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  1. AU="Gewurz, H"
  2. AU="Linares, Mauricio"
  3. AU="Gnesi, Marco"
  4. AU="Park, Jinny"
  5. AU="Hill, Benjamin D"
  6. AU=Huang Chunfa
  7. AU="Skonieczny, Paul"
  8. AU="LIVINGSTON, M S"
  9. AU="Lidia Gonzalez-Quereda"
  10. AU="Korkmaz, Asli"
  11. AU="Patel, Mrinal"
  12. AU="Louis Chauvel"
  13. AU="Jampen, Laurent"
  14. AU="Tan, Jiacheng"
  15. AU="Weiss, Jonathan D"

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  1. Artikel: Biology of C-reactive protein and the acute phase response.

    Gewurz, H

    Hospital practice (Hospital ed.)

    1982  Band 17, Heft 6, Seite(n) 67–81

    Mesh-Begriff(e) Animals ; Blood Sedimentation ; C-Reactive Protein/biosynthesis ; C-Reactive Protein/blood ; C-Reactive Protein/physiology ; Complement Activation ; Erythrocyte Aggregation/blood ; Humans ; Infection/blood ; Inflammation/blood ; Isoelectric Point ; Liver/metabolism ; Lymphocytes/metabolism ; Mice ; Microscopy, Electron ; Molecular Weight ; Opsonin Proteins ; Platelet Aggregation ; Polymers ; Prostaglandins/metabolism ; Protein Binding ; Spleen/metabolism ; Wounds and Injuries/blood
    Chemische Substanzen Opsonin Proteins ; Polymers ; Prostaglandins ; C-Reactive Protein (9007-41-4)
    Sprache Englisch
    Erscheinungsdatum 1982-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 8755-4542
    ISSN 8755-4542
    DOI 10.1080/21548331.1982.11702332
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Perspective.

    Gewurz, H

    Science (New York, N.Y.)

    1974  Band 184, Heft 4144, Seite(n) 1327

    Sprache Englisch
    Erscheinungsdatum 1974-06-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.184.4144.1327-a
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Interaction between endotoxic lipopolysaccharides (LPS) and the complement (C) system: solubilization of C-consuming substances during brief absorbtions at 0 degrees.

    Gewurz, H

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

    1971  Band 136, Heft 2, Seite(n) 561–564

    Mesh-Begriff(e) Animals ; Antibodies ; Complement System Proteins
    Chemische Substanzen Antibodies ; Complement System Proteins (9007-36-7)
    Sprache Englisch
    Erscheinungsdatum 1971-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.3181/00379727-136-35311
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Regulation of complement activation by C-reactive protein.

    Mold, C / Gewurz, H / Du Clos, T W

    Immunopharmacology

    1999  Band 42, Heft 1-3, Seite(n) 23–30

    Abstract: C-reactive protein (CRP) is an acute-phase serum protein and a mediator of innate immunity. CRP binds to microbial polysaccharides and to ligands exposed on damaged cells. Binding of CRP to these substrates activates the classical complement pathway ... ...

    Abstract C-reactive protein (CRP) is an acute-phase serum protein and a mediator of innate immunity. CRP binds to microbial polysaccharides and to ligands exposed on damaged cells. Binding of CRP to these substrates activates the classical complement pathway leading to their uptake by phagocytic cells. Complement activation by CRP is restricted to C1, C4, C2 and C3 with little consumption of C5-9. Surface bound CRP reduces deposition of and generation of C5b-9 by the alternative pathway and deposition of C3b and lysis by the lectin pathway. These activities of CRP are the result of recruitment of factor H resulting in regulation of C3b on bacteria or erythrocytes. Evidence is presented for direct binding of H to CRP. H binding to CRP or C3b immobilized on microtiter wells was demonstrated by ELISA. Attachment of CRP to a surface was required for H binding. H binding to CRP was not inhibited by EDTA or phosphocholine, which inhibit ligand binding, but was inhibited by a 13 amino acid CRP peptide. The peptide sequence was identical to the region of CRP that showed the best alignment to H binding peptides from Streptococcus pyogenes (M6) and Neisseria gonorrhoeae (Por1A). The results suggest that CRP bound to a surface provides secondary binding sites for H resulting in greater regulation of alternative pathway amplification and C5 convertases. Complement activation by CRP may help limit the inflammatory response by providing opsonization with minimal generation of C5a and C5b-9.
    Mesh-Begriff(e) Amino Acid Sequence ; Animals ; Binding Sites ; C-Reactive Protein/immunology ; C-Reactive Protein/metabolism ; Complement Activation/immunology ; Humans ; Molecular Sequence Data
    Chemische Substanzen C-Reactive Protein (9007-41-4)
    Sprache Englisch
    Erscheinungsdatum 1999-05
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 424423-0
    ISSN 1879-047X ; 0162-3109
    ISSN (online) 1879-047X
    ISSN 0162-3109
    DOI 10.1016/s0162-3109(99)00007-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Complement in endotoxin shock: effect of complement depletion on the early hypotensive phase.

