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  1. Article ; Online: Tomografia a coerenza ottica e ateromasia dilatativa: l’importanza dell’imaging intracoronarico per ottimizzare il risultato dell’angioplastica.

    Bendandi, Francesco / Ghetti, Gabriele / Taglieri, Nevio

    Giornale italiano di cardiologia (2006)

    2021  Volume 22, Issue 12 Suppl 2, Page(s) 42–44

    Abstract: Percutaneous coronary intervention (PCI) in coronary artery ectasia is technically challenging, particularly regarding appropriate stent sizing, and it is associated with a higher incidence of adverse events. In this case report, a 63-year-old male ... ...

    Title translation Optical coherence tomography and coronary artery ectasia: the critical role of intracoronary imaging for optimal results of percutaneous coronary intervention.
    Abstract Percutaneous coronary intervention (PCI) in coronary artery ectasia is technically challenging, particularly regarding appropriate stent sizing, and it is associated with a higher incidence of adverse events. In this case report, a 63-year-old male patient, heart transplant recipient, underwent elective follow-up coronary angiography in the absence of clinical symptoms. Five years previously the patient was treated with coronary angioplasty and drug-eluting stent implantation for critical lesions of the left anterior descending coronary artery. Angiographic images showed a focal in-stent haziness at the level of an ectatic segment. To elucidate this finding, optical coherence tomography (OCT) was performed. Intracoronary imaging showed severe malapposition of the proximal end of the stent, with an intraluminal signal-rich structure, suggestive of organized stent thrombosis. Stent dilation was performed to maximal recommended diameter, with significant reduction of the malapposed area, as shown by repeated OCT pullbacks. Intracoronary imaging is particularly valuable in PCI of ectatic vessels to guide appropriate stent sizing and avoid stent malapposition. OCT, thanks to its superior spatial resolution in comparison with other intravascular imaging techniques, provides advantages for stent optimization and evaluation of stent failure causes. However, its limited imaging area and possible incomplete blood clearance may limit its usefulness in severely ectatic vessels.
    MeSH term(s) Coronary Vessels/diagnostic imaging ; Dilatation, Pathologic/etiology ; Drug-Eluting Stents ; Humans ; Male ; Middle Aged ; Percutaneous Coronary Intervention/methods ; Tomography, Optical Coherence/methods
    Language Italian
    Publishing date 2021-11-01
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/3723.37140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The role of the vascular surgeon in transcatheter aortic valve implantation.

    Gallitto, Enrico / Faggioli, Gianluca / Saia, Francesco / Palmerini, Tullio / Pini, Rodolfo / Bruno, Antonio Giulio / Feroldi, Francesca Maria / Alaidros, Moad / Ghetti, Gabriele / Taglieri, Nevio / Caputo, Stefania / Donati, Francesco / Marrozzini, Cinzia / Gargiulo, Mauro

    Vascular

    2024  , Page(s) 17085381241237844

    Abstract: Background: Transcatheter aortic valve implantation (TAVI) has become the standard treatment for severe aortic valve stenosis in patients at increased surgical risk. Percutaneous transfemoral (TF) is the access of choice due to its reduced invasiveness ... ...

