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  1. Article ; Online: Effects of swimming exercise on neuropathic pain in a rat model: role of glutamate.

    Ghanbari, Ali / Ghasemi, Sahar / Khaleghian, Ali

    Neurological research

    2024  Volume 46, Issue 4, Page(s) 330–338

    Abstract: Objective: The pain-reducing effects of the exercise were exerted through different mechanisms. Knowing more clear mechanisms helps to find more approach that is therapeutic. The objective of the present study is the evaluation of cerebrospinal fluid ( ... ...

    Abstract Objective: The pain-reducing effects of the exercise were exerted through different mechanisms. Knowing more clear mechanisms helps to find more approach that is therapeutic. The objective of the present study is the evaluation of cerebrospinal fluid (CSF) glutamate level alteration in neuropathic pain rats and whether physical activity could modulate it.
    Methods: In the present study 104 male
    Results: Findings indicated that mechanical and thermal thresholds significantly (
    In conclusion: The present findings provide new evidence showing that medium-intensity swimming exercise attenuates pain-like behaviors in neuropathic pain animals, which is possibly due to decreasing CSF glutamate level and its neurotransmission.
    MeSH term(s) Rats ; Male ; Animals ; Pain Threshold/physiology ; Swimming ; Rats, Sprague-Dawley ; Rats, Wistar ; Glutamic Acid ; Hyperalgesia/therapy ; Neuralgia/therapy
    Chemical Substances Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 424428-x
    ISSN 1743-1328 ; 0161-6412
    ISSN (online) 1743-1328
    ISSN 0161-6412
    DOI 10.1080/01616412.2024.2313901
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  2. Article: Mathematical prediction of the spreading rate of COVID-19 using entropy-based thermodynamic model.

    Ghanbari, A / Khordad, R / Ghaderi-Zefrehei, Mostafa

    Indian journal of physics and proceedings of the Indian Association for the Cultivation of Science (2004)

    2021  Volume 95, Issue 12, Page(s) 2567–2573

    Abstract: In the COVID-19 pandemic era, undoubtedly mathematical modeling helps epidemiological scientists and authorities to take informing decisions about pandemic planning, wise resource allocation, introducing relevant non-pharmaceutical interventions and ... ...

    Abstract In the COVID-19 pandemic era, undoubtedly mathematical modeling helps epidemiological scientists and authorities to take informing decisions about pandemic planning, wise resource allocation, introducing relevant non-pharmaceutical interventions and implementation of social distancing measures. The current coronavirus disease (COVID-19) emerged in the end of 2019, Wuhan, China, spreads quickly in the world. In this study, an entropy-based thermodynamic model has been used for predicting and spreading the rate of COVID-19. In our model, all the epidemic details were considered into a single time-dependent parameter. The parameter was analytically determined using four constraints, including the existence of an inflexion point and a maximum value. Our model has been layout-based the Shannon entropy and the maximum rate of entropy production of postulated complex system. The results show that our proposed model fits well with the number of confirmed COVID-19 cases in daily basis. Also, as a matter of fact that Shannon entropy is an intersection of information, probability theory, (non)linear dynamical systems and statistical physics, the proposed model in this study can be further calibrated to fit much better on COVID-19 observational data, using the above formalisms.
    Language English
    Publishing date 2021-01-02
    Publishing country India
    Document type Journal Article
    ISSN 0973-1458
    ISSN 0973-1458
    DOI 10.1007/s12648-020-01930-0
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  3. Book ; Online: ObjSim

    Ghanbari, Ali

    Lightweight Automatic Patch Prioritization via Object Similarity

    2020  

    Abstract: In the context of test case based automatic program repair (APR), patches that pass all the test cases but fail to fix the bug are called overfitted patches. Currently, patches generated by APR tools get inspected manually by the users to find and adopt ... ...

    Abstract In the context of test case based automatic program repair (APR), patches that pass all the test cases but fail to fix the bug are called overfitted patches. Currently, patches generated by APR tools get inspected manually by the users to find and adopt genuine fixes. Being a laborious activity hindering widespread adoption of APR, automatic identification of overfitted patches has lately been the topic of active research. This paper presents engineering details of ObjSim: a fully automatic, lightweight similarity-based patch prioritization tool for JVM-based languages. The tool works by comparing the system state at the exit point(s) of patched method before and after patching and prioritizing patches that result in state that is more similar to that of original, unpatched version on passing tests while less similar on failing ones. Our experiments with patches generated by the recent APR tool PraPR for fixable bugs from Defects4J v1.4.0 show that ObjSim prioritizes 16.67% more genuine fixes in top-1 place. A demo video of the tool is located at https://bit.ly/2K8gnYV.

