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  1. Article ; Conference proceedings: International Myeloma Working Group (IMWG) score accuracy in multiple myeloma patients: need for action

    Papageorgiou, L / Vandreden, P / Garderet, L / Elalamy, I / Gerotziafas, G

    Hämostaseologie

    2021  Volume 41, Issue S 01

    Event/congress 65th Annual Meeting of the Society of Thrombosis and Haemostasis Research, simply online, 2021-02-22
    Language German
    Publishing date 2021-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0041-1728212
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1631: Show issues Location:
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  2. Article ; Conference proceedings: Prolonged chemotherapeutic stress is accompanied by an aggressive and singular vascularization process with a high thrombogenic potential in Colorectal Cancer

    Thouroude, S / Van Dreden, P / Gerotziafas, G / Larsen, AK

    Hämostaseologie

    2021  Volume 41, Issue S 01

    Event/congress 65th Annual Meeting of the Society of Thrombosis and Haemostasis Research, simply online, 2021-02-22
    Language German
    Publishing date 2021-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0041-1728211
    Database Thieme publisher's database

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  3. Article ; Conference proceedings: Differences in the coagulation profile in women with mild and severe eclampsia

    Lefkou, E / Rousseau, A / Vandreden, P / Papageorgiou, L / Gerotziafas, G

    Hämostaseologie

    2021  Volume 41, Issue S 01

    Event/congress 65th Annual Meeting of the Society of Thrombosis and Haemostasis Research, simply online, 2021-02-22
    Language German
    Publishing date 2021-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0041-1728116
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  4. Article ; Online: The procoagulant signature of cancer cells drives fibrin network formation in tumor microenvironment and impacts its quality. Implications in cancer cell migration and the resistance to anticancer agents.

    Tran, Huong Chi Mai / Mbemba, Elisabeth / Mourot, Noémie / Faltas, Beshoy / Rousseau, Aurélie / Lefkou, Elmina / Sabbah, Michèle / van Dreden, Patrick / Gerotziafas, Grigoris

    Thrombosis research

    2024  Volume 238, Page(s) 172–183

    Abstract: Introduction: Cancer cells induce hypercoagulability in the tumoral microenvironment by expressing Tissue Factor (TF). We aimed to study the impact of the procoagulant signature of cancer cells on the quality and structure of fibrin network. We also ... ...

    Abstract Introduction: Cancer cells induce hypercoagulability in the tumoral microenvironment by expressing Tissue Factor (TF). We aimed to study the impact of the procoagulant signature of cancer cells on the quality and structure of fibrin network. We also studied the impact of fibrin clot shield (FCS) on the efficiency of anticancer agents and the migration of cancer cells.
    Materials and methods: Pancreatic cancer cells BXPC3 and breast cancer cells MDA-MB231 and MCF7, were cultured in the presence of normal Platelet Poor Plasma (PPP), diluted 10 % in conditioning media. Their potential to induce thrombin generation and their fibrinolytic activity were assessed. The structure of fibrin network was analyzed with Scanning Electron Microscopy (SEM). Cancer cells' mobility with fibrin clot and their interactions with fibrin were observed. Cancer cells were treated with paclitaxel (PTX) or 4-hydroxy-tamoxifen (4OHTam) in the presence or absence of FCS.
    Results: Cancer cells, in presence of PPP, induced fibrin network formation. High TF-expressing cancer cells (BXPC3 and MDA-MB23 cells), led to dense fibrin network with fine fibers. Low TF expressing cells MCF7 led to thick fibers. Exogenous TF enhanced the density of fibrin network formed by MCF7 cells. Cancer cells through their inherent profibrinolytic potential migrated within the fiber scaffold. The BXPC3 and MCF7 cells moved in clusters whereas the MDA-MB231 cells moved individually within the fibrin network. FCS decreased the efficiency of PTX and 4OHTam on the viability of cancer cells.
    Conclusions: The procoagulant signature of cancer cells is determinant for the quality and structure of fibrin network in the microenvironment. Original SEM images show the architecture of "bird's nest"-like fibrin network being in touch with the cell membranes and surrounding cancer cells. Fibrin network constructed by triggering thrombin generation by cancer cells, provides a scaffold for cell migration. Fibrin clot shields protect cancer cells against PTX and 4OHTam.
    MeSH term(s) Humans ; Cell Movement/drug effects ; Fibrin/metabolism ; Tumor Microenvironment/drug effects ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Drug Resistance, Neoplasm/drug effects ; MCF-7 Cells ; Female ; Breast Neoplasms/pathology ; Breast Neoplasms/metabolism ; Breast Neoplasms/drug therapy ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/metabolism ; Blood Coagulation/drug effects
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2024.04.015
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    Zs.A 863: Show issues Location:
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  5. Article ; Online: Venous thromboembolism in cancer patients: ESMO Clinical Practice Guideline.

