Article ; Online: Cabotegravir/Rilpivirine: the last FDA-approved drug to treat HIV.
Expert review of anti-infective therapy
2022 Volume 20, Issue 8, Page(s) 1135–1147
Abstract: Introduction: The development of long-acting (LA) drugs has changed the management of common medical conditions for human replication immunodeficiency virus (HIV). Cabenuva (cabotegravir/Rilpivirine) is the first LA antiretroviral injectable drug ... ...
Abstract | Introduction: The development of long-acting (LA) drugs has changed the management of common medical conditions for human replication immunodeficiency virus (HIV). Cabenuva (cabotegravir/Rilpivirine) is the first LA antiretroviral injectable drug composed of nano-formulation of cabotegravir (CAB) and rilpivirine (RPV). Areas covered: In this review article, we aim to have a brief overview of results of major clinical trials that administrated Cabotegravir/Rilpivirine for patients considering the efficacy and safety profiles. Moreover, we discuss about CAB and RPV chemical structure, mechanism of action, activity against drug-sensitive and -resistant HIV, and pharmacodynamics/pharmacokinetics properties. Expert opinion: Based on the results of the ATLAS and FLAIR trials, Cabotegravir/Rilpivirine regimen once-monthly has shown equal effectivity to oral combination antiretroviral therapy (cART) in maintaining HIV-1 suppression in patients. Furthermore, ATLAS-2 M study revealed the non-inferiority of Cabotegravir/Rilpivirine regimen every 8 weeks compared to every 4 weeks. The injectable LA ART reduces the number of treatment intake as well as increases adherence, especially in patients with HIV-related stigma. Administration of extended-release agents probably minimize the risk of treatment-related toxicity and resistance related to sub-optimal adherence to oral ART, so Cabotegravir/Rilpivirine can be suggested as a suitable alternative for HIV infection control in current era. |
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MeSH term(s) | Anti-HIV Agents/adverse effects ; Anti-Retroviral Agents/therapeutic use ; Diketopiperazines ; Drug Combinations ; HIV Infections/drug therapy ; Humans ; Pharmaceutical Preparations ; Pyridones ; Rilpivirine/adverse effects |
Chemical Substances | Anti-HIV Agents ; Anti-Retroviral Agents ; Diketopiperazines ; Drug Combinations ; Pharmaceutical Preparations ; Pyridones ; cabotegravir, rilpivirine drug combination ; Rilpivirine (FI96A8X663) ; cabotegravir (HMH0132Z1Q) |
Language | English |
Publishing date | 2022-06-13 |
Publishing country | England |
Document type | Journal Article ; Review |
ZDB-ID | 2181279-2 |
ISSN | 1744-8336 ; 1478-7210 |
ISSN (online) | 1744-8336 |
ISSN | 1478-7210 |
DOI | 10.1080/14787210.2022.2081153 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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