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  1. Article ; Online: Limited interstitial abnormalities on CT associated with hiatus hernia: a pathogenetic pathway

    George, Peter M / Wells, Athol U

    The European respiratory journal

    2023  Volume 61, Issue 1

    MeSH term(s) Humans ; Hernia, Hiatal/complications ; Hernia, Hiatal/diagnostic imaging ; Thorax ; Tomography, X-Ray Computed ; Biological Products ; Lung/pathology
    Chemical Substances Biological Products
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01900-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2322: Show issues Location:
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  2. Article ; Online: Dissecting the role of the small airways in idiopathic pulmonary fibrosis.

    George, Peter M

    The Lancet. Respiratory medicine

    2020  Volume 8, Issue 6, Page(s) 529–531

    MeSH term(s) Humans ; Idiopathic Pulmonary Fibrosis ; Retrospective Studies
    Language English
    Publishing date 2020-02-13
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(20)30057-6
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  3. Book: The lymphomas

    Canellos, George P.

    2006  

    Author's details ed. George P. Canellos
    Keywords Lymphoma ; Lymphomas
    Subject code 616.99446
    Language English
    Size XIV, 582 S., [10] Bl. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Saunders Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT014728168
    ISBN 0-7216-0081-6 ; 978-0-7216-0081-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2006 A 2732 order for loan Magazin

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  4. Article: Rubinstein-Taybi syndrome.

    Ravella, Ranjith / George, Peter

    The Indian journal of medical research

    2022  Volume 152, Issue Suppl 1, Page(s) S236–S237

    MeSH term(s) Humans ; Rubinstein-Taybi Syndrome/complications ; Rubinstein-Taybi Syndrome/diagnosis ; Rubinstein-Taybi Syndrome/genetics
    Language English
    Publishing date 2022-03-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_2399_19
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  5. Article ; Online: Incidence, prevalence and mortality of idiopathic pulmonary fibrosis in England from 2008 to 2018: a cohort study.

    Gupta, Rikisha / Morgan, Ann Dorothy / George, Peter M / Quint, Jennifer K

    Thorax

    2024  

    Abstract: Background: Owing to discrepancies in methodologies and how idiopathic pulmonary fibrosis (IPF) is diagnosed it is challenging to establish a consistent understanding of the disease burden In the UK, over 10 years ago, the incidence and prevalence of ... ...

    Abstract Background: Owing to discrepancies in methodologies and how idiopathic pulmonary fibrosis (IPF) is diagnosed it is challenging to establish a consistent understanding of the disease burden In the UK, over 10 years ago, the incidence and prevalence of IPF were reported as 2.8-8.7 per 100 000 person-years (from 2000 to 2012) and 39 per 100 000 persons (in 2012), respectively. Here, we estimated the incidence and prevalence of IPF in England from 2008 to 2018 and investigated IPF mortality.
    Methods: Using Clinical Practice Research Datalink Aurum and Hospital Episode Statistics (HES) linked datasets, we estimated incidence and prevalence using four validated diagnostic-code-based algorithms. Using the registered number of deaths (from Office of National Statistics) with the underlying cause being recorded as IPF, we estimated IPF mortality for the same period.
    Results: Using Aurum-based definitions, incidence increased over time by 100% for Aurum narrow (3-6.1 per 100 000 person-years) and by 25% for Aurum broad (22.4-28.6 per 100 000 person-years). However, using HES-based definitions showed a decrease in incidence over the same period and lay between the two extremes derived for Aurum-based definition. IPF mortality in 2018 was 7.9 per 100 000 person-years and increased by 53% between 2008 and 2018.
    Interpretation: When using best-case definitions, incidence rose throughout the study period. Scaling this to England's population (2018), our best estimate would be in the range of 8000-9000 new cases per year which is higher than previously reported estimates (5000-6000). This increased burden in the new cases of IPF each year impacts future health service planning and resource allocation.
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2023-220887
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  6. Article ; Online: COVID-19 pneumonia and the pulmonary vasculature: a marriage made in hell.

