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Article: Role of Calcitonin and Strontium Ranelate in Osteoporosis.

Ghani, Abdul / Arfee, Sakib

2023 Volume 57, Issue Suppl 1, Page(s) 115–119

Abstract: Background: Both Strontium Ranelate (SR) and Calcitonin (CT) can be used to treat osteoporosis. Calcitonin was actually one of the very initial medicines used to treat osteoporosis, especially in postmenopausal cases. However, the fracture prevention ... ...

Abstract	Background: Both Strontium Ranelate (SR) and Calcitonin (CT) can be used to treat osteoporosis. Calcitonin was actually one of the very initial medicines used to treat osteoporosis, especially in postmenopausal cases. However, the fracture prevention effect of Calcitonin is only proven to be in vertebrae and that too with nasal route only. When comparing Calcitonin with other conventional medications in treating osteoporosis, Calcitonin has got no additional advantages. Strontium Ranelate has got double effect, i.e., less bone resorption and more bone formation. Therefore, it can lead to an increase in bone mass significantly. Strontium Ranelate has been proven to decrease the risk of non-vertebral fractures as well as vertebral fractures. Conclusion: Both Calcitonin and Strontium Ranelate are used only as a second-line therapy for the treatment of osteoporosis and not as first-line therapy, mainly because of their safety concern and also because they do not provide any advantages compared to other therapy for the treatment of osteoporosis.
Language	English
Publishing date	2023-12-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	603194-8
ISSN	0019-5413
ISSN	0019-5413
DOI	10.1007/s43465-023-01034-x
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Article ; Online: Tansley Review No. 110.: Numerical and physical properties of orchid seeds and their biological implications.

Arditti, Joseph / Ghani, Abdul Karim Abdul

The New phytologist

2021 Volume 145, Issue 3, Page(s) 367–421

Abstract: Orchid seeds are very small, extremely light and produced in great numbers. Most range in length from c. 0.05 to 6.0 mm, with the difference between the longest and shortest known seeds in the family being 120-fold. The 'widest' seed at 0.9 mm is 90-fold ...

Abstract	Orchid seeds are very small, extremely light and produced in great numbers. Most range in length from c. 0.05 to 6.0 mm, with the difference between the longest and shortest known seeds in the family being 120-fold. The 'widest' seed at 0.9 mm is 90-fold wider than the 'thinnest' one, which measures 0.01 mm (because orchid seeds are tubular or balloon-like, 'wide' and 'thin' actually refer to diameter). Known seed weights extend from 0.31 lg to 24 μg (a 78-fold difference). Recorded numbers of seeds per fruit are as high as 4000000 and as low as 20-50 (80000-200000-fold difference). Testae are usually transparent, with outer cell walls that may be smooth or reticulated. Ultrasonic treatments enhance germination, which suggests that the testae can be restrictive. Embryos are even smaller: their volume is substantially smaller than that of the testa. As a result, orchid seeds have large internal air spaces that render them balloon-like. They can float in the air for long periods, a property that facilitates long-distance dispersal. The difficult-to-wet outer surfaces of the testa and large internal air spaces enable the seeds to float on water for prolonged periods. This facilitates distribution through tree effluates and/or small run-off rivulets that may follow rains. Due to their size and characteristics, orchid seeds may also be transported in and on land animals and birds (in fur, feathers or hair, mud on feet, and perhaps also following ingestion). contents Summary 367 I. Introduction 367 II. Number 368 III. Size 379 IV. Air space in the seeds 381 V. Floatation and dispersal 383 VI. Conclusions 417 Acknowledgements 417 References 418.
Language	English
Publishing date	2021-03-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1046/j.1469-8137.2000.00587.x
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Article ; Online: Time to Reconsider the Inhaled Drugs for<br /> Tuberculosis.

Kumari, Usha / Ghani, Abdul / Abbas, Fakhar

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2022 Volume 32, Issue 6, Page(s) 831–832

Abstract: Null. ...

Abstract	Null.
MeSH term(s)	Administration, Inhalation ; Humans ; Tuberculosis/drug therapy
Language	English
Publishing date	2022-01-04
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2022.06.831
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Article: School Health Education Program in Pakistan (SHEPP): findings from a feasibility trial in pre-adolescent school children from a lower middle-income country.

