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  1. Article: Mortality Predictors for Adult Patients with Mild-to-Moderate Traumatic Brain Injury: A Literature Review.

    Eghzawi, Ansam / Alsabbah, Alameen / Gharaibeh, Shatha / Alwan, Iktimal / Gharaibeh, Abeer / Goyal, Anita V

    Neurology international

    2024  Volume 16, Issue 2, Page(s) 406–418

    Abstract: Traumatic brain injuries (TBIs) represent a significant public health concern, with mild-to-moderate cases comprising a substantial portion of incidents. Understanding the predictors of mortality among adult patients with mild-to-moderate TBIs is crucial ...

    Abstract Traumatic brain injuries (TBIs) represent a significant public health concern, with mild-to-moderate cases comprising a substantial portion of incidents. Understanding the predictors of mortality among adult patients with mild-to-moderate TBIs is crucial for optimizing clinical management and improving outcomes. This literature review examines the existing research to identify and analyze the mortality predictors in this patient population. Through a comprehensive review of peer-reviewed articles and clinical studies, key prognostic factors, such as age, Glasgow Coma Scale (GCS) score, the presence of intracranial hemorrhage, pupillary reactivity, and coexisting medical conditions, are explored. Additionally, this review investigates the role of advanced imaging modalities, biomarkers, and scoring systems in predicting mortality following a mild-to-moderate TBI. By synthesizing the findings from diverse studies, this review aims to provide clinicians and researchers with valuable insights into the factors influencing mortality outcomes in adult patients with a mild-to-moderate TBI, thus facilitating more informed decision making and targeted interventions in clinical practice.
    Language English
    Publishing date 2024-04-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2514727-4
    ISSN 2035-8377 ; 2035-8385
    ISSN (online) 2035-8377
    ISSN 2035-8385
    DOI 10.3390/neurolint16020030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Reducing Spread of Infections with a Photocatalytic Reactor-Potential Applications in Control of Hospital

    Gharaibeh, Abeer / Smith, Richard H / Conway, Michael J

    Infectious disease reports

    2021  Volume 13, Issue 1, Page(s) 58–71

    Abstract: Contaminated surfaces and indoor environments are important sources of infectious spread within hospital and non-hospital facilities. Bacterial infections such as infections ... ...

    Abstract Contaminated surfaces and indoor environments are important sources of infectious spread within hospital and non-hospital facilities. Bacterial infections such as infections with
    Language English
    Publishing date 2021-01-11
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr13010008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comment on "Vascular Endothelial Growth Factor (VEGF) as a Vital Target for Brain Inflammation during the COVID-19 Outbreak".

    Rabab'h, Omar / Al-Ramadan, Ali / Gharaibeh, Abeer

    ACS chemical neuroscience

    2021  Volume 12, Issue 14, Page(s) 2712–2713

    MeSH term(s) COVID-19 ; Disease Outbreaks ; Encephalitis ; Humans ; SARS-CoV-2 ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors
    Chemical Substances Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors
    Language English
    Publishing date 2021-07-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.1c00359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A Novel Electromagnetic-Neurobiologic Interface for Functional Animation of Dormant Motor Nerve Roots in Spinal Cord Injury via Neuromodulation.

    Shah, Jawad / Smith, Richard H / Al-Gharaibeh, Abeer

    Frontiers in surgery

    2020  Volume 6, Page(s) 73

    Abstract: Complete spinal cord injury is a devastating occurrence afflicting millions of people worldwide with no available treatment for functional motor recovery. In this report, we describe a procedure in which we used parts of a device available for chronic ... ...

    Abstract Complete spinal cord injury is a devastating occurrence afflicting millions of people worldwide with no available treatment for functional motor recovery. In this report, we describe a procedure in which we used parts of a device available for chronic pain treatment to provide a neuromodulation of motor nerve roots in a case with complete motor and sensory paraplegia. By using a retrograde trans-foraminal approach to implant electrodes close to L2-S1 motor nerve roots bilaterally, we were able to stimulate those nerves and induce precise movements at the joints of lower extremity in a T5 complete spinal cord injury case. We believe that our approach shows potential of the device as a rehabilitation system with the possibility of a parallel electric circuitry that can bridge a damaged spinal cord.
    Language English
    Publishing date 2020-01-10
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2019.00073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Acute and Post-Acute Neurological Complications of COVID-19.