    Abstract Background: Transcatheter aortic valve implantation (TAVI) has become the standard treatment for severe aortic valve stenosis in patients at increased surgical risk. Percutaneous transfemoral (TF) is the access of choice due to its reduced invasiveness and perioperative morbidity/mortality compared with the trans-axillary, aortic, and apical routes. On the other hand, vascular access complications (VACs) of the TF access are associated with prolonged hospitalization, 30-day, and 1-year mortality. In addition, the concomitance of peripheral arterial disease may require associated endovascular management. A multidisciplinary team with Interventional Cardiologists and Vascular Surgeons may minimize the rate of VACs in patients with challenging femoral-iliac access or concomitant disease of other vascular districts, thus optimizing the outcome of TF-TAVI. The aim of this study was to evaluate the role of Vascular Surgeons in TF TAVI procedures.
    Methods: We conducted a retrospective single-center review of all TF-TAVI procedures assisted by Vascular Surgeons between January 2016 and December 2020 in a high-volume tertiary hospital. Pre, intra, and postoperative data were analyzed by a dedicated group of Interventional Cardiologists and Vascular Surgeons. VACs were defined according with the Valve Academic Research Consortium (VARC) three guidelines. The outcomes of TF-TAVI procedures with Vascular Surgeons involvement were assessed as study's endpoints.
    Results: Overall, 937 TAVI procedures were performed with a TF approach ranging between 78% (2016) and 98% (2020). Vascular Surgeons were involved in 67 (7%) procedures with the following indications: concomitant abdominal aortic aneurysm (EVAR + TAVI) - 3 (4%), carotid stenosis (TAVI + CAS) - 2 (3%), hostile femoral/iliac access, or VACs - 62 (93%). Balloon angioplasty of iliac artery pre-TAVI implantation was performed in 51 cases (conventional PTA: 38/51%-75%; conventional PTA + intravascular lithotripsy: 13/51%-25%; stenting: 5/51%-10%). TAVI procedure was successfully completed by percutaneous TF approach in all 62 cases with challenging femoral/iliac access. VACs necessitating interventions were 18/937 (2%) cases, localized to the common femoral or common/external iliac artery in 15/18 (83%) and 3/18 (17%) cases, respectively. They were managed by surgical or endovascular maneuvers in 3/18 (17%) and 15/18 (83%) cases, respectively. Fifteen/18 (83%) VACs were treated during the index procedure. There was no procedure-related mortality or 30-day readmission.
    Conclusion: In our experience, Vascular Surgeon assistance in TAVI procedures was not infrequent and allowed safe and effective device introduction through challenging TF access. Similarly, the concomitant significant disease of other vascular districts could be safely addressed, potentially reducing postoperative related mortality and morbidity. The implementation of multidisciplinary team with interventional cardiologists and vascular surgeons should be encouraged whenever possible.
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2137151-9
    ISSN 1708-539X ; 1708-5381
    ISSN (online) 1708-539X
    ISSN 1708-5381
    DOI 10.1177/17085381241237844
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  3. Article ; Online: Off-label Use of Balloon-Expandable Transcatheter Valves to Treat Pure Aortic Regurgitation.

    Orzalkiewicz, Mateusz / Foroni, Marco / Chietera, Francesco / Bendandi, Francesco / Mazzapicchi, Alessandro / Bruno, Antonio Giulio / Ghetti, Gabriele / Taglieri, Nevio / Marrozzini, Cinzia / Galiè, Nazzareno / Palmerini, Tullio / Saia, Francesco

    The American journal of cardiology

    2024  

    Abstract: Transcatheter aortic valve implantation (TAVI) in native pure aortic regurgitation (AR) with off-label use of balloon expandable valves (BEV) has been reported. However, there are scant data regarding optimal oversizing and its safety and our study ... ...

    Abstract Transcatheter aortic valve implantation (TAVI) in native pure aortic regurgitation (AR) with off-label use of balloon expandable valves (BEV) has been reported. However, there are scant data regarding optimal oversizing and its safety and our study assessed BEV oversizing and outcomes of TAVI. Thirteen consecutive tricuspid aortic valve patients undergoing transfemoral TAVIs for pure AR with Sapien BEV at our centre between 2019 and 2023 (69.2% males, mean age 80.8 years, STS 4.0%) were divided into small annulus group (≤618mm
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2024.04.030
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  4. Article ; Online: Predictors of bail-out stenting in patients with small vessel disease treated with drug-coated balloon percutaneous coronary intervention.

    Ghetti, Gabriele / Bendandi, Francesco / Donati, Francesco / Ciurlanti, Leonardo / Nardi, Elena / Bruno, Antonio Giulio / Orzalkiewicz, Mateusz / Palmerini, Tullio / Saia, Francesco / Marrozzini, Cinzia / Galié, Nazzareno / Taglieri, Nevio

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2023  Volume 102, Issue 1, Page(s) 18–24

    Abstract: Background: Drug-coated balloons (DCBs) have shown comparable results with drug-eluting stents in small vessel disease (SVD) percutaneous coronary intervention (PCI) in terms of target vessel revascularization and a reduced incidence of myocardial ... ...