Almas, Aysha / Iqbal, Romaina / Ghani, Abdul / Samad, Zainab / Sabir, Sania / Kazmi, Khawar

Pilot and feasibility studies

2023 Volume 9, Issue 1, Page(s) 123

Abstract: Background: The school environment plays an essential role in promoting health education and physical activity for children and adolescents. We aim to assess the feasibility of threefold health education program in children and its potential efficacy on ...

Abstract	Background: The school environment plays an essential role in promoting health education and physical activity for children and adolescents. We aim to assess the feasibility of threefold health education program in children and its potential efficacy on physical activity and diet and cardiometabolic risk factors including blood pressure, body mass index (BMI), and waist circumference. Methods: The SHEPP was a parallel group feasibility intervention trial conducted in two schools over 23 months. All children aged 9-11 years enrolled in the schools were included. The SHEPP intervention comprised of health education on healthy lifestyle and physical activity sessions for children, training of teachers, and awareness sessions for parents conducted over 10 months. One school received the intervention of SHEPP while the other school continued routine activity. The primary outcome was the feasibility of SHEPP in terms of recruitment, retention, and treatment fidelity. Secondary outcomes were physical activity levels, dietary intake (of fruits and vegetables), and cardiometabolic risk factors (blood pressure, BMI, and waist circumference (WC)). Results: A total of 1280 preadolescent children were assessed for eligibility and 1191 were found eligible. The overall recruitment n (%) was 982/1191(82.5%) with 505(51.4) from SHEPP intervention school and 477(48.6) in routine activity school. The overall retention rate n (%) at 10-month follow-up was 912/982(92.8), with 465/505(92) in SHEPP intervention school and 447/477(93.7) in routine activity school. In treatment fidelity, 132/144(92) %). Physical activity sessions and all (100%) health education sessions were conducted for each of the twelve classes. Mean (SD) Seven-day Physical activity increased by 134 (196) min in the SHEPP intervention school v 29.8(177) in the routine activity school (P value < 0.001) from baseline to follow-up. Overall, there was an increase in vegetable intake (> 3 serving /day) in SHEPP intervention school of 5.5 to 21.4% from baseline to follow-up compared to 7.5 to 14.9% in routine activity school. The mean change (SD) in systolic blood pressure was 1.3(12) mmHg, 2.2(19.0) mm Hg in in diastolic blood pressure, - 0.09(5.4) kg/m Conclusion: We found that intervention using SHEPP is feasible in schools and may help children to adopt a healthy lifestyle as they age by increasing physical activity. However, the potentially beneficial effect on diet, MI, and BP needs further exploration and a longer follow-up, more specifically at the juncture of teenage and adulthood. Trial registration: NCT03303287.
Language	English
Publishing date	2023-07-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2809935-7
ISSN	2055-5784
ISSN	2055-5784
DOI	10.1186/s40814-023-01344-9
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Article: Subthalamic Nucleus (STN)-Deep Brain Stimulation Reduces the Power of Mu and Beta Rhythms and Enhances Synchrony at the Motor Cortices in Parkinson's Disease: A Report of Two Cases.

Zakaria, Zaitun / Idris, Zamzuri / Abdul Halim, Sanihah / Ghani, Abdul Rahman Izaini / Abdullah, Jafri M

Cureus

2023 Volume 15, Issue 2, Page(s) e35057

Abstract: The motor circuit in Parkinson's disease (PD) involves the basal ganglia, thalamus, motor cortex, and cerebellum. Hence, subthalamic nucleus (STN) or globus pallidus internus deep brain stimulation is commonly used in treating refractory Parkinson's ... ...

Abstract	The motor circuit in Parkinson's disease (PD) involves the basal ganglia, thalamus, motor cortex, and cerebellum. Hence, subthalamic nucleus (STN) or globus pallidus internus deep brain stimulation is commonly used in treating refractory Parkinson's patients. During the procedure, the local field potential (LPF) is commonly made along the trajectory of the STN. Two cases were assessed, where an electroencephalographic recording at the sensorimotor cortices was also performed with and without stimulation at the optimal STN electrode site. The 'on' stimulation state associated with clinical improvement correlated with a marked reduction in the late theta (7.5 Hz), alpha (10.5 Hz) (Mu wave), and beta (20 Hz) wave power. Besides, more synchronized and coherent brainwaves were noted when the stimulation was 'on'.
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.35057
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Article: Dorsal Column Bedside Examination Test: Tips for the Neurosurgical Resident.