    George, Peter M / Desai, Sujal R

    The European respiratory journal

    2021  Volume 58, Issue 3

    MeSH term(s) COVID-19 ; Cardiovascular System ; Humans ; Marriage ; SARS-CoV-2
    Language English
    Publishing date 2021-09-16
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00811-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 292: Show issues

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  7. Article: Dermatofibrosarcoma protuberans: Case series in a tropical setting and review of literature.

    Ashindoitiang, John Adi / Canice Nwagbara, Victor Ikechukwu / Ipeh, Ugbem Theophilus / Owusu, George Peter / Asuquo, Maurice Efana

    Rare tumors

    2024  Volume 16, Page(s) 20363613241234243

    Abstract: Dermatofibrosarcoma protuberans (DFSP) is an infrequent cutaneous tumour that may involve subcutaneous fat and in some cases fascia, muscles and bone. The infrequent occurrence lessens its clinical awareness in addition to its clinical semblance to many ... ...

    Abstract Dermatofibrosarcoma protuberans (DFSP) is an infrequent cutaneous tumour that may involve subcutaneous fat and in some cases fascia, muscles and bone. The infrequent occurrence lessens its clinical awareness in addition to its clinical semblance to many common cutaneous lesions. It is characterized by proclivity for local recurrence. We evaluated the clinical presentation and treatment outcomes of six consecutive cases of DFSP with histologic diagnosis in the University of Calabar Teaching Hospital, Calabar seen between January 2013 and December 2022. This was compared with total cutaneous malignances in the same period. The six consecutive patients comprised of two males and four females (M = F: 1:2) whose ages ranged from 21 to 57 years (mean of 36.5 years) and accounted for 7% of cutaneous malignancies. The site distribution was trunk (back) involved in 3 (50%) of the patients, limbs 3 (50%); upper 1 (17%) and lower limb 2 (33%). Clinical presentation was in the form of firm cutaneous mass with some ulcerated lesions that bled and some fungated. 50 percent of the patients presented with recurrent lesions and in all there was no regional lymphadenopathy or evidence of metastasis. There was a patient with Neurofibromatosis- 1 who had a huge fungated limb lesion offered amputation, four had wide local excision and one incision biopsy. Follow up was poor and the period ranged from 2 to 14 months (mean 7 months). Dermatofibrosarcoma protuberans is an uncommon tumour with clinical semblance to other cutaneous lesions. Early presentation, preoperative histologic diagnosis will enhance the goal of ensuring adequate excision. Adjuvant therapy with Imatinib with or without adjuvant radiotherapy are recommended in the treatment plan in view of the frequency of late presentation with advanced recurrent lesions and poor follow up.
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Case Reports
    ZDB-ID 2514363-3
    ISSN 2036-3613 ; 2036-3605
    ISSN (online) 2036-3613
    ISSN 2036-3605
    DOI 10.1177/20363613241234243
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  8. Article ; Online: Validation of the recording of idiopathic pulmonary fibrosis in routinely collected electronic healthcare records in England.

    Morgan, Ann / Gupta, Rikisha Shah / George, Peter M / Quint, Jennifer K

    BMC pulmonary medicine

    2023  Volume 23, Issue 1, Page(s) 256

    Abstract: Background: Routinely-collected healthcare data provide a valuable resource for epidemiological research. Validation studies have shown that for most conditions, simple lists of clinical codes can reliably be used for case finding in primary care, ... ...

