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  1. Article ; Online: Epiligament or paratenon is more appropriate for describing the enveloping tissue of the cruciate ligaments of the human knee?

    Georgiev, G P

    Folia morphologica

    2021  Volume 81, Issue 1, Page(s) 258–259

    MeSH term(s) Humans ; Knee Joint ; Ligaments, Articular ; Lower Extremity
    Language English
    Publishing date 2021-02-26
    Publishing country Poland
    Document type Letter ; Comment
    ZDB-ID 419361-1
    ISSN 1644-3284 ; 0015-5659
    ISSN (online) 1644-3284
    ISSN 0015-5659
    DOI 10.5603/FM.a2021.0021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 577: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Nerve entrapment vs. possible nerve entrapment in terms of meticulous description of potential possibility of nerve compression by variant anatomical structures in cadaver.

    Georgiev, G P

    Morphologie : bulletin de l'Association des anatomistes

    2021  Volume 106, Issue 352, Page(s) 70–71

    MeSH term(s) Cadaver ; Humans ; Nerve Compression Syndromes
    Language English
    Publishing date 2021-02-10
    Publishing country France
    Document type Editorial ; Comment
    ZDB-ID 1443319-9
    ISSN 1286-0115
    ISSN 1286-0115
    DOI 10.1016/j.morpho.2021.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Abductor pollicis longus muscle - is it a new variant of the extensor forearm and thenar eminence or a well-known variation?

    Georgiev, G P

    Folia morphologica

    2020  Volume 79, Issue 2, Page(s) 417

    MeSH term(s) Forearm ; Hand ; Muscle, Skeletal ; Thumb
    Language English
    Publishing date 2020-04-24
    Publishing country Poland
    Document type Journal Article ; Comment
    ZDB-ID 419361-1
    ISSN 1644-3284 ; 0015-5659
    ISSN (online) 1644-3284
    ISSN 0015-5659
    DOI 10.5603/FM.a2020.0047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 577: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Unreported bilateral thoracic muscle - is it a new variant or a well-known subcostal muscle?

    Georgiev, G P / Olewnik, Ł

    Folia morphologica

    2022  Volume 82, Issue 2, Page(s) 447

    MeSH term(s) Thoracic Wall ; Muscle, Skeletal
    Language English
    Publishing date 2022-05-24
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 419361-1
    ISSN 1644-3284 ; 0015-5659
    ISSN (online) 1644-3284
    ISSN 0015-5659
    DOI 10.5603/FM.a2022.0050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 577: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Selection of an Amino Acid Site with One of the Fastest Cleavage Kinetics by the Endosomal Protease Cathepsin B for Potential Use in Drug Delivery Systems.

    Khramtsov, Y V / Georgiev, G P / Sobolev, A S

    Doklady. Biochemistry and biophysics

    2023  Volume 509, Issue 1, Page(s) 78–80

    Abstract: On the basis of known published data, six peptide sequences were selected that are potentially capable of being rapidly cleaved by the endosomal protease cathepsin B. For comparison, the cleavage of common linker sequences, polyglycine and polyglycine- ... ...

    Abstract On the basis of known published data, six peptide sequences were selected that are potentially capable of being rapidly cleaved by the endosomal protease cathepsin B. For comparison, the cleavage of common linker sequences, polyglycine and polyglycine-serine, by cathepsin B was also studied. Different ends of these peptides were labeled with sulfoCyanine3 and sulfoCyanine5 fluorescent dyes, between which Förster resonant energy transfer (FRET) is possible. The kinetics of cleavage of peptides by cathepsin B was studied on a multimodal plate reader by FRET signal reduction. FKFL and FRRG cleavage sites have been shown to be the most suitable for potential use in various drug delivery systems. These sites are much more efficiently cleaved under slightly acidic conditions of endosomes than at neutral extracellular pH.
    MeSH term(s) Cathepsin B/chemistry ; Cathepsin B/metabolism ; Amino Acids/metabolism ; Kinetics ; Peptides/chemistry ; Endosomes/metabolism ; Drug Delivery Systems
    Chemical Substances Cathepsin B (EC 3.4.22.1) ; Amino Acids ; Peptides
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2062390-2
    ISSN 1608-3091 ; 1607-6729
    ISSN (online) 1608-3091
    ISSN 1607-6729
    DOI 10.1134/S1607672922600221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Quantitative Description of the N-Protein of the SARS-CoV-2 Virus Degradation in Cells Stably Expressing It under the Influence of New Modular Nanotransporters.