    Abstract Background: Drug-coated balloons (DCBs) have shown comparable results with drug-eluting stents in small vessel disease (SVD) percutaneous coronary intervention (PCI) in terms of target vessel revascularization and a reduced incidence of myocardial infarction. However, the relatively high rate of bail-out stenting (BOS) still represents a major drawback of DCB PCI.
    Aims: The aim of the study was to investigate the clinical, anatomic, and procedural features predictive of BOS after DCB PCI in SVD.
    Methods: We included all consecutive patients undergoing PCI at our institution between January 2020 and May 2022 who were treated with DCB PCI of a de novo lesion in a coronary vessel with a reference vessel diameter (RVD) between 2.0 and 2.5 mm. Angiographic success was defined as a residual stenosis <30% without flow-limiting dissection. Patients who did not meet these criteria underwent BOS.
    Results: A total of 168 consecutive patients and 216 coronary stenoses were included. The rate of bail-out stent was 13.9%. On multivariate analysis, DCB/RVD ratio (odds ratio [OR]: 4.39, 95% confidence interval [CI]: 1.71-11.29, p < 0.01), vessel tortuosity (OR: 7.00, 95% CI: 1.66-29.62, p < 0.01), distal vessel disease (OR: 5.66, 95% CI: 2.02-15.83, p < 0.01), and high complexity (Grade C of ACC/AHA classification) coronary stenoses (OR: 6.31, 95% CI: 1.53-26.04, p = 0.01) were independent predictors of BOS.
    Conclusions: BOS is not an infrequent occurrence in DCB PCI of small vessels and is correlated with vessel tortuosity, distal diffuse vessel disease, higher lesion complexity, and balloon diameter oversizing.
    MeSH term(s) Humans ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Coronary Artery Disease/complications ; Angioplasty, Balloon, Coronary/adverse effects ; Treatment Outcome ; Stents/adverse effects ; Vascular Diseases/complications ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/therapy ; Coronary Stenosis/complications ; Coronary Restenosis/etiology ; Coronary Angiography/adverse effects ; Coated Materials, Biocompatible
    Chemical Substances Coated Materials, Biocompatible
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.30688
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  5. Article ; Online: Coronary ectasia in different scenarios, primarily in myocardial infarction with nonobstructive coronary artery disease.

    Ghetti, Gabriele / Chietera, Francesco / Donati, Francesco / Bendandi, Francesco / Minnucci, Matteo / Bruno, Antonio Giulio / Orzalkiewicz, Mateusz / Nardi, Elena / Palmerini, Tullio / Saia, Francesco / Marrozzini, Cinzia / Galié, Nazzareno / Taglieri, Nevio

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2023  Volume 24, Issue 3, Page(s) 167–171

    Abstract: Aims: Several causes have been reported for coronary artery ectasia (CAE), mostly atherosclerosis and tunica media abnormalities. The main aim of the present study was to investigate if CAE extension differs in distinct clinical settings.: Methods: ... ...

    Abstract Aims: Several causes have been reported for coronary artery ectasia (CAE), mostly atherosclerosis and tunica media abnormalities. The main aim of the present study was to investigate if CAE extension differs in distinct clinical settings.
    Methods: Three hundred and forty-one patients with diagnosis of CAE were identified among 9659 coronary angiographies and divided into four groups according to the patient's admission diagnosis: stable or unstable angina (S-UA), myocardial infarction (MI), aortic disease, aortic valvular disease (AVD). S-UA and MI were subgrouped according to the presence of obstructive coronary artery disease (OCAD). Multivariable logistic regression was used to investigate the relationship between clinical diagnosis and CAE extension as expressed by Markis classification and number of coronary vessels affected by CAE.
    Results: No significant differences in CAE extension were found among the four groups, in terms of vessels affected by CAE (P = 0.37) or Markis class (P = 0.33). CAE was not related to the extension of OCAD as assessed by the Gensini score, which was higher in MI and S-UA groups (P < 0.01). However, when ischemic patients were sub-divided on the basis of the presence of OCAD, MI without obstructive coronary artery disease (MINOCA) was associated with a higher extension of CAE in terms of Markis class 1 (OR 5.08, 95% CI 1.61-16.04; P < 0.01).
    Conclusion: The extension of CAE is comparable in patients referred to coronary angiography for different clinical scenarios, including S-UA, MI, aortic disease, and AVD; however, patients with MINOCA were associated with a higher extension of CAE.Graphical abstract: Difference in coronary artery ectasia extension in terms of Markis class severity, respectively, stratified by clinical presentation and obstructive coronary artery disease presence, http://links.lww.com/JCM/A519.
    MeSH term(s) Humans ; Coronary Artery Disease/diagnostic imaging ; Dilatation, Pathologic ; MINOCA ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/etiology ; Coronary Angiography ; Coronary Vessels/diagnostic imaging ; Coronary Aneurysm
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001445
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  6. Article ; Online: Transcatheter Aortic Valve Replacement for Pure Aortic Regurgitation in a Large and Noncalcified Annulus.

