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  1. Book: Surgical Strategies in Endourology for Stone Disease

    Goonewardene, Sanchia S. / Ventii, Karen / Albala, David M. / Leveillee, Raymond J. / Gharib, Ali

    2021  

    Author's details Sanchia Goonewardene qualified from Birmingham Medical School with Honours in Clinical Science and a BMedSc Degree in Medical Genetics and Molecular Medicine. She has served on the EAU Guidelines Panel on Chronic Pelvic Pain. She has been an MSc Thesis examiner for the University of Edinburgh/ Royal College of Surgeons of Edinburgh ESSQ course. She is an Associate Editor for the Journal of Robotic Surgery and is on the review board of BMJ case reports. Additionally, she is on the working group of The International Continence Society Terminology Panel on Pelvic Floor Dysfunction and Male LUTS and the Good Urodynamic Practice Panel. She has published 6 books and is Series Editor for Management of Urology, Springer Nature. Her first book published, 'Core Surgical Procedures for Urology Trainees Editor) has since ranked Number 3 in Book Authority's 100 Best Urology Books of all Time
    Keywords Imagining In Endourology ; Complications with Lithoclast ; Complex Cases In Endourology ; PCNL Tract ; Stone Disease Management ; Rigid Ureteroscopy ; Therapeutics for Endourology ; Types of Dialysis ; Retrograde Studies ; Surgical Strategies
    Language English
    Size 308 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_13
    Format 160 x 241 x 22
    ISBN 9783030821425 ; 3030821420
    Database PDA

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  2. Article ; Online: Inducing Cytotoxicity in Colon Cancer Cells and Suppressing Cancer Stem Cells by Dolasetron and Ketoprofen through Inhibition of RNA Binding Protein PUM1.

    Gor, Ravi / Gharib, Ali / Dharshini Balaji, Priya / Madhavan, Thirumurthy / Ramalingam, Satish

    Toxics

    2023  Volume 11, Issue 8

    Abstract: Clinical trials of new drugs often face a high failure rate of approximately 45 percent due to safety and toxicity concerns. Repurposing drugs with well-established safety profiles becomes crucial in addressing this challenge. Colon cancer ranks as the ... ...

    Abstract Clinical trials of new drugs often face a high failure rate of approximately 45 percent due to safety and toxicity concerns. Repurposing drugs with well-established safety profiles becomes crucial in addressing this challenge. Colon cancer ranks as the third most prevalent cancer and the second leading cause of cancer related mortality worldwide. This study focuses on the RNA-binding protein pumilio1 (PUM1), a member of the PUF family involved in post-transcriptional gene expression regulation. By utilizing molecular docking techniques and FDA-approved drugs, potential inhibitors against PUM1 were identified. Notably, dolasetron and ketoprofen demonstrated promising results, exhibiting strong binding affinity, hydrophobic interactions, and favorable chemical reactivity according to Conceptual-DFT calculations. Both compounds effectively reduced cell viability, with IC50 values of 150 µM and 175 µM, respectively and shows long term inhibitory effects as seen by reduced in number of colonies. Moreover, they exhibited inhibitory effects on colon cancer stem cells, as indicated by reduced colonospheroid size and numbers. Apoptosis is induced by these compounds and has triggered activation of executioner caspase 3/7 in HCT116 cells which is evident through a caspase 3/7 assay and AO/EB staining, while the non-toxic effect of these compounds was evident from viability against non-cancerous cell line and hemolysis assay. Additionally, the treatment group showed a significant decrease in PUM1 and cancer stem cell markers expression compared to the control group. In conclusion, this study highlights the potential of targeting PUM1 as a novel approach to colon cancer treatment. Dolasetron and ketoprofen demonstrate promise as effective anti-cancer and anti-cancer stem cell drugs, inducing apoptosis in colon cancer cells through inhibition of PUM1.
    Language English
    Publishing date 2023-08-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11080669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Risk analysis of gas leakage in gas pressure reduction station and its consequences: A case study for Zahedan.

