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Article: Differences in the accumulaiton of ascorbic acid in normal, myeloperoxidase deficient and NADPH-oxidase deficient granulocytes

Gerber, C.E / Niethammer, D / Bruchelt, G

International journal for vitamin and nutrition research July 2002. v. 72 (4)

2002

Abstract: Granulocytes contain large quantities of ascorbic acid (AA). The uptake mechanism is mainly restricted to the accumulation of the oxidized form, dehydroascorbate (DHA). We investigated the uptake of ascorbic acid and dehydroascorbate of normal, ... ...

Abstract	Granulocytes contain large quantities of ascorbic acid (AA). The uptake mechanism is mainly restricted to the accumulation of the oxidized form, dehydroascorbate (DHA). We investigated the uptake of ascorbic acid and dehydroascorbate of normal, myeloperoxidase (MPO)-deficient, and NADPH-oxidase-deficient granulocytes. The accumulation of ascorbic acid was increased in all types of granulocytes after stimulation with phorbol-myristate-acetate, whereas the NADPH-oxidase-deficient cells showed a decreased uptake compared to normal and MPO-deficient cells. The intracellular concentration of ascorbic acid was further enhanced after incubation of granulocytes with DHA, most prominently in NADPH-oxidase-deficient granulocytes. MPO-deficient granulocytes are not able to produce HOCl after activation. The granulocytes of one individual with total MPO deficiency accumulated ascorbate in higher concentrations than did cells, with partial MPO deficiency, indicating that HOCl is of minor importance for the oxidation of ascorbate. Since the ability of MPO-deficient cells to kill microorganisms is pronounced in contrast to NADPH-oxidase-deficient cells, effective mechanisms of compensating for the absence of HOCl must exist. We hypothesize that the enhanced uptake of ascorbic acid combined with an enhanced superoxide anion production may favor the generation of OH radicals via the Fenton reaction.
Keywords	granulocytes ; ascorbic acid ; peroxidases ; oxidoreductases ; chemical composition ; nutrient uptake ; dehydroascorbic acid
Language	English
Dates of publication	2002-07
Size	p. 251-256.
Document type	Article
ZDB-ID	120692-8
ISSN	0300-9831
ISSN	0300-9831
Database	NAL-Catalogue (AGRICOLA)

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Article: Detection by ELISA of low transferrin levels in bronchoalveolar secretions of preterm infants.

Gerber, C E / Bruchelt, G / Götze-Speer, B / Speer, C P

Journal of immunological methods

2000 Volume 233, Issue 1-2, Page(s) 41–45

Abstract: Transferrin levels in bronchoalveolar secretions (BAS) are very low compared to serum levels in humans. For the exact measurement of transferrin concentrations in BAS a very sensitive assay was developed as a double sandwich enzyme immunoassay using the ... ...

Abstract	Transferrin levels in bronchoalveolar secretions (BAS) are very low compared to serum levels in humans. For the exact measurement of transferrin concentrations in BAS a very sensitive assay was developed as a double sandwich enzyme immunoassay using the combination of a polyclonal and a monoclonal antibody against human transferrin. The measurable range of the assay was 1.5 to 100 ng/ml of human transferrin. The lowest measurable value was 0.84 ng/ml and the sensitivity of the assay was 0.88 ng/ml. The coefficient of variation was 14.1% for 25 ng/ml (intra-assay) and 11-20% (inter-assay). The levels measured in 123 samples of BAS of preterm infants ranged between 0.03 and 8.93 (microgram/microgram secretory component (SC)). The determination of transferrin in BAS of preterm infants is helpful in determining oxidative damage, e.g. the availability of free iron, in the neonatal lung. The transferrin concentration in BAS of neonates who recovered from respiratory distress syndrome (RDS) in the first six days of life was 0.48 compared to 0.52 ((microgram/microgram SC), median range) for infants who developed chronic lung disease.
MeSH term(s)	Antibodies, Monoclonal ; Bronchi/metabolism ; Bronchoalveolar Lavage Fluid/chemistry ; Enzyme-Linked Immunosorbent Assay/methods ; Enzyme-Linked Immunosorbent Assay/statistics & numerical data ; Evaluation Studies as Topic ; Humans ; Infant, Newborn ; Infant, Premature/physiology ; Pulmonary Alveoli/metabolism ; Respiratory Distress Syndrome, Newborn/physiopathology ; Sensitivity and Specificity ; Transferrin/analysis ; Transferrin/immunology ; Transferrin/metabolism
Chemical Substances	Antibodies, Monoclonal ; Transferrin
Language	English
Publishing date	2000-01-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120142-6
ISSN	1872-7905 ; 0022-1759
ISSN (online)	1872-7905
ISSN	0022-1759
DOI	10.1016/s0022-1759(99)00191-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 795: Show issues

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Article: Presence of bleomycin-detectable free iron in the alveolar system of preterm infants.

Gerber, C E / Bruchelt, G / Stegmann, H / Schweinsberg, F / Speer, C P

Biochemical and biophysical research communications

1999 Volume 257, Issue 1, Page(s) 218–222

Abstract: Chronic lung disease (CLD) is a major cause of long term morbidity in preterm infants. Reactive oxygen species (ROS) play an important role in the pathogenesis of CLD. We show that a high percentage (63 to 83%) of the investigated bronchoalveolar ... ...

