LIVIVO - Search results -

Search results

Result 1 - 10 of total 82

Search options

Article ; Online: A unique subset of low-risk Wilms tumors is characterized by loss of function of TRIM28 (KAP1), a gene critical in early renal development: A Children's Oncology Group study.

Armstrong, Amy E / Gadd, Samantha / Huff, Vicki / Gerhard, Daniela S / Dome, Jeffrey S / Perlman, Elizabeth J

PloS one

2018 Volume 13, Issue 12, Page(s) e0208936

Abstract: This study explores the genomic alterations that contribute to the formation of a unique subset of low-risk, epithelial differentiated, favorable histology Wilms tumors (WT), tumors that have been characterized by their expression of post-induction renal ...

Abstract	This study explores the genomic alterations that contribute to the formation of a unique subset of low-risk, epithelial differentiated, favorable histology Wilms tumors (WT), tumors that have been characterized by their expression of post-induction renal developmental genes (Subset 1 WT). We demonstrate copy neutral loss of heterozygosity involving 19q13.32-q13.43, unaccompanied by evidence for imprinting by DNA methylation. We further identified loss-of-function somatic mutations in TRIM28 (also known as KAP1), located at 19q13, in 8/9 Subset 1 tumors analyzed. An additional germline TRIM28 mutation was identified in one patient. Retrospective evaluation of previously analyzed WT outside of Subset 1 identified an additional tumor with anaplasia and both TRIM28 and TP53 mutations. A major function of TRIM28 is the repression of endogenous retroviruses early in development. We depleted TRIM28 in HEK293 cells, which resulted in increased expression of endogenous retroviruses, a finding also demonstrated in TRIM28-mutant WT. TRIM28 has been shown by others to be active during early renal development, and to interact with WTX, another gene recurrently mutated in WT. Our findings suggest that inactivation of TRIM28 early in renal development contributes to the formation of this unique subset of FHWTs, although the precise manner in which TRIM28 impacts both normal renal development and oncogenesis remains elusive.
MeSH term(s)	Anaplasia/genetics ; Anaplasia/pathology ; Carcinogenesis/genetics ; DNA Methylation/genetics ; Female ; Germ-Line Mutation/genetics ; HEK293 Cells ; Humans ; Infant ; Infant, Newborn ; Kidney/growth & development ; Kidney/metabolism ; Kidney/pathology ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Loss of Function Mutation/genetics ; Male ; Risk Factors ; Tripartite Motif-Containing Protein 28/genetics ; Wilms Tumor/genetics ; Wilms Tumor/pathology
Chemical Substances	TRIM28 protein, human (EC 2.3.2.27) ; Tripartite Motif-Containing Protein 28 (EC 2.3.2.27)
Language	English
Publishing date	2018-12-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0208936
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Germline pathogenic variants in 786 neuroblastoma patients.

Kim, Jung / Vaksman, Zalman / Egolf, Laura E / Kaufman, Rebecca / Evans, J Perry / Conkrite, Karina L / Danesh, Arnavaz / Lopez, Gonzalo / Randall, Michael P / Dent, Maiah H / Farra, Lance M / Menghani, Neil / Dymek, Malwina / Desai, Heena / Hausler, Ryan / Auvil, Jaime Guidry / Gerhard, Daniela S / Hakonarson, Hakon / Maxwell, Kara N /

Cole, Kristina A / Pugh, Trevor J / Bosse, Kristopher R / Khan, Javed / Wei, Jun S / Maris, John M / Stewart, Douglas R / Diskin, Sharon J

medRxiv : the preprint server for health sciences

2023

Abstract: Importance: Neuroblastoma accounts for 12% of childhood cancer deaths. The genetic contribution of rare pathogenic germline variation in patients without a family history remains unclear.: Objective: To define the prevalence, spectrum, and clinical ... ...

