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  1. Article: The Hygiene of the Hair.

    Jackson, George Thomas

    Buffalo medical and surgical journal

    2023  Volume 26, Issue 10, Page(s) 453–460

    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 426472-1
    ISSN 1040-3825
    ISSN 1040-3825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    AMP -365/384-: Show issues

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  2. Article ; Online: Cleansing the augean stables - Time to reclassify coronary artery disease

    George Thomas

    Journal of the Practice of Cardiovascular Sciences, Vol 7, Iss 3, Pp 179-

    2021  Volume 181

    Abstract: Although there have been spectacular developments in the diagnosis and treatment of coronary artery disease (CAD), the diagnostic terminology has not evolved accordingly. The present diagnostic terms are symptom, complication, and electrocardiogram based ...

    Abstract Although there have been spectacular developments in the diagnosis and treatment of coronary artery disease (CAD), the diagnostic terminology has not evolved accordingly. The present diagnostic terms are symptom, complication, and electrocardiogram based instead of the causative pathology. In the present era of excellent therapies, angina and infarction need not occur. When our efforts are directed at preventing these ill effects of CAD, the present diagnostic terms seem anachronistic. This article presents a simple, logical, and practical approach to CAD terminology.
    Keywords classification ; coronary artery disease ; obstructions ; terminology ; Medicine ; R ; Surgery ; RD1-811 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Iodide of Potassium.

    Jackson, George Thomas

    The Southern medical record

    2022  Volume 13, Issue 8, Page(s) 296–301

    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Interactive architecture-UV protection unfolding above you!

    Kapelos, George Thomas

    The Lancet. Oncology

    2019  Volume 20, Issue 4, Page(s) 479–480

    MeSH term(s) Ambient Intelligence ; Architecture/education ; Architecture/methods ; Architecture/trends ; Climate Change ; Environment Design ; Environment, Controlled ; Humans ; Radiation Exposure/adverse effects ; Radiation Exposure/prevention & control ; Ultraviolet Rays/adverse effects
    Language English
    Publishing date 2019-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(19)30141-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 460: Show issues

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  5. Article ; Online: Lateral Filter Array Microfluidic Devices for Detecting Circulating Tumor Cells.

    Chen, Kangfu / George, Thomas J / Fan, Z Hugh

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2679, Page(s) 1–13

    Abstract: Circulating tumor cells (CTCs) are an important liquid biopsy biomarker for next-generation cancer diagnosis and prognosis. However, their clinical usage is hindered by the rarity of CTCs in patient's peripheral blood. Microfluidics has shown unique ... ...

    Abstract Circulating tumor cells (CTCs) are an important liquid biopsy biomarker for next-generation cancer diagnosis and prognosis. However, their clinical usage is hindered by the rarity of CTCs in patient's peripheral blood. Microfluidics has shown unique advantages in CTC isolation and detection. We have developed lateral filter array microfluidic (LFAM) devices for highly efficient CTC isolation. In this chapter, we describe in detail the design and fabrication of the LFAM devices and their applications for CTC enumeration from clinical blood samples.
    MeSH term(s) Humans ; Neoplastic Cells, Circulating/pathology ; Cell Separation ; Microfluidics ; Lab-On-A-Chip Devices ; Liquid Biopsy ; Neuromuscular Diseases ; Cell Line, Tumor ; Microfluidic Analytical Techniques
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3271-0_1
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  6. Article ; Online: H yposidra talaca NPV (HytaNPV)

    Bhabesh Deka / Azariah Babu / Suman Sarkar / Boney Kuriakose / George Thomas

    Egyptian Journal of Biological Pest Control, Vol 33, Iss 1, Pp 1-

    a potential baculovirus for efficient control of the black inch worm, Hyposidra talaca Walker (Lepidoptera: Geometridae), a major pest of tea Camellia sinensis (Ericales: Theaceae (L.) O. Kuntze)

    2023  Volume 10

    Abstract: Abstract Background The black inch worm (BIW), Hyposidra talaca Walker (Lepidoptera: Geometridae), is a pest that defoliates tea leaves in India, posing a significant threat to the tea industry. Nucleopolyhedrovirus (NPV) is capable of infecting larvae ... ...

    Abstract Abstract Background The black inch worm (BIW), Hyposidra talaca Walker (Lepidoptera: Geometridae), is a pest that defoliates tea leaves in India, posing a significant threat to the tea industry. Nucleopolyhedrovirus (NPV) is capable of infecting larvae of this species, which has raised the possibility of its use as a biocontrol agent. Results Rearing larvae in a semi-synthetic artificial diet produced healthy adults, which is sufficient for mass culture of H. talaca to support one of the IPM components using baculovirus. In artificial diets, the NPV was evaluated for its insecticidal activity against H. talaca. The bioassay findings of inoculated H. talaca nucleopolyhedrovirus virus (HytaNPV) at various concentrations showed that it was effective in killing the BIW. Purified polyhedral inclusion bodies (PIBs) were estimated to a concentration of 1 × 1010 PIBs per ml by mixing with water, and various concentrations of 0.25, 0.5, 1, 2, 5, 7.5, 10 ml/l were evaluated against BIW. Both laboratory and field studies revealed that HytaNPV is an eco-friendly and ecologically safe agent for controlling BIW. Besides no residue was estimated in made tea after the seventh day of exposure, and it is nontoxic to non-target species. Conclusion It was found that NPV is environmentally beneficial for the control of pests on tea plants and in production of pesticide-free tea. Tea ecosystems can reduce their reliance on conventional insecticides by using HytaNPV as an alternative bio-insecticide.
    Keywords Black inch worm ; Tea ; Hyposidra talaca ; Baculovirus ; Agriculture ; S
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Role of Immunohistochemical Expression of p53 in Intestinal Epithelial Cells to Detect Dysplasia in Patients with Inflammatory Bowel Disease

    Neethu Elizabeth George / Sarojini / George Thomas

    Journal of Clinical and Diagnostic Research, Vol 16, Iss 2, Pp EC26-EC

    2022  Volume 29

    Abstract: Introduction: Inflammatory Bowel Disease (IBD) has a genetic predisposition, in which patients are more prone to develop colorectal carcinoma. Dysplasia, a precursor of malignancy, can be very difficult to detect based on histopathological features alone. ...

