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  1. Book: Venipuncture for the Application of Blood Concentrates

    Ghanaati, Shahram

    2024  

    Abstract: The benefits of PRF and other blood concentrates are well known in the dental profession, but venipuncture is not a skill dentists naturally possess. In this, as in every form of treatment, providing high-quality care is essential. Patient safety must be ...

    Author's details Prof Shahram Ghanaati is a specialist in oral and maxillofacial surgery with a triple doctorate in medicine, dentistry, and science (MD, DMD, PhD) from Johannes Gutenberg University in Mainz and Frankfurt. Today he leads the Head and Neck Oncology section at the University Cancer Center at Johann Wolfgang Goethe University in Frankfurt and is an associate professor in the Clinic of Oral, Cranio-Maxillofacial and Plastic Surgery there. In 2009, he founded the FORM-Lab (Frankfurt Orofacial Regenerative Medicine), a research laboratory that performs basic science and clinical studies focusing on understanding the biomaterial-based regeneration process. In his research, Prof Ghanaati has participated in the development of over 10 biomaterials from the bench to the clinic. He has worked with Dr Joseph Choukroun, the inventor of platelet-rich fibrin (PRF), to develop advanced preparation protocols, and in 2016 he and his team established the so-called LSCC (low-speed centrifugation concep
    Abstract The benefits of PRF and other blood concentrates are well known in the dental profession, but venipuncture is not a skill dentists naturally possess. In this, as in every form of treatment, providing high-quality care is essential. Patient safety must be ensured, and the procedures used should be maximally efficient and effective. Shahram Ghanaati developed this tidy little textbook to empower dental professionals to perform blood collection and the preparation of blood concentrates safely, e...
    Keywords dentistry ; general dentistry ; venipuncture ; blood ; PRF ; blood concentrates ; vein ; arm veins
    Language English
    Size 64 p.
    Edition 1
    Publisher Quintessence Publishing Co, Inc
    Document type Book
    Note PDA Manuell_25
    Format 172 x 241
    ISBN 9781647241940 ; 1647241944
    Database PDA

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  2. Article ; Online: Focus on craniomaxillofacial injuries in trauma patients.

    Ghanaati, Shahram

    European journal of trauma and emergency surgery : official publication of the European Trauma Society

    2022  Volume 48, Issue 4, Page(s) 2511–2512

    MeSH term(s) Facial Injuries/surgery ; Humans ; Skull Fractures/diagnostic imaging
    Language English
    Publishing date 2022-08-08
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 2275480-5
    ISSN 1863-9941 ; 1863-9933
    ISSN (online) 1863-9941
    ISSN 1863-9933
    DOI 10.1007/s00068-022-02036-4
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  3. Article: Editorial. Ein ganzheitlicher Blick ist entscheidend

    Ghanaati, Shahram

    Implantologie-Journal

    2023  Volume 27, Issue 9, Page(s) 3

    Language German
    Document type Article
    ZDB-ID 1464637-7
    ISSN 1435-6139
    Database Current Contents Medicine

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  4. Article ; Online: Platelet rich fibrin as a bioactive matrix with proosteogenic and proangiogenic properties on human healthy primary cells in vitro.

    Dohle, Eva / Schmeinck, Lena / Parkhoo, Kamelia / Sader, Robert / Ghanaati, Shahram

    Platelets

    2024  Volume 35, Issue 1, Page(s) 2316744

    Abstract: Blood concentrates like platelet rich fibrin (PRF) have been established as a potential autologous source of cells and growth factors with regenerative properties in the field of dentistry and regenerative medicine. To further analyze the effect of PRF ... ...

    Abstract Blood concentrates like platelet rich fibrin (PRF) have been established as a potential autologous source of cells and growth factors with regenerative properties in the field of dentistry and regenerative medicine. To further analyze the effect of PRF on bone tissue regeneration, this study investigated the influence of liquid PRF matrices on human healthy primary osteoblasts (pOB) and co-cultures composed of pOB and human dermal vascular endothelial cells (HDMEC) as
    MeSH term(s) Humans ; Platelet-Rich Fibrin/metabolism ; Osteogenesis ; Endothelial Cells ; Bone and Bones ; Coculture Techniques
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2024.2316744
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  5. Article: Three Milliliters of Peripheral Blood Is Sufficient for Preparing Liquid Platelet-Rich Fibrin (PRF): An In Vitro Study.

    Al-Maawi, Sarah / Dohle, Eva / Sader, Robert / Ghanaati, Shahram

    Bioengineering (Basel, Switzerland)

    2024  Volume 11, Issue 3

    Abstract: Platelet-rich fibrin (PRF) has assumed an important role in supporting tissue regeneration in different fields. To date, the standard protocol for liquid PRF requires at least 10 mL of peripheral blood. The present study aimed to analyze the composition, ...