Khoo, Yee Hwa / Abdullah, Jafri Malin / Idris, Zamzuri / Ghani, Abdul Rahman Izaini / Halim, Sanihah Abdul

The Malaysian journal of medical sciences : MJMS

2023 Volume 30, Issue 2, Page(s) 172–179

Abstract: The dorsal column medial lemniscus (DCML) system is a sensory pathway of the central nervous system; it carries sensations of soft touch, vibration, proprioception, two-point discrimination, and pressure from the skin and joints. The clinical signs of ... ...

Abstract	The dorsal column medial lemniscus (DCML) system is a sensory pathway of the central nervous system; it carries sensations of soft touch, vibration, proprioception, two-point discrimination, and pressure from the skin and joints. The clinical signs of the DCML pathway lesions include loss of soft touch, vibratory sense, proprioception, discrimination sense, and a positive Rhomberg test. Diseases that affect this pathway are usually degenerative, for example, spinal cord degeneration due to vitamin B12 deficiency; it can also be affected by trauma or infarction of the posterior spinal artery causing posterior cord syndrome. This video manuscript provides a step-by-step examination technique of the dorsal column examination, specially catered for Malaysian medical students and trainees. A series of videos show the techniques for soft touch sensation examination, examination of the vibratory sense, examination of the joint position sense, examination of two-point discrimination and the Rhomberg test. We hope that students can adhere to these techniques and apply them in their daily neurological assessments.
Language	English
Publishing date	2023-04-18
Publishing country	Malaysia
Document type	Journal Article
ZDB-ID	2197205-9
ISSN	2180-4303 ; 1394-195X
ISSN (online)	2180-4303
ISSN	1394-195X
DOI	10.21315/mjms2023.30.2.16
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Article ; Online: Cerebral venous sinus thrombosis 2 weeks after the first dose of mRNA SARS-CoV-2 vaccine.

Zakaria, Zaitun / Sapiai, Nur Asma / Ghani, Abdul Rahman Izaini

Acta neurochirurgica

2021 Volume 163, Issue 8, Page(s) 2359–2362

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19) is a highly transmissible virus and has become pandemic. Part of the prevention of disease spread by the Malaysian government is by ... ...

Abstract	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19) is a highly transmissible virus and has become pandemic. Part of the prevention of disease spread by the Malaysian government is by getting COVID-19 vaccine. Using the mRNA technology, the Pfizer/BioNTech vaccine is one of the vaccines been approved by the Drug Control Authority in Malaysia. Herein, we report an immediate complication of cerebral VST after the first dose of the Pfizer/BioNTech vaccine.
MeSH term(s)	COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Humans ; Male ; Middle Aged ; Sinus Thrombosis, Intracranial/chemically induced ; Sinus Thrombosis, Intracranial/diagnostic imaging ; Time Factors ; Vaccines, Synthetic/adverse effects ; mRNA Vaccines
Chemical Substances	COVID-19 Vaccines ; Vaccines, Synthetic
Language	English
Publishing date	2021-06-08
Publishing country	Austria
Document type	Case Reports ; Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-021-04860-w
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Article: An Approach to the Examination of the Lumbar Plexus for Neurosurgical Residents: A Video Manuscript.

Hamzah, Nurul Ashikin / Lee, Wei Lun / Fathil, Mohd Fakhri Md / Abdullah, Jafri Malin / Idris, Zamzuri / Ghani, Abdul Rahman Izaini / Halim, Sanihah Abdul

The Malaysian journal of medical sciences : MJMS

2024 Volume 31, Issue 1, Page(s) 235–242

Abstract: The lumbar plexus provides innervation to the lower limbs and is essential in enabling motor movement and sensation in the lower limbs. Some of its branches also innervate the muscles in the pelvic girdle. Compared to the brachial plexus in the upper ... ...

