate regression analyses, were performed to identify potential predictors of adverse events. Results: During the study period, 750 TCAR procedures were performed at our combined health systems, resulting in 24 (3.2%) individuals who experienced either stroke and/or death in the perioperative period. Of these, we observed nine (1.2%) mortality events and 18 (2.4%) strokes. On univariate analysis, candidate protectors of stroke/death were found to be coronary artery disease (odds ratio [OR], 0.43; 95% confidence interval [CI], 0.18-1.01; P = 0.05) and protamine reversal (0.51; 0.21-1.21; P = 0.15). Candidate predictors of the primary outcome were anticoagulant usage (3.03; 1.26-7.24; P = 0.01), postprocedural debris in the filter (2.30; 0.97-5.43; P = 0.06), symptomatic carotid lesion (2.03; 0.90-4.50), and cardiac arrhythmia (1.98; 0.80-4.03; P = 0.14). On multivariate analysis, two predictors remained, cardiac arrhythmia (4.21; 1.10-16.16; P = 0.04) and symptomatic carotid lesion (14.49; 1.80-116.94; P = 0.01). Conclusions: A symptomatic carotid lesion, and to a lesser extent cardiac arrhythmia, are strong predictors of 30-day stroke/death after TCAR. Surgeons should be cognizant of the increased risk of adverse events in the perioperative period in these patients.
MeSH term(s)	Humans ; Endovascular Procedures/adverse effects ; Carotid Stenosis/complications ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; Stents/adverse effects ; Stroke/etiology ; Risk Assessment
Language	English
Publishing date	2022-11-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2022.10.028
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Article ; Online: Microelectromechanical System Measurement of Platelet Contraction: Direct Interrogation of Myosin Light Chain Phosphorylation.

George, Mitchell J / Litvinov, Julia / Aroom, Kevin / Spangler, Leland J / Caplan, Henry / Wade, Charles E / Cox, Charles S / Gill, Brijesh S

International journal of molecular sciences

2021 Volume 22, Issue 12

Abstract: Myosin Light Chain (MLC) regulates platelet contraction through its phosphorylation by Myosin Light Chain Kinase (MLCK) or dephosphorylation by Myosin Light Chain Phosphatase (MLCP). The correlation between platelet contraction force and levels of MLC ... ...

Abstract	Myosin Light Chain (MLC) regulates platelet contraction through its phosphorylation by Myosin Light Chain Kinase (MLCK) or dephosphorylation by Myosin Light Chain Phosphatase (MLCP). The correlation between platelet contraction force and levels of MLC phosphorylation is unknown. We investigate the relationship between platelet contraction force and MLC phosphorylation using a novel microelectromechanical (MEMS) based clot contraction sensor (CCS). The MLCK and MLCP pair were interrogated by inhibitors and activators of platelet function. The CCS was fabricated from silicon using photolithography techniques and force was validated over a range of deflection for different chip spring constants. The force of platelet contraction measured by the clot contraction sensor (CCS) was compared to the degree of MLC phosphorylation by Western Blotting (WB) and ELISA. Stimulators of MLC phosphorylation produced higher contraction force, higher phosphorylated MLC signal in ELISA and higher intensity bands in WB. Inhibitors of MLC phosphorylation produced the opposite. Contraction force is linearly related to levels of phosphorylated MLC. Direct measurements of clot contractile force are possible using a MEMS sensor platform and correlate linearly with the degree of MLC phosphorylation during coagulation. Measured force represents the mechanical output of the actin/myosin motor in platelets regulated by myosin light chain phosphorylation.
MeSH term(s)	Algorithms ; Biosensing Techniques ; Blood Platelets/physiology ; Blood Platelets/ultrastructure ; Enzyme-Linked Immunosorbent Assay ; Micro-Electrical-Mechanical Systems/instrumentation ; Micro-Electrical-Mechanical Systems/methods ; Models, Theoretical ; Myosin Light Chains/metabolism ; Phosphorylation ; Platelet Function Tests/instrumentation ; Platelet Function Tests/methods
Chemical Substances	Myosin Light Chains
Language	English
Publishing date	2021-06-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22126448
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Article ; Online: A Novel Platelet Function Assay for Trauma.