Abstract	Chronic lung disease (CLD) is a major cause of long term morbidity in preterm infants. Reactive oxygen species (ROS) play an important role in the pathogenesis of CLD. We show that a high percentage (63 to 83%) of the investigated bronchoalveolar secretions (BAS) of neonates contain bleomycin-detectable free iron concentrations (0. 04-0.124 nmol/micrograms SC, median range). Beside the presence of redox-active iron several iron-binding proteins like transferrin, ferritin and lactoferrin were determined in BAS. Comparison of protein distribution within the first three days of life showed slight differences between the group of preterm infants who developed CLD and the neonates who recovered from RDS. Because of the existence of free iron we suggest a higher risk of hydroxyl radical formation in the alveolar space. In an artificial system with addition of iron and hydrogen peroxide we were able to demonstrate OH-radical production in BAS by electron paramagnetic resonance (EPR). OH-radical formation by H2O2 and iron in buffer solution was slightly enhanced in the presence of BAS, indicating the absence of OH-radical-scavengers in BAS.
MeSH term(s)	Albumins/metabolism ; Bleomycin/pharmacology ; Bronchoalveolar Lavage Fluid/chemistry ; Electron Spin Resonance Spectroscopy ; Ferritins/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; Hydroxyl Radical/metabolism ; Infant, Newborn ; Infant, Premature/metabolism ; Iron/metabolism ; Lactoferrin/metabolism ; Oxidation-Reduction/drug effects ; Pulmonary Alveoli/metabolism ; Reactive Oxygen Species/metabolism ; Respiratory Distress Syndrome, Newborn/etiology ; Respiratory Distress Syndrome, Newborn/metabolism ; Transferrin/metabolism ; Xanthine/metabolism ; Xanthine Oxidase/metabolism
Chemical Substances	Albumins ; Reactive Oxygen Species ; Transferrin ; Bleomycin (11056-06-7) ; Xanthine (1AVZ07U9S7) ; Hydroxyl Radical (3352-57-6) ; Ferritins (9007-73-2) ; Hydrogen Peroxide (BBX060AN9V) ; Iron (E1UOL152H7) ; Xanthine Oxidase (EC 1.17.3.2) ; Lactoferrin (EC 3.4.21.-)
Language	English
Publishing date	1999-04-02
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1006/bbrc.1999.0435
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 116: Show issues

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Article: Phagocytic activity and oxidative burst of granulocytes in persons with myeloperoxidase deficiency.

Gerber, C E / Kuçi, S / Zipfel, M / Niethammer, D / Bruchelt, G

European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies

1996 Volume 34, Issue 11, Page(s) 901–908

Abstract: In the present study, phagocytosis and the oxidative metabolism of neutrophil granulocytes from five clinically healthy persons with different degrees of myeloperoxidase deficiency were investigated and compared to those of normal persons. The ... ...

Abstract	In the present study, phagocytosis and the oxidative metabolism of neutrophil granulocytes from five clinically healthy persons with different degrees of myeloperoxidase deficiency were investigated and compared to those of normal persons. The identification of individuals with myeloperoxidase deficiency was performed with the Bayer/Technicon H3 blood cell counter, which differentiates the leukocytes by measuring the peroxidase activity. Neutrophils of three out of five investigated myeloperoxidase deficient persons showed extremely low peroxidase indices (-53 and lower), but only the neutrophils of one person totally lacked myeloperoxidase. This was demonstrated by comparing myeloperoxidase mass concentration measured with an enzyme immunoassay, lack of HOCl production, and was further confirmed by measuring luminol- and lucigenin-enhanced chemiluminescence. Characteristically, myeloperoxidase deficient granulocytes showed a strikingly decreased luminol-enhanced chemiluminescence while the lucigenin-enhanced chemiluminescence was significantly increased compared to normal granulocytes. Although there is a DNA sequence homology of about 70%, the activity of peroxidase in eosinophils was not affected in any myeloperoxidase deficient person investigated. Moreover, a person with a very rare defect of eosinophil peroxidase had completely normal myeloperoxidase activity. The lack of myeloperoxidase activity is compensated for by an increased phagocytic activity, an increased production of superoxide anion (lucigenin-chemiluminescence) and probably by an alternative metabolism of H2O2; since persons lacking myeloperoxidase activity do not normally suffer from severe infections, H2O2 is obviously metabolized to other reactive oxygen substrates than HOCl, e.g. to OH-radicals.
MeSH term(s)	Adult ; Female ; Granulocytes/immunology ; Granulocytes/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; Luminescent Measurements ; Male ; Middle Aged ; Oxygen Consumption ; Peroxidase/deficiency ; Phagocytosis ; Respiratory Burst
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Peroxidase (EC 1.11.1.7)
Language	English
Publishing date	1996-11
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1064000-9
ISSN	0939-4974
ISSN	0939-4974
DOI	10.1515/cclm.1996.34.11.901
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 121: Show issues

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Article: Reconstitution of bactericidal activity in chronic granulomatous disease cells by glucose-oxidase-containing liposomes.

Gerber, C E / Bruchelt, G / Falk, U B / Kimpfler, A / Hauschild, O / Kuçi, S / Bächi, T / Niethammer, D / Schubert, R

Blood

2001 Volume 98, Issue 10, Page(s) 3097–3105

Abstract: Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency characterized by phagocytes devoid of a functioning nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. The failure of CGD phagocytes to produce reactive oxygen species ...

