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  1. Article ; Online: Nebulization as a tool for photosensitizer delivery to the respiratory tract.

    Kassab, Giulia / Geralde, Mariana C / Inada, Natalia M / Achiles, Ana E / Guerra, Vádila G / Bagnato, Vanderlei S

    Journal of biophotonics

    2018  Volume 12, Issue 4, Page(s) e201800189

    Abstract: To this day, any photosensitizers for the photodynamic treatment of pulmonary illnesses have been administered intravenously. There is, however, an intrinsic difficulty in reaching the target cells or bacteria in the respiratory system. Nebulization ... ...

    Abstract To this day, any photosensitizers for the photodynamic treatment of pulmonary illnesses have been administered intravenously. There is, however, an intrinsic difficulty in reaching the target cells or bacteria in the respiratory system. Nebulization could overcome distribution problems and alleviate side effects by delivering the photosensitizers directly to the lungs. In this study, we evaluated the viability of three photosensitizers (indocyanine green, the chlorine Photodithazine, and the porphyrin Photogem) was evaluated comparatively in a jet nebulizer. Quantitative analysis was performed by looking at the droplet size, extent of nebulization, output over time and stability of the solutions. All of the tested photosensitizers were found to be adequately nebulized. We also demonstrated the delivery of indocyanine green to the pulmonary tract and its activation with infrared light in a murine model using extracorporeal detection of fluorescence. This was an important step toward clinical implementation of the extracorporeally illuminated photodynamic inactivation of pneumonia, recently demonstrated in vivo by this research group.
    MeSH term(s) Animals ; Drug Delivery Systems/instrumentation ; Female ; Lung/metabolism ; Mice ; Mice, Inbred BALB C ; Nebulizers and Vaporizers ; Photosensitizing Agents/administration & dosage
    Chemical Substances Photosensitizing Agents
    Language English
    Publishing date 2018-12-26
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.201800189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6723: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Pneumonia treatment by photodynamic therapy with extracorporeal illumination - an experimental model.

    Geralde, Mariana C / Leite, Ilaiáli S / Inada, Natalia M / Salina, Ana Carolina G / Medeiros, Alexandra I / Kuebler, Wolfgang M / Kurachi, Cristina / Bagnato, Vanderlei S

    Physiological reports

    2017  Volume 5, Issue 5

    Abstract: Infectious pneumonia is a major cause of morbidity/mortality, mainly because of the increasing rate of microorganisms resistant to antibiotics. Photodynamic Therapy (PDT) is emerging as a promising approach, as effects are based on oxidative stress, ... ...

    Abstract Infectious pneumonia is a major cause of morbidity/mortality, mainly because of the increasing rate of microorganisms resistant to antibiotics. Photodynamic Therapy (PDT) is emerging as a promising approach, as effects are based on oxidative stress, preventing microorganism resistance. In two previous studies, the in vitro inactivation of
    MeSH term(s) Animals ; Disease Models, Animal ; Indocyanine Green/pharmacology ; Mice ; Photochemotherapy/methods ; Photosensitizing Agents/pharmacology ; Phototherapy/methods ; Pneumonia, Pneumococcal/therapy ; Streptococcus pneumoniae ; Treatment Outcome
    Chemical Substances Photosensitizing Agents ; Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2017-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.13190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Near-infrared photodynamic inactivation of S. pneumoniae and its interaction with RAW 264.7 macrophages.

    Leite, Ilaiáli S / Geralde, Mariana C / Salina, Ana C G / Medeiros, Alexandra I / Dovigo, Lívia N / Bagnato, Vanderlei S / Inada, Natalia M

    Journal of biophotonics

    2017  Volume 11, Issue 1

    Abstract: Pneumonia is the main cause of children mortality worldwide, and its major treatment obstacle stems from the microorganisms increasing development of resistance to several antibiotics. Photodynamic therapy has been presenting, for the last decades, ... ...

    Abstract Pneumonia is the main cause of children mortality worldwide, and its major treatment obstacle stems from the microorganisms increasing development of resistance to several antibiotics. Photodynamic therapy has been presenting, for the last decades, promising results for some subtypes of cancer and infections. In this work we aimed to develop a safe and efficient in vitro protocol for photodynamic inactivation of Streptococcus pneumoniae, one of the most commonly found bacteria in pneumonia cases, using two near-infrared light sources and indocyanine green, a FDA approved dye. Photodynamic inactivation experiments with bacteria alone allowed to determine the best parameters for microbial inactivation. Cytotoxicity assays with RAW 264.7 macrophages evaluated the safety of the PDI. To determine if the photodynamic inactivation had a positive or negative effect on the natural killing action of macrophages, we selected and tested fewer indocyanine green concentrations and 10 J/cm
    MeSH term(s) Animals ; Coculture Techniques ; Indocyanine Green/pharmacology ; Infrared Rays ; Macrophages/drug effects ; Macrophages/microbiology ; Macrophages/radiation effects ; Mice ; Microbial Viability/drug effects ; Microbial Viability/radiation effects ; Photosensitizing Agents/pharmacology ; RAW 264.7 Cells ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/physiology ; Streptococcus pneumoniae/radiation effects
    Chemical Substances Photosensitizing Agents ; Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2017-05-18
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.201600283
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6723: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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