    Dadkani, Peiman / Noorzai, Esmatullah / Ghanbari, AmirHossein / Gharib, Ali

    Heliyon

    2021  Volume 7, Issue 5, Page(s) e06911

    Abstract: Industrial accidents have increased the importance of dealing with the risks of toxic exposure, fire and explosion. Despite the measures taken in the chemical industry to prevent accidents, the accidents occur often due to human error or process faults ... ...

    Abstract Industrial accidents have increased the importance of dealing with the risks of toxic exposure, fire and explosion. Despite the measures taken in the chemical industry to prevent accidents, the accidents occur often due to human error or process faults during repairs. Although several studies have been conducted on the accidents in the process industry, no research has modeled the risks caused by the leakage of toxic substances in the gas pressure reduction station. The consequences of gas leak and fire in Zahedan's gas pressure reduction station were investigated in Iran. This research aims to determine the safe range of the station and observe the safety measures required for the gas pressure reduction station in Zahedan. For modelling gas leak and fire, the ALOHA software was used to display the threat zone. In this research, with respect to the environmental data, the desired scenario was modeled. The results, based on two scenarios of gas leak and fire in both hot and cold seasons, indicate that the gas leak scenario in hot seasons and the fire scenario in cold seasons influence a larger region.
    Language English
    Publishing date 2021-05-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2021.e06911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Multi-Objective Optimization of a Path-following MPC for Vehicle Guidance

    Gharib, Ali / Stenger, David / Ritschel, Robert / Voßwinkel, Rick

    A Bayesian Optimization Approach

    2021  

    Abstract: This paper tackles the multi-objective optimization of the cost functional of a path-following model predictive control for vehicle longitudinal and lateral control. While the inherent optimal character of the model predictive control and the direct ... ...

    Abstract This paper tackles the multi-objective optimization of the cost functional of a path-following model predictive control for vehicle longitudinal and lateral control. While the inherent optimal character of the model predictive control and the direct consideration of constraints gives a very powerful tool for many applications, is the determination of an appropriate cost functional a non-trivial task. This results on the one hand from the number of degrees of freedom or the multitude of adjustable parameters and on the other hand from the coupling of these. To overcome this situation a Bayesian optimization procedure is present, which gives the possibility to determine optimal cost functional parameters for a given desire. Moreover, a Pareto-front for a whole set of possible configurations can be computed.

    Comment: This work has been accepted for publication at 2021 European Control Conference
    Keywords Computer Science - Robotics ; Electrical Engineering and Systems Science - Systems and Control
    Subject code 510
    Publishing date 2021-04-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article: Risk analysis of gas leakage in gas pressure reduction station and its consequences: A case study for Zahedan

    Dadkani, Peiman / Noorzai, Esmatullah / Ghanbari, AmirHossein / Gharib, Ali

    Heliyon. 2021 May, v. 7, no. 5

    2021  

    Abstract: Industrial accidents have increased the importance of dealing with the risks of toxic exposure, fire and explosion. Despite the measures taken in the chemical industry to prevent accidents, the accidents occur often due to human error or process faults ... ...

    Abstract Industrial accidents have increased the importance of dealing with the risks of toxic exposure, fire and explosion. Despite the measures taken in the chemical industry to prevent accidents, the accidents occur often due to human error or process faults during repairs. Although several studies have been conducted on the accidents in the process industry, no research has modeled the risks caused by the leakage of toxic substances in the gas pressure reduction station. The consequences of gas leak and fire in Zahedan's gas pressure reduction station were investigated in Iran. This research aims to determine the safe range of the station and observe the safety measures required for the gas pressure reduction station in Zahedan. For modelling gas leak and fire, the ALOHA software was used to display the threat zone. In this research, with respect to the environmental data, the desired scenario was modeled. The results, based on two scenarios of gas leak and fire in both hot and cold seasons, indicate that the gas leak scenario in hot seasons and the fire scenario in cold seasons influence a larger region.
    Keywords case studies ; chemical industry ; cold ; computer software ; risk analysis ; toxicity ; Iran
    Language English
    Dates of publication 2021-05
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2021.e06911
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Utilization of Stockwell Transform, Support Vector Machine and D-STATCOM for the Identification, Classification and Mitigation of Power Quality Problems

    Epaphros Mengistu / Baseem Khan / Yazeed Qasaymeh / Ali S. Alghamdi / Muhammad Zubair / Ahmed Bilal Awan / Muhammad Gul Bahar Ashiq / Samia Gharib Ali / Cristina Mazas Pérez-Oleaga

    Sustainability, Vol 15, Iss 6007, p

    2023  Volume 6007

    Abstract: Power Quality (PQ) has become a significant issue in power networks. Power quality disturbances must be precisely and appropriately identified. This activity involves identifying, classifying, and mitigating power quality problems. A case study of the ... ...

