Article ; Online: Invited review: Muscle protein breakdown and its assessment in periparturient dairy cows.
2022 Volume 106, Issue 2, Page(s) 822–842
Abstract: Mobilization of body reserves including fat, protein, and glycogen is necessary to overcome phases of negative nutrient balance typical for high-yielding dairy cows during the periparturient period. Skeletal muscle, the largest internal organ in mammals, ...
Abstract | Mobilization of body reserves including fat, protein, and glycogen is necessary to overcome phases of negative nutrient balance typical for high-yielding dairy cows during the periparturient period. Skeletal muscle, the largest internal organ in mammals, plays a crucial role in maintaining metabolic homeostasis. However, unlike in liver and adipose tissue, the metabolic and regulatory role of skeletal muscle in the adaptation of dairy cows to the physiological needs of pregnancy and lactation has not been studied extensively. The functional integrity and quality of skeletal muscle are maintained through a constant turnover of protein, resulting from both protein breakdown and protein synthesis. Thus, muscle protein breakdown (MPB) and synthesis are intimately connected and tightly controlled to ensure proper protein homeostasis. Understanding the regulation of MPB, the catabolic component of muscle turnover, and its assessment are therefore important considerations to provide information about the timing and extent of tissue mobilization in periparturient dairy cows. Based on animal models and human studies, it is now evident that MPB occurs via the integration of 3 main systems: autophagy-lysosomal, calpain Ca |
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MeSH term(s) | Animals ; Cattle ; Female ; Pregnancy ; Adipose Tissue/metabolism ; Diet/veterinary ; Lactation/physiology ; Muscle Proteins/metabolism ; Muscle, Skeletal/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Ubiquitin/metabolism ; Peripartum Period/metabolism ; Pregnancy, Animal/metabolism ; Proteolysis |
Chemical Substances | Muscle Proteins ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Ubiquitin |
Language | English |
Publishing date | 2022-11-29 |
Publishing country | United States |
Document type | Journal Article ; Review |
ZDB-ID | 242499-x |
ISSN | 1525-3198 ; 0022-0302 |
ISSN (online) | 1525-3198 |
ISSN | 0022-0302 |
DOI | 10.3168/jds.2022-22068 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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