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  1. Article ; Online: Sodium-hyaluronate Cystic-like Lesion in the Anterior Chamber Following Cataract Surgery

    Christina Mitsi / Minas Bakirtzis / Eirini-Kanella Panagiotopoulou / Georgios Labiris

    Acta Medica, Vol 66, Iss 2, Pp 72-

    A Case Report

    2023  Volume 74

    Abstract: This is a case report describing the uncommon finding of a cystic-like lesion and its management in the anterior chamber of a male patient after cataract surgery. ...

    Abstract This is a case report describing the uncommon finding of a cystic-like lesion and its management in the anterior chamber of a male patient after cataract surgery.
    Keywords Medicine ; R
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Karolinum Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Impact of Light Conditions on Visual Performance following Premium Pseudophakic Presbyopia Corrections

    Eirini-Kanella Panagiotopoulou / Kostas Boboridis / Ioannis Seimenis / Georgios Labiris

    Journal of Clinical Medicine, Vol 12, Iss 4324, p

    2023  Volume 4324

    Abstract: The primary objective of this study was to objectively compare the visual performance of patients following premium pseudophakic presbyopia corrections in different light combinations for near- and intermediate-vision activities of daily living (ADLs). ... ...

    Abstract The primary objective of this study was to objectively compare the visual performance of patients following premium pseudophakic presbyopia corrections in different light combinations for near- and intermediate-vision activities of daily living (ADLs). This is a prospective, comparative study. A total of 75 patients populated three study groups: G1-patients with bilateral trifocal implantation, G2-patients with bilateral bifocal implantation, and G3-patients with bilateral monofocal implantation. All participants addressed 10 ADLs in nine combinations of light temperature (3000 K, 4000 K, and 6000 K) and light intensity (25 fc, 50 fc, and 75 fc) and declared their subjectively optimal light combination while reading. G2 and G3 had the best total ADL scores in 6000 K/75 fc, while G1 had the best total ADL score in 4000 K/75 fc. Total ADL, easy ADL, and moderate difficulty ADL scores were significantly better in G2, while difficult ADL score was significantly better in G1. The majority of all groups selected 6000 K/75 fc as the most comfortable light combination, and no group selected 3000 K and 25 fc. In conclusion, trifocal patients benefit from intense daylight, while bifocal and monofocal patients benefit from intense, cold lighting. Trifocal patients present superior near-vision capacity in difficult near-vision daily tasks, while bifocal patients present superiority in easy and moderate-difficulty ADLs.
    Keywords activities of daily living ; light intensity ; light temperature ; presbyopia ; multifocal intraocular lens ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Catquest-9SF questionnaire

    Panagiotis Nanos / Vasiliki Kouteliari / Eirini-Kanella Panagiotopoulou / Nikolaos Papadopoulos / Panagiota Ntonti / Georgios Labiris

    PLoS ONE, Vol 17, Iss

    Validation in a Greek-speaking population using Rasch analysis

    2022  Volume 12

    Abstract: Purpose The Catquest-9SF questionnaire is a tool measuring visual disability and vision-related limitation in patients’ daily activities. The primary objective of this study was the validation of Catquest-9SF in a Greek-speaking cataract population. ... ...

    Abstract Purpose The Catquest-9SF questionnaire is a tool measuring visual disability and vision-related limitation in patients’ daily activities. The primary objective of this study was the validation of Catquest-9SF in a Greek-speaking cataract population. Methods The questionnaire was translated into Greek and translated back into English. A pre-final Greek version was formed and tested by 10 Greek-English bilingual participants and by the translation team, and the final version was produced. Patients scheduled for cataract surgery completed the questionnaire preoperatively and postoperatively. Rasch analysis was performed for the assessment of the Catquest-9SF psychometric properties, including response category ordering, item fit statistics, principal components analysis, precision, differential item functioning and targeting for preoperative and postoperative data collectively. Results A total of 100 (55 men, 45 women, mean age = 71.94±6.63) cataract patients completed the Greek version of Catquest-9SF questionnaire preoperatively and postoperatively. Rasch analysis showed a significant improvement in the median person Rasch score from −1.49 preoperatively to −4.71 logits postoperatively, while the effect size was 1.3. Unidimensionality was confirmed since infit and outfit mean square values varied between 0.66 and 1.37. Rasch analysis showed good precision and separation ability (Person Separation Index of 3.28, and Person Reliability of 0.92). Four response categories were found for all items. The item-person means difference was -1.83 logits. The difference between preoperative and postoperative Catquest-9SF logit score was positively correlated with preoperative Catquest-9SF logit score (coeff. = 0.798, p<0.0001) and negatively correlated with postoperative spherical equivalent (coeff. = -0.825, p = 0.011). Conclusion The Greek version of Catquest-9SF proved to be reliable, valid, unidimensional and responsive to changes after cataract surgery presenting good psychometric properties for cataract patients. ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 150
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The Effect of Antiglaucoma Procedures (Trabeculectomy vs. Ex-PRESS Glaucoma Drainage Implant) on the Corneal Biomechanical Properties