Abstract	Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency characterized by phagocytes devoid of a functioning nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. The failure of CGD phagocytes to produce reactive oxygen species (ROS) results in a marked increase in the susceptibility of affected patients to life-threatening bacterial and fungal infections. This study investigated whether loading of CGD phagocytes with glucose oxidase (GO)-containing liposomes (GOLs) could restore cellular production of bactericidal ROS (eg, H2O2 and HOCl) in vitro. Results indicate that GO encapsulated in liposomes enabled NADPH oxidase-deficient phagocytes to use H2O2 for the production of highly bactericidal HOCl. The intracellular colocalization of bacteria and liposomes (or liposome-derived ferritin) was demonstrated by confocal laser microscopy and electron microscopy. After uptake of GOLs (approximately 0.2 U/mL at 1 mM total lipid concentration, size approximately 180 nm), CGD granulocytes produced HOCl levels comparable to those of normal phagocytes. Remarkably, after treatment with GOLs, CGD phagocytes killed Staphylococcus aureus as efficiently as normal granulocytes. Moreover, treated cells retained sufficient motility toward chemotactic stimuli as measured by chemotaxis assay. Side effects were evaluated by measuring the H2O2 concentrations and the production of methemoglobin in whole blood. These studies revealed that H2O2 produced by GOLs was degraded immediately by the antioxidative capacity of whole blood. Elevated methemoglobin levels were observed only after application of extremely high amounts of GOLs (2 U/mL). In summary, the application of negatively charged GOLs might provide a novel effective approach in the treatment of patients with CGD at high risk for life-threatening infections.
MeSH term(s)	Blood/drug effects ; Cells, Cultured ; Chemotaxis ; Drug Compounding ; Glucose Oxidase/administration & dosage ; Glucose Oxidase/pharmacology ; Granulomatous Disease, Chronic/blood ; Granulomatous Disease, Chronic/pathology ; Humans ; Hydrogen Peroxide/metabolism ; Hypochlorous Acid/metabolism ; Liposomes ; Methemoglobin/biosynthesis ; Microscopy, Confocal ; Microscopy, Electron ; Neutrophils/drug effects ; Neutrophils/enzymology ; Neutrophils/pathology ; Phagocytosis ; Reactive Oxygen Species ; Staphylococcus aureus
Chemical Substances	Liposomes ; Reactive Oxygen Species ; Hypochlorous Acid (712K4CDC10) ; Methemoglobin (9008-37-1) ; Hydrogen Peroxide (BBX060AN9V) ; Glucose Oxidase (EC 1.1.3.4)
Language	English
Publishing date	2001-11-15
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.v98.10.3097
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: The Layer 0 Inner Silicon Detector of the D0 Experiment

Angstadt, R. / Bagby, L. / Bean, A. / Bolton, T. / Buchholz, D. / Butler, D. / Christofek, L. / Cooper, W. E. / Daly, C. H. / Demarteau, M. / Foglesong, J. / Gerber, C. E. / Gonzalez, H. / Green, J. / Guldenman, H. / Hanagaki, K. / Herner, K. / Howell, J. / Hrycyk, M. /

Johnson, M. / Kirby, M. / Krempetz, K. / Kuykendall, W. / Lehner, F. / Lipton, R. / Lubatti, H. J. / Markley, D. / Matulik, M. / McCarthy, R. L. / Nomerotski, A. / Olis, D. / Orlov, Y. / Garzon, G. J. Otero y / Roman, M. / Rucinski, R. / Schultz, K. / Shabalina, E. / Smith, R. P. / Strom, D. / Taylor, R. D. / Tsybychev, D. / Tuttle, M. / Utes, M. / Wang, J. / Weber, M. / Wesson, T. / Youn, S. W. / Zhou, T. / Zieminski, A.

2009

Abstract: This paper describes the design, fabrication, installation and performance of the new inner layer called Layer 0 (L0) that was inserted in the existing Run IIa Silicon Micro-Strip Tracker (SMT) of the D0 experiment at the Fermilab Tevatron collider. L0 ... ...

Abstract	This paper describes the design, fabrication, installation and performance of the new inner layer called Layer 0 (L0) that was inserted in the existing Run IIa Silicon Micro-Strip Tracker (SMT) of the D0 experiment at the Fermilab Tevatron collider. L0 provides tracking information from two layers of sensors, which are mounted with center lines at a radial distance of 16.1 mm and 17.6 mm respectively from the beam axis. The sensors and readout electronics are mounted on a specially designed and fabricated carbon fiber structure that includes cooling for sensor and readout electronics. The structure has a thin polyimide circuit bonded to it so that the circuit couples electrically to the carbon fiber allowing the support structure to be used both for detector grounding and a low impedance connection between the remotely mounted hybrids and the sensors. Comment: 28 pages, 9 figures
Keywords	Physics - Instrumentation and Detectors ; High Energy Physics - Experiment
Subject code	621
Publishing date	2009-11-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Odderon Exchange from Elastic Scattering Differences between pp and pp[over ¯] Data at 1.96 TeV and from pp Forward Scattering Measurements.

Abazov, V M / Abbott, B / Acharya, B S / Adams, M / Adams, T / Agnew, J P / Alexeev, G D / Alkhazov, G / Alton, A / Alves, G A / Antchev, G / Askew, A / Aspell, P / Assis Jesus, A C S / Atanassov, I / Atkins, S / Augsten, K / Aushev, V / Aushev, Y /

