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Article ; Online: Unveiling the HER2-low phenomenon: exploring immunohistochemistry and gene expression to characterise HR-positive HER2-negative early breast cancer.

Gaudio, M / Jacobs, F / Benvenuti, C / Saltalamacchia, G / Gerosa, R / De Sanctis, R / Santoro, A / Zambelli, A

2023 Volume 203, Issue 3, Page(s) 487–495

Abstract: Purpose: HER2-low breast cancer (BC) is a novel entity with relevant therapeutic implications, especially in hormone receptor (HR) positive BC. This study examines whether HER2 mRNA through the 21-gene assay, Oncotype DX (ODX), can refine the diagnosis ... ...

Abstract	Purpose: HER2-low breast cancer (BC) is a novel entity with relevant therapeutic implications, especially in hormone receptor (HR) positive BC. This study examines whether HER2 mRNA through the 21-gene assay, Oncotype DX (ODX), can refine the diagnosis of HER2-low and HER2-zero, obtained by immunohistochemistry (IHC). Methods: Between Jan 2021 and Jan 2023, 229 consecutive HR-positive HER2-negative early BC (T1-3 N0-1) have been characterised by IHC and ODX. HER2 status by IHC was either zero (IHC-0) or low (IHC-1 + and IHC-2 + /ISH-negative) while HER2-zero was further divided into HER2-null (IHC-0) and HER2-ultralow (IHC-1-10%). HER2 gene expression by ODX was negative if lower 10.7. Results: The distribution of HER2 IHC was as follows: 53.3% HER2-0, 29.25% HER2-1 + , and 17.5% HER2-2 + . The clinicopathological characteristics were similar in the three groups, with higher PgR-negative rate in HER2-zero (13.9% vs 3% vs 5%). The distribution of RS was homogeneous in the three groups with the median HER2 gene expression of 9.20 [IQR: 8.70-9.60]. HER2 gene expression gradually increased as the IHC score, with substantial overlap. After adjusting for confounders, HER2-1 + and HER2 2 + had a significant positive correlation between HER2 gene expression and IHC [OR 1.42, 95% CI 1.21 to 1.68, p < 0.001; OR 1.96, 95% CI 1.61 to 2.37, p < 0.001] compared to the HER2-zero group. HER2 gene expression did not differ between HER2-null and HER2-ultralow subgroups. Conclusion: Due to the substantial overlap, the HER2 gene expression is unable to properly distinguish HER2-low and HER2-zero IHC whose accurate identification is critical in the context of HER2-negative BC.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Immunohistochemistry ; Gene Expression
Chemical Substances	Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2023-11-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-023-07151-3
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Article ; Online: Ribociclib-Induced Cutaneous Adverse Events in Metastatic HR+/HER2- Breast Cancer: Incidence, Multidisciplinary Management, and Prognostic Implication.

Borroni, Riccardo Giovanni / Bartolini, Michela / Gaudio, Mariangela / Jacobs, Flavia / Benvenuti, Chiara / Gerosa, Riccardo / Tiberio, Paola / Manara, Sofia Ada Assunta Maria / Solferino, Alessandra / Santoro, Armando / De Sanctis, Rita

The oncologist

2024

Abstract: Background: Ribociclib is approved for hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer (ABC) treatment, in combination with endocrine therapy. Hematological, hepatic, and cardiac adverse ... ...