Abstract	Importance: Neuroblastoma accounts for 12% of childhood cancer deaths. The genetic contribution of rare pathogenic germline variation in patients without a family history remains unclear. Objective: To define the prevalence, spectrum, and clinical significance of pathogenic germline variation in cancer predisposition genes (CPGs) in neuroblastoma patients. Design setting and participants: Germline DNA sequencing was performed on the peripheral blood from 786 neuroblastoma patients unselected for family history. Rare variants mapping to CPGs were evaluated for pathogenicity and the percentage of cases harboring pathogenic (P) or likely pathogenic (LP) variants was quantified. The frequency of CPG P-LP variants in neuroblastoma cases was compared to two distinct cancer-free control cohorts to assess enrichment. Matched tumor DNA sequencing was evaluated for "second hits" at CPGs and germline DNA array data from 5,585 neuroblastoma cases and 23,505 cancer-free control children was analyzed to identify rare germline copy number variants (CNVs) affecting genes with an excess burden of P-LP variants in neuroblastoma. Neuroblastoma patients with germline P-LP variants were compared to those without P-LP variants to test for association with clinical characteristics, tumor features, and patient survival. Main outcomes and measures: Rare variant prevalence, pathogenicity, enrichment, and association with clinical characteristics, tumor features, and patient survival. Results: We observed 116 P-LP variants in CPGs involving 13.9% (109/786) of patients, representing a significant excess burden of P-LP variants compared to controls (9.1%; P = 5.14 × 10 Conclusions and relevance: Neuroblastoma patients harboring germline P-LP variants in CPGs have worse overall survival and
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.23.23284864
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival.

Kim, Jung / Vaksman, Zalman / Egolf, Laura E / Kaufman, Rebecca / Evans, J Perry / Conkrite, Karina L / Danesh, Arnavaz / Lopez, Gonzalo / Randall, Michael P / Dent, Maiah H / Farra, Lance M / Menghani, Neil L / Dymek, Malwina / Desai, Heena / Hausler, Ryan / Hicks, Belynda / Auvil, Jaime Guidry / Gerhard, Daniela S / Hakonarson, Hakon /

Maxwell, Kara N / Cole, Kristina A / Pugh, Trevor J / Bosse, Kristopher R / Khan, Javed / Wei, Jun S / Maris, John M / Stewart, Douglas R / Diskin, Sharon J

Journal of the National Cancer Institute

2023 Volume 116, Issue 1, Page(s) 149–159

Abstract: Background: Neuroblastoma is an embryonal cancer of the developing sympathetic nervous system. The genetic contribution of rare pathogenic or likely pathogenic germline variants in patients without a family history remains unclear.: Methods: Germline ...

Abstract	Background: Neuroblastoma is an embryonal cancer of the developing sympathetic nervous system. The genetic contribution of rare pathogenic or likely pathogenic germline variants in patients without a family history remains unclear. Methods: Germline DNA sequencing was performed on 786 neuroblastoma patients. The frequency of rare cancer predisposition gene pathogenic or likely pathogenic variants in patients was compared with 2 cancer-free control cohorts. Matched tumor DNA sequencing was evaluated for second hits, and germline DNA array data from 5585 neuroblastoma patients and 23 505 cancer-free control children were analyzed to identify rare germline copy number variants. Patients with germline pathogenic or likely pathogenic variants were compared with those without to test for association with clinical characteristics, tumor features, and survival. Results: We observed 116 pathogenic or likely pathogenic variants involving 13.9% (109 of 786) of neuroblastoma patients, representing a statistically significant excess burden compared with cancer-free participants (odds ratio [OR] = 1.60, 95% confidence interval [CI] = 1.27 to 2.00). BARD1 harbored the most statistically significant enrichment of pathogenic or likely pathogenic variants (OR = 32.30, 95% CI = 6.44 to 310.35). Rare germline copy number variants disrupting BARD1 were identified in patients but absent in cancer-free participants (OR = 29.47, 95% CI = 1.52 to 570.70). Patients harboring a germline pathogenic or likely pathogenic variant had a worse overall survival compared with those without (P = 8.6 x 10-3). Conclusions: BARD1 is an important neuroblastoma predisposition gene harboring both common and rare germline pathogenic or likely pathogenic variations. The presence of any germline pathogenic or likely pathogenic variant in a cancer predisposition gene was independently predictive of worse overall survival. As centers move toward paired tumor-normal sequencing at diagnosis, efforts should be made to centralize data and provide an infrastructure to support cooperative longitudinal prospective studies of germline pathogenic variation.
MeSH term(s)	Child ; Humans ; Genetic Predisposition to Disease ; Prospective Studies ; BRCA1 Protein/genetics ; Germ-Line Mutation ; Neuroblastoma/genetics ; Tumor Suppressor Proteins/genetics ; Ubiquitin-Protein Ligases/genetics
Chemical Substances	BRCA1 Protein ; BARD1 protein, human (EC 2.3.2.27) ; Tumor Suppressor Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2023-09-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2992-0
ISSN	1460-2105 ; 0027-8874 ; 0198-0157
ISSN (online)	1460-2105
ISSN	0027-8874 ; 0198-0157
DOI	10.1093/jnci/djad183
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.131: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Somatic structural variation targets neurodevelopmental genes and identifies

