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  1. Article ; Online: Carnoy solution versus GEWF solution for lymph node revealing in colorectal cancer: a randomized controlled trial.

    Ghezzi, Tiago L / Pereira, Márcia P / Corleta, Oly C / Kalil, Antonio N

    International journal of colorectal disease

    2019  Volume 34, Issue 12, Page(s) 2189–2193

    Abstract: Purpose: This study aimed to compare the performance of two lymph node revealing solutions.: Methods: This randomized clinical trial (NTC02704988) investigated patients with colon or rectal cancer who underwent surgical resection with D2 ... ...

    Abstract Purpose: This study aimed to compare the performance of two lymph node revealing solutions.
    Methods: This randomized clinical trial (NTC02704988) investigated patients with colon or rectal cancer who underwent surgical resection with D2 lymphadenectomy. Specimens submitted for conventional pathological examination were randomly assigned for additional fixation with Carnoy or GEWF solution, and dissection was performed to examine the missed lymph nodes. The number of lymph nodes retrieved, additional identified metastatic lymph nodes, lymph node upstaging, and complementary indication of adjuvant therapy were investigated.
    Results: The number of lymph nodes retrieved was significantly higher with the use of lymph node revealing solutions than with the conventional method in colon cancer (GEWF: 29.5 vs 27; p < 0.001; Carnoy: 27.7 vs 25.2; p < 0.001) and rectal cancer (GEWF: 25.8 vs 23.6; p < 0.001; Carnoy: 23.1 vs 20.8; p < 0.001). There were no differences between the solutions and conventional examination with respect to the median number of additional metastatic lymph nodes identified (0 in all arms), the number of patients with lymph node upstaging (colon cancer: 1 in the Carnoy arm, 0 in the GEWF arm; rectal cancer: 1 in the GEWF arm, 0 in the Carnoy arm), or the number of patients with complementary indication of adjuvant therapy (colon cancer: 1 in the Carnoy arm, 0 in the GEWF arm; rectal cancer: 0 in both arms).
    Conclusion: Despite the higher number of lymph nodes retrieved, neither solution resulted in significant changes in patient staging or treatment. Both solutions exhibited equal performance with respect to all outcomes.
    Trial registration: NTC02704988.
    MeSH term(s) Acetic Acid/chemistry ; Chemotherapy, Adjuvant ; Chloroform/chemistry ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Digestive System Surgical Procedures ; Ethanol/chemistry ; Female ; Fixatives/chemistry ; Formaldehyde/chemistry ; Humans ; Lymph Node Excision ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Staging ; Predictive Value of Tests ; Solutions/chemistry ; Tissue Fixation/methods ; Treatment Outcome
    Chemical Substances Carnoy's solution ; Fixatives ; Solutions ; gewf solution ; Formaldehyde (1HG84L3525) ; Ethanol (3K9958V90M) ; Chloroform (7V31YC746X) ; Acetic Acid (Q40Q9N063P)
    Language English
    Publishing date 2019-11-15
    Publishing country Germany
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-019-03437-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Young patients with benign anal diseases and rectal bleeding: should a colonoscopy be performed?

    Muller, Belisa G / Contu, Paulo C / Tarta, Cláudio / Lazzaron, Anderson R / Ghezzi, Tiago L / Damin, Daniel C

    International journal of colorectal disease

    2019  Volume 34, Issue 12, Page(s) 2069–2073

    Abstract: Background and aim: There is no consensus whether a colonoscopy should be recommended for patients under 50 years of age who present with both anal bleeding and benign anal diseases. The aim of this study is to evaluate the effectiveness of colonoscopy ... ...

    Abstract Background and aim: There is no consensus whether a colonoscopy should be recommended for patients under 50 years of age who present with both anal bleeding and benign anal diseases. The aim of this study is to evaluate the effectiveness of colonoscopy to detect neoplastic lesions in this specific group of patients.
    Methods: A prospective study analyzing the results of colonoscopies performed in patients younger than 50 years of age who reported a rectal bleeding and also had a diagnosis of benign anal disease at first clinical visit.
    Results: One hundred and eighty-seven consecutive patients were prospectively included in this study. In 35 patients (18.7%), adenomatous polyps were diagnosed. Thirty-seven percent of those lesions (13 cases) were further classified as either advanced adenomas or serrated adenomas. The prevalence of adenomas was 14.6% among patients under the age of 40 and 20% among those between 40 and 50 years of age. Thirty-one percent of the adenomas (11 cases) were located in the right colon, without any other concomitant lesion in the distal colon. In addition, an unsuspected case of sigmoid carcinoma was diagnosed.
    Conclusion: The performance of colonoscopy in young patients with benign anal diseases and hematochezia resulted in a high rate of detection of neoplastic lesions. The method might be considered as a valid strategy of investigation in this frequent clinical situation.
    MeSH term(s) Adenomatous Polyps/epidemiology ; Adenomatous Polyps/pathology ; Adult ; Age Factors ; Anus Diseases/epidemiology ; Anus Diseases/pathology ; Brazil/epidemiology ; Clinical Decision-Making ; Colonic Polyps/epidemiology ; Colonic Polyps/pathology ; Colonoscopy ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/pathology ; Female ; Gastrointestinal Hemorrhage/epidemiology ; Humans ; Male ; Middle Aged ; Patient Selection ; Predictive Value of Tests ; Prevalence ; Prospective Studies ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2019-11-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-019-03425-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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