Article: [Pregnancy-preserving and maternal-fetal management in a patient with rare large cell neuroendocrine carcinoma of the uterine cervix].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
2021 Volume 41, Issue 1, Page(s) 1–9
Abstract: Objective: To explore the strategy of pregnancy-preserving and maternal- fetal management in patients with primary gynecologic neuroendocrine tumors (gNETs) during pregnancy.: Methods: We performed whole genome sequencing (WGS) for analyzing maternal ...
| Abstract | Objective: To explore the strategy of pregnancy-preserving and maternal- fetal management in patients with primary gynecologic neuroendocrine tumors (gNETs) during pregnancy. Methods: We performed whole genome sequencing (WGS) for analyzing maternal and fetal somatic and germline single nucleotide variations (SNVs) and small insertions and deletions (InDels) for a 29-year-old pregnant woman diagnosed with stage IB2 large cell neuroendocrine carcinoma (LCNEC) and adenocarcinoma in the cervix. A systematic literature review was performed to explore the strategies for treatment of such rare histological type while maintaining pregnancy. Results: Global case analysis of cervical NETs during pregnancy suggested that negative lymph node metastasis and an early FIGO stage were potentially associated with a good prognosis of the patients. In the case presented herein, a pregnancy-preserving strategy was adopted and favorable maternal-fetal outcomes were achieved after neoadjuvant chemotherapy, radical surgery and postoperative systemic chemotherapy. At 35 Conclusions: Although gNETs in pregnancy are rare and highly risky, pregnancy-preserving managements of gNETs can still be considered and favorable maternalfetal outcomes are possible with proper assessment of the clinical indications and implementation of multimodal treatments. Precise treatment and follow-up strategies based on the results of WGS for risk-reducing intervention of cancer recurrence or occurrence can potentially benefit the patient and the neonate. |
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| MeSH term(s) | Adenocarcinoma ; Adult ; Carcinoma, Neuroendocrine/genetics ; Child ; Female ; Humans ; Infant, Newborn ; Neoplasm Recurrence, Local ; Pregnancy ; Uterine Cervical Neoplasms/genetics |
| Language | Chinese |
| Publishing date | 2021-01-25 |
| Publishing country | China |
| Document type | Case Reports ; Journal Article ; Systematic Review |
| ZDB-ID | 2250951-3 |
| ISSN | 1673-4254 |
| ISSN | 1673-4254 |
| DOI | 10.12122/j.issn.1673-4254.2021.01.01 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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