Article: Possible neglected transient (T) polyagglutination in critically ill patients with coronavirus disease-2019 (Covid-19).
Pakistan journal of pharmaceutical sciences
2023 Volume 36, Issue 4, Page(s) 1211–1215
Abstract: T-activation polyagglutination can be caused by bacteria or viruses and has been associated with haemolytic anaemia. Coronavirus disease-19 (COVID-19) is also associated with haemolytic anaemia. The presented study aims to determine T activation ... ...
| Abstract | T-activation polyagglutination can be caused by bacteria or viruses and has been associated with haemolytic anaemia. Coronavirus disease-19 (COVID-19) is also associated with haemolytic anaemia. The presented study aims to determine T activation polyagglutination in critically ill COVID-19 patients. Anti-T Arachis hypogaea lectin was incubated with the red blood cells of the COVID-19 patient and checked for agglutination. Thirty-four percent (34.3%) of COVID-19 patients in the intensive care unit (ICU) had potentially activated T cells and polyagglutinable red blood cells, as demonstrated by their cryptantigen exposure that caused agglutination. The study revealed a high prevalence of anti-T among ICU-admitted COVID-19 patients, suggesting that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may cause transient T activation, polyagglutination in critically ill COVID-19 patients in vitro and possibly haemolysis in vivo. |
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| MeSH term(s) | Humans ; COVID-19 ; SARS-CoV-2 ; Critical Illness ; Antibodies ; Cell Death | |||||
| Chemical Substances | Antibodies | |||||
| Language | English | |||||
| Publishing date | 2023-08-21 | |||||
| Publishing country | Pakistan | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 885131-1 | |||||
| ISSN | 1011-601X | |||||
| ISSN | 1011-601X | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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