George, Mitchell J / Aroom, Kevin R / Wade, Charles E / Cox, Charles S / Gill, Brijesh S

The Journal of surgical research

2019 Volume 246, Page(s) 605–613

Abstract: Background: Platelet function tests such as thrombelastography platelet mapping and impedance aggregometry have demonstrated universal platelet dysfunction in trauma patients. In this study, we introduce the measurement of platelet contraction force as ... ...

Abstract	Background: Platelet function tests such as thrombelastography platelet mapping and impedance aggregometry have demonstrated universal platelet dysfunction in trauma patients. In this study, we introduce the measurement of platelet contraction force as a test of platelet function. We hypothesize that force will correlate with established coagulation tests such as thrombelastography, demonstrate significant differences between healthy subjects and trauma patients, and identify critically ill trauma patients. Methods: Blood samples were prospectively collected from level 1 trauma patients at initial presentation, assayed for force of and time to contraction and compared with thrombelastography. Blood from healthy subjects was assayed to establish a reference range. Results from trauma patients were compared with healthy controls and trauma patients that died. Results: The study includes one hundred trauma patients with mean age 45 y, 74% were male, and median injury severity score of 14 ± 12. Patients that survived (n = 90) demonstrated significantly elevated platelet contraction force compared with healthy controls (n = 12) (6390 ± 2340 versus 4790 ± 470 μN, P = 0.043) and trauma patients that died (n = 10) (6390 ± 2340 versus 2860 ± 1830 μN, P = 0.0001). Elapsed time to start of platelet contraction was faster in trauma patients that survived compared with healthy controls (660 ± 467 versus 1130 ± 140 s, P = 0.0022) and those that died (660 ± 470 versus 1460 ± 1340 s, P < 0.0001). Conclusions: In contrast with all existing platelet function tests reported in the literature, which report platelet dysfunction in trauma patients, contractile force demonstrates hyperfunction in surviving trauma patients and dysfunction in nonsurvivors. Platelet contraction reflects platelet metabolic reserve and thus may be a potential biomarker for survival after trauma. Contractile force warrants further investigation to predict mortality in severely injured trauma patients.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Blood Coagulation/physiology ; Blood Platelet Disorders/blood ; Blood Platelet Disorders/diagnosis ; Blood Platelet Disorders/etiology ; Blood Platelet Disorders/physiopathology ; Blood Platelets/physiology ; Female ; Humans ; Injury Severity Score ; Male ; Middle Aged ; Platelet Function Tests/methods ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; ROC Curve ; Thrombelastography ; Wounds and Injuries/blood ; Wounds and Injuries/complications ; Wounds and Injuries/diagnosis ; Wounds and Injuries/mortality ; Young Adult
Language	English
Publishing date	2019-10-23
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2019.09.052
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Article ; Online: Platelet biomechanics, platelet bioenergetics, and applications to clinical practice and translational research.

George, Mitchell J / Bynum, James / Nair, Prajeeda / Cap, Andrew P / Wade, Charles E / Cox, Charles S / Gill, Brijesh S

Platelets

2018 Volume 29, Issue 5, Page(s) 431–439

Abstract: The purpose of this review is to explore the relationship between platelet bioenergetics and biomechanics and how this relationship affects the clinical interpretation of platelet function devices. Recent experimental and technological advances highlight ...

Abstract	The purpose of this review is to explore the relationship between platelet bioenergetics and biomechanics and how this relationship affects the clinical interpretation of platelet function devices. Recent experimental and technological advances highlight platelet bioenergetics and biomechanics as alternative avenues for collecting clinically relevant data. Platelet bioenergetics drive energy production for key biomechanical processes like adhesion, spreading, aggregation, and contraction. Platelet function devices like thromboelastography, thromboelastometry, and aggregometry measure these biomechanical processes. Platelet storage, stroke, sepsis, trauma, or the activity of antiplatelet drugs alters measures of platelet function. However, the specific mechanisms governing these alterations in platelet function and how they relate to platelet bioenergetics are still under investigation.
MeSH term(s)	Biomechanical Phenomena/immunology ; Blood Platelets/metabolism ; Energy Metabolism/immunology ; Humans ; Platelet Function Tests/instrumentation ; Platelet Function Tests/methods ; Translational Medical Research/methods
Language	English
Publishing date	2018-03-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1034283-7
ISSN	1369-1635 ; 0953-7104
ISSN (online)	1369-1635
ISSN	0953-7104
DOI	10.1080/09537104.2018.1453062
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