    From, A H / Gewurz, H / Gruninger, R P / Pickering, R J / Spink, W W

    Infection and immunity

    2006  Band 2, Heft 1, Seite(n) 38–41

    Abstract: The complement (C) inhibition caused by bacterial endotoxin is well known, but the relationship of this reaction to endotoxin shock is unclear. Anesthetized dogs were therefore given Escherichia coli endotoxin intravenously with or without prior C ... ...

    Abstract The complement (C) inhibition caused by bacterial endotoxin is well known, but the relationship of this reaction to endotoxin shock is unclear. Anesthetized dogs were therefore given Escherichia coli endotoxin intravenously with or without prior C depletion by a purified cobra venom factor (CVF). Mean aortic blood pressures (MAP) and C levels were measured. Intravenous CVF usually caused an early transient drop of MAP and a profound, long-lasting drop in C. Bacterial lipopolysaccharide (LPS) alone always caused a sudden (within 2 min) drop in MAP which was followed by partial recovery and then more long-lasting depression. Moderate drops in C usually occurred. In animals pretreated with CVF so that C levels were markedly depressed (<25% of control), LPS did not elicit the immediate MAP drops; however, a later (after 5 to 20 min) MAP drop always occurred. CVF pretreatment did not modify LPS-induced mortality. CVF effects were not caused by LPS contamination. These data show that the early hemodynamic responses of the dog to LPS may be mediated through the complement system.
    Sprache Englisch
    Erscheinungsdatum 2006-01-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.2.1.38-41.1970
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: C-reactive protein in aging Lobund Wistar rats.

    Siegel, J N / Gewurz, H

    Progress in clinical and biological research

    1989  Band 287, Seite(n) 127–132

    Mesh-Begriff(e) Aging ; Animals ; C-Reactive Protein/metabolism ; Germ-Free Life ; Rats ; Rats, Inbred Strains
    Chemische Substanzen C-Reactive Protein (9007-41-4)
    Sprache Englisch
    Erscheinungsdatum 1989
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 0361-7742
    ISSN 0361-7742
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Mannose binding lectin (MBL) and HIV.

    Ji, Xin / Gewurz, Henry / Spear, Gregory T

    Molecular immunology

    2005  Band 42, Heft 2, Seite(n) 145–152

    Abstract: The envelope protein (gp120/gp41) of HIV-1 is highly glycosylated with about half of the molecular mass of gp120 consisting of N-linked carbohydrates. While glycosylation of HIV gp120/gp41 provides a formidable barrier for development of strong antibody ... ...

    Abstract The envelope protein (gp120/gp41) of HIV-1 is highly glycosylated with about half of the molecular mass of gp120 consisting of N-linked carbohydrates. While glycosylation of HIV gp120/gp41 provides a formidable barrier for development of strong antibody responses to the virus, it also provides a potential site of attack by the innate immune system through the C-type lectin mannose binding lectin (MBL) (also called mannan binding lectin or mannan binding protein). A number of studies have clearly shown that MBL binds to HIV. Binding of MBL to HIV is dependent on the high-mannose glycans on gp120 while host cell glycans incorporated into virions do not contribute substantially to this interaction. It is notable that MBL, due to its specificity for the types of glycans that are abundant on gp120, has been shown to interact with all tested HIV strains. While direct neutralization of HIV produced in T cell lines by MBL has been reported, neutralization is relatively low for HIV primary isolates. However, drugs that alter processing of carbohydrates enhance neutralization of HIV primary isolates by MBL. Complement activation on gp120 and opsonization of HIV due to MBL binding have also been observed but these immune mechanisms have not been studied in detail. MBL has also been shown to block the interaction between HIV and DC-SIGN. Clinical studies show that levels of MBL, an acute-phase protein, increase during HIV disease. The effects of MBL on HIV disease progression and transmission are equivocal with some studies showing positive effects and other showing no effect or negative effects. Because of apparently universal reactivity with HIV strains, MBL clearly represents an important mechanism for recognition of HIV by the immune system. However, further studies are needed to define the in vivo contribution of MBL to clearance and destruction of HIV, the reasons for low neutralization by MBL and ways that MBL anti-viral effects can be augmented.
    Mesh-Begriff(e) Cell Adhesion Molecules/immunology ; Complement Activation ; HIV/immunology ; HIV Envelope Protein gp120/metabolism ; HIV Infections/immunology ; Humans ; Lectins, C-Type/immunology ; Mannose-Binding Lectins/immunology ; Mannose-Binding Lectins/metabolism ; Mannose-Binding Lectins/therapeutic use ; Receptors, Cell Surface/immunology
    Chemische Substanzen Cell Adhesion Molecules ; DC-specific ICAM-3 grabbing nonintegrin ; HIV Envelope Protein gp120 ; Lectins, C-Type ; Mannose-Binding Lectins ; Receptors, Cell Surface
    Sprache Englisch
    Erscheinungsdatum 2005-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2004.06.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Structure and function of the pentraxins.