    Abstract Power Quality (PQ) has become a significant issue in power networks. Power quality disturbances must be precisely and appropriately identified. This activity involves identifying, classifying, and mitigating power quality problems. A case study of the Awada industrial zone in Ethiopia is taken into consideration to show the practical applicability of the proposed work. It is found that the current harmonic distortion levels exceed the restrictions with a maximum percentage Total Harmonic Distortion of Current (THDI) value of up to 23.09%. The signal processing technique, i.e., Stockwell Transform (ST) is utilized for the identification of power quality issues, and it covers the most important and common power quality issues. The Support Vector Machine (SVM) method is used to categorize power quality issues, which enhances the classification procedure. The ST scored better in terms of accuracy than the Wavelet Transform (WT), Fourier Transform (FT), and Hilbert Transform (HT), obtaining 97.1%, as compared to 91.08%, 88.91%, and 86.8%, respectively. The maximum classification accuracy of SVM was 98.3%. To lower the current level of harmonic distortion in the industrial sector, a Distribution Static Compensator (D-STATCOM) is developed in the current control mode. To evaluate the performance of the D-STATCOM, the performance of the distribution network with and without D-STATCOM is simulated. The simulation results show that THDI is reduced to 4.36% when the suggested D-STATCOM is applied in the system.
    Keywords current distortion ; distribution static compensator ; stockwell transform ; support vector machine ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 670
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Catalytic tetrahydropyranylation of phenols and alcohols using vanadium(V)-substituted polyoxomolybdates

    Gharib Ali / Jahangir Manouchehr

    Journal of the Serbian Chemical Society, Vol 77, Iss 3, Pp 287-

    2012  Volume 296

    Abstract: Alcohols and phenols were tetrahydropyranylated in the presence of H7[PMo8V4O40] in good to excellent yields in acetonitrile and under solventfree reaction conditions. A mild and convenient method for the formation and deprotection of tetrahydropyranyl ... ...

    Abstract Alcohols and phenols were tetrahydropyranylated in the presence of H7[PMo8V4O40] in good to excellent yields in acetonitrile and under solventfree reaction conditions. A mild and convenient method for the formation and deprotection of tetrahydropyranyl ethers (THP ethers) is described. The formation of THP ethers from the corresponding alcohols was accomplished in the presence of acid-sensitive functional groups.
    Keywords THP ether ; heteropolyacid ; protecting group ; tetrahydropyranylation ; detetrahydropyranylation ; Chemistry ; QD1-999
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Serbian Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Thesis: Influence of demerol and nembutal on arterial ether blood concentration in man undergoing surgery

    Gharib, Ali

    1954  

    MeSH term(s) Meperidine
    Keywords Barbiturates / Effects ; Ether
    Language English
    Size 26 l., ill.
    Publishing place Minneapolis
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Thesis (M. S. in Anesthesiology) - Univ. of Minnesota
    Note Typewritten copy.
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article: Catalytic Synthesis of 3,4-dihydropyrimidin-2(1H)-ones under Green Conditions and by Keggin type heteropolyacid catalyst H7[PMo8V4O40]

    Gharib, Ali / Agricultural Researches&services center and Islamic Azad University

    Gazi University Journal of Science; Vol 25, No 4 (2012); 823-834

    Abstract: This paper describes an improved procedure and simple and green method for the efficient and facile synthesis of 3,4-dihydropyrimidinones with excellent yields using inexpensive heteropolyacid catalyst in the presence of green solvent. ...

    Abstract This paper describes an improved procedure and simple and green method for the efficient and facile synthesis of 3,4-dihydropyrimidinones with excellent yields using inexpensive heteropolyacid catalyst in the presence of green solvent.
    Language English
    Document type Article
    ISSN 2147-1762
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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