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  1. Book: Frontotemporal dementias

    Ghetti, Bernardino / Buratti, Emanuele / Boeve, Bradley / Rademakers, Rosa

    emerging milestones of the 21st Century

    (Advances in experimental medicine and biology ; 1281)

    2021  

    Author's details Bernadino Ghetti, Emanuele Buratti, Bradley Boeve, Rosa Rademakers editors
    Series title Advances in experimental medicine and biology ; 1281
    Collection
    Language English
    Size x, 320 Seiten, Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT020708955
    ISBN 978-3-030-51139-5 ; 9783030511401 ; 3-030-51139-1 ; 3030511405
    Database Catalogue ZB MED Medicine, Health

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    Zs A 3192 -1281- not available for loan Zeitschriften-Lesesaal

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  2. Book: Prion diseases

    Ghetti, Bernardino

    (Clinics in laboratory medicine ; 23,1)

    2003  

    Author's details Bernardino Ghetti ..., guest ed
    Series title Clinics in laboratory medicine ; 23,1
    Collection
    Language English
    Size XVI, 255 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013694773
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1695 -23,1- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: Cryo-EM Structures of Chronic Traumatic Encephalopathy Tau Filaments with PET Ligand Flortaucipir.

    Shi, Yang / Ghetti, Bernardino / Goedert, Michel / Scheres, Sjors H W

    Journal of molecular biology

    2023  Volume 435, Issue 11, Page(s) 168025

    Abstract: Positron emission tomography (PET) imaging allows monitoring the progression of amyloid aggregation in the living brain. [ ...

    Abstract Positron emission tomography (PET) imaging allows monitoring the progression of amyloid aggregation in the living brain. [
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Brain/metabolism ; Chronic Traumatic Encephalopathy/metabolism ; Chronic Traumatic Encephalopathy/pathology ; Cryoelectron Microscopy ; Ligands ; Positron-Emission Tomography/methods ; tau Proteins/chemistry ; Tauopathies/metabolism ; Tauopathies/pathology ; Intermediate Filaments/chemistry ; Carbolines/chemistry ; Protein Binding ; Radioactive Tracers
    Chemical Substances 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (J09QS3Z3WB) ; Ligands ; tau Proteins ; Carbolines ; Radioactive Tracers
    Language English
    Publishing date 2023-06-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2023.168025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 867: Show issues Location:
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  4. Article ; Online: Classification of diseases with accumulation of Tau protein.

    Kovacs, Gabor G / Ghetti, Bernardino / Goedert, Michel

    Neuropathology and applied neurobiology

    2022  Volume 48, Issue 3, Page(s) e12792

    MeSH term(s) Alzheimer Disease/metabolism ; Animals ; Disease Models, Animal ; Humans ; Mice ; Mice, Transgenic ; Tauopathies/metabolism ; tau Proteins/metabolism
    Chemical Substances tau Proteins
    Language English
    Publishing date 2022-02-09
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80371-6
    ISSN 1365-2990 ; 0305-1846
    ISSN (online) 1365-2990
    ISSN 0305-1846
    DOI 10.1111/nan.12792
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    Zs.A 1241: Show issues Location:
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  5. Article ; Online: Cryo-EM Structures of Chronic Traumatic Encephalopathy Tau Filaments with PET Ligand Flortaucipir

    Shi, Yang / Ghetti, Bernardino / Goedert, Michel / Scheres, Sjors H.W.

    Journal of Molecular Biology. 2023 June, v. 435, no. 11 p.168025-

    2023  

    Abstract: Positron emission tomography (PET) imaging allows monitoring the progression of amyloid aggregation in the living brain. [¹⁸F]-Flortaucipir is the only approved PET tracer compound for the visualisation of tau aggregation. Here, we describe cryo-EM ... ...