Abstract	Background: Ribociclib is approved for hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer (ABC) treatment, in combination with endocrine therapy. Hematological, hepatic, and cardiac adverse events (AEs) emerged from pivotal trials, but little is known about cutaneous adverse events (CAEs). Patients and methods: We report data from a retrospective cohort study of all patients with HR+/HER2- ABC treated with ribociclib at Humanitas Cancer Center between June 2017 and December 2022. We recorded clinical-pathological data, the incidence, and treatment of ribociclib-related CAEs. These were evaluated according to the NCI-CTCAE v5.0 classification. Progression-free survival (PFS) was estimated by Kaplan-Meier method and the log-rank test was used to analyze differences between groups. Results: Thirteen of 91 patients (14.3%) experienced treatment-related CAEs (mean time to the occurrence: 3.9 months). The most frequent CAEs were eczematous dermatitis (53.8%) and maculo-papular reaction (15.4%). Itch was reported by all 13 patients. The grade was G3 in 8 cases, G2 in 4, and G1 in 1. An integrated approach based on ribociclib dose modulation and dermatological interventions (oral antihistamine, moisturized cream, topical, and/or systemic steroids) could prevent ribociclib discontinuation in most patients. At a median follow-up of 20 months, the median PFS was 13 months (range, 1-66) with a better PFS curves for patients experiencing CAEs (P = .04). Conclusion: We mapped frequency and types of ribociclib-induced CAEs. An interdisciplinary management of CAEs incorporated into routine care may reduce the rate of drug discontinuation thus potentially contributing to better long-term outcomes.
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1093/oncolo/oyae004
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Zs.A 4845: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Common Misconceptions about Diet and Breast Cancer: An Unclear Issue to Dispel.

Lalioti, Anastasia / Verzeletti, Laura / Tiberio, Paola / Gerosa, Riccardo / Gaudio, Mariangela / Saltalamacchia, Giuseppe / Pastore, Manuela / Zambelli, Alberto / Santoro, Armando / De Sanctis, Rita

Cancers

2024 Volume 16, Issue 2

Abstract: Breast cancer (BC) constitutes a prevalent health condition among women. Recent years have witnessed the identification of dietary proto-oncogenic factors that deserve attention. Besides the well-known role of alcohol and red and processed meat in BC ... ...

Abstract	Breast cancer (BC) constitutes a prevalent health condition among women. Recent years have witnessed the identification of dietary proto-oncogenic factors that deserve attention. Besides the well-known role of alcohol and red and processed meat in BC development, the impact of other dietary components remains unclear. Our narrative review aims to explore the diet-BC relationship, focusing on sugar, dairy, and soy consumption. We conducted a PubMed literature search covering the last decade (2013-2023) and included 35 papers. We found limited evidence on the association between high sugar intake and BC incidence. On the other hand, dairy and soy consumption displayed a protective effect in the majority of the analyzed papers. However, a significant degree of heterogeneity was reported among the results. Menopausal status and the specific BC molecular subtypes were the main factors influencing the interpretation of the results. Exploring dietary factors and BC revealed inconsistencies: high glycemic index post-menopause may be a risk factor, while sugar-sweetened drinks and artificial sweeteners yielded conflicting results; fermented dairy showed potential benefits, non-fermented dairy presented inconsistent findings; soy impact on BC varied according to molecular subtype, with some studies suggesting a positive association in luminal-like BC. Hence, further investigation is crucial to obtain a uniform consensus on the diet-BC relationship.
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16020306
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Article: Charting the Course in Sequencing Antibody-Drug Conjugates in Breast Cancer.

Saltalamacchia, Giuseppe / Torrisi, Rosalba / De Sanctis, Rita / Masci, Giovanna / Miggiano, Chiara / Gaudio, Mariangela / Benvenuti, Chiara / Jacobs, Flavia / Gerosa, Riccardo / Santoro, Armando / Zambelli, Alberto

Biomedicines

2024 Volume 12, Issue 3

Abstract: Based on the unprecedented results observed in recent clinical trials, antibody-drug conjugates (ADCs) have revolutionized the treatment algorithm of metastatic breast cancer (mBC). The strategy of sequencing different ADCs in other lines of therapy is ... ...

