Artikel ; Online: Effect of defensins-containing eye cream on periocular rhytids and skin quality.
Journal of cosmetic dermatology
2020 Band 19, Heft 8, Seite(n) 2000–2005
Abstract: Background: Defensins are peptides shown to activate LGR6 stem cells to stimulate the production of new basal stem cells in the epidermis. Use of topical definsin-containing products has been shown to address signs of global skin aging including ... ...
Abstract | Background: Defensins are peptides shown to activate LGR6 stem cells to stimulate the production of new basal stem cells in the epidermis. Use of topical definsin-containing products has been shown to address signs of global skin aging including decrease of wrinkles and increase of epidermal thickness. Aims: To investigate the ability of a topical defensin-containing skincare product in improving the structure and function of aging periocular skin using objective and subjective outcome measures. Patients/methods: A prospective pilot trial of a defensin-containing eye cream was performed in patients with periocular rhytids over 6 weeks. Subjective changes in skin quality and aging characteristics were compared using a patient survey tool. Objective changes in periocular skin quality were analyzed using the QuantifiCare imaging system and the DermLab ultrasound scanner by blinded reviewers. Results: A total of eight patients completed treatment; two were male, and six were female. The average age was 51 years (range 37-63). Compliance with product application as reported on the participant application log was over 90%. Overall, there was an average 2.1 point improvement in subjective measures of skin quality on the consumer questionnaire (P = .002). QuantifiCare imaging of pores, wrinkles, and oiliness showed 370% improvement, 55% improvement, and 12% improvement, respectively. DermaLab noninvasive measurements of elasticity, skin thickness, and hydration showed improvement of 120%, 28%, and 6%, respectively. Conclusion: The use of topical formulations of definsin-containing eye cream statically improves patient-reported outcomes of skin quality, especially redness, sensitivity to weather, age spots, and crow's feet. |
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Mesh-Begriff(e) | Adult ; Defensins ; Epidermis ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Skin ; Skin Aging ; Skin Cream |
Chemische Substanzen | Defensins |
Sprache | Englisch |
Erscheinungsdatum | 2020-07-02 |
Erscheinungsland | England |
Dokumenttyp | Journal Article |
ZDB-ID | 2280551-5 |
ISSN | 1473-2165 ; 1473-2130 |
ISSN (online) | 1473-2165 |
ISSN | 1473-2130 |
DOI | 10.1111/jocd.13424 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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