Avati, V / Avila, C / Badaud, F / Baechler, J / Bagby, L / Baldenegro Barrera, C / Baldin, B / Bandurin, D V / Banerjee, S / Barberis, E / Baringer, P / Barreto, J / Bartlett, J F / Bassler, U / Bazterra, V / Bean, A / Begalli, M / Bellantoni, L / Berardi, V / Beri, S B / Bernardi, G / Bernhard, R / Berretti, M / Bertram, I / Besançon, M / Beuselinck, R / Bhat, P C / Bhatia, S / Bhatnagar, V / Blazey, G / Blessing, S / Bloom, K / Boehnlein, A / Boline, D / Boos, E E / Borchsh, V / Borissov, G / Borysova, M / Bossini, E / Bottigli, U / Bozzo, M / Brandt, A / Brandt, O / Brochmann, M / Brock, R / Bross, A / Brown, D / Bu, X B / Buehler, M / Buescher, V / Bunichev, V / Burdin, S / Burkhardt, H / Buszello, C P / Cafagna, F S / Camacho-Pérez, E / Carvalho, W / Casey, B C K / Castilla-Valdez, H / Catanesi, M G / Caughron, S / Chakrabarti, S / Chan, K M / Chandra, A / Chapon, E / Chen, G / Cho, S W / Choi, S / Choudhary, B / Cihangir, S / Claes, D / Clutter, J / Cooke, M / Cooper, W E / Corcoran, M / Couderc, F / Cousinou, M-C / Csanád, M / Csörgő, T / Cuth, J / Cutts, D / da Motta, H / Das, A / Davies, G / Deile, M / de Jong, S J / De La Cruz-Burelo, E / De Leonardis, F / Déliot, F / Demina, R / Denisov, D / Denisov, S P / De Oliveira Martins, C / Desai, S / Deterre, C / DeVaughan, K / Diehl, H T / Diesburg, M / Ding, P F / Dominguez, A / Doubek, M / Drutskoy, A / Druzhkin, D / Dubey, A / Dudko, L V / Duperrin, A / Dutt, S / Eads, M / Edmunds, D / Eggert, K / Ellison, J / Elvira, V D / Enari, Y / Eremin, V / Evans, H / Evdokimov, A / Evdokimov, V N / Fauré, A / Feng, L / Ferbel, T / Ferro, F / Fiedler, F / Fiergolski, A / Filthaut, F / Fisher, W / Fisk, H E / Forthomme, L / Fortner, M / Fox, H / Franc, J / Fuess, S / Garbincius, P H / Garcia, F / Garcia-Bellido, A / García-González, J A / Gavrilov, V / Geng, W / Georgiev, V / Gerber, C E / Gershtein, Y / Giani, S / Ginther, G / Gogota, O / Golovanov, G / Grannis, P D / Greder, S / Greenlee, H / Grenier, G / Gris, Ph / Grivaz, J-F / Grohsjean, A / Grünendahl, S / Grünewald, M W / Grzanka, L / Guillemin, T / Gutierrez, G / Gutierrez, P / Haley, J / Hammerbauer, J / Han, L / Harder, K / Harel, A / Hauptman, J M / Hays, J / Head, T / Hebbeker, T / Hedin, D / Hegab, H / Heinson, A P / Heintz, U / Hensel, C / Heredia-De La Cruz, I / Herner, K / Hesketh, G / Hildreth, M D / Hirosky, R / Hoang, T / Hobbs, J D / Hoeneisen, B / Hogan, J / Hohlfeld, M / Holzbauer, J L / Howley, I / Hubacek, Z / Hynek, V / Iashvili, I / Ilchenko, Y / Illingworth, R / Isidori, T / Ito, A S / Ivanchenko, V / Jabeen, S / Jaffré, M / Janda, M / Jayasinghe, A / Jeong, M S / Jesik, R / Jiang, P / Johns, K / Johnson, E / Johnson, M / Jonckheere, A / Jonsson, P / Joshi, J / Jung, A W / Juste, A / Kajfasz, E / Karev, A / Karmanov, D / Kašpar, J / Katsanos, I / Kaur, M / Kaynak, B / Kehoe, R / Kermiche, S / Khalatyan, N / Khanov, A / Kharchilava, A / Kharzheev, Y N / Kiselevich, I / Kohli, J M / Kopal, J / Kozelov, A V / Kraus, J / Kumar, A / Kundrát, V / Kupco, A / Kurča, T / Kuzmin, V A / Lami, S / Lammers, S / Latino, G / Lebrun, P / Lee, H S / Lee, S W / Lee, W M / Le, X / Lellouch, J / Li, D / Li, H / Li, L / Li, Q Z / Lim, J K / Lincoln, D / Lindsey, C / Linhart, R / Linnemann, J / Lipaev, V V / Lipton, R / Liu, H / Liu, Y / Lobodenko, A / Lokajicek, M / Lokajíček, M V / Lopes de Sa, R / Losurdo, L / Lucas Rodríguez, F / Luna-Garcia, R / Lyon, A L / Maciel, A K A / Macrí, M / Madar, R / Magaña-Villalba, R / Malawski, M / Malbouisson, H B / Malik, S / Malyshev, V L / Mansour, J / Martínez-Ortega, J / McCarthy, R / McGivern, C L / Meijer, M M / Melnitchouk, A / Menezes, D / Mercadante, P G / Merkin, M / Meyer, A / Meyer, J / Miconi, F / Minafra, N / Minutoli, S / Molina, J / Mondal, N K / Mulhearn, M / Mundim, L / Naaranoja, T / Nagy, E / Narain, M / Nayyar, R / Neal, H A / Negret, J P / Nemes, F / Neustroev, P / Nguyen, H T / Niewiadomski, H / Novák, T / Nunnemann, T / Oguri, V / Oliveri, E / Oljemark, F / Orduna, J / Oriunno, M / Osman, N / Österberg, K / Pal, A / Palazzi, P / Parashar, N / Parihar, V / Park, S K / Partridge, R / Parua, N / Pasechnik, R / Passaro, V / Patwa, A / Penning, B / Perfilov, M / Peroutka, Z / Peters, Y / Petridis, K / Petrillo, G / Pétroff, P / Pleier, M-A / Podstavkov, V M / Popov, A V / Prado da Silva, W L / Prewitt, M / Price, D / Procházka, J / Prokopenko, N / Qian, J / Quadt, A / Quinn, B / Quinto, M / Raben, T G / Radermacher, E / Radicioni, E / Rangel, M / Ratoff, P N / Ravotti, F / Razumov, I / Ripp-Baudot, I / Rizatdinova, F / Robutti, E / Rodrigues, R F / Rominsky, M / Ross, A / Royon, C / Rubinov, P / Ruchti, R / Ruggiero, G / Saarikko, H / Sajot, G / Samoylenko, V D / Sánchez-Hernández, A / Sanders, M P / Santoro, A / Santos, A S / Savage, G / Savitskyi, M / Sawyer, L / Scanlon, T / Schamberger, R D / Scheglov, Y / Schellman, H / Schott, M / Schwanenberger, C / Schwienhorst, R / Scribano, A / Sekaric, J / Severini, H / Shabalina, E / Shary, V / Shaw, S / Shchukin, A A / Shkola, O / Simak, V / Siroky, J / Skubic, P / Slattery, P / Smajek, J / Snoeys, W / Snow, G R / Snow, J / Snyder, S / Söldner-Rembold, S / Sonnenschein, L / Soustruznik, K / Stark, J / Stefaniuk, N / Stefanovitch, R / Ster, A / Stoyanova, D A / Strauss, M / Suter, L / Svoisky, P / Szanyi, I / Sziklai, J / Taylor, C / Tcherniaev, E / Titov, M / Tokmenin, V V / Tsai, Y-T / Tsybychev, D / Tuchming, B / Tully, C / Turini, N / Urban, O / Uvarov, L / Uvarov, S / Uzunyan, S / Vacek, V / Van Kooten, R / van Leeuwen, W M / Varelas, N / Varnes, E W / Vasilyev, I A / Vavroch, O / Verkheev, A Y / Vertogradov, L S / Verzocchi, M / Vesterinen, M / Vilanova, D / Vokac, P / Wahl, H D / Wang, C / Wang, M H L S / Warchol, J / Watts, G / Wayne, M / Weichert, J / Welti, J / Welty-Rieger, L / Williams, J / Williams, M R J / Wilson, G W / Wobisch, M / Wood, D R / Wyatt, T R / Xie, Y / Yamada, R / Yang, S / Yasuda, T / Yatsunenko, Y A / Ye, W / Ye, Z / Yin, H / Yip, K / Youn, S W / Yu, J M / Zennamo, J / Zhao, T G / Zhou, B / Zhu, J / Zich, J / Zielinski, K / Zielinski, M / Zieminska, D / Zivkovic, L