    Aristeidis Konstantinidis / Eirini-Kanella Panagiotopoulou / Georgios D. Panos / Haris Sideroudi / Aysel Mehmet / Georgios Labiris

    Journal of Clinical Medicine, Vol 10, Iss 4, p

    2021  Volume 802

    Abstract: The aim of this study is to investigate the effect of two antiglaucoma procedures, namely trabeculectomy and Ex-PRESS mini-shunt insertion on the biomechanical properties of the cornea. This is a prospective study. Thirty patients (30 eyes) were included ...

    Abstract The aim of this study is to investigate the effect of two antiglaucoma procedures, namely trabeculectomy and Ex-PRESS mini-shunt insertion on the biomechanical properties of the cornea. This is a prospective study. Thirty patients (30 eyes) were included in the study. Nineteen eyes had an Ex-PRESS shunt inserted (Group 1) and 11 had trabeculectomy (Group 2). The examination time points for both groups were one to three weeks preoperatively and at month 1, 6, and 12 postoperatively. Corneal biomechanical properties (corneal hysteresis (CH) corneal resistance factor (CRF)) were measured with the Ocular Response Analyzer (ORA). In group 1, CH was significantly increased at 6 and 12 months compared to baseline values. Corneal hysteresis was also higher at 1 month postoperatively, but this increase did not reach statistical significance. In group 2, the CH was significantly increased at all time points compared to the preoperative values. CRF decreased at all time points postoperatively compared to the preoperative values in both groups. The difference (preoperative values to postoperative values at all time points) of the CH and CRF between the two groups was also compared and no significant differences were detected between the two surgical techniques. Trabeculectomy and the EX-PRESS mini-shunt insertion significantly alter the corneal biomechanical properties as a result of the surgical trauma and the presence of the shunt in the corneal periphery. When compared between them, they affect the corneal biomechanical properties in a similar way.
    Keywords glaucoma ; trabeculectomy ; corneal hysteresis ; corneal resistance factor ; Medicine ; R
    Subject code 796
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Development and Validation of the First Smart TV-Based Visual Acuity Test

    Georgios Labiris / Konstantinos Delibasis / Eirini-Kanella Panagiotopoulou / Vassilis Pigadas / Minas Bakirtzis / Christos Panagis / Doukas Dardabounis / Panagiota Ntonti

    Healthcare, Vol 10, Iss 2117, p

    A Prospective Study

    2022  Volume 2117

    Abstract: 1) Background: While smartphones are among the primary devices used in telemedical applications, smart TV healthcare apps are not prevalent despite smart TVs’ penetrance in home settings. The present study’s objective was to develop and validate the ... ...

    Abstract (1) Background: While smartphones are among the primary devices used in telemedical applications, smart TV healthcare apps are not prevalent despite smart TVs’ penetrance in home settings. The present study’s objective was to develop and validate the first smart TV-based visual acuity (VA) test (Democritus Digital Visual Acuity Test (DDiVAT)) that allows a reliable VA self-assessment. (2) Methods: This is a prospective validation study. DDiVAT introduces several advanced features for reliable VA self-testing; among them: automatic calibration, voice recognition, voice guidance, automatic calculation of VA indexes, and a smart TV-based messaging system. Normal and low vision participants were included in the validation. DDiVAT VA results (VA DDiVAT ) were compared against the ones from: (a) the gold-standard conventional ETDRS (VA ETDRS ), and, (b) an independent ophthalmologist who monitored the self-examination testing (VA RES ). Comparisons were performed by noninferiority test (set at 2.5-letters) and intraclass correlation coefficients (ICCs). DDiVAT’s test-retest reliability was assessed within a 15-day time-window. (3) Results: A total of 300 participants (185 and 115 with normal and low vision, respectively) responded to ETDRS and DDiVAT. Mean difference in letters was −0.05 for VA ETDRS –VA RES , 0.62 for VA RES –VA DDiVAT , and 0.67 for VA ETDRS –VA DDiVAT , significantly lower than the 2.5 letter noninferiority margin. ICCs indicated an excellent level of agreement, collectively and for each group (0.922-0.996). All displayed letters in DDiVAT presented a similar difficulty. The overall accuracy of the voice recognition service was 96.01%. ICC for VA DDiVAT test-retest was 0.957. (4) Conclusions: The proposed DDiVAT presented non-significant VA differences with the ETDRS, suggesting that it can be used for accurate VA self-assessment in telemedical settings, both for normal and low-vision patients.
    Keywords visual acuity test ; smart TV ; smartphone ; home ; validation ; telemedicine ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Corneal Graft Success Rates in HSV Keratitis