    Al-Ramadan, Ali / Rabab'h, Omar / Shah, Jawad / Gharaibeh, Abeer

    Neurology international

    2021  Volume 13, Issue 1, Page(s) 102–119

    Abstract: Coronavirus disease 2019 (COVID-19) is an emerging global health emergency caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The global outbreak of SARS-CoV-2 infection has been declared a global pandemic by ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is an emerging global health emergency caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The global outbreak of SARS-CoV-2 infection has been declared a global pandemic by the World Health Organization (WHO). The clinical presentation of SARS-CoV-2 infection depends on the severity of the disease and may range from an asymptomatic infection to a severe and lethal illness. Fever, cough, and shortness of breath are among the most common symptoms associated with SARS-CoV-2 infection. Accumulating evidence indicates that COVID-19 patients commonly develop neurological symptoms, such as headache, altered mental status, anosmia, and myalgia. In this comprehensive literature review, we have summarized the most common neurological complications and reported neurological case studies associated with COVID-19, and neurological side effects associated with COVID-19 treatments. Additionally, the post-acute COVID-19 syndrome and long-term neurological complications were discussed. We also explained the proposed mechanisms that are involved in the pathogenesis of these neurological complications.
    Language English
    Publishing date 2021-03-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2514727-4
    ISSN 2035-8377 ; 2035-8385
    ISSN (online) 2035-8377
    ISSN 2035-8385
    DOI 10.3390/neurolint13010010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Pharmacological Approaches in Neurofibromatosis Type 1-Associated Nervous System Tumors.

    Rabab'h, Omar / Gharaibeh, Abeer / Al-Ramadan, Ali / Ismail, Manar / Shah, Jawad

    Cancers

    2021  Volume 13, Issue 15

    Abstract: Neurofibromatosis type 1 is an autosomal dominant genetic disease and a common tumor predisposition syndrome that affects 1 in 3000 to 4000 patients in the USA. Although studies have been conducted to better understand and manage this disease, the ... ...

    Abstract Neurofibromatosis type 1 is an autosomal dominant genetic disease and a common tumor predisposition syndrome that affects 1 in 3000 to 4000 patients in the USA. Although studies have been conducted to better understand and manage this disease, the underlying pathogenesis of neurofibromatosis type 1 has not been completely elucidated, and this disease is still associated with significant morbidity and mortality. Treatment options are limited to surgery with chemotherapy for tumors in cases of malignant transformation. In this review, we summarize the advances in the development of targeted pharmacological interventions for neurofibromatosis type 1 and related conditions.
    Language English
    Publishing date 2021-08-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13153880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Twenty Years After Glioblastoma Multiforme Diagnosis: A Case of Long-Term Survival.

    Rabab'h, Omar / Al-Ramadan, Ali / Shah, Jawad / Lopez-Negrete, Hugo / Gharaibeh, Abeer

    Cureus

    2021  Volume 13, Issue 6, Page(s) e16061

    Abstract: Glioblastoma multiforme (GBM) is an aggressive tumor that has a poor prognosis with a median survival of 15 months with treatment and 3-4 months without treatment. Subsets of patients are found to survive longer than two years, some survivors lived more ... ...

    Abstract Glioblastoma multiforme (GBM) is an aggressive tumor that has a poor prognosis with a median survival of 15 months with treatment and 3-4 months without treatment. Subsets of patients are found to survive longer than two years, some survivors lived more than 10 years, and rare cases survived 20 years or more with treatment. Better prognosis has been found to be associated with many factors. Some of these factors are related to patients' characteristics, biological factors that impact tumor aggressiveness, and/or factors associated with treatment. However, the exact contribution for extended survival is still not known. Finding the factors that have a strong impact on the long survival is of high importance and can help give hope to better treat glioblastoma cases. In this report, we present a case of a glioblastoma patient who was diagnosed at the age of 47 years with more than 20-year survival. We further discuss the suggested factors that may have contributed to a better prognosis with a focus on the possible role of varicella-zoster infection in mediating long-term survival.
    Language English
    Publishing date 2021-06-30
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.16061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Housing R6/2 Mice with Wild-Type Littermates Increases Lifespan.

    Story, Darren / Gallien, John / Al-Gharaibeh, Abeer / Sandstrom, Michael / Rossignol, Julien / Dunbar, Gary L

    Journal of Huntington's disease

    2021  Volume 10, Issue 4, Page(s) 455–458

    Abstract: The R6/2 murine model of Huntington's disease (HD) is extensively used in HD research. The current study replicates and extends previous work assessing the impact of housing R6/2 mice with healthy wild-type (WT) littermates on disease progression. The ... ...

    Abstract The R6/2 murine model of Huntington's disease (HD) is extensively used in HD research. The current study replicates and extends previous work assessing the impact of housing R6/2 mice with healthy wild-type (WT) littermates on disease progression. The current study extends the previous finding by including male cohorts and the use of a standard diet and water regimen, as opposed to the enhanced diet used in the previous study. This study found that the inclusion of healthy wild-type (WT) littermates, alone, improved survivabilty in R6/2 mice, but did not have a significant impact on weight loss.
    MeSH term(s) Animals ; Disease Models, Animal ; Housing ; Huntington Disease/genetics ; Longevity/genetics ; Male ; Mice ; Mice, Transgenic
    Language English
    Publishing date 2021-09-12
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2673033-9
    ISSN 1879-6400 ; 1879-6397
    ISSN (online) 1879-6400
    ISSN 1879-6397
    DOI 10.3233/JHD-210474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Management of Phantom Limb Pain through Thalamotomy of the Centro-Median Nucleus.