Physical review letters

2021 Volume 127, Issue 6, Page(s) 62003

Abstract: We describe an analysis comparing the pp[over ¯] elastic cross section as measured by the D0 Collaboration at a center-of-mass energy of 1.96 TeV to that in pp collisions as measured by the TOTEM Collaboration at 2.76, 7, 8, and 13 TeV using a model- ... ...

Abstract	We describe an analysis comparing the pp[over ¯] elastic cross section as measured by the D0 Collaboration at a center-of-mass energy of 1.96 TeV to that in pp collisions as measured by the TOTEM Collaboration at 2.76, 7, 8, and 13 TeV using a model-independent approach. The TOTEM cross sections, extrapolated to a center-of-mass energy of sqrt[s]=1.96 TeV, are compared with the D0 measurement in the region of the diffractive minimum and the second maximum of the pp cross section. The two data sets disagree at the 3.4σ level and thus provide evidence for the t-channel exchange of a colorless, C-odd gluonic compound, also known as the odderon. We combine these results with a TOTEM analysis of the same C-odd exchange based on the total cross section and the ratio of the real to imaginary parts of the forward elastic strong interaction scattering amplitude in pp scattering for which the significance is between 3.4σ and 4.6σ. The combined significance is larger than 5σ and is interpreted as the first observation of the exchange of a colorless, C-odd gluonic compound.
Language	English
Publishing date	2021-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.062003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Measurement of the Effective Weak Mixing Angle in pp[over ¯]→Z/γ^{*}→ℓ^{+}ℓ^{-} Events.

Abazov, V M / Abbott, B / Acharya, B S / Adams, M / Adams, T / Agnew, J P / Alexeev, G D / Alkhazov, G / Alton, A / Askew, A / Atkins, S / Augsten, K / Aushev, V / Aushev, Y / Avila, C / Badaud, F / Bagby, L / Baldin, B / Bandurin, D V /