Abstract	Based on the unprecedented results observed in recent clinical trials, antibody-drug conjugates (ADCs) have revolutionized the treatment algorithm of metastatic breast cancer (mBC). The strategy of sequencing different ADCs in other lines of therapy is highly attractive, but the proportion of patients who have undergone such a strategy in the context of published clinical trials is still limited, especially for modern ADCs. HER2-positive disease is primarily managed with a sequence of different ADCs. Historically, trastuzumab emtansine (T-DM1) has been the most commonly used ADC for both early and metastatic HER2-positive disease. Considering the recent evidence related to trastuzumab deruxtecan (T-DXd), it is expected to assume the role of the main ADC in our clinical practice. Herein, we report a retrospective analysis of the sequence of different ADCs relying on available published data from clinical trials.
Language	English
Publishing date	2024-02-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12030500
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Article ; Online: Cyclin-dependent kinase 2 (CDK2) inhibitors and others novel CDK inhibitors (CDKi) in breast cancer: clinical trials, current impact, and future directions.

Gerosa, Riccardo / De Sanctis, Rita / Jacobs, Flavia / Benvenuti, Chiara / Gaudio, Mariangela / Saltalamacchia, Giuseppe / Torrisi, Rosalba / Masci, Giovanna / Miggiano, Chiara / Agustoni, Francesco / Pedrazzoli, Paolo / Santoro, Armando / Zambelli, Alberto

Critical reviews in oncology/hematology

2024 Volume 196, Page(s) 104324

Abstract: Aberrant cyclin-dependent kinase 2 (CDK2) activation has been identified as a main resistance mechanism to CDK4/6 inhibition in hormone-receptor positive (HR+) breast cancer. Additionally, consistent preclinical evidence states its crucial role in MYC ... ...

Abstract	Aberrant cyclin-dependent kinase 2 (CDK2) activation has been identified as a main resistance mechanism to CDK4/6 inhibition in hormone-receptor positive (HR+) breast cancer. Additionally, consistent preclinical evidence states its crucial role in MYC and CCNE1 overexpressed cancer survival, such as triple-negative breast cancers (TNBC), thus representing an appealing and relatively unexplored target treatment opportunity. Despite emerging initial results of novel CDK2 inhibitors (CDK2i) activity, a comprehensive outcomes collection is currently absent from the scientific literature. We aim to provide an overview of ongoing clinical trials involving CDK2i in the context of metastatic breast cancer (mBC), either as monotherapy or in combination with other agents. The review extends beyond CDK2i to encompass novel emerging CDK4 inhibitors, combined CDK2/4/6 inhibitors, and the well-known pan-CDK inhibitors including those specifically directed at CDK2. Delving into the results, we critically appraise the observed clinical efficacy and offer valuable insights into their potential impact and future applications.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; Cyclin-Dependent Kinase 2 ; Cyclin-Dependent Kinase 4 ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Cell Cycle Checkpoints ; Triple Negative Breast Neoplasms/drug therapy ; Cyclin-Dependent Kinase 6
Chemical Substances	Cyclin-Dependent Kinase 2 (EC 2.7.11.22) ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; Protein Kinase Inhibitors ; Cyclin-Dependent Kinase 6 (EC 2.7.11.22) ; CDK2 protein, human (EC 2.7.11.22)
Language	English
Publishing date	2024-03-08
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	605680-5
ISSN	1879-0461 ; 0737-9587 ; 1040-8428
ISSN (online)	1879-0461
ISSN	0737-9587 ; 1040-8428
DOI	10.1016/j.critrevonc.2024.104324
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Zs.A 1931: Show issues

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Book ; Thesis: Pasolini romantico

Gerosa, Ricarda

regressive Impulse einer progressiven Poetik

(Untersuchungen zu Künsten in Theorie und Praxis ; 2)

2013

Author's details	Ricarda Gerosa
Series title	Untersuchungen zu Künsten in Theorie und Praxis ; 2
Keywords	Film ; Romantik ; Realismus ; Literatur ; Ästhetik
Language	German
Size	367 S., 21 cm
Publisher	Scaneg-Verl
Publishing place	München
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Bern, 2011
Note	Literaturverz. S. 349 - 361
ISBN	9783892352822 ; 3892352828
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Metals release from stainless steel knives in simulated food contact.