    Pérez de la Torre, Ramiro A / Rodríguez Hernández, Job J / Al-Ramadan, Ali / Gharaibeh, Abeer

    Neurology international

    2021  Volume 13, Issue 4, Page(s) 587–593

    Abstract: Background: Phantom limb syndrome is defined as the perception of intense pain or other sensations that are secondary to a neural lesion in a limb that does not exist. It can be treated using pharmacological and surgical interventions. Most medications ... ...

    Abstract Background: Phantom limb syndrome is defined as the perception of intense pain or other sensations that are secondary to a neural lesion in a limb that does not exist. It can be treated using pharmacological and surgical interventions. Most medications are prescribed to improve patients' lives; however, the response rate is low. In this case report, we present a case of phantom limb syndrome in a 42-year-old female with a history of transradial amputation of the left thoracic limb due to an accidental compression one year before. The patient underwent placement of a deep brain stimulator at the ventral posteromedial nucleus (VPM) on the right side and removal secondary to loss of battery. The patient continued to have a burning pain throughout the limb with a sensation of still having the limb, which was subsequently diagnosed as phantom limb syndrome. After a thorough discussion with the patient, a right stereotactic centro-median thalamotomy was offered. An immediate response was reported with a reduction in pain severity on the visual analogue scale (VAS) from a value of 9-10 preoperative to a value of 2 postoperative, with no postoperative complications. Although phantom limb pain is one of the most difficult to treat conditions, centro-median thalamotomy may provide an effective stereotactic treatment procedure with adequate outcomes.
    Language English
    Publishing date 2021-11-10
    Publishing country Italy
    Document type Case Reports
    ZDB-ID 2514727-4
    ISSN 2035-8377 ; 2035-8385
    ISSN (online) 2035-8377
    ISSN 2035-8385
    DOI 10.3390/neurolint13040058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer's Disease.

    Paladugu, Leela / Gharaibeh, Abeer / Kolli, Nivya / Learman, Cameron / Hall, Tia C / Li, Lixin / Rossignol, Julien / Maiti, Panchanan / Dunbar, Gary L

    International journal of molecular sciences

    2021  Volume 22, Issue 2

    Abstract: Recent clinical and epidemiological studies support the contention that diabetes mellitus (DM) is a strong risk factor for the development of Alzheimer's disease (AD). The use of insulin cell toxin, streptozotocin (STZ), when injected into the lateral ... ...

    Abstract Recent clinical and epidemiological studies support the contention that diabetes mellitus (DM) is a strong risk factor for the development of Alzheimer's disease (AD). The use of insulin cell toxin, streptozotocin (STZ), when injected into the lateral ventricles, develops an insulin resistant brain state (IRBS) and represents a non-transgenic, or sporadic AD model (SAD), with several AD-like neuropathological features. The present study explored the effects of an anti-diabetic drug, liraglutide (LIR), in reversing major pathological hallmarks in the prodromal disease stage of both the 5xFAD transgenic and SAD mouse models of AD. Three-month-old 5xFAD and age-matched wild type mice were given a single intracerebroventricular (i.c.v) injection of STZ or vehicle (saline) and were subsequently treated with LIR, intraperitoneally (IP), once a day for 30 days. The extent of neurodegeneration, Aβ plaque load, and key proteins associated with the insulin signaling pathways were measured using Western blot and neuroinflammation (via immunohistological assays) in the cortical and hippocampal regions of the brain were assessed following a series of behavioral tests used to measure cognitive function after LIR or vehicle treatments. Our results indicated that STZ significantly increased neuroinflammation, Aβ plaque deposition and disrupted insulin signaling pathway, while 25 nmol/kg LIR, when injected IP, significantly decreased neuroinflammatory responses in both SAD and 5xFAD mice before significant cognitive changes were observed, suggesting LIR can reduce early neuropathology markers prior to the emergence of overt memory deficits. Our results indicate that LIR has neuroprotective effects and has the potential to serve as an anti-inflammatory and anti-amyloid prophylactic therapy in the prodromal stages of AD.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/etiology ; Alzheimer Disease/genetics ; Amyloid beta-Peptides/drug effects ; Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Liraglutide/administration & dosage ; Liraglutide/pharmacology ; Liraglutide/therapeutic use ; Mice ; Neuroprotective Agents/administration & dosage ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Presenilins/genetics ; Streptozocin/toxicity
    Chemical Substances Amyloid beta-Peptides ; Anti-Inflammatory Agents ; Neuroprotective Agents ; Presenilins ; Streptozocin (5W494URQ81) ; Liraglutide (839I73S42A)
    Language English
    Publishing date 2021-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22020860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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