Banerjee, S / Barberis, E / Baringer, P / Bartlett, J F / Bassler, U / Bazterra, V / Bean, A / Begalli, M / Bellantoni, L / Beri, S B / Bernardi, G / Bernhard, R / Bertram, I / Besançon, M / Beuselinck, R / Bhat, P C / Bhatia, S / Bhatnagar, V / Blazey, G / Blessing, S / Bloom, K / Boehnlein, A / Boline, D / Boos, E E / Borissov, G / Borysova, M / Brandt, A / Brandt, O / Brochmann, M / Brock, R / Bross, A / Brown, D / Bu, X B / Buehler, M / Buescher, V / Bunichev, V / Burdin, S / Buszello, C P / Camacho-Pérez, E / Casey, B C K / Castilla-Valdez, H / Caughron, S / Chakrabarti, S / Chan, K M / Chandra, A / Chapon, E / Chen, G / Cho, S W / Choi, S / Choudhary, B / Cihangir, S / Claes, D / Clutter, J / Cooke, M / Cooper, W E / Corcoran, M / Couderc, F / Cousinou, M-C / Cuth, J / Cutts, D / Das, A / Davies, G / de Jong, S J / De La Cruz-Burelo, E / Déliot, F / Demina, R / Denisov, D / Denisov, S P / Desai, S / Deterre, C / DeVaughan, K / Diehl, H T / Diesburg, M / Ding, P F / Dominguez, A / Drutskoy, A / Dubey, A / Dudko, L V / Duperrin, A / Dutt, S / Eads, M / Edmunds, D / Ellison, J / Elvira, V D / Enari, Y / Evans, H / Evdokimov, A / Evdokimov, V N / Fauré, A / Feng, L / Ferbel, T / Fiedler, F / Filthaut, F / Fisher, W / Fisk, H E / Fortner, M / Fox, H / Franc, J / Fuess, S / Garbincius, P H / Garcia-Bellido, A / García-González, J A / Gavrilov, V / Geng, W / Gerber, C E / Gershtein, Y / Ginther, G / Gogota, O / Golovanov, G / Grannis, P D / Greder, S / Greenlee, H / Grenier, G / Gris, Ph / Grivaz, J-F / Grohsjean, A / Grünendahl, S / Grünewald, M W / Guillemin, T / Gutierrez, G / Gutierrez, P / Haley, J / Han, L / Harder, K / Harel, A / Hauptman, J M / Hays, J / Head, T / Hebbeker, T / Hedin, D / Hegab, H / Heinson, A P / Heintz, U / Hensel, C / Heredia-De La Cruz, I / Herner, K / Hesketh, G / Hildreth, M D / Hirosky, R / Hoang, T / Hobbs, J D / Hoeneisen, B / Hogan, J / Hohlfeld, M / Holzbauer, J L / Howley, I / Hubacek, Z / Hynek, V / Iashvili, I / Ilchenko, Y / Illingworth, R / Ito, A S / Jabeen, S / Jaffré, M / Jayasinghe, A / Jeong, M S / Jesik, R / Jiang, P / Johns, K / Johnson, E / Johnson, M / Jonckheere, A / Jonsson, P / Joshi, J / Jung, A W / Juste, A / Kajfasz, E / Karmanov, D / Katsanos, I / Kaur, M / Kehoe, R / Kermiche, S / Khalatyan, N / Khanov, A / Kharchilava, A / Kharzheev, Y N / Kiselevich, I / Kohli, J M / Kozelov, A V / Kraus, J / Kumar, A / Kupco, A / Kurča, T / Kuzmin, V A / Lammers, S / Lebrun, P / Lee, H S / Lee, S W / Lee, W M / Lei, X / Lellouch, J / Li, D / Li, H / Li, L / Li, Q Z / Lim, J K / Lincoln, D / Linnemann, J / Lipaev, V V / Lipton, R / Liu, H / Liu, Y / Lobodenko, A / Lokajicek, M / Lopes de Sa, R / Luna-Garcia, R / Lyon, A L / Maciel, A K A / Madar, R / Magaña-Villalba, R / Malik, S / Malyshev, V L / Mansour, J / Martínez-Ortega, J / McCarthy, R / McGivern, C L / Meijer, M M / Melnitchouk, A / Menezes, D / Mercadante, P G / Merkin, M / Meyer, A / Meyer, J / Miconi, F / Mondal, N K / Mulhearn, M / Nagy, E / Narain, M / Nayyar, R / Neal, H A / Negret, J P / Neustroev, P / Nguyen, H T / Nunnemann, T / Orduna, J / Osman, N / Pal, A / Parashar, N / Parihar, V / Park, S K / Partridge, R / Parua, N / Patwa, A / Penning, B / Perfilov, M / Peters, Y / Petridis, K / Petrillo, G / Pétroff, P / Pleier, M-A / Podstavkov, V M / Popov, A V / Prewitt, M / Price, D / Prokopenko, N / Qian, J / Quadt, A / Quinn, B / Ratoff, P N / Razumov, I / Ripp-Baudot, I / Rizatdinova, F / Rominsky, M / Ross, A / Royon, C / Rubinov, P / Ruchti, R / Sajot, G / Sánchez-Hernández, A / Sanders, M P / Santos, A S / Savage, G / Savitskyi, M / Sawyer, L / Scanlon, T / Schamberger, R D / Scheglov, Y / Schellman, H / Schott, M / Schwanenberger, C / Schwienhorst, R / Sekaric, J / Severini, H / Shabalina, E / Shary, V / Shaw, S / Shchukin, A A / Shkola, O / Simak, V / Skubic, P / Slattery, P / Snow, G R / Snow, J / Snyder, S / Söldner-Rembold, S / Sonnenschein, L / Soustruznik, K / Stark, J / Stefaniuk, N / Stoyanova, D A / Strauss, M / Suter, L / Svoisky, P / Titov, M / Tokmenin, V V / Tsai, Y-T / Tsybychev, D / Tuchming, B / Tully, C / Uvarov, L / Uvarov, S / Uzunyan, S / Van Kooten, R / van Leeuwen, W M / Varelas, N / Varnes, E W / Vasilyev, I A / Verkheev, A Y / Vertogradov, L S / Verzocchi, M / Vesterinen, M / Vilanova, D / Vokac, P / Wahl, H D / Wang, C / Wang, M H L S / Warchol, J / Watts, G / Wayne, M / Weichert, J / Welty-Rieger, L / Williams, M R J / Wilson, G W / Wobisch, M / Wood, D R / Wyatt, T R / Xiang, Y / Xie, Y / Yamada, R / Yang, S / Yasuda, T / Yatsunenko, Y A / Ye, W / Ye, Z / Yin, H / Yip, K / Youn, S W / Yu, J M / Zennamo, J / Zhao, T G / Zhou, B / Zhu, J / Zielinski, M / Zieminska, D / Zivkovic, L

Physical review letters

2018 Volume 120, Issue 24, Page(s) 241802

Abstract: We present a measurement of the effective weak mixing angle parameter sin^{2}θ_{eff}^{ℓ} in pp[over ¯]→Z/γ^{*}→μ^{+}μ^{-} events at a center-of-mass energy of 1.96 TeV, collected by the D0 detector at the Fermilab Tevatron Collider and corresponding to 8. ...

Abstract	We present a measurement of the effective weak mixing angle parameter sin^{2}θ_{eff}^{ℓ} in pp[over ¯]→Z/γ^{}→μ^{+}μ^{-} events at a center-of-mass energy of 1.96 TeV, collected by the D0 detector at the Fermilab Tevatron Collider and corresponding to 8.6 fb^{-1} of integrated luminosity. The measured value of sin^{2}θ_{eff}^{ℓ}[μμ]=0.23016±0.00064 is further combined with the result from the D0 measurement in pp[over ¯]→Z/γ^{}→e^{+}e^{-} events, resulting in sin^{2}θ_{eff}^{ℓ}[comb]=0.23095±0.00040. This combined result is the most precise measurement from a single experiment at a hadron collider and is the most precise determination using the coupling of the Z/γ^{*} to light quarks.
Language	English
Publishing date	2018-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.120.241802
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Search for Scalar Leptoquarks Produced via τ-Lepton-Quark Scattering in pp Collisions at sqrt[s]=13 TeV.