Lopez, Gonzalo / Conkrite, Karina L / Doepner, Miriam / Rathi, Komal S / Modi, Apexa / Vaksman, Zalman / Farra, Lance M / Hyson, Eric / Noureddine, Moataz / Wei, Jun S / Smith, Malcolm A / Asgharzadeh, Shahab / Seeger, Robert C / Khan, Javed / Auvil, Jaime Guidry / Gerhard, Daniela S / Maris, John M / Diskin, Sharon J

Genome research

2020 Volume 30, Issue 9, Page(s) 1228–1242

Abstract: Neuroblastoma is a malignancy of the developing sympathetic nervous system that accounts for 12% of childhood cancer deaths. Like many childhood cancers, neuroblastoma shows a relative paucity of somatic single-nucleotide variants (SNVs) and small ... ...

Abstract	Neuroblastoma is a malignancy of the developing sympathetic nervous system that accounts for 12% of childhood cancer deaths. Like many childhood cancers, neuroblastoma shows a relative paucity of somatic single-nucleotide variants (SNVs) and small insertions and deletions (indels) compared to adult cancers. Here, we assessed the contribution of somatic structural variation (SV) in neuroblastoma using a combination of whole-genome sequencing (WGS) of tumor-normal pairs (
MeSH term(s)	Cell Line, Tumor ; Chromothripsis ; Cohort Studies ; DNA Breaks ; DNA Copy Number Variations ; Female ; Genes, Tumor Suppressor ; Genomic Structural Variation ; Humans ; Male ; N-Myc Proto-Oncogene Protein/genetics ; Nerve Tissue Proteins/genetics ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Neurogenesis/genetics ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; RNA, Neoplasm ; RNA-Seq ; Risk Assessment ; Telomerase/genetics ; Tumor Cells, Cultured ; Whole Genome Sequencing
Chemical Substances	MYCN protein, human ; N-Myc Proto-Oncogene Protein ; Nerve Tissue Proteins ; RNA, Neoplasm ; SHANK2 protein, human ; TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49)
Language	English
Publishing date	2020-08-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1284872-4
ISSN	1549-5469 ; 1088-9051 ; 1054-9803
ISSN (online)	1549-5469
ISSN	1088-9051 ; 1054-9803
DOI	10.1101/gr.252106.119
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3729: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 8: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: An expanded universe of cancer targets.

Cell

2021 Volume 184, Issue 5, Page(s) 1142–1155

Abstract: The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles ... ...

Abstract	The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes. Here we describe a framework for this expanded list of cancer targets, providing novel opportunities for clinical translation.
MeSH term(s)	Animals ; Clinical Trials as Topic ; Disease Models, Animal ; Drug Delivery Systems ; Genomics ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Tumor Escape/drug effects ; Tumor Microenvironment/drug effects
Language	English
Publishing date	2021-02-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2021.02.020
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A community challenge for a pancancer drug mechanism of action inference from perturbational profile data.

Douglass, Eugene F / Allaway, Robert J / Szalai, Bence / Wang, Wenyu / Tian, Tingzhong / Fernández-Torras, Adrià / Realubit, Ron / Karan, Charles / Zheng, Shuyu / Pessia, Alberto / Tanoli, Ziaurrehman / Jafari, Mohieddin / Wan, Fangping / Li, Shuya / Xiong, Yuanpeng / Duran-Frigola, Miquel / Bertoni, Martino / Badia-I-Mompel, Pau / Mateo, Lídia /

Guitart-Pla, Oriol / Chung, Verena / Tang, Jing / Zeng, Jianyang / Aloy, Patrick / Saez-Rodriguez, Julio / Guinney, Justin / Gerhard, Daniela S / Califano, Andrea

Cell reports. Medicine

2022 Volume 3, Issue 1, Page(s) 100492

Abstract: The Columbia Cancer Target Discovery and Development (CTD2) Center is developing PANACEA, a resource comprising dose-responses and RNA sequencing (RNA-seq) profiles of 25 cell lines perturbed with ∼400 clinical oncology drugs, to study a tumor-specific ... ...