    Abstract Platelet-rich fibrin (PRF) has assumed an important role in supporting tissue regeneration in different fields. To date, the standard protocol for liquid PRF requires at least 10 mL of peripheral blood. The present study aimed to analyze the composition, growth factor release, and effects on the cell proliferation of PRF samples produced using 3 mL vs. 10 mL of peripheral blood in vitro. Peripheral venous blood from six healthy donors was used to prepare liquid PRF using either 3 mL or 10 mL tubes. Three different centrifugation protocols were used according to the low-speed centrifugation concept. The cellular distribution was evaluated using immunohistology and automated cell count. ELISA was used to determine the release of different growth factors (EGF, TGF-β1, and PDGF) and interleukin 8 at different time points. Primary human osteoblasts (pOBs) were cultivated for 7 days using PRF-conditioned media acquired from either 3 mL or 10 mL of peripheral blood. The results showed that 3 mL of peripheral blood is sufficient to produce a liquid PRF concentrate similar to that acquired when using 10 mL blood. The concentrations of platelets and leukocytes were comparable regardless of the initial blood volume (3 mL vs. 10 mL). Similarly, the release of growth factors (EGF, TGF-β1, and PDGF) and interleukin 8 was often comparable in both groups over 7 days. The cultivation of pOBs using PRF-conditioned media showed a similar proliferation rate regardless of the initial blood volume. This proliferation rate was also similar to that of pOBs treated with 20% FBS-conditioned media. These findings validated the use of 3 mL of peripheral blood to generate liquid PRF matrices according to the low-speed centrifugation concept, which may open new application fields for research purposes such as in vivo experiments and clinical applications such as pediatric surgery.
    Language English
    Publishing date 2024-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering11030253
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  6. Article ; Online: Histologic evaluation of edentulous alveolar ridge horizontal bone augmentations using a xenogeneic bone substitute and autologous platelet concentrates: a case series.

    Nagy, Pal / Nemeth, Florina / Ghanaati, Shahram / Heselich, Anja / Windisch, Peter

    Quintessence international (Berlin, Germany : 1985)

    2024  Volume 55, Issue 4, Page(s) 314–326

    Abstract: Objectives: This case series aimed to assess the efficacy of a novel horizontal ridge augmentation modality using histology. Combinations of "sticky bone" and tenting screws without autologous bone were used as augmentative materials.: Method and ... ...

    Abstract Objectives: This case series aimed to assess the efficacy of a novel horizontal ridge augmentation modality using histology. Combinations of "sticky bone" and tenting screws without autologous bone were used as augmentative materials.
    Method and materials: Five individuals presenting healed, atrophic, partially edentulous sites that required horizontal bone augmentation before implant placement were enrolled. Patients underwent the same augmentation type and 5 months of postoperative reentry procedures. The first surgery served as implant site development, whereas the biopsy and corresponding implant placement were performed during reentry. The bone was qualitatively analyzed using histology and histomorphometry and quantitatively evaluated using CBCT.
    Results: Four individuals healed uneventfully. Early wound dehiscence occurred in one case. Histology showed favorable bone substitute incorporation into the newly formed bone and intimate contact between de novo bone and graft material in most cases. Histomorphometry revealed an average of 48 ± 28% newly formed bone, 19 ± 13% graft material, and 33 ± 26% soft tissue components. The CBCT-based mean alveolar ridge horizontal increase was 3.9 ± 0.6 mm at 5 months postoperatively.
    Conclusions: The described augmentation method appears suitable for implant site development resulting in favorable bone quality according to histology. However, clinicians must accommodate 1 to 2 mm of resorption in augmentative material width at the buccal aspect.
    MeSH term(s) Humans ; Alveolar Ridge Augmentation/methods ; Female ; Male ; Middle Aged ; Cone-Beam Computed Tomography ; Bone Substitutes/therapeutic use ; Dental Implantation, Endosseous/methods ; Treatment Outcome ; Jaw, Edentulous, Partially ; Adult ; Biopsy ; Aged ; Bone Screws
    Chemical Substances Bone Substitutes
    Language English
    Publishing date 2024-03-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 7436-6
    ISSN 1936-7163 ; 0033-6572
    ISSN (online) 1936-7163
    ISSN 0033-6572
    DOI 10.3290/j.qi.b5104947
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  7. Article: CME / DGZI Peer-Reviewed. Autologes Blutkonzentrat PRF im Weichgewebsmanagement

    Ghanaati, Shahram / Heselich, Anja

    Implantologie-Journal

    2023  Volume 27, Issue 9, Page(s) 6

    Language German
    Document type Article
    ZDB-ID 1464637-7
    ISSN 1435-6139
    Database Current Contents Medicine

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  8. Article ; Online: Volume reduction of vascularized flaps in the field of cranio-maxillofacial surgery: A narrative-style review.