Hayrapetyan, A / Tumasyan, A / Adam, W / Andrejkovic, J W / Bergauer, T / Chatterjee, S / Damanakis, K / Dragicevic, M / Escalante Del Valle, A / Hussain, P S / Jeitler, M / Krammer, N / Liko, D / Mikulec, I / Schieck, J / Schöfbeck, R / Schwarz, D / Sonawane, M / Templ, S /

Waltenberger, W / Wulz, C-E / Darwish, M R / Janssen, T / Van Mechelen, P / Bols, E S / D'Hondt, J / Dansana, S / De Moor, A / Delcourt, M / El Faham, H / Lowette, S / Makarenko, I / Müller, D / Sahasransu, A R / Tavernier, S / Tytgat, M / Van Putte, S / Vannerom, D / Clerbaux, B / De Lentdecker, G / Favart, L / Hohov, D / Jaramillo, J / Khalilzadeh, A / Lee, K / Mahdavikhorrami, M / Malara, A / Paredes, S / Pétré, L / Postiau, N / Thomas, L / Vanden Bemden, M / Vander Velde, C / Vanlaer, P / De Coen, M / Dobur, D / Hong, Y / Knolle, J / Lambrecht, L / Mestdach, G / Rendón, C / Samalan, A / Skovpen, K / Van Den Bossche, N / Wezenbeek, L / Benecke, A / Bruno, G / Caputo, C / Delaere, C / Donertas, I S / Giammanco, A / Jaffel, K / Jain, Sa / Lemaitre, V / Lidrych, J / Mastrapasqua, P / Mondal, K / Tran, T T / Wertz, S / Alves, G A / Coelho, E / Hensel, C / Menezes De Oliveira, T / Moraes, A / Rebello Teles, P / Soeiro, M / Aldá Júnior, W L / Alves Gallo Pereira, M / Barroso Ferreira Filho, M / Brandao Malbouisson, H / Carvalho, W / Chinellato, J / Da Costa, E M / Da Silveira, G G / De Jesus Damiao, D / Fonseca De Souza, S / Martins, J / Mora Herrera, C / Mota Amarilo, K / Mundim, L / Nogima, H / Santoro, A / Silva Do Amaral, S M / Sznajder, A / Thiel, M / Vilela Pereira, A / Bernardes, C A / Calligaris, L / Tomei, T R Fernandez Perez / Gregores, E M / Mercadante, P G / Novaes, S F / Orzari, B / Padula, Sandra S / Aleksandrov, A / Antchev, G / Hadjiiska, R / Iaydjiev, P / Misheva, M / Shopova, M / Sultanov, G / Dimitrov, A / Ivanov, T / Litov, L / Pavlov, B / Petkov, P / Petrov, A / Shumka, E / Keshri, S / Thakur, S / Cheng, T / Guo, Q / Javaid, T / Mittal, M / Yuan, L / Bauer, G / Hu, Z / Liu, J / Yi, K / Chen, G M / Chen, H S / Chen, M / Iemmi, F / Jiang, C H / Kapoor, A / Liao, H / Liu, Z-A / Monti, F / Shahzad, M A / Sharma, R / Song, J N / Tao, J / Wang, C / Wang, J / Wang, Z / Zhang, H / Agapitos, A / Ban, Y / Levin, A / Li, C / Li, Q / Mao, Y / Qian, S J / Sun, X / Wang, D / Yang, H / Zhang, L / Zhou, C / You, Z / Lu, N / Gao, X / Leggat, D / Okawa, H / Zhang, Y / Lin, Z / Lu, C / Xiao, M / Avila, C / Barbosa Trujillo, D A / Cabrera, A / Florez, C / Fraga, J / Reyes Vega, J A / Mejia Guisao, J / Ramirez, F / Rodriguez, M / Ruiz Alvarez, J D / Giljanovic, D / Godinovic, N / Lelas, D / Sculac, A / Kovac, M / Sculac, T / Bargassa, P / Brigljevic, V / Chitroda, B K / Ferencek, D / Mishra, S / Starodumov, A / Susa, T / Attikis, A / Christoforou, K / Konstantinou, S / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Rykaczewski, H / Saka, H / Stepennov, A / Finger, M / Kveton, A / Ayala, E / Carrera Jarrin, E / Assran, Y / Elgammal, S / Abdullah Al-Mashad, M / Mahmoud, M A / Dewanjee, R K / Ehataht, K / Kadastik, M / Lange, T / Nandan, S / Nielsen, C / Pata, J / Raidal, M / Tani, L / Veelken, C / Kirschenmann, H / Osterberg, K / Voutilainen, M / Bharthuar, S / Brücken, E / Garcia, F / Havukainen, J / Kallonen, K T S / Kim, M S / Kinnunen, R / Lampén, T / Lassila-Perini, K / Lehti, S / Lindén, T / Lotti, M / Martikainen, L / Myllymäki, M / Rantanen, M M / Siikonen, H / Tuominen, E / Tuominiemi, J / Luukka, P / Petrow, H / Tuuva, T / Besancon, M / Couderc, F / Dejardin, M / Denegri, D / Faure, J L / Ferri, F / Ganjour, S / Gras, P / Hamel de Monchenault, G / Lohezic, V / Malcles, J / Rander, J / Rosowsky, A / Sahin, M Ö / Savoy-Navarro, A / Simkina, P / Titov, M / Baldenegro Barrera, C / Beaudette, F / Buchot Perraguin, A / Busson, P / Cappati, A / Charlot, C / Damas, F / Davignon, O / De Wit, A / Falmagne, G / Fontana Santos Alves, B A / Ghosh, S / Gilbert, A / Granier de Cassagnac, R / Hakimi, A / Harikrishnan, B / Kalipoliti, L / Liu, G / Motta, J / Nguyen, M / Ochando, C / Portales, L / Salerno, R / Sarkar, U / Sauvan, J B / Sirois, Y / Tarabini, A / Vernazza, E / Zabi, A / Zghiche, A / Agram, J-L / Andrea, J / Apparu, D / Bloch, D / Brom, J-M / Chabert, E C / Collard, C / Falke, S / Goerlach, U / Grimault, C / Haeberle, R / Le Bihan, A-C / Sessini, M A / Van Hove, P / Beauceron, S / Blancon, B / Boudoul, G / Chanon, N / Choi, J / Contardo, D / Depasse, P / Dozen, C / El Mamouni, H / Fay, J / Gascon, S / Gouzevitch, M / Greenberg, C / Grenier, G / Ille, B / Laktineh, I B / Lethuillier, M / Mirabito, L / Perries, S / Purohit, A / Vander Donckt, M / Verdier, P / Xiao, J / Khvedelidze, A / Lomidze, I / Tsamalaidze, Z / Botta, V / Feld, L / Klein, K / Lipinski, M / Meuser, D / Pauls, A / Röwert, N / Teroerde, M / Diekmann, S / Dodonova, A / Eich, N / Eliseev, D / Engelke, F / Erdmann, M / Fackeldey, P / Fischer, B / Hebbeker, T / Hoepfner, K / Ivone, F / Jung, A / Lee, M Y / Mastrolorenzo, L / Merschmeyer, M / Meyer, A / Mukherjee, S / Noll, D / Novak, A / Nowotny, F / Pozdnyakov, A / Rath, Y / Redjeb, W / Rehm, F / Reithler, H / Sarkisovi, V / Schmidt, A / Schuler, S C / Sharma, A / Stein, A / Torres Da Silva De Araujo, F / Vigilante, L / Wiedenbeck, S / Zaleski, S / Dziwok, C / Flügge, G / Haj Ahmad, W / Kress, T / Nowack, A / Pooth, O / Stahl, A / Ziemons, T / Zotz, A / Aarup Petersen, H / Aldaya Martin, M / Alimena, J / Amoroso, S / An, Y / Baxter, S / Bayatmakou, M / Becerril Gonzalez, H / Behnke, O / Belvedere, A / Bhattacharya, S / Blekman, F / Borras, K / Brunner, D / Campbell, A / Cardini, A / Cheng, C / Colombina, F / Consuegra Rodríguez, S / Correia Silva, G / De Silva, M / Eckerlin, G / Eckstein, D / Estevez Banos, L I / Filatov, O / Gallo, E / Geiser, A / Giraldi, A / Greau, G / Guglielmi, V / Guthoff, M / Hinzmann, A / Jafari, A / Jeppe, L / Jomhari, N Z / Kaech, B / Kasemann, M / Kaveh, H / Kleinwort, C / Kogler, R / Komm, M / Krücker, D / Lange, W / Leyva Pernia, D / Lipka, K / Lohmann, W / Mankel, R / Melzer-Pellmann, I-A / Mendizabal Morentin, M / Metwally, J / Meyer, A B / Milella, G / Mussgiller, A / Nürnberg, A / Otarid, Y / Pérez Adán, D / Ranken, E / Raspereza, A / Ribeiro Lopes, B / Rübenach, J / Saggio, A / Scham, M / Schnake, S / Schütze, P / Schwanenberger, C / Selivanova, D / Shchedrolosiev, M / Sosa Ricardo, R E / Sreelatha Pramod, L P / Stafford, D / Vazzoler, F / Ventura Barroso, A / Walsh, R / Wang, Q / Wen, Y / Wichmann, K / Wiens, L / Wissing, C / Wuchterl, S / Yang, Y / Zimermmane Castro Santos, A / Albrecht, A / Albrecht, S / Antonello, M / Bein, S / Benato, L / Bonanomi, M / Connor, P / Eich, M / El Morabit, K / Fischer, Y / Fröhlich, A / Garbers, C / Garutti, E / Grohsjean, A / Hajheidari, M / Haller, J / Jabusch, H R / Kasieczka, G / Keicher, P / Klanner, R / Korcari, W / Kramer, T / Kutzner, V / Labe, F / Lange, J / Lobanov, A / Matthies, C / Mehta, A / Moureaux, L / Mrowietz, M / Nigamova, A / Nissan, Y / Paasch, A / Pena Rodriguez, K J / Quadfasel, T / Raciti, B / Rieger, M / Savoiu, D / Schindler, J / Schleper, P / Schröder, M / Schwandt, J / Sommerhalder, M / Stadie, H / Steinbrück, G / Tews, A / Wolf, M / Brommer, S / Burkart, M / Butz, E / Chwalek, T / Dierlamm, A / Droll, A / Faltermann, N / Giffels, M 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Physical review letters