Abstract	The lumbar plexus provides innervation to the lower limbs and is essential in enabling motor movement and sensation in the lower limbs. Some of its branches also innervate the muscles in the pelvic girdle. Compared to the brachial plexus in the upper limbs, the lumbar plexus appears to garner less recognition among physicians and surgeons. However, it is important to understand the anatomy of the lumbar plexus and its branches along with the innervation they enable, as injury to them can cause plexopathies and pathologies that should be recognised by any treating clinician. Lumbar disc herniation, trauma and entrapment by muscles or hypertrophic ligaments are common causes of lumbar plexus or nerve injuries. A video was produced to demonstrate the examination techniques explained in this article. To provide comprehensive examination of the lower limbs, the sciatic nerve and its branches are also included in the examination video.
Language	English
Publishing date	2024-02-28
Publishing country	Malaysia
Document type	Journal Article
ZDB-ID	2197205-9
ISSN	2180-4303 ; 1394-195X
ISSN (online)	2180-4303
ISSN	1394-195X
DOI	10.21315/mjms2024.31.1.19
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Article: Analysis on Short-Term Outcomes for Cerebral Protection Treatment in Post Severe Traumatic Brain Injury Patients: A Single Neurosurgical Centre Study.

Mustafa, Ahmad Fikri Muhammad / Ab Mukmin, Laila / Mazlan, Mohd Zulfakar / Ghani, Abdul Rahman Izaini / Wan Hassan, Wan Mohd Nazaruddin / Hassan, Mohamad Hasyizan

The Malaysian journal of medical sciences : MJMS

2024 Volume 31, Issue 2, Page(s) 142–152

Abstract: Background: Severe traumatic brain injury (TBI) is a leading cause of disability worldwide and cerebral protection (CP) management might determine the outcome of the patient. CP in severe TBI is to protect the brain from further insults, optimise ... ...

Abstract	Background: Severe traumatic brain injury (TBI) is a leading cause of disability worldwide and cerebral protection (CP) management might determine the outcome of the patient. CP in severe TBI is to protect the brain from further insults, optimise cerebral metabolism and prevent secondary brain injury. This study aimed to analyse the short-term Glasgow Outcome Scale (GOS) at the intensive care unit (ICU) discharge and a month after ICU discharge of patients post CP and factors associated with the favourable outcome. Methods: This is a prospective cohort study from January 2021 to January 2022. The short-term outcomes of patients were evaluated upon ICU discharge and 1 month after ICU discharge using GOS. Favourable outcome was defined as GOS 4 and 5. Generalised Estimation Equation (GEE) was adopted to conduct bivariate GEE and subsequently multivariate GEE to evaluate the factors associated with favourable outcome at ICU discharge and 1 month after discharge. Results: A total of 92 patients with severe TBI with GOS of 8 and below admitted to ICU received CP management. Proportion of death is 17% at ICU discharge and 0% after 1 month of ICU discharge. Proportion of favourable outcome is 26.1% at ICU discharge and 61.1% after 1 month of ICU discharge. Among factors evaluated, age (odds ratio [OR] = 0.96; 95% CI: 0.94, 0.99; Conclusion: CP in younger age, longer duration of CP and patient not receiving hyperosmolar therapy are associated with favourable outcomes. We recommend further clinical trial to assess long term outcome of CP.
Language	English
Publishing date	2024-04-23
Publishing country	Malaysia
Document type	Journal Article
ZDB-ID	2197205-9
ISSN	2180-4303 ; 1394-195X
ISSN (online)	2180-4303
ISSN	1394-195X
DOI	10.21315/mjms2024.31.2.12
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Article: Review of CHESS Score in SAH Patients in Local Malaysian Population.

Yee, Sze-Voon / Ghani, Abdul Rahman / Raffiq, Azman

Journal of neurosciences in rural practice

2020 Volume 11, Issue 1, Page(s) 113–118

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2020-03-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2601242-X
ISSN	0976-3155 ; 0976-3147
ISSN (online)	0976-3155
ISSN	0976-3147
DOI	10.1055/s-0039-3402573
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