    Thoenissen, Philipp / Najafi, Ramin / Sader, Robert / Ghanaati, Shahram

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

    2023  Volume 52, Issue 2, Page(s) 203–211

    MeSH term(s) Humans ; Surgical Flaps/surgery ; Plastic Surgery Procedures ; Surgery, Oral
    Language English
    Publishing date 2023-12-12
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 91267-0
    ISSN 1878-4119 ; 1010-5182 ; 0301-0503
    ISSN (online) 1878-4119
    ISSN 1010-5182 ; 0301-0503
    DOI 10.1016/j.jcms.2023.12.002
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  9. Article ; Online: Long-Term Peri-Implant Health and Papilla Formation at Healed Sites by Chairside Provisionalization of Single-Tooth Implants: A Prospective Case Series.

    Lorenz, Jonas / Blume, Maximilian / Schwarz, Frank / Weigl, Paul / Ghanaati, Shahram / Sader, Rober A

    The International journal of prosthodontics

    2024  , Page(s) 1–20

    Abstract: Purpose: Several procedures are performed to achieve optimal esthetic results in single-tooth implants. However, there is discordance regarding the potential benefit and risks of immediate implant loading/provisionalization. The aim of this prospective ... ...

    Abstract Purpose: Several procedures are performed to achieve optimal esthetic results in single-tooth implants. However, there is discordance regarding the potential benefit and risks of immediate implant loading/provisionalization. The aim of this prospective case series is to investigate the effect of immediate provisionalization of single-tooth implants at healed sites for periimplant soft-tissue conditions, focusing on papilla formation around single implants.
    Materials and methods: Twelve patients received a total of 12 implants in the incisor, canine or premolar region of the upper and lower jaw at healed sites with immediate chair-side provisionalization. Four months later, the temporary crown was replaced by the permanent crown. After 40±13.1 months, clinical follow-up was conducted, assessing Probing pocket depth (PPD); Bleeding on Probing(BoP); Mucosal recession (MR) and Width of Keratinized Mucosa (KM). Papilla index (PI) was determined immediately after implant placement (baseline), before removing the temporary crown (t1), 4 weeks after insertion of the definitive crown (t2) and at the final follow-up examination (t3) to evaluate papilla formation and its change over time.
    Results: None of the implants were lost. The mean PPD was 2.5±0.39 mm, BoP of 25% and 3.5 mm of KM were observed at the final follow-up. No implants showed MR. PI increased in all patients from 1.5±0.45 at baseline to 2.4±0.56 at t1, 2.6±0.47 at t2 and 3.02.6±0 at t3. The increase in PI between t0 and each individual timepoint from t1-t3 showed statistical significance.
    Conclusion: The present results indicate the suitability and benefit of immediate provisionalization to achieve favorable peri-implant soft-tissue conditions and papilla formation.
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645046-5
    ISSN 1942-4426 ; 0893-2174
    ISSN (online) 1942-4426
    ISSN 0893-2174
    DOI 10.11607/ijp.8719
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  10. Article: Immunomodulation of Cancer Cells Using Autologous Blood Concentrates as a Patient-Specific Cell Culture System: A Comparative Study on Osteosarcoma and Fibrosarcoma Cell Lines.

    Dohle, Eva / Parkhoo, Kamelia / Bennardo, Francesco / Schmeinck, Lena / Sader, Robert / Ghanaati, Shahram

    Bioengineering (Basel, Switzerland)

    2024  Volume 11, Issue 4

    Abstract: The understanding that tumor cells might evade immunity through various mutations and the potential of an augmented immune system to eliminate abnormal cells led to the idea of utilizing platelet-rich fibrin (PRF), a blood concentrate containing the body' ...

    Abstract The understanding that tumor cells might evade immunity through various mutations and the potential of an augmented immune system to eliminate abnormal cells led to the idea of utilizing platelet-rich fibrin (PRF), a blood concentrate containing the body's immune elements as an adjunctive therapy for localized tumors. This study is the first that evaluated the effect of PRF generated with different relative centrifugal forces (RCFs) on osteoblastic and fibroblastic tumor cell lines MG63 and HT1080 with regard to cell viability, cytokine and growth factor release, and the gene expression of factors related to the cell cycle and apoptosis. Our findings could demonstrate decreased cell proliferation of MG63 and HT1080 when treated indirectly with PRF compared to cell cultures without PRF. This effect was more distinct when the cells were treated with low-RCF PRF, where higher concentrations of growth factors and cytokines with reduced RCFs can be found. Similar patterns were observed when assessing the regulation of gene expression related to the cell cycle and apoptosis in both MG63 and HT1080 cells treated with PRF. Despite variations, there was a consistent trend of an up-regulation of tumor-suppressive genes and a down-regulation of anti-apoptotic genes in both cell types following treatment with high- and, particularly, low-RCF PRF formulations.
    Language English
    Publishing date 2024-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering11040303
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