    Abstract Positron emission tomography (PET) imaging allows monitoring the progression of amyloid aggregation in the living brain. [¹⁸F]-Flortaucipir is the only approved PET tracer compound for the visualisation of tau aggregation. Here, we describe cryo-EM experiments on tau filaments in the presence and absence of flortaucipir. We used tau filaments isolated from the brain of an individual with Alzheimer’s disease (AD), and from the brain of an individual with primary age-related tauopathy (PART) with a co-pathology of chronic traumatic encephalopathy (CTE). Unexpectedly, we were unable to visualise additional cryo-EM density for flortaucipir for AD paired helical or straight filaments (PHFs or SFs), but we did observe density for flortaucipir binding to CTE Type I filaments from the case with PART. In the latter, flortaucipir binds in a 1:1 molecular stoichiometry with tau, adjacent to lysine 353 and aspartate 358. By adopting a tilted geometry with respect to the helical axis, the 4.7 Å distance between neighbouring tau monomers is reconciled with the 3.5 Å distance consistent with π-π-stacking between neighbouring molecules of flortaucipir.
    Keywords amyloid ; aspartic acid ; brain ; encephalopathy ; geometry ; ligands ; lysine ; molecular biology ; positron-emission tomography ; stoichiometry ; cryo-EM ; Tau ; Flortaucipir ; PET compounds
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2023.168025
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  6. Article ; Online: Thiophene-Based Ligands for Specific Assignment of Distinct Aβ Pathologies in Alzheimer's Disease.

    Klingstedt, Therése / Lantz, Linda / Shirani, Hamid / Ge, Junyue / Hanrieder, Jörg / Vidal, Ruben / Ghetti, Bernardino / Nilsson, K Peter R

    ACS chemical neuroscience

    2024  Volume 15, Issue 7, Page(s) 1581–1595

    Abstract: Aggregated species of amyloid-β (Aβ) are one of the pathological hallmarks in Alzheimer's disease (AD), and ligands that selectively target different Aβ deposits are of great interest. In this study, fluorescent thiophene-based ligands have been used to ... ...

    Abstract Aggregated species of amyloid-β (Aβ) are one of the pathological hallmarks in Alzheimer's disease (AD), and ligands that selectively target different Aβ deposits are of great interest. In this study, fluorescent thiophene-based ligands have been used to illustrate the features of different types of Aβ deposits found in AD brain tissue. A dual-staining protocol based on two ligands, HS-276 and LL-1, with different photophysical and binding properties, was developed and applied on brain tissue sections from patients affected by sporadic AD or familial AD associated with the
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Thiophenes/chemistry ; Ligands ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Plaque, Amyloid/metabolism
    Chemical Substances Thiophenes ; Ligands ; Amyloid beta-Peptides
    Language English
    Publishing date 2024-03-24
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.4c00021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Thiophene-Based Ligands for Histological Multiplex Spectral Detection of Distinct Protein Aggregates in Alzheimer's Disease.

    Lantz, Linda / Shirani, Hamid / Ghetti, Bernardino / Vidal, Ruben / Klingstedt, Therése / Nilsson, K Peter R

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 21, Page(s) e202203568

    Abstract: The aggregation and accumulation of proteins in the brain is the defining feature of many devastating neurodegenerative diseases. The development of fluorescent ligands that bind to these accumulations, or deposits, is essential for the characterization ... ...

    Abstract The aggregation and accumulation of proteins in the brain is the defining feature of many devastating neurodegenerative diseases. The development of fluorescent ligands that bind to these accumulations, or deposits, is essential for the characterization of these neuropathological lesions. We report the synthesis of donor-acceptor-donor (D-A-D) thiophene-based ligands with different emission properties. The D-A-D ligands displayed selectivity towards distinct disease-associated protein deposits in histological sections from postmortem brain tissue of individuals affected by Alzheimer's disease (AD). The ability of the ligands to selectively identify AD-associated pathological alterations, such as deposits composed of aggregates of the amyloid-β (Aβ) peptide or tau, was reduced when the chemical composition of the ligands was altered. When combining the D-A-D ligands with conventional thiophene-based ligands, superior spectral separation of distinct protein aggregates in AD tissue sections was obtained. Our findings provide the structural and functional basis for the development of new fluorescent ligands that can distinguish between aggregated proteinaceous species, as well as offer novel strategies for developing multiplex fluorescence detection of protein aggregates in tissue sections.
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Protein Aggregates ; Thiophenes/chemistry ; Ligands ; Amyloid beta-Peptides/chemistry ; Brain/metabolism ; tau Proteins/metabolism
    Chemical Substances Protein Aggregates ; Thiophenes ; Ligands ; Amyloid beta-Peptides ; tau Proteins
    Language English
    Publishing date 2023-03-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202203568
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  8. Article: Distinct Heterocyclic Moieties Govern the Selectivity of Thiophene-Vinylene-Based Ligands Towards Aβ or Tau Pathology in Alzheime's Disease.