    Abstract Introduction: Inflammatory Bowel Disease (IBD) has a genetic predisposition, in which patients are more prone to develop colorectal carcinoma. Dysplasia, a precursor of malignancy, can be very difficult to detect based on histopathological features alone. Tumour suppressor gene, p53, is overexpressed in IBD even when there is no histological evidence of dysplasia. Therefore, p53 can be used as a tissue biomarker for routine surveillance to initiate treatment for prevention of carcinoma. Aim: To identify the diagnostic utility of p53 immunohistochemistry in the detection of dysplasia in patients with IBD. Materials and Methods: This cross-sectional diagnostic study was conducted in the Department of Pathology at Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla, Kerala, India, from June 2016 to June 2018. Total 31 cases of intestinal biopsies in patients with chronic bloody diarrhoea were selected for the study. Immunohistochemical (IHC) staining using anti p53 antibody was done in all the cases to detect the expressed protein. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) version 20.0. Significance of p53 immunostains was done using Fischer’sexact test. Results: The age group of patients with IBD ranged from 15- 73 years with a bimodal age peak between 20-29 years and 60-69 years. Male predominance was seen among 20 cases while 11 cases were among females. Negative staining for p53 was seen in 28 cases which were negative for dysplasia histopathologically. Only one case which was histopathologically positive for dysplasia and one of the negative cases of dysplasia showed p53 positivity. Another case which was histopathologically positive for dysplasia showed negative staining for p53. Sensitivity of p53 in this study was 50% while the specificity was 96.55%. Conclusion: The finding of positive p53 expression in dysplasia positive case follows the fact that p53 mutations found in dysplastic mucosa precedes progression to neoplasia. In contrast, ...
    Keywords crohn’s disease ; colorectal cancer ; tumour suppressor gene ; ulcerative colitis ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Generic Anticancer Drugs of the Jan Aushadhi Scheme in India and Their Branded Counterparts: The First Cost Comparison Study.

    George, Thomas / Baliga, Manjeshwar S

    Cureus

    2021  Volume 13, Issue 11, Page(s) e19231

    Abstract: Introduction:  In India, the costs of cancer drugs are exorbitant and cause significant financial toxicity to the affected patient and their family members. Considering this, Jan Aushadhi pharmacy stores were established across the country by the ... ...

    Abstract Introduction:  In India, the costs of cancer drugs are exorbitant and cause significant financial toxicity to the affected patient and their family members. Considering this, Jan Aushadhi pharmacy stores were established across the country by the government of India with the objective of providing cheap generic medicines to patients. The objective of this study was to perform a cost comparison study of generic chemotherapeutic drugs provided through Jan Aushadhi pharmacies versus their branded counterparts. This will help patients and physicians get first-hand information on the cost variation between generic and branded anticancer drugs in India.
    Materials and methods:  The cost of Jan Aushadhi generic drugs and the cost of the most expensive and cheapest marketed branded drugs for the same molecule and dose were ascertained and presented in both Indian Rupees (INR) and US Dollars (as of July 2021). Finally, the difference in costs in INR, cost ratio, and cost variance were calculated, comparing the price of the Jan Aushadhi generic drugs with the most expensive and the cheapest branded drug in the same category.
    Results: Compared to branded drugs, all the Jan Ausadhi generic drugs were cheaper, except one (methotrexate). The highest cost difference was observed for docetaxel, while the least was observed for methotrexate tablets (2.5 mg). The highest cost ratio (22.24) and cost variance (3327.56) were observed for doxorubicin injection (50 mg).
    Conclusion:  The current study compares the cost difference between the marketed branded and Jan Aushadhi generic anticancer drugs for the first time. Replacing the costly branded anticancer drugs with Jan Aushadhi generic drugs can result in substantial cost savings. The information obtained from this cost difference analysis will be helpful for the healthcare fraternity, patients, policymakers, and society at large.
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.19231
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  9. Article ; Online: Using Circulating Tumor DNA for Colon Cancer Adjuvant Therapy: To Be or Not to Be?

    Morris, Van K / George, Thomas J

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2021  Volume 28, Issue 3, Page(s) 438–440

    Abstract: Detection of circulating tumor DNA (ctDNA) postoperatively is prognostic for recurrence for patients with stage III colon cancer. Those with sustained undetectable ctDNA will likely be cured. Eradication of minimal residual disease (per ctDNA clearance) ... ...

    Abstract Detection of circulating tumor DNA (ctDNA) postoperatively is prognostic for recurrence for patients with stage III colon cancer. Those with sustained undetectable ctDNA will likely be cured. Eradication of minimal residual disease (per ctDNA clearance) with chemotherapy did not occur in most ctDNA-positive patients and led to eventual disease relapse.
    MeSH term(s) Circulating Tumor DNA/genetics ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/genetics ; Humans ; Neoplasm Recurrence, Local/pathology ; Prognosis ; Prospective Studies
    Chemical Substances Circulating Tumor DNA
    Language English
    Publishing date 2021-11-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-21-3564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: The sunburst sign

    S Sheetal / Ancil George Thomas

    Archives of Medicine and Health Sciences, Vol 8, Iss 2, Pp 316-

    2020  Volume 317

    Keywords Medicine ; R
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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