    Falanga, A / Ay, C / Di Nisio, M / Gerotziafas, G / Jara-Palomares, L / Langer, F / Lecumberri, R / Mandala, M / Maraveyas, A / Pabinger, I / Sinn, M / Syrigos, K / Young, A / Jordan, K

    Annals of oncology : official journal of the European Society for Medical Oncology

    2023  Volume 34, Issue 5, Page(s) 452–467

    MeSH term(s) Humans ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology ; Venous Thromboembolism/therapy ; Anticoagulants/therapeutic use ; Risk Factors ; Neoplasms/complications ; Neoplasms/epidemiology ; Neoplasms/therapy
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-01-10
    Publishing country England
    Document type Practice Guideline ; Research Support, Non-U.S. Gov't ; Journal Article
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1016/j.annonc.2022.12.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2862: Show issues Location:
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  6. Article ; Online: Combined Vaccination Approaches for COVID-19. Will These Improve the Efficacy Spectrum?

    Van Dreden, Patrick / Fareed, Jawed / Elalamy, Ismail / Gerotziafas, Grigoris

    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

    2021  Volume 27, Page(s) 10760296211033906

    MeSH term(s) COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/immunology ; Clinical Trials as Topic ; Humans ; Immunization Schedule ; Immunogenicity, Vaccine ; Research Design ; Time Factors ; Treatment Outcome ; Vaccination
    Chemical Substances COVID-19 Vaccines ; ChAdOx1 COVID-19 vaccine (B5S3K2V0G8) ; BNT162 vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Letter
    ZDB-ID 1237357-6
    ISSN 1938-2723 ; 1076-0296
    ISSN (online) 1938-2723
    ISSN 1076-0296
    DOI 10.1177/10760296211033906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Conference proceedings: Aggressiveness of breast cancer cells is related with tissue factor expression and procoagulant activity.

    Mbemba, E / Amrane, R / Ferrand, N / Sabbah, M / Vandreden, P / Gerotziafas, G

    Hämostaseologie

    2021  Volume 41, Issue S 01

    Event/congress 65th Annual Meeting of the Society of Thrombosis and Haemostasis Research, simply online, 2021-02-22
    Language German
    Publishing date 2021-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0041-1728081
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  8. Article ; Conference proceedings: Cancer cell-derived microparticles expressing tissue factor have pivotal role on the procoagulant shift of endothelial cells

    Djedidi - Amrane, R / Van Dreden, P / Mbemba, E / Sabbah, M / Gerotziafas, G

    Hämostaseologie

    2021  Volume 41, Issue S 01

    Event/congress 65th Annual Meeting of the Society of Thrombosis and Haemostasis Research, simply online, 2021-02-22
    Language German
    Publishing date 2021-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0041-1728162
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  9. Article ; Conference proceedings: Analysis of adherence to therapy comparing DOAC Dipstick test with plasma concentration of rivaroxaban and apixaban in outpatients with venous thromboembolic disease

    Papageorgiou, L / Auge, F / Harenberg, J / Elalamy, I / Vandreden, P / Gerotziafas, G

    Hämostaseologie

    2021  Volume 41, Issue S 01

    Event/congress 65th Annual Meeting of the Society of Thrombosis and Haemostasis Research, simply online, 2021-02-22
    Language German
    Publishing date 2021-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0041-1728168
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  10. Article ; Conference proceedings: Modelization the impact of antithrombotic agents on pancreatic tumoral micro-environment.

    Tran, H / Amrane, R / Mbemba, E / Sabbah, M / Vandreden, P / Gerotziafas, G

    Hämostaseologie

    2021  Volume 41, Issue S 01

    Event/congress 65th Annual Meeting of the Society of Thrombosis and Haemostasis Research, simply online, 2021-02-22
    Language German
    Publishing date 2021-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0041-1728080
    Database Thieme publisher's database

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