    Comment: Proceedings of the 29th ACM SIGSOFT International Symposium on Software Testing and Analysis (ISSTA '20), July 18--22, 2020, Virtual Event, USA
    Keywords Computer Science - Software Engineering ; D.2.5
    Subject code 000
    Publishing date 2020-06-08
    Publishing country us
    Document type Book ; Online
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  4. Article ; Online: Exercise induced myelin protein zero improvement in neuropathic pain rats.

    Ghanbari, Ali / Ghasemi, Sahar / Zarbakhsh, Sam

    Somatosensory & motor research

    2023  Volume 40, Issue 4, Page(s) 141–146

    Abstract: Purpose: Aerobic exercise including swimming plays a suitable role in improving somatosensory injuries. Neuropathic pain is a debilitating condition that occurs following injury or diseases of somatosensory system. In the present study, we tried to ... ...

    Abstract Purpose: Aerobic exercise including swimming plays a suitable role in improving somatosensory injuries. Neuropathic pain is a debilitating condition that occurs following injury or diseases of somatosensory system. In the present study, we tried to investigate the effect of exercise on myelin protein zero of sciatic nerve injured rats.
    Materials and methods: Forty male rats (180-220 g) were divided into five groups (intact, sham, sham + exercise, neuropathy, and neuropathy + exercise). Right Sciatic nerve of anesthetized rats was exposed and loosely ligated (four ligations with 1 mm apart) using catgut chromic sutures to induce neuropathy. After 3 days of recovery, swimming exercise began (20 min/day/5 days a week/4 weeks). Mechanical allodynia and thermal hyperalgesia were detected using Von Frey filaments and plantar test, respectively. Sciatic nerve at the place of injury was dissected out to measure the myelin protein zero by western blot analysis. In the intact and sham groups, sciatic nerve removed at the place similar to injured group.
    Results: We found that neuropathy significantly (
    Conclusions: Swimming exercise improves myelin protein zero level in neuropathic rats along with attenuating neuropathic pain. This is a promising approach in improving neuropathological disorders including Charcot-Marie-Tooth and Dejerine-Sottas disease.
    MeSH term(s) Rats ; Male ; Animals ; Myelin P0 Protein ; Rats, Sprague-Dawley ; Pain Measurement ; Neuralgia/etiology ; Neuralgia/therapy ; Hyperalgesia/etiology ; Hyperalgesia/therapy ; Sciatic Nerve/pathology
    Chemical Substances Myelin P0 Protein
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1042336-9
    ISSN 1369-1651 ; 0899-0220
    ISSN (online) 1369-1651
    ISSN 0899-0220
    DOI 10.1080/08990220.2022.2158800
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  5. Article ; Online: Prediction models of macro-nutrient content in plant organs of

    Keshtehgar, Abbas / Dahmardeh, Mahdi / Ghanbari, Ahmad / Khammari, Issa

    PeerJ

    2023  Volume 11, Page(s) e15417

    Abstract: Background: Undoubtedly, the importance of food and food security as one of the present and future challenges is not invisible to anyone. Nowadays, the development of methods for monitoring the nutrient content in crop products is an essential issue for ...

    Abstract Background: Undoubtedly, the importance of food and food security as one of the present and future challenges is not invisible to anyone. Nowadays, the development of methods for monitoring the nutrient content in crop products is an essential issue for implementing reasonable and logical soil properties management. The modeling technique can evaluate the soil properties of fields and study the subject of crop yield through soil management. This study aims to predict fruit yield and macro-nutrient content in plant organs of
    Methodology: In the spring of 2020, this study was done as a factorial test in a randomized complete block design with three replications. The first factor was the use of fertilizers in six levels: no fertilizer (control), cow manure (30 t ha
    Results: According to the results, when the data sets of the nitrogen, phosphorus, and potassium in the fruit uses as input, the accuracy of these models was higher than 80.0% (R
    Conclusions: Because the fruit values had the highest contribution in prediction than observed values, thus identified as the best plant organs in response to soil elements. Based on our findings, the importance of fruit phosphorus identifies as a determinant that strongly influenced melon prediction models. More significant values of soil elements do not affect increasing fruit yield and macro-nutrient content in plant organs, and excessive application may not be economical. Therefore, our studies provide an efficient approach with potentially high accuracy to estimate fruit yield and macro-nutrient in the fruits of
    MeSH term(s) Animals ; Sheep ; Soil/chemistry ; Fertilizers/analysis ; Cucumis melo ; Manure ; Nutrients ; Phosphorus ; Nitrogen/analysis ; Potassium/analysis
    Chemical Substances Soil ; Fertilizers ; Manure ; Phosphorus (27YLU75U4W) ; Nitrogen (N762921K75) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Randomized Controlled Trial, Veterinary ; Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.15417
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  6. Book ; Online: Validation of Automatically Generated Patches

    Ghanbari, Ali

    An Appetizer

    2019  

    Abstract: In the context of test case based automated program repair (APR), the research community call the patches that pass all the test cases but fail to actually fix the bug test case overfitted patches. Currently, overfitted patches has to be manually ... ...