Casaroli, Andrea / Boniardi, Marco / Gerosa, Riccardo / Bilo, Fabjola / Borgese, Laura / Cirelli, Paola / Depero, Laura E

Food additives & contaminants. Part B, Surveillance

2022 Volume 15, Issue 3, Page(s) 203–211

Abstract: The release of chromium, nickel, and manganese from knives stainless steel produced in Italy and People's Republic of China was investigated with the aim to check their quality and compliance with Italian Ministerial Decree 21.03.73, which is the most ... ...

Abstract	The release of chromium, nickel, and manganese from knives stainless steel produced in Italy and People's Republic of China was investigated with the aim to check their quality and compliance with Italian Ministerial Decree 21.03.73, which is the most detailed text for the hygiene regulation of packaging, containers, and tools intended for food contact. Temperature effect on metal release is investigated in 18 sets of knives. Tests are performed by simulating discontinuous contact using a 3% glacial acetic acid solution in distilled water at 50°C and 100°C. Chromium, nickel, and manganese quantification is performed by total reflection X-Ray fluorescence. Chemical composition highlights low sulphur content, and most of them belong to the American Iron and Steel Institute (AISI) 420 type A stainless steel group. Tests performed at 100°C revealed higher concentration of released metals. Only three knives tested at 100°C exceed the limit of 100 µg L
MeSH term(s)	Allergens ; Chromium/analysis ; Food Contamination ; Humans ; Manganese/analysis ; Metals ; Nickel/analysis ; Stainless Steel/chemistry
Chemical Substances	Allergens ; Metals ; Chromium (0R0008Q3JB) ; Stainless Steel (12597-68-1) ; Manganese (42Z2K6ZL8P) ; Nickel (7OV03QG267)
Language	English
Publishing date	2022-06-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2447868-4
ISSN	1939-3229 ; 1939-3210
ISSN (online)	1939-3229
ISSN	1939-3210
DOI	10.1080/19393210.2022.2075473
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Article ; Online: Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation.

Helbling, Patrick M / Piñeiro-Yáñez, Elena / Gerosa, Rahel / Boettcher, Steffen / Al-Shahrour, Fátima / Manz, Markus G / Nombela-Arrieta, César

Cell reports

2019 Volume 29, Issue 10, Page(s) 3313–3330.e4

Abstract: Bone marrow (BM) stromal cells provide the regulatory framework for hematopoiesis and contribute to developmental stage-specific niches, such as those preserving hematopoietic stem cells. Despite advances in our understanding of stromal function, little ... ...

Abstract	Bone marrow (BM) stromal cells provide the regulatory framework for hematopoiesis and contribute to developmental stage-specific niches, such as those preserving hematopoietic stem cells. Despite advances in our understanding of stromal function, little is known about the transcriptional changes that this compartment undergoes throughout lifespan and during adaptation to stress. Using RNA sequencing, we perform transcriptional analyses of four principal stromal subsets, namely CXCL12-abundant reticular, platelet-derived growth factor receptor (PDGFR)-α
MeSH term(s)	Aging/genetics ; Animals ; Bone Marrow/physiology ; Bone Marrow Cells/physiology ; Cell Differentiation/genetics ; Cells, Cultured ; Cellular Microenvironment/genetics ; Chemokine CXCL12/genetics ; Embryonic Development/genetics ; Endothelial Cells/physiology ; Gene Expression Profiling/methods ; Hematopoiesis/genetics ; Hematopoietic Stem Cells/physiology ; Inflammation/genetics ; Male ; Mesenchymal Stem Cells/physiology ; Mice ; Mice, Inbred C57BL ; Stem Cell Niche/genetics ; Transcriptome/genetics
Chemical Substances	Chemokine CXCL12
Language	English
Publishing date	2019-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2019.11.004
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Article ; Online: NobelGuide™ influence in the perception of postoperative pain.

Bertossi, D / Gerosa, R / Schembri, E / Zanotti, G / Rossini, N / Colletti, G / Rossetto, A / Chiarini, L / Nocini, P F

Minerva stomatologica

2013

Abstract: Aim: The aim of this study was to evaluate the perception of pain after Computer-aided-implantology Implant Surgery (NobelGuideTM, Nobel Biocare, Göteborg, Sweden) compared to the conventional implant surgery. Methods: Eighteen patients from dental and ... ...