Abstract	The Columbia Cancer Target Discovery and Development (CTD2) Center is developing PANACEA, a resource comprising dose-responses and RNA sequencing (RNA-seq) profiles of 25 cell lines perturbed with ∼400 clinical oncology drugs, to study a tumor-specific drug mechanism of action. Here, this resource serves as the basis for a DREAM Challenge assessing the accuracy and sensitivity of computational algorithms for
MeSH term(s)	Algorithms ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasms/drug therapy ; Neural Networks, Computer ; Polypharmacology ; Protein Kinases/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Transcription, Genetic
Chemical Substances	RNA, Messenger ; Protein Kinases (EC 2.7.-)
Language	English
Publishing date	2022-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2021.100492
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Framework for quality assessment of whole genome cancer sequences.

Nature communications

2020 Volume 11, Issue 1, Page(s) 5040

Abstract: Bringing together cancer genomes from different projects increases power and allows the investigation of pan-cancer, molecular mechanisms. However, working with whole genomes sequenced over several years in different sequencing centres requires a ... ...

Abstract	Bringing together cancer genomes from different projects increases power and allows the investigation of pan-cancer, molecular mechanisms. However, working with whole genomes sequenced over several years in different sequencing centres requires a framework to compare the quality of these sequences. We used the Pan-Cancer Analysis of Whole Genomes cohort as a test case to construct such a framework. This cohort contains whole cancer genomes of 2832 donors from 18 sequencing centres. We developed a non-redundant set of five quality control (QC) measurements to establish a star rating system. These QC measures reflect known differences in sequencing protocol and provide a guide to downstream analyses and allow for exclusion of samples of poor quality. We have found that this is an effective framework of quality measures. The implementation of the framework is available at: https://dockstore.org/containers/quay.io/jwerner_dkfz/pancanqc:1.2.2 .
MeSH term(s)	Chromosome Mapping/standards ; Chromosomes, Human/genetics ; DNA Mutational Analysis/standards ; Female ; Genome, Human/genetics ; Genomics/methods ; Genomics/standards ; High-Throughput Nucleotide Sequencing/standards ; Humans ; Male ; Mutation ; Neoplasms/genetics ; Quality Control ; Software ; Whole Genome Sequencing/standards
Language	English
Publishing date	2020-10-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-18688-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: CTD2 Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network.

Aksoy, Bülent Arman / Dancík, Vlado / Smith, Kenneth / Mazerik, Jessica N / Ji, Zhou / Gross, Benjamin / Nikolova, Olga / Jaber, Nadia / Califano, Andrea / Schreiber, Stuart L / Gerhard, Daniela S / Hermida, Leandro C / Jagu, Subhashini / Sander, Chris / Floratos, Aris / Clemons, Paul A

Database : the journal of biological databases and curation

2017 Volume 2017

Abstract: Database url: https://ctd2-dashboard.nci.nih.gov/. ...

Abstract	Database url: https://ctd2-dashboard.nci.nih.gov/.
MeSH term(s)	Computational Biology/methods ; Databases, Factual ; Humans ; Internet ; Neoplasms/genetics ; User-Computer Interface
Language	English
Publishing date	2017-12-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2496706-3
ISSN	1758-0463 ; 1758-0463
ISSN (online)	1758-0463
ISSN	1758-0463
DOI	10.1093/database/bax054
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma.

Thomas, Nicole / Dreval, Kostiantyn / Gerhard, Daniela S / Hilton, Laura K / Abramson, Jeremy S / Ambinder, Richard F / Barta, Stefan / Bartlett, Nancy L / Bethony, Jeffrey / Bhatia, Kishor / Bowen, Jay / Bryan, Anthony C / Cesarman, Ethel / Casper, Corey / Chadburn, Amy / Cruz, Manuela / Dittmer, Dirk P / Dyer, Maureen A / Farinha, Pedro /

Gastier-Foster, Julie M / Gerrie, Alina S / Grande, Bruno M / Greiner, Timothy / Griner, Nicholas B / Gross, Thomas G / Harris, Nancy L / Irvin, John D / Jaffe, Elaine S / Henry, David / Huppi, Rebecca / Leal, Fabio E / Lee, Michael S / Martin, Jean Paul / Martin, Marie-Reine / Mbulaiteye, Sam M / Mitsuyasu, Ronald / Morris, Vivian / Mullighan, Charles G / Mungall, Andrew J / Mungall, Karen / Mutyaba, Innocent / Nokta, Mostafa / Namirembe, Constance / Noy, Ariela / Ogwang, Martin D / Omoding, Abraham / Orem, Jackson / Ott, German / Petrello, Hilary / Pittaluga, Stefania / Phelan, James D / Ramos, Juan Carlos / Ratner, Lee / Reynolds, Steven J / Rubinstein, Paul G / Sissolak, Gerhard / Slack, Graham / Soudi, Shaghayegh / Swerdlow, Steven H / Traverse-Glehen, Alexandra / Wilson, Wyndham H / Wong, Jasper / Yarchoan, Robert / ZenKlusen, Jean C / Marra, Marco A / Staudt, Louis M / Scott, David W / Morin, Ryan D

