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Article ; Online: In vivo sedative and muscle relaxants activity of Diospyros lotus L

Abdur Rauf / Ghias Uddin / Bina Shaheen Siddiqui / Haroon Khan

Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 4, Pp 277-

2015 Volume 280

Abstract: Objective: To evaluate the sedative effect of Diospyros lotus L (D. lotus) extract in mice using the open field and Rota rod tests. Methods: For the sedative and muscle relaxants activities of extract/fractions of the plant, in-vivo open field and ... ...

Abstract	Objective: To evaluate the sedative effect of Diospyros lotus L (D. lotus) extract in mice using the open field and Rota rod tests. Methods: For the sedative and muscle relaxants activities of extract/fractions of the plant, in-vivo open field and phenobarbitone-induced sleeping time were used, while the Roda rod test was employed in animals for the assessment of muscle relaxant activity. Results: Results from this investigation revealed that the extracts of D. lotus have exhibited significant sedative effect in mice (45.98%) at 100 mg/kg i.p. When the extract was partitioned with different solvents, the n-hexane fraction was inactive whereas the chloroform fraction was the most active with 82.67% sedative effect at 50 and 100 mg/kg i.p. On the other hand, the ethyl acetate and n-butanol fractions displayed significant sedative effects (55.65% and 40.87%, respectively) at 100 mg/kg i.p. Among the tested extract/fractions, only chloroform and ethyl acetate fractions showed significant (P < 0.05) muscle relaxant activity in the Rota rod test. Conclusions: In short, our study provided scientific background to the traditional uses of D. lotus as sedative.
Keywords	Diospyros lotus ; Ebenaceae ; Sedative ; Muscle relaxants activity ; Arctic medicine. Tropical medicine ; RC955-962 ; Biology (General) ; QH301-705.5
Subject code	630
Language	English
Publishing date	2015-04-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis, Bioactivity Assessment, and Molecular Docking of Non-sulfonamide Benzimidazole-Derived N‑Acylhydrazone Scaffolds as Carbonic Anhydrase-II Inhibitors

Muhammad Saadiq / Ghias Uddin / Abdul Latif / Mumtaz Ali / Nazia Akbar / Ammara / Sardar Ali / Manzoor Ahmad / Mohammad Zahoor / Ajmal Khan / Ahmed Al-Harrasi

ACS Omega, Vol 7, Iss 1, Pp 705-

2021 Volume 715

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
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Article ; Online: Predictive factors for increased aortic pulse wave velocity in renal transplant recipients and its relation to graft outcome

Muazam Ayub / Kifayat Ullah / Imtiaz Masroor / Ghias Uddin Butt

Saudi Journal of Kidney Diseases and Transplantation, Vol 26, Iss 6, Pp 1130-

2015 Volume 1134

Abstract: To evaluate aortic stiffness in renal transplant patients and to determine the correlation of renal insufficiency and estimated glomerular filtration rate (eGFR) with aortic pulse wave velocity (APWV), we studied 96 renal transplant patients followed-up ... ...

Abstract	To evaluate aortic stiffness in renal transplant patients and to determine the correlation of renal insufficiency and estimated glomerular filtration rate (eGFR) with aortic pulse wave velocity (APWV), we studied 96 renal transplant patients followed-up at our center. We measured the APWV using transcutaneous Doppler flow recordings and the foot-to-foot method, and calculated the eGFR using the Modification of Diet in Renal Disease equation. The study included 81 (84.4%) males and 15 (15.6%) females. The mean age of the patients was 37.84 ± 10.10 years. The mean duration of transplant was 47.90 ± 34.40 months. The eGFR of the patients ranged from 1 to 120 mL/min, with a mean GFR of 72.6 ± 23.2 mL/min. Sixty-seven (69.8%) patients had eGFR > 60 mL/min and hence had stages 1 and 2 chronic kidney disease (CKD), 27 (28.1%) patients had eGFR 30-60 mL/min and hence had stage 3 CKD and two (2.1%) patients had eGFR <30 mL/min and hence had stages 4 and 5 CKD. The APWV of the patients ranged from 4 to 14.2 m/s, with a mean of 7.49 ± 2.47 m/s. A significant inverse correlation was found between the APWV and eGFR (Pearson correlation coefficient, -0.427, P = 0.00). The mean APWV was significantly higher among patients with higher CKD stage, P = 0.004. We conclude that the APWV is related to the renal graft dysfunction as measured by eGFR. The poorer the renal function, the higher was the APWV. Determination of the APWV may be helpful in predicting the outcome in renal transplant recipients.
Keywords	Medicine ; R
Subject code	616
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Predictive factors for increased aortic pulse wave velocity in renal transplant recipients and its relation to graft outcome.