    Konstantinos Skarentzos / Eleftherios Chatzimichael / Eirini-Kanella Panagiotopoulou / Sergios Taliantzis / Aristeidis Konstantinidis / Georgios Labiris

    Acta Medica, Vol 63, Iss 4, Pp 150-

    A Systematic Review

    2020  Volume 158

    Abstract: Herpes Simplex Virus (HSV) has worldwide prevalence. The primary objective of this systematic review was to compare penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) regarding the efficacy and complications of the treatment of ... ...

    Abstract Herpes Simplex Virus (HSV) has worldwide prevalence. The primary objective of this systematic review was to compare penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) regarding the efficacy and complications of the treatment of corneal scarring caused by herpes simplex keratitis. Out of the 469 articles identified during the combined search of the literature based on the PubMed and Cochrane libraries, 10 retrospective and 2 prospective studies published from January 2010 to December 2019 were included. The study outcomes indicated that both surgical approaches resulted in a comparable improvement of visual acuity (VA). However, DALK demonstrated fewer complications in the majority of studies. Higher graft survival rates were associated with higher acyclovir (ACV) doses (above 800 mg/day), topical steroid and antibiotic drops. In conclusion, in terms of postoperative VA, both PK and DALK demonstrate comparable efficacy. However, DALK, which is applied in less severe HSK cases, is associated with fewer complications and better graft survival rates. High dosages of ACV, topical steroids and antibiotics contribute significantly to improved postoperative outcomes.
    Keywords herpes simplex virus ; herpes simplex keratitis ; penetrating keratoplasty ; deep anterior lamellar keratoplasty ; systematic review ; Medicine ; R
    Subject code 306 ; 610
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Karolinum Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Development and Validation of the Life for Low Vision Questionnaire (LIFE4LVQ) Using Rasch Analysis

    Stavroula Almpanidou / Diamantis Almaliotis / Leonidas Karamitopoulos / Fotios Topouzis / Anastasios-Georgios Konstas / Georgios Labiris / Theodoros Dardavesis / Konstantinos N. Fountoulakis / Konstantinos Ch. Chatzisavvas / Vasileios Karampatakis

    Journal of Clinical Medicine, Vol 12, Iss 2549, p

    A Questionnaire Evaluating Ability and Independence

    2023  Volume 2549

    Abstract: Low vision (LV) has a substantial impact on an individual’s daily functionality and patient-reported outcome measures (PROMs) are increasingly incorporated into the evaluation of this problem. The objective of this study was to describe the design of the ...

    Abstract Low vision (LV) has a substantial impact on an individual’s daily functionality and patient-reported outcome measures (PROMs) are increasingly incorporated into the evaluation of this problem. The objective of this study was to describe the design of the new “Life for Low Vision Questionnaire (LIFE4LVQ)”, as a measure of daily functionality in LV and to explore its psychometric properties. A total of 294 participants completed the LIFE4LVQ and the data were subjected to Rasch analysis to determine the psychometric properties of the questionnaire, including response category ordering, item fit statistics, principal component analysis, precision, differential item functioning, and targeting. Test–retest reliability was evaluated with an interval of three weeks and intraclass correlation coefficients (ICC) were used. The correlation between the questionnaire score and Best Corrected Visual Acuity (BCVA) was examined using Spearman’s correlation coefficient. Rasch analysis revealed that for most items the infit and outfit mean square fit values were close to 1, both for the whole scale and its subscales (ability and independence). The separation index for person measures was 5.18 with a reliability of 0.96, indicating good discriminant ability and adequate model fit. Five response categories were found for all items. The ICC was 0.96 (p < 0.001; 95% CI, 0.93–0.98), suggesting excellent repeatability of the measure. Poorer BCVA was significantly associated with worse scores (rho = 0.559, p < 0.001), indicating excellent convergent validity. The functional, 40-item LIFE4LVQ proved to be a reliable and valid tool that effectively measures the impact of LV on ability and independence.
    Keywords low vision ; functionality ; ability ; independence ; Rasch analysis ; PROMs ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Α Case of Severe Thyroid Eye Disease Treated with Tocilizumab

    Aysel Mehmet / Eirini-Kanella Panagiotopoulou / Aristeidis Konstantinidis / Charalampos Papagoras / Panagiotis Skendros / Doukas Dardabounis / Athanasia Maria Mikropoulou / Georgios Labiris

    Acta Medica, Vol 64, Iss 1, Pp 64-

    2021  Volume 69

    Abstract: This is a case report describing a patient with severe thyroid eye disease complicated with dysthyroid optic neuropathy that was unresponsive to intravenous steroids and orbital radiotherapy but responded well to intravenous tocilizumab. ...