    Khramtsov, Y V / Ulasov, A V / Lupanova, T N / Georgiev, G P / Sobolev, A S

    Doklady. Biochemistry and biophysics

    2024  Volume 513, Issue Suppl 1, Page(s) S63–S66

    Abstract: Two eukaryotic cell lines, A549 and A431, with stable expression of the nucleocapsid protein (N-protein) of the SARS-CoV-2 virus fused with the red fluorescent protein mRuby3 were obtained. Using microscopy, the volumes of the cytoplasm and nucleus were ... ...

    Abstract Two eukaryotic cell lines, A549 and A431, with stable expression of the nucleocapsid protein (N-protein) of the SARS-CoV-2 virus fused with the red fluorescent protein mRuby3 were obtained. Using microscopy, the volumes of the cytoplasm and nucleus were determined for these cells. Using quantitative immunoblotting techniques, the concentrations of the N-mRuby3 fusion protein in their cytoplasm were assessed. They were 19 and 9 μM for A549 and A431 cells, respectively. Using these concentrations, the initial rate of N-protein degradation in the studied cells was estimated from the decrease in cell fluorescence. In A549 and A431 cells, it was the same (84 nM per hour). The approach of quantitatively describing the degradation process can be applied to analyze the effectiveness of a wide class of antiviral drugs that cause degradation of viral proteins.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/metabolism ; Nucleocapsid Proteins/metabolism ; Cytoplasm/metabolism ; Proteolysis
    Chemical Substances Nucleocapsid Proteins
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2062390-2
    ISSN 1608-3091 ; 1607-6729
    ISSN (online) 1608-3091
    ISSN 1607-6729
    DOI 10.1134/S1607672923700709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Modular Nanotransporters Capable of Causing Intracellular Degradation of the N-Protein of the SARS-CoV-2 Virus in A549 Cells with Temporary Expression of This Protein Fused with a Fluorescent Protein mRuby3.

    Khramtsov, Y V / Ulasov, A V / Lupanova, T N / Georgiev, G P / Sobolev, A S

    Doklady. Biochemistry and biophysics

    2024  Volume 513, Issue Suppl 1, Page(s) S60–S62

    Abstract: Modular nanotransporters (MNTs) containing an antibody-like molecule, monobody, to the N‑protein of the SARS-CoV-2 virus, as well as an amino acid sequence that recruits the Keap1 E3 ligase (E3BP) were created. This MNT also included a site for cleavage ... ...

    Abstract Modular nanotransporters (MNTs) containing an antibody-like molecule, monobody, to the N‑protein of the SARS-CoV-2 virus, as well as an amino acid sequence that recruits the Keap1 E3 ligase (E3BP) were created. This MNT also included a site for cleavage of the E3BP monobody from the MNT in acidic endocytic compartments. It was shown that this cleavage by the endosomal protease cathepsin B leads to a 2.7-fold increase in the affinity of the E3BP monobody for the N-protein. Using A549 cells with transient expression of the N-protein fused with the fluorescent protein mRuby3, it was shown that incubation with MNT leads to a significant decrease in mRuby3 fluorescence. It is assumed that the developed MNTs can serve as a basis for the creation of new antiviral drugs against the SARS-CoV-2 virus.
    MeSH term(s) Humans ; A549 Cells ; SARS-CoV-2 ; Kelch-Like ECH-Associated Protein 1 ; COVID-19 ; NF-E2-Related Factor 2
    Chemical Substances Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2062390-2
    ISSN 1608-3091 ; 1607-6729
    ISSN (online) 1608-3091
    ISSN 1607-6729
    DOI 10.1134/S1607672923700710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: HspBP1 in Complex with the Peptide of the Innate Immunity Protein Tag7 is Able to Lyse Tumor Cells Carrying TNFR1 Receptor.

    Romanova, E A / Yurkina, D M / Yashin, D V / Sashchenko, L P / Georgiev, G P

    Doklady. Biochemistry and biophysics

    2024  Volume 515, Issue 1, Page(s) 36–40

    Abstract: The search for new cytotoxic agents capable of lysing tumor cells is an important task in the fight against cancer. Here we have shown that the HspBP1 protein, the chaperone of the heat shock protein Hsp70, is able to form a complex with the previously ... ...