    Orzalkiewicz, Mateusz / Bruno, Antonio Giulio / Taglieri, Nevio / Ghetti, Gabriele / Marrozzini, Cinzia / Galiè, Nazzareno / Palmerini, Tullio / Saia, Francesco

    JACC. Cardiovascular interventions

    2021  Volume 14, Issue 19, Page(s) e271–e273

    MeSH term(s) Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Insufficiency/diagnostic imaging ; Aortic Valve Insufficiency/etiology ; Aortic Valve Insufficiency/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis ; Humans ; Prosthesis Design ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2021-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2021.08.010
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  7. Article ; Online: Coronary Stent Infection and Subsequent Abscessualization Causing Dislocation in Extravascular Position.

    Bendandi, Francesco / Bruno, Antonio Giulio / Donati, Francesco / Ciurlanti, Leonardo / Orzalkiewicz, Mateusz / Palmerini, Tullio / Marrozzini, Cinzia / Saia, Francesco / Galiè, Nazzareno / Martin Suarez, Sofia / Taglieri, Nevio / Ghetti, Gabriele

    JACC. Cardiovascular interventions

    2022  Volume 15, Issue 16, Page(s) e189–e191

    MeSH term(s) Coronary Artery Bypass ; Coronary Artery Disease ; Humans ; Percutaneous Coronary Intervention/adverse effects ; Stents ; Treatment Outcome
    Language English
    Publishing date 2022-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2022.05.048
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  8. Article ; Online: Predicting and improving outcomes of transcatheter aortic valve replacement in older adults and the elderly.

    Bruno, Antonio Giulio / Santona, Laura / Palmerini, Tullio / Taglieri, Nevio / Marrozzini, Cinzia / Ghetti, Gabriele / Orzalkiewicz, Mateusz / Galiè, Nazzareno / Saia, Francesco

    Expert review of cardiovascular therapy

    2020  Volume 18, Issue 10, Page(s) 663–680

    Abstract: Introduction: Indications for transcatheter aortic valve replacement (TAVR) are progressively extending to younger and lower risk patients. In this scenario, minimizing periprocedural complications and optimizing procedural result are both crucial to ... ...

    Abstract Introduction: Indications for transcatheter aortic valve replacement (TAVR) are progressively extending to younger and lower risk patients. In this scenario, minimizing periprocedural complications and optimizing procedural result are both crucial to achieve an excellent long-term outcome.
    Areas covered: In this review, we summarize the main strategies that can be adopted before, during, and after TAVR to predict and prevent complications, to optimize procedural results and ultimately improve outcomes, with an emphasis on more recent evidence, new devices, and new techniques.
    Expert opinion: In the next future TAVR will probably represent the first treatment option for patients affected by aortic valve stenosis who are candidates to receive a biological valve. Continuous refinement of TAVR devices has been key to allow safer and most effective procedures and further progress is expected. Development of new techniques and devices, such as ultrasound-guided puncture and intravascular lithotripsy, will expand safety and eligibility to transfemoral procedures. Effective preemptive measures for coronary occlusion have been developed. Open issues include cerebral protection, re-access to coronary arteries, post-procedural management, and therapy.
    MeSH term(s) Aged ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Coronary Occlusion/etiology ; Humans ; Risk Factors ; Transcatheter Aortic Valve Replacement/methods ; Treatment Outcome
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1080/14779072.2020.1778465
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  9. Article ; Online: Correlation between aortic root dimension and coronary ectasia.

    Ghetti, Gabriele / Taglieri, Nevio / Donati, Francesco / Minnucci, Matteo / Bruno, Antonio Giulio / Palmerini, Tullio / Saia, Francesco / Marrozzini, Cinzia / Galié, Nazzareno

    Coronary artery disease

    2020  Volume 32, Issue 4, Page(s) 335–339

    Abstract: Background: Aortic aneurysms are associated with coronary artery ectasia (CAE). However, the relation between the extent of CAE and the severity of aortic dilatation is not understood. This study was undertaken to investigate the relationship between ... ...