2024 Volume 132, Issue 6, Page(s) 61801

Abstract: The first search for scalar leptoquarks produced in τ-lepton-quark collisions is presented. It is based on a set of proton-proton collision data recorded with the CMS detector at the LHC at a center-of-mass energy of 13 TeV corresponding to an integrated ...

Abstract	The first search for scalar leptoquarks produced in τ-lepton-quark collisions is presented. It is based on a set of proton-proton collision data recorded with the CMS detector at the LHC at a center-of-mass energy of 13 TeV corresponding to an integrated luminosity of 138 fb^{-1}. The reconstructed final state consists of a jet, significant missing transverse momentum, and a τ lepton reconstructed through its hadronic or leptonic decays. Limits are set on the product of the leptoquark production cross section and branching fraction and interpreted as exclusions in the plane of the leptoquark mass and the leptoquark-τ-quark coupling strength.
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.132.061801
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Search for Inelastic Dark Matter in Events with Two Displaced Muons and Missing Transverse Momentum in Proton-Proton Collisions at sqrt[s]=13 TeV.

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Physical review letters

2024 Volume 132, Issue 4, Page(s) 41802

Abstract: A search for dark matter in events with a displaced nonresonant muon pair and missing transverse momentum is presented. The analysis is performed using an integrated luminosity of 138 fb^{-1} of proton-proton (pp) collision data at a center-of-mass ... ...

Abstract	A search for dark matter in events with a displaced nonresonant muon pair and missing transverse momentum is presented. The analysis is performed using an integrated luminosity of 138 fb^{-1} of proton-proton (pp) collision data at a center-of-mass energy of 13 TeV produced by the LHC in 2016-2018. No significant excess over the predicted backgrounds is observed. Upper limits are set on the product of the inelastic dark matter production cross section σ(pp→A^{'}→χ_{1}χ_{2}) and the decay branching fraction B(χ_{2}→χ_{1}μ^{+}μ^{-}), where A^{'} is a dark photon and χ_{1} and χ_{2} are states in the dark sector with near mass degeneracy. This is the first dedicated collider search for inelastic dark matter.
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.132.041802
Database	MEDical Literature Analysis and Retrieval System OnLINE

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