    Abstract Background: Routinely-collected healthcare data provide a valuable resource for epidemiological research. Validation studies have shown that for most conditions, simple lists of clinical codes can reliably be used for case finding in primary care, however, studies exploring the robustness of this approach are lacking for diseases such as idiopathic pulmonary fibrosis (IPF) which are largely managed in secondary care.
    Method: Using the UK's Clinical Practice Research Datalink (CPRD) Aurum dataset, which comprises patient-level primary care records linked to national hospital admissions and cause-of-death data, we compared the positive predictive value (PPV) of eight diagnostic algorithms. Algorithms were developed based on the literature and IPF diagnostic guidelines using combinations of clinical codes in primary and secondary care (SNOMED-CT or ICD-10) with/without additional information. The positive predictive value (PPV) was estimated for each algorithm using the death record as the gold standard. Utilization of the reviewed codes across the study period was observed to evaluate any change in coding practices over time.
    Result: A total of 17,559 individuals had a least one record indicative of IPF in one or more of our three linked datasets between 2008 and 2018. The PPV of case-finding algorithms based on clinical codes alone ranged from 64.4% (95%CI:63.3-65.3) for a "broad" codeset to 74.9% (95%CI:72.8-76.9) for a "narrow" codeset comprising highly-specific codes. Adding confirmatory evidence, such as a CT scan, increased the PPV of our narrow code-based algorithm to 79.2% (95%CI:76.4-81.8) but reduced the sensitivity to under 10%. Adding evidence of hospitalisation to the standalone code-based algorithms also improved PPV, (PPV = 78.4 vs. 64.4%; sensitivity = 53.5% vs. 38.1%). IPF coding practices changed over time, with the increased use of specific IPF codes.
    Conclusion: High diagnostic validity was achieved by using a restricted set of IPF codes. While adding confirmatory evidence increased diagnostic accuracy, the benefits of this approach need to be weighed against the inevitable loss of sample size and convenience. We would recommend use of an algorithm based on a broader IPF code set coupled with evidence of hospitalisation.
    MeSH term(s) Humans ; Secondary Care ; England ; Algorithms ; Idiopathic Pulmonary Fibrosis/diagnosis ; Electronics
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-023-02550-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The psycho-sensory wake drive-a power source for power naps and other common sleep-wake phenomena: a hypothesis.

    George, Peter T

    Sleep & breathing = Schlaf & Atmung

    2017  Volume 22, Issue 1, Page(s) 41–48

    Abstract: Power naps are extensively practiced worldwide and there exists ample documentation of their efficacy in reversing daytime sleepiness. The source of their efficacy, however, as well as the cause and manifestation of many other common sleep-wake phenomena, ...

    Abstract Power naps are extensively practiced worldwide and there exists ample documentation of their efficacy in reversing daytime sleepiness. The source of their efficacy, however, as well as the cause and manifestation of many other common sleep-wake phenomena, cannot be entirely explained by the most commonly accepted model of sleep-wake regulation, the two-process model of Borbély, which considers the drives of the circadian and homeostatic sleep processes only. When considering the causes and manifestations of these unexplained phenomena, there appears to be evidence of a wake-promoting drive that is independent of the circadian oscillator indicated in the two-process model of sleep-wake regulation. Although this posited secondary wake drive, herein referred to as the psycho-sensory wake drive, is always active during the awake state, its strength unpredictably varies during a normal day and, therefore, cannot be incorporated into the prevalent two-process model by any current mathematical formula. However, a supplemental graphic model superimposing it on the drives of Process S and Process C can provides plausible and parsimonious explanations for many otherwise unexplainable sleep-wake phenomena and enables rational guidelines for their effective practical management.
    MeSH term(s) Circadian Rhythm/physiology ; Homeostasis/physiology ; Humans ; Models, Biological ; Sleep/physiology ; Sleep Stages/physiology ; Sleepiness ; Wakefulness/physiology
    Language English
    Publishing date 2017-04-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1500381-4
    ISSN 1522-1709 ; 1520-9512
    ISSN (online) 1522-1709
    ISSN 1520-9512
    DOI 10.1007/s11325-017-1505-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Contemporary Concise Review 2019: Interstitial lung disease.

    George, Peter M / Wells, Athol U

    Respirology (Carlton, Vic.)

    2020  Volume 25, Issue 7, Page(s) 756–763

    Language English
    Publishing date 2020-03-18
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13803
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