    Abstract Background: Aortic aneurysms are associated with coronary artery ectasia (CAE). However, the relation between the extent of CAE and the severity of aortic dilatation is not understood. This study was undertaken to investigate the relationship between angiographic extension of CAE and aortic dimension.
    Patients and methods: We retrospectively include 135 patients with angiographic diagnosis of CAE defined as dilatation of coronary segment more than 1.5 times than an adjacent healthy one. Study population was divided in four groups according to the maximum diameter of ascending aorta beyond sinus of Valsalva obtained in the parasternal long-axis view (group 1: <40 mm; group 2: 40-45 mm; group 3: 45-55 mm; group 4: >55 mm or previous surgery because of aortic aneurysm/dissection). The relationship between aortic dimension and the extension of CAE was investigated by means of multivariable linear regression, including variables selected at univariable analysis (P < 0.1). The total estimated ectatic area (EEA total) was used as dependent variable.
    Results: Baseline characteristics of study groups were well balanced. Patients in group 4 were more likely to have both higher neutrophil count and neutrophil to lymphocyte ratio. On univariable analysis ascending aorta diameter [Coef. = 0.075; 95% confidence interval (CI) 0.052-0.103, P < 0.01] and c-reactive protein (CRP) values [Coef. = 0.033, 95% CI 0.003-0.174, P = 0.04] showed a linear association with total EEA. After adjustment for CRP values only the ascending aorta diameter was still associated with the extent of CAE (95% CI 0.025-0.063, P < 0.01).
    Conclusion: In patients with diagnosis of CAE, a strong linear association between aortic dimension and coronary ectasia extent exists.
    MeSH term(s) Aged ; Aorta/diagnostic imaging ; C-Reactive Protein/analysis ; Coronary Angiography ; Coronary Vessels/diagnostic imaging ; Dilatation, Pathologic/diagnostic imaging ; Female ; Humans ; Lymphocyte Count ; Male ; Neutrophils/metabolism ; Retrospective Studies
    Chemical Substances C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2020-10-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1047268-x
    ISSN 1473-5830 ; 0954-6928
    ISSN (online) 1473-5830
    ISSN 0954-6928
    DOI 10.1097/MCA.0000000000000977
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  10. Article ; Online: Target Lesion Failure With Current Drug-Eluting Stents: Evidence From a Comprehensive Network Meta-Analysis.

    Taglieri, Nevio / Bruno, Antonio G / Ghetti, Gabriele / Marrozzini, Cinzia / Saia, Francesco / Galié, Nazzareno / Palmerini, Tullio

    JACC. Cardiovascular interventions

    2020  Volume 13, Issue 24, Page(s) 2868–2878

    Abstract: Objectives: The aim of this study was to investigate the efficacy and safety of currently used drug-eluting stents (DES).: Background: Head-to-head comparisons among newer DES have shown conflicting results.: Methods: For this network meta- ... ...

    Abstract Objectives: The aim of this study was to investigate the efficacy and safety of currently used drug-eluting stents (DES).
    Background: Head-to-head comparisons among newer DES have shown conflicting results.
    Methods: For this network meta-analysis, randomized controlled trials comparing different types of currently used DES were searched in PubMed, Scopus, and proceedings of international meetings. The primary endpoint was target lesion failure (TLF) at 1 year and at long-term follow-up.
    Results: Seventy-seven trials with 99,039 patients were selected for this network meta-analysis. Among the 10 DES included in the meta-analysis, 4 received the most extensive investigation: Orsiro, XIENCE, Nobori/BioMatrix, and Resolute. At 1 year, the Orsiro stent was associated with lower rates of TLF compared with XIENCE (odds ratio [OR]: 0.84; 95% confidence interval [CI]: 0.71 to 0.98; p = 0.03), Resolute (OR: 0.81; 95% CI: 0.68 to 0.95; p = 0.01), and Nobori/BioMatrix (OR: 0.81; 95% CI: 0.67 to 0.98; p = 0.03). Orsiro had the highest probability to be the best (70.8%), with a surface under the cumulative ranking curve value of 95.9%. However, after a median follow-up period of 50 months (range: 24 to 60 months), no significant difference was apparent in the rates of TLF between any DES, although Orsiro still ranked as the best stent (58.6% probability to be the best). In addition, Orsiro had a lower rate of long-term definite stent thrombosis compared with Nobori/BioMatrix (OR: 0.60; 95% CI: 0.36 to 0.98; p = 0.04) and lower rates of definite and probable stent thrombosis compared with Resolute (OR: 0.66; 95% CI: 0.45 to 0.99; p = 0.04). No differences in cardiac mortality between any DES were observed.
    Conclusions: Orsiro is associated with a lower 1-year rate of TLF compared with XIENCE, Resolute, and Nobori/BioMatrix but with an attenuation of the efficacy signal at long-term follow-up.
    MeSH term(s) Coronary Artery Disease ; Drug-Eluting Stents ; Humans ; Network Meta-Analysis ; Percutaneous Coronary Intervention ; Prosthesis Design ; Sirolimus ; Treatment Outcome
    Chemical Substances Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2020-12-23
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2020.09.014
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