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  1. Article ; Online: Differences in clinical and lab characteristics of sepsis between opium user patients and patients with no illicit drug addiction.

    Mehrpour, Omid / Alemzadeh, Effat / Ghasemi, Saeedeh / Farkhondeh, Tahereh / Ziaee, Masood

    Cardiovascular & hematological agents in medicinal chemistry

    2023  

    Abstract: Background: Sepsis is a significant cause of mortality worldwide. This study aimed to compare clinical and laboratory characteristics of sepsis in patients addicted to illicit drugs versus patients with no illicit drug addiction.: Methods: In this ... ...

    Abstract Background: Sepsis is a significant cause of mortality worldwide. This study aimed to compare clinical and laboratory characteristics of sepsis in patients addicted to illicit drugs versus patients with no illicit drug addiction.
    Methods: In this cross-sectional study, all patients hospitalized with sepsis diagnosis were recruited within six months from September to March 2019. Sixty patients for each group (illicit drug-addicted and non-addicted individuals) were selected. The data relating to illicit drug consumption, serum indices, the current focus of infection, duration of hospitalization, and disease outcomes were collected. Patients who had an illicit drug addiction were compared with non-addicted patients in terms of clinical and laboratory parameters. The data collected were analyzed using SPSS software (version 19).
    Results: The bacterial load in the urine culture was statistically significant in both groups and higher in the non-addicted group. The frequency distributions of focus of infection, duration of hospitalization, and outcome were not significantly different between the two groups. The serum sodium and total neutrophils were significantly higher in the addicted group. However, the MCHC level was significantly lower (p<0.05).
    Conclusion: Opium may have stimulated the immune system and reduced bacterial infection in septic patient users.
    Language English
    Publishing date 2023-05-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2215710-4
    ISSN 1875-6182 ; 1871-5257
    ISSN (online) 1875-6182
    ISSN 1871-5257
    DOI 10.2174/1871525721666230518101627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: An Evaluation of Antibacterial Effects of Human Amniotic Fluid on Pathogenic and Probiotic Bacteria

    Ghanbarzadeh, Nahid / Mohammadparast-Tabas, Pouria / Aramjoo, Hamed / Allahyari, Elahe / Ghasemi, Saeedeh / Erfani, Soheila / Mesbahzadeh, Behzad / Dehghan, Hamideh / Zare-Bidaki, Majid

    Journal of reproduction & infertility

    2023  Volume 24, Issue 2, Page(s) 101–107

    Abstract: Background: Amniotic fluid in the uterus is beneficial for the fetus growth and protection due to its nutritional elements as well as its antibacterial and anti-inflammatory properties. Today, body membranes are increasingly being used in multiple ... ...

    Abstract Background: Amniotic fluid in the uterus is beneficial for the fetus growth and protection due to its nutritional elements as well as its antibacterial and anti-inflammatory properties. Today, body membranes are increasingly being used in multiple fields. The purpose of the current study was evaluation of the antibacterial effects of amniotic fluid and comparison of its effects on pathogenic and probiotic bacteria.
    Methods: This experimental study was conducted on amniotic fluid obtained from 43 healthy mothers who gave birth by selective cesarean section. Then, antibacterial effects of amniotic fluids were investigated on 8 standard bacterial strains, including Bacillus cereus, Escherichia coli, Staphylococcus aureus, Shigella flexneri, Pseudomonas aeruginosa, Klebsiella pneumoniae, Bacillus cereus, and Lactobacillus plantarum by agar well-diffusion method. Data analysis was performed by SPSS software,
    Results: Amniotic fluid revealed an inhibitory effect on the growth of bacterial strains. Staphylococcus aureus and Streptococcus pyogenes strains showed growth inhibition in 39% and 17% of samples, respectively. In other bacterial strains, there was growth inhibition in less than 5% of the samples. Also, the zone of growth inhibition for Staphylococcus aureus and Streptococcus pyogenes was significantly higher than the other strains. Amniotic fluid samples had an antibacterial effect on all pathogen strains in general, but not on the Lactobacillus plantarum probiotic strain.
    Conclusion: Our findings suggest that the antibacterial effect of amniotic fluid on pathogenic bacteria is significantly higher than the Lactobacillus plantarum as a probiotic one. Overall, the findings support the use of natural substances as alternative therapeutic agents to combat antibiotic resistance.
    Language English
    Publishing date 2023-06-30
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2548922-7
    ISSN 2251-676X ; 1735-8507 ; 2228-5482 ; 1726-7536
    ISSN (online) 2251-676X ; 1735-8507
    ISSN 2228-5482 ; 1726-7536
    DOI 10.18502/jri.v24i2.12495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Possible Potential Effects of Honey and Its Main Components Against Covid-19 Infection.