    Abstract The search for new cytotoxic agents capable of lysing tumor cells is an important task in the fight against cancer. Here we have shown that the HspBP1 protein, the chaperone of the heat shock protein Hsp70, is able to form a complex with the previously discovered peptide (17.1) of the innate immunity protein Tag7. Experiments using thermophoresis demonstrated that the affinity of the Tag7 protein peptide 17.1 to the HspBP1 molecule is 100 times higher than that of the full-sized Tag7 molecule. The addition of the 17.1-HspBP1 complex to tumor cells induces apoptosis and necroptosis in them. The results obtained in this work can be used to develop promising antitumor drugs.
    MeSH term(s) Apoptosis ; HSP70 Heat-Shock Proteins/metabolism ; Immunity, Innate ; Peptides/pharmacology ; Receptors, Tumor Necrosis Factor, Type I
    Chemical Substances HSP70 Heat-Shock Proteins ; Peptides ; Receptors, Tumor Necrosis Factor, Type I
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2062390-2
    ISSN 1608-3091 ; 1607-6729
    ISSN (online) 1608-3091
    ISSN 1607-6729
    DOI 10.1134/S1607672923700631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Discovery of Nuclear DNA-like RNA (dRNA, hnRNA) and Ribonucleoproteins Particles Containing hnRNA.

    Georgiev, G P

    Acta naturae

    2016  Volume 8, Issue 1, Page(s) 6–12

    Abstract: On August 9-11, 2014, Cold Spring Harbor (USA) hosted a special symposium dedicated to the discovery of messenger or informational RNA and the main events in the subsequent studies of its synthesis, regulation of synthesis, maturation, and transport. The ...

    Abstract On August 9-11, 2014, Cold Spring Harbor (USA) hosted a special symposium dedicated to the discovery of messenger or informational RNA and the main events in the subsequent studies of its synthesis, regulation of synthesis, maturation, and transport. The existence of mRNA in bacteria was first suggested in 1961 by Jacob and Monod, based on genetic studies [1]. The same year, Brenner et al. confirmed the hypothesis [2]. Our laboratory played a key role in the discovery of messenger RNA in eukaryotes, as well as in the discovery of the nuclear ribonucleoproteins that contain it and in the elucidation of their structural organization. Therefore, I was invited to represent Russia at the Symposium and deliver a speech on these topics. However, my visa had only been issued after the end of the Symposium, and, therefore, the presentation was delivered by my former colleague G.N. Yenikolopov, who works at Cold Spring Harbor Laboratory. The transcript of the lecture is presented below.
    Language English
    Publishing date 2016-04-20
    Publishing country Russia (Federation)
    Document type Journal Article
    ISSN 2075-8251
    ISSN 2075-8251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Mechanisms of Action of the PGLYRP1/Tag7 Protein in Innate and Acquired Immunity.

    Yashin, D V / Sashchenko, L P / Georgiev, G P

    Acta naturae

    2021  Volume 13, Issue 1, Page(s) 91–101

    Abstract: One of the promising fields of modern molecular biology is the search for new proteins that regulate the various stages of the immune response and the investigation of the molecular mechanisms of action of these proteins. Such proteins include the ... ...

    Abstract One of the promising fields of modern molecular biology is the search for new proteins that regulate the various stages of the immune response and the investigation of the molecular mechanisms of action of these proteins. Such proteins include the multifunctional protein PGLYRP1/Tag7, belonging to the PGRP-S protein family, whose gene was discovered in mice at the Institute of Gene Biology, Russian Academy of Sciences, in 1996. PGLYRP1/Tag7 is classified as a protein of innate immunity; however, it can also participate in the regulation of acquired immunity mechanisms. In this paper, we consider the involvement of PGLYRP1/Tag7 in the triggering of antimicrobial defense mechanisms and formation of subsets of cytotoxic lymphocytes that kill tumor cells. The paper emphasizes that the multifaceted functional activity of Tag7 in the immune response has to do with its ability to interact with various proteins to form stable protein complexes. Hsp70-associated Tag7 can induce the death of tumor cells carrying the TNFR1 receptor. Tag7, associated with the Mts1 (S100A4) protein, can stimulate the migration of innate and adaptive immune cytotoxic lymphocytes to a lesion site. Involvement of Tag7 in the regulation of immunological processes suggests that it may be considered as a promising agent in cancer therapy. These properties of Tag7 were used to develop autologous vaccines that have passed the first and second phases of clinical trials in patients with end-stage melanoma and renal cancer. The C-terminal peptide of Tag7, isolated by limited proteolysis, was shown to protect the cartilage and bone tissue of the ankle joint in mice with induced autoimmune arthritis and may be a promising drug for suppressing the development of inflammatory processes.
    Language English
    Publishing date 2021-04-15
    Publishing country Russia (Federation)
    Document type Journal Article
    ISSN 2075-8251
    ISSN 2075-8251
    DOI 10.32607/actanaturae.11102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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