Abstract	Aim: The aim of this study was to evaluate the perception of pain after Computer-aided-implantology Implant Surgery (NobelGuideTM, Nobel Biocare, Göteborg, Sweden) compared to the conventional implant surgery. Methods: Eighteen patients from dental and maxillo-facial clinic of Policlinico G. B. Rossi (Verona, Italy) have been recruited: 9 were treated with the NobelGuide™ Technique, and 9 with the conventional one (approved by Local Ethical Committee) After the operation, painkillers (Ibuprofene tablets of 400 mg) were prescribed to the patients. Patients were asked to answer a questionnaire during the postoperative days and to report on the Visual Analogue Scale form (VAS), the intensity of pain and the number of painkillers used. Results: The VAS mean one day after the operation (peak of maximum pain) was 47.22 for the conventional technique, and 12.77 for the NobelGuide™ technique, and also the number of painkillers assumed is smaller for the NobelGuide™ technique. The 5th day after the operation all the patients treated with the NobelGuide™ Technique stopped painkillers and nobody felt pain, while the patients treated with the conventional technique felt more pain and for a longer period. They also took painkillers until the 7th day. Conclusion: Pain is minor and disappears more quickly with the Nobelguide™ Implant Surgery compared with the conventional surgical technique. Nobelguide™ Implant Surgery can reduce hospitalization improving the compliance of odontophobic patients towards implant therapy.
Language	English
Publishing date	2013-08-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	416059-9
ISSN	1827-174X ; 0026-4970
ISSN (online)	1827-174X
ISSN	0026-4970
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Zs.B 159: Show issues

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Article ; Online: Experimental analysis about the evaluation of tungsten carbide-bur, piezoelectric and laser osteotomies.

De Santis, D / Gerosa, R / Zanotti, G / Cigikov, N / Cenzi, A / Chiarini, L / Rossetto, A / Nocini, P F / Bertossi, D

Minerva stomatologica

2013

Abstract: Aim: Osteotomies are performed in oral surgery with five kinds of cutting instruments: 1) burs (Tungsten carbide cylindric burs), 2-3) ultrasound Piezosurgery (type I and II), 4-5) and lasers (Er:YAG; Er,Cr:YSGG). This study compares the quality of ... ...

Abstract	Aim: Osteotomies are performed in oral surgery with five kinds of cutting instruments: 1) burs (Tungsten carbide cylindric burs), 2-3) ultrasound Piezosurgery (type I and II), 4-5) and lasers (Er:YAG; Er,Cr:YSGG). This study compares the quality of cutting of every single instruments, evaluating accuracy (length, thickness, depth and morphology), velocity (number of passages and time) and entity of damage. Methods: In vitro experiments with ten osteotomies were performed on one-hundred of cow ribs with each instrument. In vivo surgery was performed on New Zealand white rabbit: two osteotomies are made with all instruments on the mandible and on the shinbone, totalizing four osteotomies for each instrument. Samples are processed to be evaluated through histological exam at stereomicroscopy Discussion: Results show a statistically significant variability on "thickness" (p value=0.001), "time" (p value=0.001), "depth" and penetration speed (p-value=0.001; p-value=0.001) and the "number of passages" (p-value=0.001). No differences have been observed in "length" (p-value=0.078). Histological analysis reveals that osteotomy performed with laser and Piezosurgery II generates major damage to osteocytes near cutting surfaces. Conclusion: Currently, purchase and management elevated costs, minor versatility of use, and long training times for equipments such as Piezosurgery and laser limit their general use, but remain advantageous in case of risky interventions near noble structures. Choice of device depends on experience maturated by operator in time, characteristics of operation and patient's clinical conditions.
Language	English
Publishing date	2013-08-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	416059-9
ISSN	1827-174X ; 0026-4970
ISSN (online)	1827-174X
ISSN	0026-4970
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