    Abedi, Farshid / Ghasemi, Saeedeh / Farkhondeh, Tahereh / Azimi-Nezhad, Mohsen / Shakibaei, Mehdi / Samarghandian, Saeed

    Dose-response : a publication of International Hormesis Society

    2021  Volume 19, Issue 1, Page(s) 1559325820982423

    Abstract: Coronavirus disease 2019 (COVID-19) is a viral pneumonia that is spreading rapidly worldwide. The main feature of this disease is a severe acute respiratory syndrome and caused by coronavirus 2 (SARS-CoV-2). There are several unknowns about the ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is a viral pneumonia that is spreading rapidly worldwide. The main feature of this disease is a severe acute respiratory syndrome and caused by coronavirus 2 (SARS-CoV-2). There are several unknowns about the pathogenesis and therapeutically treatment of COVID-19 infection. In addition, available treatment protocols have not been effective in managing COVID-19 infection. It is proposed that natural anti-oxidants such as lemon, green tea, saffron, curcuma longa, etc. with high flavonoids like safranal, crocin, crocetin, catechins, resveratrol, calebin A, curcumin have therapeutic potential against viral infections. In this context, honey and its main components are being investigated as an option for patients with COVID-19. The present study may indicate that honey and its main components inhibit the entry of the virus into the host cell and its replication as well as modulate the inflammatory cascade. This review provides basic information for the possible potential effects of honey and its main components for fighting with SARS-CoV-2.
    Language English
    Publishing date 2021-03-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2440820-7
    ISSN 1559-3258
    ISSN 1559-3258
    DOI 10.1177/1559325820982423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Efficacy of the barley-based remedy, a Persian medicine formula, in coronavirus disease 2019 (COVID-19) hospitalized patients: An open-labeled randomized controlled trial.

    Hasheminasab, Fatemeh Sadat / Azimi, Maryam / Khodadoost, Mahmood / Chouban, Bahram / Shakeri, Nezhat / Ghasemi, Saeedeh / Farokhi, Azam / Mokaberinajad, Roshanak

    Advances in integrative medicine

    2022  Volume 9, Issue 3, Page(s) 185–190

    Abstract: Background: With the pandemic of coronavirus disease 2019 (COVID-19), and the growing attention of people around the world to the use of traditional and complementary medicines to control of the disease, evaluating the effectiveness of these treatments ... ...

    Abstract Background: With the pandemic of coronavirus disease 2019 (COVID-19), and the growing attention of people around the world to the use of traditional and complementary medicines to control of the disease, evaluating the effectiveness of these treatments has received special attention.
    Aim: This study aimed to assess the clinical efficacy of a barley-based (
    Materials and methods: Seventy COVID-19 patients were randomly divided into barley-based remedy plus conventional medicine (barley-based remedy group) and conventional therapy (control group). Both groups were treated for 5 days. The outcomes were oxygen saturation, main symptoms (fever, respiratory rate, cough, and fatigue), and laboratory data (lymphocytic count, and CRP); they were measured for 6 days.
    Results: In comparison to the control group, the oxygen saturation level in the barley-based remedy group significantly increased, from the second day of the intervention (P < 0.05). The herbal remedy significantly improved fatigue from the third day (P < 0.05). Meanwhile, the severity and frequency of cough between the groups were not significantly different. The herbal remedy had no significant effect on the CRP and the lymphocytic count of every time points of measurement. The average of respiratory rate and temperature of patients were in the normal range in both groups during the intervention.
    Conclusion: Barley-based remedy could significantly enhance the blood oxygen saturation and reduce fatigue. However, it needs to be confirmed by large sample size trials.
    Language English
    Publishing date 2022-04-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2727661-2
    ISSN 2212-9588
    ISSN 2212-9588
    DOI 10.1016/j.aimed.2022.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The effects of opium on the cardiovascular system: a review of side effects, uses, and potential mechanisms.

    Nakhaee, Samaneh / Ghasemi, Saeedeh / Karimzadeh, Kimiya / Zamani, Nasim / Alinejad-Mofrad, Samaneh / Mehrpour, Omid

    Substance abuse treatment, prevention, and policy

    2020  Volume 15, Issue 1, Page(s) 30

    Abstract: Background: In Iran, as in many other Asian and Middle Eastern countries, some believe that opium has beneficial effects on cardiovascular system. Dependent patients suppose that opium has positive effects on cardiovascular function and can prevent or ... ...

    Abstract Background: In Iran, as in many other Asian and Middle Eastern countries, some believe that opium has beneficial effects on cardiovascular system. Dependent patients suppose that opium has positive effects on cardiovascular function and can prevent or improve cardiovascular diseases; however, only few comprehensive studies evaluating such effects have been performed.
    Objectives: In this study, we sought to clarify the effect of opium on cardiovascular problems by incorporating the previous findings and the current information on the issue and to explain the possible mechanisms of this effect.
    Methods: The available human studies published up to October 30, 2019, were searched in different databases. Case-control, cohort, and cross-sectional studies were retrieved. Papers published in English or those with an English abstract were included. The risk of bias for each included study was assessed based on the Newcastle-Ottawa Scale (NOS). We then categorized the effects of opium on cardiovascular problems along with its probable underlying mechanisms of action.
    Results: In this study, most of the published articles suggested the adverse effects of opium on the cardiovascular system, including atherosclerosis, myocardial infarction, arrhythmia, low ejection fraction, and cardiovascular mortality; however, some articles reported the beneficial or impartial effects of opium on the cardiovascular system. In this article, we have categorized all the effects of opium on cardiovascular system; also, the proposed mechanisms of action of opium in each of the above-mentioned disorders are summarized.
    Conclusion: Although the available evidences were incoherent, it was mostly suggested that opium use does not protect against or improve cardiovascular problems.
    MeSH term(s) Cardiovascular System/drug effects ; Cross-Sectional Studies ; Female ; Humans ; Iran/epidemiology ; Male ; Opioid-Related Disorders/mortality ; Opium/adverse effects ; Risk Factors
    Chemical Substances Opium (8008-60-4)
    Language English
    Publishing date 2020-04-17
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2222956-5
    ISSN 1747-597X ; 1747-597X
    ISSN (online) 1747-597X
    ISSN 1747-597X
    DOI 10.1186/s13011-020-00272-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Methadone associated long term hearing loss and nephrotoxicity; a case report and literature review.

    Ghasemi, Saeedeh / Izadpanahi, Shadi / Yaghoubi, Mohammad Ali / Brent, Jeffrey / Mehrpour, Omid

    Substance abuse treatment, prevention, and policy

    2019  Volume 14, Issue 1, Page(s) 48

    Abstract: Background: Methadone is a long-acting opioid receptor agonist. Reported adverse effects of methadone include constipation, respiratory depression, dizziness, nausea, vomiting, itching, sweating, rhabdomyolysis, QT prolongation, and orthostatic ... ...

    Abstract Background: Methadone is a long-acting opioid receptor agonist. Reported adverse effects of methadone include constipation, respiratory depression, dizziness, nausea, vomiting, itching, sweating, rhabdomyolysis, QT prolongation, and orthostatic hypotension. Hearing loss has been rarely reported following methadone use, and when reported, long term follow-up is rare. Herein we report a case of methadone poisoning with rhabdomyolysis, acute kidney injury, and persistent hearing loss documented by a 2 year follow up.
    Case presentation: The patient was a 34 years old male who presented with a reduced level of consciousness and acute hearing loss after suicidal ingestion of 40 mg of methadone while experiencing family-related stresses. He had no prior history of methadone use, abuse, or addiction. Initial laboratory testing was significant for a serum creatinine concentration of 4.1 mg/dl, a mixed metabolic and respiratory acidosis, thrombocytopenia, abnormal hepatic transaminases, and coagulation tests. The patient then developed severe rhabdomyolysis. Also, audiometry showed a bilateral sensorineural hearing loss. The patient required hemodialysis for 11 days while his metabolic abnormalities gradually resolved. However, his hearing loss was persistent, as demonstrated by 2 years of follow up.
    Conclusion: Our patient simultaneously had kidney failure, rhabdomyolysis, and permanent hearing loss following methadone poisoning. Although rare, ototoxicity and permanent hearing loss may happen in cases of methadone poisoning. While opioid-induced hearing loss is uncommon, methadone toxicity should be taken into account for any previously healthy patient presenting with acute hearing loss with or without rhabdomyolysis.
    MeSH term(s) Adult ; Analgesics, Opioid/adverse effects ; Hearing Loss, Sensorineural/chemically induced ; Hearing Loss, Sensorineural/complications ; Humans ; Male ; Methadone/poisoning ; Renal Insufficiency/chemically induced ; Renal Insufficiency/complications ; Rhabdomyolysis/chemically induced ; Rhabdomyolysis/complications
    Chemical Substances Analgesics, Opioid ; Methadone (UC6VBE7V1Z)
    Language English
    Publishing date 2019-11-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1747-597X
    ISSN (online) 1747-597X
    DOI 10.1186/s13011-019-0236-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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