Ayub, Muazam / Ullah, Kifayat / Masroor, Imtiaz / Butt, Ghias Uddin

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

2015 Volume 26, Issue 6, Page(s) 1130–1134

Abstract	To evaluate aortic stiffness in renal transplant patients and to determine the correlation of renal insufficiency and estimated glomerular filtration rate (eGFR) with aortic pulse wave velocity (APWV), we studied 96 renal transplant patients followed-up at our center. We measured the APWV using transcutaneous Doppler flow recordings and the foot-to-foot method, and calculated the eGFR using the Modification of Diet in Renal Disease equation. The study included 81 (84.4%) males and 15 (15.6%) females. The mean age of the patients was 37.84 ± 10.10 years. The mean duration of transplant was 47.90 ± 34.40 months. The eGFR of the patients ranged from 1 to 120 mL/min, with a mean GFR of 72.6 ± 23.2 mL/min. Sixty-seven (69.8%) patients had eGFR > 60 mL/min and hence had stages 1 and 2 chronic kidney disease (CKD), 27 (28.1%) patients had eGFR 30-60 mL/min and hence had stage 3 CKD and two (2.1%) patients had eGFR <30 mL/min and hence had stages 4 and 5 CKD. The APWV of the patients ranged from 4 to 14.2 m/s, with a mean of 7.49 ± 2.47 m/s. A significant inverse correlation was found between the APWV and eGFR (Pearson correlation coefficient, -0.427, P = 0.00). The mean APWV was significantly higher among patients with higher CKD stage, P = 0.004. We conclude that the APWV is related to the renal graft dysfunction as measured by eGFR. The poorer the renal function, the higher was the APWV. Determination of the APWV may be helpful in predicting the outcome in renal transplant recipients.
MeSH term(s)	Adolescent ; Adult ; Female ; Glomerular Filtration Rate ; Humans ; Kidney Transplantation ; Male ; Middle Aged ; Postoperative Period ; Renal Insufficiency/physiopathology ; Vascular Stiffness/physiology ; Young Adult
Language	English
Publishing date	2015-11
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	1379955-1
ISSN	1319-2442
ISSN	1319-2442
DOI	10.4103/1319-2442.168581
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Article: Identification, Structure Elucidation, and Antioxidant Potential of a New Compound from Diospyros lotus

Rauf, Abdur / Bashir Ahmad / Ghias Uddin / Saud Bawazeer / Seema Patel / Taibi Ben Hadda / Tareq Abu-Izneid

Chemistry of natural compounds. 2017 Sept., v. 53, no. 5

2017

Abstract: A new dimeric naphthoquinone, named 5,8,5 â² -trihydroxy-8 â² -methoxy-6,6 â² -dimethyl-7,3-binaphthyl-1,4,1 â² ,4 â² -tetraone (1), was isolated from Diospyros lotus stem. The structure of the compound was elucidated by advance spectroscopic ... ...

Abstract	A new dimeric naphthoquinone, named 5,8,5 â² -trihydroxy-8 â² -methoxy-6,6 â² -dimethyl-7,3-binaphthyl-1,4,1 â² ,4 â² -tetraone (1), was isolated from Diospyros lotus stem. The structure of the compound was elucidated by advance spectroscopic analysis including 1D and 2D experiments such as HMBC, NOESY, and J-resolved (JRES). Compound 1 was assessed for antioxidant activity, which showed good activity even at low concentration.
Keywords	antioxidant activity ; Diospyros lotus ; spectral analysis ; stems
Language	English
Dates of publication	2017-09
Size	p. 849-851.
Publishing place	Springer US
Document type	Article
ZDB-ID	213866-9
ISSN	0009-3130
ISSN	0009-3130
DOI	10.1007/s10600-017-2138-5
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Antipyretic and antinociceptive activity of Diospyros lotus L. in animals

Abdur Rauf / Ghias Uddin / Bina S. Siddiqui / Naveed Muhammad / Haroon Khan

Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss S1, Pp S382-S

2014 Volume 386

Abstract: Objective: To evaluate pharmacologically the traditional use of Diospyros lotus as antipyretic and antinociceptive in various animal models. Methods: In vivo experimental models were used in this study. Antipyretic activity of extract/fractions was ... ...