    Abstract In the context of test case based automated program repair (APR), the research community call the patches that pass all the test cases but fail to actually fix the bug test case overfitted patches. Currently, overfitted patches has to be manually inspected by the users. Being a labor intensive activity that hinders widespread adoption of APR tools, automatic validation of APR-generated patches has been the topic of research in recent years. In this paper, we point out the limitations of the existing techniques/methodologies that call for further research, and introduce two promising directions toward effective automatic patch validation: (1) motivated by the relative effectiveness of anti-patterns, we propose to use statistical techniques to avoid the uncomputability of applying some of the anti-pattern rules and automate the technique. Our results show that we achieve at least 57% precision. (2) We present a proposal for a semi-automatic technique that helps the programmers in finding properties of the patched methods and stress testing the patches based on those properties so as to filter out overfitted ones as many as possible.

    Comment: Insufficient empirical evidence needed to draw a reliable conclusion
    Keywords Computer Science - Software Engineering
    Subject code 006
    Publishing date 2019-11-29
    Publishing country us
    Document type Book ; Online
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  7. Article: The effect of salt supplements on thyroid hormones and quality of pregnancy in female hypothyroid rats.

    Shakeri Moghaddam, F / Ghanbari, A / Fereidouni, A / Khaleghian, A

    Acta endocrinologica (Bucharest, Romania : 2005)

    2021  Volume 16, Issue 4, Page(s) 396–401

    Abstract: Background: The use of nutrient supplements along with medication to optimize the treatment of diseases yields desirable outcomes. Hypothyroidism causes abnormalities in cells, and organs, and induces gene expression changes. The use of salt supplements ...

    Abstract Background: The use of nutrient supplements along with medication to optimize the treatment of diseases yields desirable outcomes. Hypothyroidism causes abnormalities in cells, and organs, and induces gene expression changes. The use of salt supplements and vitamins considerably helps to treat hypothyroidism.
    Objectives: To evaluate the effect of a food supplement containing iron, iodine, and folic acid on thyroid hormones changes as well as the quality and quantity of hypothyroid female rat's offspring.
    Materials and methods: In the current experimental study, 40 female rats were divided into six experimental and two control groups. The study was conducted in three phases. In the first phase, the role of a combinatory supplement along with levothyroxine to treat hypothyroidism by assessing T3, T4, and TSH hormones was investigated. In the second phase, the dose-depended effects of a combinatory supplement were investigated. Additionally, in the third phase, the quality and quantity of the next generation were measured in the hypothyroid female rats receiving the salt supplement.
    Results: The plasma level of T3, T4 and TSH in hypothyroid rats receiving nutrient supplements indicated that the use of combinatory supplements along with levothyroxine could have desirable effects on the treatment of hypothyroidism to such an extent that the level of T3 and T4 hormones in the intervention group was significantly higher than that of the control group (P≤0.01). The second phase demonstrated that the desired effects of combinatory supplements on the serum levels of T3, T4, and TSH hormones were dose-dependent so that by increasing the dosage of supplementation, a significant decrease in the TSH level was observed (P <0.05), while T3 and T4 levels increased (P <0.01).The results of the third phase demonstrated that salt supplements could be effective in reducing the number of dead or preterm pups, and the use of mineral salts along with levothyroxine could promote a healthy birth.
    Conclusion: Salt supplements have considerable effects on the health status of the offspring of hypothyroid rats, resulting in the birth of more healthy pups and reducing the rate of abortion or preterm births.
    Language English
    Publishing date 2021-04-09
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 1433812-9
    ISSN 1843-066X ; 1841-0987
    ISSN (online) 1843-066X
    ISSN 1841-0987
    DOI 10.4183/aeb.2020.396
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  8. Article ; Online: Coadministration of doxorubicin with vitamin D3, Lactobacillus acidophilus, and Lactobacillus casei in the 4T1 mouse model of breast cancer: anticancer and enteroprotective effects.

    Mirzadeh, Mohammad Ali / Eslami, Majid / Ghanbari, Ali / Zarbakhsh, Sam / Yosefi, Sedighe / Pakdel, Abbas

    Medical oncology (Northwood, London, England)

    2024  Volume 41, Issue 5, Page(s) 111

    Abstract: The use of doxorubicin (Dox) in the treatment of breast cancer negatively affects the intestines and other tissues. Many studies have proven that probiotics and vitamin D3 have antitumor and intestinal tissue-protecting properties. To achieve ... ...