    Björk, Linnea / Shirani, Hamid / Todarwal, Yogesh / Linares, Mathieu / Vidal, Ruben / Ghetti, Bernardino / Norman, Patrick / Klingstedt, Therése / Nilsson, K Peter R

    European journal of organic chemistry

    2023  Volume 26, Issue 41

    Abstract: Distinct aggregated proteins are correlated with numerous neurodegenerative diseases and the development of ligands that selectively detect these pathological hallmarks is vital. Recently, the synthesis of thiophene-based optical ligands, denoted bi- ... ...

    Abstract Distinct aggregated proteins are correlated with numerous neurodegenerative diseases and the development of ligands that selectively detect these pathological hallmarks is vital. Recently, the synthesis of thiophene-based optical ligands, denoted bi-thiophene-vinyl-benzothiazoles (bTVBTs), that could be utilized for selective assignment of tau pathology in brain tissue with Alzheime's disease (AD) pathology, was reported. Herein, we investigate the ability of these ligands to selectively distinguish tau deposits from aggregated amyloid-β (Aβ), the second AD associated pathological hallmark, when replacing the terminal thiophene moiety with other heterocyclic motifs. The selectivity for tau pathology was reduced when introducing specific heterocyclic motifs, verifying that specific molecular interactions between the ligands and the aggregates are necessary for selective detection of tau deposits. In addition, ligands having certain heterocyclic moieties attached to the central thiophene-vinylene building block displayed selectivity to aggregated Aβ pathology. Our findings provide chemical insights for the development of ligands that can distinguish between aggregated proteinaceous species consisting of different proteins and might also aid in creating novel agents for clinical imaging of tau pathology in AD.
    Language English
    Publishing date 2023-09-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1475010-7
    ISSN 1099-0690 ; 1434-193X
    ISSN (online) 1099-0690
    ISSN 1434-193X
    DOI 10.1002/ejoc.202300583
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  9. Article ; Online: Old age before cognitive impairment.

    Ghetti, Bernardino

    Current Alzheimer research

    2009  Volume 6, Issue 4, Page(s) 323

    MeSH term(s) Aging/psychology ; Cognition Disorders/psychology ; Humans ; Memory Disorders/psychology
    Language English
    Publishing date 2009-09-01
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2205170-3
    ISSN 1875-5828 ; 1567-2050
    ISSN (online) 1875-5828
    ISSN 1567-2050
    DOI 10.2174/156720509788929327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6235: Show issues Location:
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  10. Article ; Online: Cryo-EM structures of amyloid-β and tau filaments in Down syndrome.

    Fernandez, Anllely / Hoq, Md Rejaul / Hallinan, Grace I / Li, Daoyi / Bharath, Sakshibeedu R / Vago, Frank S / Zhang, Xiaoqi / Ozcan, Kadir A / Newell, Kathy L / Garringer, Holly J / Jiang, Wen / Ghetti, Bernardino / Vidal, Ruben

    Nature structural & molecular biology

    2024  

    Abstract: Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there is a difference between AD in DS and AD regarding the structure of amyloid-β (Aβ) and tau filaments is unknown. Here we report the structure of Aβ and tau filaments ... ...

    Abstract Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there is a difference between AD in DS and AD regarding the structure of amyloid-β (Aβ) and tau filaments is unknown. Here we report the structure of Aβ and tau filaments from two DS brains. We found two Aβ
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/s41594-024-01252-3
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    Zs.MG 56: Show issues

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