    Abstract This is a case report describing a patient with severe thyroid eye disease complicated with dysthyroid optic neuropathy that was unresponsive to intravenous steroids and orbital radiotherapy but responded well to intravenous tocilizumab.
    Keywords thyroid eye disease ; tocilizumab ; Medicine ; R
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Karolinum Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Determinants of compliance to the facemask directive in Greece

    Georgios Labiris / Eirini-Kanella Panagiotopoulou / Asli Perente / Eleftherios Chatzimichael / Ioannis Fotiadis / Sergios Taliantzis / Aristeidis Konstantinidis / Doukas Dardabounis

    PLoS ONE, Vol 16, Iss 3, p e

    A population study.

    2021  Volume 0248929

    Abstract: Purpose Primary objective of this study was to identify potential difficulties and/or discomfort when using a facemask. Moreover, to explore the impact of spectacles, contact lenses and visual acuity on the compliance to the facemask directive. Methods ... ...

    Abstract Purpose Primary objective of this study was to identify potential difficulties and/or discomfort when using a facemask. Moreover, to explore the impact of spectacles, contact lenses and visual acuity on the compliance to the facemask directive. Methods This is a prospective study that was conducted at the Department of Ophthalmology, University Hospital of Alexandroupolis, Greece between June 2020 and August 2020. Greek speaking citizens with permanent residency in Greece above 18 years old were included. A custom questionnaire (DeMask-20) was constructed and validated, which pertained to the perceived difficulty and discomfort when using a facemask. It contained 20 items grouped in 8 subscales (driving, near vision, distance vision, ocular discomfort, role limitation, collaboration, dependency on others, emotional stress). Perceived difficulty and discomfort when using a facemask, compliance and correlations of compliance with DeMask-20 scores, demographics, spectacle and/or contact lens use, and visual acuity were evaluated. Results The number of factors was determined through factor analysis. Cronbach's alpha ranged from 0.716 for the "Role limitation" subscale to 0.938 for "Ocular discomfort" subscale. 1,214 participants (402 men, 812 women, mean age 36.79±12.50 years) completed the DeMask-20 instrument. Mean DeMask-20 score of all study participants was 3.79±0.71. Significant differences in DeMask-20 score were detected in gender (p = 0.009), spectacle use (p = 0.034), contact lens use (p = 0.049), and binocular distance visual acuity (bDVA) (p = 0.001). Mean compliance of all participants was 4.05±0.96. Men, people <50 years and spectacle wearers showed significantly worse compliance (p<0.05). Moreover, professional workers and professional drivers demonstrated significantly better compliance (p = 0.008 and p = 0.047). Significant correlation was detected between compliance and DeMask-20 score (p<0.001, R2 = 0.471). Significant correlations were detected with driving, near vision, distance vision, ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 150
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Serpiginous Choroiditis Complicated with Choroidal Neovascular Membrane Detected using Optical Coherence Tomography Angiography

    Asli Perente / Dimitra Kotsiliti / Sergios Taliantzis / Eirini Kanella Panagiotopoulou / Maria Gkika / Irfan Perente / Doukas Dardabounis / Georgios Labiris

    Türk Oftalmoloji Dergisi, Vol 51, Iss 5, Pp 326-

    A Case Series and Literature Review

    2021  Volume 333

    Abstract: Serpiginous choroiditis (SC) is a rare, chronic, recurrent, progressive disease of unknown origin. The inflammatory process of SC can disrupt Bruch’s membrane, allowing occasional choroidal vascular growth, leading to significant visual loss even in the ... ...

    Abstract Serpiginous choroiditis (SC) is a rare, chronic, recurrent, progressive disease of unknown origin. The inflammatory process of SC can disrupt Bruch’s membrane, allowing occasional choroidal vascular growth, leading to significant visual loss even in the healed stages of the disease. Optical coherence tomography angiography (OCTA) can help in the detection of choroidal neovascular membrane (CNV), leading to a definitive diagnosis and thereby guide the initiation of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment. We report herein two cases of SC complicated with a CNV detected with OCTA and treated with a series of anti-VEGF injections.
    Keywords serpiginous choroiditis ; neovascular membrane ; optical coherence tomography angiography ; anti-vegf ; Medicine ; R ; Ophthalmology ; RE1-994
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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