    Gewurz, H / Zhang, X H / Lint, T F

    Current opinion in immunology

    1995  Band 7, Heft 1, Seite(n) 54–64

    Abstract: Over the past two years, the three-dimensional structure of the serum amyloid P component was defined by X-ray diffraction, the first such visualization of a pentraxin. Binding sites for calcium, ligands and complement were identified. New fusion ... ...

    Abstract Over the past two years, the three-dimensional structure of the serum amyloid P component was defined by X-ray diffraction, the first such visualization of a pentraxin. Binding sites for calcium, ligands and complement were identified. New fusion proteins with amino acid sequence homology to the pentraxins were described, and new insights were gained into pentraxin phylogeny, biosynthesis, ligands, complement activation, leukocyte reactivity and biological functions in vivo.
    Mesh-Begriff(e) Alzheimer Disease/metabolism ; Amino Acid Sequence ; Animals ; C-Reactive Protein/chemistry ; C-Reactive Protein/metabolism ; C-Reactive Protein/physiology ; Complement System Proteins/metabolism ; Humans ; Lung Diseases/metabolism ; Lupus Erythematosus, Systemic/metabolism ; Molecular Sequence Data ; Phylogeny ; Serum Amyloid A Protein/chemistry ; Serum Amyloid A Protein/metabolism ; Serum Amyloid A Protein/physiology
    Chemische Substanzen Serum Amyloid A Protein ; Complement System Proteins (9007-36-7) ; C-Reactive Protein (9007-41-4)
    Sprache Englisch
    Erscheinungsdatum 1995-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/0952-7915(95)80029-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Component deficiencies. 9. The ninth component.

    Lint, T F / Gewurz, H

    Progress in allergy

    1986  Band 39, Seite(n) 307–310

    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Complement Activation ; Complement C9/deficiency ; Complement C9/genetics ; Female ; Humans ; Male
    Chemische Substanzen Complement C9
    Sprache Englisch
    Erscheinungsdatum 1986
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80351-0
    ISSN 0079-6034
    ISSN 0079-6034
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Cleaved forms of C-reactive protein are associated with platelet inhibition.

    Fiedel, B A / Gewurz, H

    Journal of immunology (Baltimore, Md. : 1950)

    1986  Band 136, Heft 7, Seite(n) 2551–2555

    Abstract: C-reactive protein (CRP) is the prototypic acute phase reactant and serves clinically as a marker of inflammation and tissue destruction. When native CRP pentamer was incubated with Streptomyces griseus protease, a newly formed and transient ability to ... ...

    Abstract C-reactive protein (CRP) is the prototypic acute phase reactant and serves clinically as a marker of inflammation and tissue destruction. When native CRP pentamer was incubated with Streptomyces griseus protease, a newly formed and transient ability to inhibit platelet aggregation stimulated by adenosine diphosphate or collagen was often elicited early during the course of enzymatic digestion. Sodium dodecyl sulfate polyacrylamide gel electrophoresis analyses of the digests revealed that platelet inhibitory activity correlated with altered electrophoretic mobility and reductions in subunit and pentameric m.w. Minimally degraded forms of CRP were also isolated "de novo" from inflammatory fluids and, like their enzyme degraded counterparts, inhibited platelet activation. Dissociation of degraded CRP with SDS followed by the removal of SDS resulted in the separation fragments which inhibited platelet function. We propose that in a degradative environment, such as at sites of inflammation/tissue damage or through the action of serum proteases, CRP may transitorily down-regulate the platelet.
    Mesh-Begriff(e) C-Reactive Protein/analysis ; C-Reactive Protein/metabolism ; C-Reactive Protein/pharmacology ; Electrophoresis, Polyacrylamide Gel ; Endopeptidases ; Epitopes/analysis ; Humans ; Molecular Weight ; Peptide Fragments/isolation & purification ; Peptide Fragments/pharmacology ; Platelet Aggregation/drug effects ; Serine Endopeptidases
    Chemische Substanzen Epitopes ; Peptide Fragments ; C-Reactive Protein (9007-41-4) ; Endopeptidases (EC 3.4.-) ; Serine Endopeptidases (EC 3.4.21.-)
    Sprache Englisch
    Erscheinungsdatum 1986-04-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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