    Abstract The use of doxorubicin (Dox) in the treatment of breast cancer negatively affects the intestines and other tissues. Many studies have proven that probiotics and vitamin D3 have antitumor and intestinal tissue-protecting properties. To achieve effectiveness and minimize side effects, the current study aims to administer Dox together with probiotics (Lactobacillus acidophilus and Lactobacillus casei) and vitamin D3. Forty-two female BALB/c inbred mice were divided into six groups: Group 1 (Control), Group 2 (Dox), Group 3 (Dox and probiotics), Group 4 (Dox and vitamin D3), Group 5 (Dox, probiotics, and vitamin D3), and Group 6 (probiotics and vitamin D3). The 4T1 mouse carcinoma cell line was injected into the mammary fat pad of each mouse. Gene expression was examined using quantitative real-time PCR. The treated groups (except group 6) showed significantly reduced tumor volume and weight compared to the control group (P < 0.05, P < 0.01). Probiotics/vitamin D3 with Dox reduced chemotherapy toxicity and a combination of supplements had a significant protective effect against Dox (P < 0.05, 0.01, 0.001). The treated groups (except 6) had significantly higher expression of Bax/Caspase 3 genes and lower expression of Bcl-2 genes than the control group (P < 0.05, 0.01). Coadministration of Dox with probiotics and vitamin D3 showed promising results in reducing tumor size, protecting intestinal tissue and influencing gene expression, suggesting a strategy to enhance the effectiveness of breast cancer treatment while reducing side effects.
    MeSH term(s) Female ; Animals ; Mice ; Lactobacillus acidophilus ; Lacticaseibacillus casei ; Doxorubicin/pharmacology ; Probiotics/pharmacology ; Disease Models, Animal ; Cholecalciferol/pharmacology ; Mice, Inbred BALB C ; Neoplasms
    Chemical Substances Doxorubicin (80168379AG) ; Cholecalciferol (1C6V77QF41)
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-024-02346-0
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  9. Article ; Online: Frontline nurses experiences about human caring during pandemic of COVID-19: A directed content analysis study.

    Taheri-Ezbarami, Zahra / Ghanbari, Atefeh / Panahi, Latif / Pouy, Somaye

    Nursing open

    2023  Volume 10, Issue 8, Page(s) 5089–5097

    Abstract: Aim: This study aims to investigate experiences of frontline nurses about human caring during COVID-19 pandemic based on the Ten Caritas Processes® of Watson's Human Caring Theory.: Design: A directed content analysis was performed.: Methods: A ... ...

    Abstract Aim: This study aims to investigate experiences of frontline nurses about human caring during COVID-19 pandemic based on the Ten Caritas Processes® of Watson's Human Caring Theory.
    Design: A directed content analysis was performed.
    Methods: A total of 15 frontline nurses were recruited by purposive sampling from Razi hospital (north of Iran), in 2020 and semi-structured interviews were conducted.
    Results: Extracted categories based on Ten Caritas Processes® included feeling satisfied in providing care to patients, effective presence with patients, moving towards self-actualization (moving towards transcendence), care with trust and compassion, experience positive and negative emotions, creativity in providing care, self-directing learning experience in the field of care, unfavourable environment for providing care, feeling acceptance and worth, uncertainty (facing the unknown). This study showed that communication skills, self-sensitivity, patient dignity, teaching-learning and problem-solving skills, holistic attention to the patient, and the provision of a healing environment are necessary for patient care.
    MeSH term(s) Humans ; Nursing Theory ; Pandemics ; Nurse-Patient Relations ; COVID-19 ; Nurses
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2809556-X
    ISSN 2054-1058 ; 2054-1058
    ISSN (online) 2054-1058
    ISSN 2054-1058
    DOI 10.1002/nop2.1744
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  10. Article: Regulatory Effect of

    Cakir, Muharrem Okan / Bilge, Ugur / Ghanbari, Arshia / Ashrafi, G Hossein

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 12

    Abstract: Cervical cancer presents a significant global health concern with high-risk human papillomaviruses (HPVs) identified as the main cause of this cancer. Although current treatment methods for cervical cancer can eliminate lesions, preventing metastatic ... ...

    Abstract Cervical cancer presents a significant global health concern with high-risk human papillomaviruses (HPVs) identified as the main cause of this cancer. Although current treatment methods for cervical cancer can eliminate lesions, preventing metastatic spread and minimizing tissue damage remain a major challenge. Therefore, the development of a safer and innovative therapeutic approach is of the utmost importance. Natural products like fig latex, derived from the
    Language English
    Publishing date 2023-12-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16121723
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