Article ; Online: The Pro-tumor and Anti-tumor Effects of NLRP3 Inflammasome as a New Therapeutic Option for Colon Cancer: a Meta-analysis of Pre-clinical Studies.
Journal of gastrointestinal cancer
2022 Volume 54, Issue 1, Page(s) 227–236
Abstract: In this review, we aimed to elaborate on these findings and explore how NLRP3 inflammasome affects CRC and which mechanism could be a potential therapeutic target. For this purpose, major indexing databases consist of Cochrane central, ISI web of science ...
| Abstract | In this review, we aimed to elaborate on these findings and explore how NLRP3 inflammasome affects CRC and which mechanism could be a potential therapeutic target. For this purpose, major indexing databases consist of Cochrane central, ISI web of science (WOS), PubMed/Medline, Scopus, and EMBASE were systematically searched using standard terms without any language, study region, or type restrictions. After applying the exclusion criteria, the main properties of 12 articles on 326 animals included in this meta-analysis. Of 12, eight were about an anti-tumoral effect, and four were on a pro-tumoral effect of the inflammasome. NLRP3 inhibition reduced IL-1β (SMD: -4.14, 95% CI: -5.49, -2.79, P < 0.00001, I |
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| MeSH term(s) | Animals ; Humans ; Colonic Neoplasms/drug therapy ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Reactive Oxygen Species/metabolism | |||||
| Chemical Substances | Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Reactive Oxygen Species | |||||
| Language | English | |||||
| Publishing date | 2022-01-24 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Meta-Analysis ; Systematic Review | |||||
| ZDB-ID | 2452514-5 | |||||
| ISSN | 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649 | |||||
| ISSN (online) | 1941-6636 ; 1559-0739 | |||||
| ISSN | 1941-6628 ; 1537-3649 | |||||
| DOI | 10.1007/s12029-022-00805-3 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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