Blood

2023 Volume 141, Issue 8, Page(s) 904–916

Abstract: Burkitt lymphoma (BL) accounts for most pediatric non-Hodgkin lymphomas, being less common but significantly more lethal when diagnosed in adults. Much of the knowledge of the genetics of BL thus far has originated from the study of pediatric BL (pBL), ... ...

Abstract	Burkitt lymphoma (BL) accounts for most pediatric non-Hodgkin lymphomas, being less common but significantly more lethal when diagnosed in adults. Much of the knowledge of the genetics of BL thus far has originated from the study of pediatric BL (pBL), leaving its relationship to adult BL (aBL) and other adult lymphomas not fully explored. We sought to more thoroughly identify the somatic changes that underlie lymphomagenesis in aBL and any molecular features that associate with clinical disparities within and between pBL and aBL. Through comprehensive whole-genome sequencing of 230 BL and 295 diffuse large B-cell lymphoma (DLBCL) tumors, we identified additional significantly mutated genes, including more genetic features that associate with tumor Epstein-Barr virus status, and unraveled new distinct subgroupings within BL and DLBCL with 3 predominantly comprising BLs: DGG-BL (DDX3X, GNA13, and GNAI2), IC-BL (ID3 and CCND3), and Q53-BL (quiet TP53). Each BL subgroup is characterized by combinations of common driver and noncoding mutations caused by aberrant somatic hypermutation. The largest subgroups of BL cases, IC-BL and DGG-BL, are further characterized by distinct biological and gene expression differences. IC-BL and DGG-BL and their prototypical genetic features (ID3 and TP53) had significant associations with patient outcomes that were different among aBL and pBL cohorts. These findings highlight shared pathogenesis between aBL and pBL, and establish genetic subtypes within BL that serve to delineate tumors with distinct molecular features, providing a new framework for epidemiologic, diagnostic, and therapeutic strategies.
MeSH term(s)	Child ; Humans ; Adult ; Burkitt Lymphoma/pathology ; Epstein-Barr Virus Infections ; Herpesvirus 4, Human ; Lymphoma, Large B-Cell, Diffuse/pathology ; Mutation
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2022016534
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 364: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade-specific epigenome and transcriptome landscapes.

Gagliardi, Alessia / Porter, Vanessa L / Zong, Zusheng / Bowlby, Reanne / Titmuss, Emma / Namirembe, Constance / Griner, Nicholas B / Petrello, Hilary / Bowen, Jay / Chan, Simon K / Culibrk, Luka / Darragh, Teresa M / Stoler, Mark H / Wright, Thomas C / Gesuwan, Patee / Dyer, Maureen A / Ma, Yussanne / Mungall, Karen L / Jones, Steven J M /

Nakisige, Carolyn / Novik, Karen / Orem, Jackson / Origa, Martin / Gastier-Foster, Julie M / Yarchoan, Robert / Casper, Corey / Mills, Gordon B / Rader, Janet S / Ojesina, Akinyemi I / Gerhard, Daniela S / Mungall, Andrew J / Marra, Marco A

Nature genetics

2020 Volume 52, Issue 8, Page(s) 800–810

Abstract: Cervical cancer is the most common cancer affecting sub-Saharan African women and is prevalent among HIV-positive ( ... ...

Abstract	Cervical cancer is the most common cancer affecting sub-Saharan African women and is prevalent among HIV-positive (HIV
MeSH term(s)	Adult ; Aged ; DNA Methylation/genetics ; Epigenome/genetics ; Female ; Humans ; Middle Aged ; Papillomaviridae/pathogenicity ; Papillomavirus Infections/genetics ; Papillomavirus Infections/virology ; Promoter Regions, Genetic/genetics ; Signal Transduction/genetics ; Transcriptome/genetics ; Uganda ; Up-Regulation/genetics ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/virology
Language	English
Publishing date	2020-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1108734-1
ISSN	1546-1718 ; 1061-4036
ISSN (online)	1546-1718
ISSN	1061-4036
DOI	10.1038/s41588-020-0673-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3613: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 46: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito