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  1. Article: Effect of COVID-19 on air pollution related illnesses in India.

    Uday, Utkarsha / Bethineedi, Lakshmi Deepak / Hasanain, Muhammad / Ghazi, Behram Khan / Nadeem, Arsalan / Patel, Prashastee / Khalid, Zaira

    Annals of medicine and surgery (2012)

    2022  Volume 78, Page(s) 103871

    Abstract: Ambient air pollution level not only causes respiratory diseases but also cardiovascular diseases, besides, increased visits to the emergency department for asthma, chronic obstructive pulmonary disease (COPD), bronchitis, allergic rhinitis, attention ... ...

    Abstract Ambient air pollution level not only causes respiratory diseases but also cardiovascular diseases, besides, increased visits to the emergency department for asthma, chronic obstructive pulmonary disease (COPD), bronchitis, allergic rhinitis, attention deficit hyperactivity disorder (ADHD) in children and premature deaths in infants. The occurrence of Coronavirus-19 (COVID-19) pandemic is both, a boon and bane. Despite the deplorable situation aroused by the pandemic, strict lockdown measures implemented to curb the drastic spread of the disease, also culminated into astonishing outcomes that were not prioritized. This article illustrates the effects of the ongoing pandemic on air pollution and provides recommendations aimed at limiting it.
    Language English
    Publishing date 2022-05-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2022.103871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: In Silico Structural and Functional Analyses of NLRP3 Inflammasomes to Provide Insights for Treating Neurodegenerative Diseases.

    Ghazi, Behram Khan / Bangash, Maria Hussain / Razzaq, Anam Abdul / Kiyani, Madiha / Girmay, Shishay / Chaudhary, Waleed Razzaq / Zahid, Usman / Hussain, Uzma / Mujahid, Huma / Parvaiz, Usama / Buzdar, Irfan Ahmed / Nawaz, Shah / Elsadek, Mohamed Farouk

    publication RETRACTED

    BioMed research international

    2023  Volume 2023, Page(s) 9819005

    Abstract: Inflammasomes are cytoplasmic intracellular multiprotein complexes that control the innate immune system's activation of inflammation in response to derived chemicals. Recent advancements increased our molecular knowledge of activation of NLRP3 ... ...

    Abstract Inflammasomes are cytoplasmic intracellular multiprotein complexes that control the innate immune system's activation of inflammation in response to derived chemicals. Recent advancements increased our molecular knowledge of activation of NLRP3 inflammasomes. Although several studies have been done to investigate the role of inflammasomes in innate immunity and other diseases, structural, functional, and evolutionary investigations are needed to further understand the clinical consequences of NLRP3 gene. The purpose of this study is to investigate the structural and functional impact of the NLRP3 protein by using a computational analysis to uncover putative protein sites involved in the stabilization of the protein-ligand complexes with inhibitors. This will allow for a deeper understanding of the molecular mechanism underlying these interactions. It was found that human NLRP3 gene coexpresses with PYCARD, NLRC4, CASP1, MAVS, and CTSB based on observed coexpression of homologs in other species. The NACHT, LRR, and PYD domain-containing protein 3 is a key player in innate immunity and inflammation as the sensor subunit of the NLRP3 inflammasome. The inflammasome polymeric complex, consisting of NLRP3, PYCARD, and CASP1, is formed in response to pathogens and other damage-associated signals (and possibly CASP4 and CASP5). Comprehensive structural and functional analyses of NLRP3 inflammasome components offer a fresh approach to the development of new treatments for a wide variety of human disorders.
    MeSH term(s) Humans ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Neurodegenerative Diseases/genetics ; Immunity, Innate ; Inflammation/genetics ; Caspase 1/metabolism
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Caspase 1 (EC 3.4.22.36)
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2023/9819005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: From black to white: A roadmap to containing the rise of candidiasis amidst COVID-19 and mucormycosis in India.

    Nawaz, Faisal A / Yaqoob, Sadia / Sharma, Abhishek / Khan, Abdul Rahman / Rackimuthu, Sudhan / Ghazi, Behram Khan / Khawaja, Uzzam Ahmed / Essar, Mohammad Yasir

    Clinical epidemiology and global health

    2021  Volume 12, Page(s) 100917

    Abstract: With numbers of active COVID-19 cases in India falling in recent weeks and the healthcare system finally showing signs of coping with the mucormycosis epidemic, several new reports of COVID-19 cases linked to "white fungus" have emerged. This has led to ... ...

    Abstract With numbers of active COVID-19 cases in India falling in recent weeks and the healthcare system finally showing signs of coping with the mucormycosis epidemic, several new reports of COVID-19 cases linked to "white fungus" have emerged. This has led to rising concern with the potential to stretch the capacity of an already burdened healthcare system. Moreover, the implications of this disease in the COVID-19 population and its consequences on the health and socio-economic structure of the country have not been vastly studied. This commentary explores the need for government efforts in the context of containing candidiasis during the pandemic and provides key recommendations on combating this imminent public health challenge.
    Language English
    Publishing date 2021-12-01
    Publishing country India
    Document type Journal Article
    ISSN 2452-0918
    ISSN 2452-0918
    DOI 10.1016/j.cegh.2021.100917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antifungal Drugs Shortage in India amidst Looming Increase in Invasive Fungal Infections among COVID-19 Patients: An Impending Crisis.

    Ghazi, Behram Khan / Zahid, Usman / Usman, Muhammad Abdullah / Kazmi, Zohra / Hunain, Reem / Riaz, Mehr Muhammad Adeel / Elmahi, Osman Kamal Osman / Essar, Mohammad Yasir / Hasan, Mohammad Mehedi

    Innovations in pharmacy

    2022  Volume 13, Issue 2

    Abstract: The widespread prevalence of fungal infections in the second wave of COVID-19 pandemic could be owed to ubiquitous and injudicious use of steroids and immunosuppressive nature of the virus. However, these fungal infections also meant increased use of ... ...

    Abstract The widespread prevalence of fungal infections in the second wave of COVID-19 pandemic could be owed to ubiquitous and injudicious use of steroids and immunosuppressive nature of the virus. However, these fungal infections also meant increased use of antifungal drugs, hence endangering their supply. Amphotericin B is the first line drug for mucormycosis which was declared as an epidemic in India during the second wave. With the increasing demand of the drug, came challenges to manufacture and supply large quantities of the drug and exploitation by creating a black market and spread of false information and imprudent usage. It is of utmost importance to be prepared with adequate supply all over the nation and implementing safety regulations in manufacturing and supply of large quantities of drugs during the demanding times and make them accessible at a reasonable rate.
    Language English
    Publishing date 2022-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2689516-X
    ISSN 2155-0417 ; 2155-0417
    ISSN (online) 2155-0417
    ISSN 2155-0417
    DOI 10.24926/iip.v13i2.4480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Antiviral and antiretroviral drug shortages amidst COVID-19: How Africa is struggling.

    Rackimuthu, Sudhan / Kazmi, Zohra / Osman Elmahi, Osman Kamal / Hunain, Reem / Ghazi, Behram Khan / Zaidi, Zain Ali / Costa, Ana Carla Dos Santos / Ahmad, Shoaib / Essar, Mohammad Yasir

    Innovations in pharmacy

    2021  Volume 12, Issue 4

    Abstract: Antiviral drugs are of paramount importance in the accomplishment of the vision of zero new cases of COVID-19 globally, through sustainable retaliation against viral diseases. However, several challenges currently exist in Africa which include ... ...

    Abstract Antiviral drugs are of paramount importance in the accomplishment of the vision of zero new cases of COVID-19 globally, through sustainable retaliation against viral diseases. However, several challenges currently exist in Africa which include insufficient infrastructure, deteriorating health systems, and rising costs of healthcare delivery with concomitant rising inequity with regards to access to health services amid the COVID-19 pandemic. The pandemic itself has stimulated an increased use of phytotherapy in Africa as a result of essential drug shortages that have been attributed to a plethora of contributing factors such as travel restrictions, reduced per capita income as well as increased expenditure on transport. As a result, the paucity of antiviral along with antiretroviral drugs used to combat COVID-19 as well as several other endemic viral diseases in Africa has created a worrisome state. This article therefore discusses and aims to underscore the causes, effects, and implications of antiviral and antiretroviral shortages amid COVID-19 in Africa.
    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2689516-X
    ISSN 2155-0417 ; 2155-0417
    ISSN (online) 2155-0417
    ISSN 2155-0417
    DOI 10.24926/iip.v12i4.4328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Emergence of a medley of invasive fungal infections amidst the coronavirus disease 2019 (COVID-19) pandemic in India.

    Rackimuthu, Sudhan / Khan, Hiba / Mohan, Anmol / Hunain, Reem / Ghazi, Behram Khan / Hasan, Mohammad Mehedi / Costa, Ana Carla Dos Santos / Ahmad, Shoaib / Essar, Mohammad Yasir

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2021  Volume 1, Issue 1, Page(s) e40

    Language English
    Publishing date 2021-11-02
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2021.198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Rampant Increase in Cases of Mucormycosis in India and Pakistan: A Serious Cause for Concern during the Ongoing COVID-19 Pandemic.

    Ghazi, Behram Khan / Rackimuthu, Sudhan / Wara, Um Ul / Mohan, Anmol / Khawaja, Uzzam Ahmed / Ahmad, Shkaib / Ahmad, Shahzaib / Hasan, Mohammad Mehedi / Dos Santos Costa, Ana Carla / Ahmad, Shoaib / Essar, Mohammad Yasir

    The American journal of tropical medicine and hygiene

    2021  Volume 105, Issue 5, Page(s) 1144–1147

    Abstract: COVID-19 is a global health crisis that continues to pose new challenges all around the world. Amidst the growing pandemic, a spike in the number of mucormycosis cases in India and Pakistan has been reported in COVID-19 patients and in those who have ... ...

    Abstract COVID-19 is a global health crisis that continues to pose new challenges all around the world. Amidst the growing pandemic, a spike in the number of mucormycosis cases in India and Pakistan has been reported in COVID-19 patients and in those who have recovered from COVID-19. This increase in cases may be related to the overuse of steroids and zinc, the use of industrial oxygen, unsterilized medical equipment, frequent intubation, a weakened immune system, and pre-existing comorbidities such as diabetes. As a result, it is critical to take steps to handle the current increase in mucormycosis cases. Therefore, this article aims to highlight the existence of mucormycosis amidst the COVID-19 pandemic in India and Pakistan, focusing on possible causes and implications, and suggests important plans of action to be taken during this pandemic.
    MeSH term(s) Antifungal Agents/therapeutic use ; COVID-19/epidemiology ; Coinfection/epidemiology ; Coinfection/microbiology ; Coinfection/virology ; Comorbidity ; Humans ; Immunocompromised Host ; India/epidemiology ; Mucorales/pathogenicity ; Mucormycosis/drug therapy ; Mucormycosis/epidemiology ; Mucormycosis/etiology ; Mucormycosis/virology ; Pakistan/epidemiology ; Risk Factors
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2021-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.21-0608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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