Abstract	Objective: To evaluate pharmacologically the traditional use of Diospyros lotus as antipyretic and antinociceptive in various animal models. Methods: In vivo experimental models were used in this study. Antipyretic activity of extract/fractions was evaluated in brewer's yeast induced hyperthermic mice while antinociceptive activity was studied in acetic acid induced writhing test at 50 and 100 mg/kg i.p. Results: The crude extract strongly ameliorated the induced pyrexia during various assessment times. Upon fractionation, the antipyretic effects were strongly augmented by the chloroform and ethyl acetate fractions of the plant. However, hexane and butanol fractions were insignificant in their effect as antipyretic. The extract showed marked inhibition on the noxious simulation induced by post acetic acid injection. The effect was strongly supported by other fraction expect hexane. Conclusions: In short, our study scientifically validated the traditional use of the plant as antipyretic.
Keywords	Diospyros lotus ; Ebenaceae ; Antipyretic ; Antinociceptive activities ; Arctic medicine. Tropical medicine ; RC955-962 ; Biology (General) ; QH301-705.5
Subject code	630
Language	English
Publishing date	2014-05-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Isolation of a Novel Indigoferamide-A from Seeds of Indigofera Heterantha Wall and its Antibacterial Activity

Taj Ur Rahman / Mohammad Arfan / Wajiha Liaqat / Ghias Uddin / M. Iqbal Choudhary

Records of Natural Products, Vol 8, Iss 4, Pp 412-

2014 Volume 416

Abstract: A new indigoferamide-A (1) along with three new source compounds dotriacontanoic acid (2), quercetin (3) and formononetin “4-hydroxy-4-methyl-2-pentanone” (4) were isolated from the seeds of Indigofera heterantha Wall. The structures of all these ... ...

Abstract	A new indigoferamide-A (1) along with three new source compounds dotriacontanoic acid (2), quercetin (3) and formononetin “4-hydroxy-4-methyl-2-pentanone” (4) were isolated from the seeds of Indigofera heterantha Wall. The structures of all these compounds were determined by using mass spectrometry, 1D-and 2D NMR techniques. The structure of the new indigoferamide-A was established by methanolysis as well as by GC-MS analysis.
Keywords	Indigofera heterantha Wall seeds ; Indigoferamide-A ; antibacterial activity ; Chemistry ; QD1-999 ; Organic chemistry ; QD241-441 ; Botany ; QK1-989
Language	English
Publishing date	2014-07-01T00:00:00Z
Publisher	ACG Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Characterization and Isolation of a New Flavonoid from Viburnum grandiflorum

Ghias Uddin / Muhammad Alam / Bina S. Siddiqui / Nizam Uddin / Anwar Sadat / Ashfaq Ahmad Khan / Naveed Muhammad

Records of Natural Products, Vol 9, Iss 4, Pp 619-

2015 Volume 622

Abstract: In the present study a new flavoniod 1 along with Betulin 2 Betulinic acid 3, Oleanolic acid 4 andUrsolic acid 5 were isolated from the aerial part of Viburnum grandiflorum Wall. ex DC as white amorphous powder from the chloroform fraction. On the bases ... ...

Abstract	In the present study a new flavoniod 1 along with Betulin 2 Betulinic acid 3, Oleanolic acid 4 andUrsolic acid 5 were isolated from the aerial part of Viburnum grandiflorum Wall. ex DC as white amorphous powder from the chloroform fraction. On the bases of different modern spectroscopic techniques such as EIMS, UV, IR, NMR, HSQC, HMBC, COSY and NOESY the structure of compound 1 was elucidate as 6,7-bis (propenyloxy)-2-ethoxy-5-hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one (Grandinoid).
Keywords	Viburnum grandiflorum ; g randinoid ; Chemistry ; QD1-999 ; Organic chemistry ; QD241-441 ; Botany ; QK1-989
Language	English
Publishing date	2015-06-01T00:00:00Z
Publisher	ACG Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Urease inhibition potential of Di-naphthodiospyrol from Diospyros lotus roots

Rauf, Abdur / Ajmal Khan / Ghias Uddin / Mohammad S. Mubarak / Muslam Raza / Noor Jehan / Saud Bawazeer / Seema Patel / Taibi Ben Hadda / Yahia Nasser Mabkhot

Natural product research. 2017 May 19, v. 31, no. 10

2017

Abstract: The dimeric napthoquione 5,8,4â²-trihydroxy-1â²-methoxy-6, 6â²-dimethyl-7,3â²-binaphtyl-1,4,5â²,8â²-tetraone (1) was isolated from the chloroform fraction of Diospyros lotus extract . Compound 1 was screened for its inhibitory effects against four ... ...

Abstract	The dimeric napthoquione 5,8,4â²-trihydroxy-1â²-methoxy-6, 6â²-dimethyl-7,3â²-binaphtyl-1,4,5â²,8â²-tetraone (1) was isolated from the chloroform fraction of Diospyros lotus extract . Compound 1 was screened for its inhibitory effects against four enzymes: urease, phosphodiesterase-I, carbonic anhydrase-II and Î± -chymotrypsin, and showed selective activity against urease enzyme with an IC ââ value of 254.1Â Â±Â 3.82Â Î¼M as compared to the standard thiourea (IC ââÂ =Â 21Â Â±Â 0.11Â Î¼M). Furthermore, in silico docking study was carried out to explain the molecular mechanism of compound 1 against the target receptor.
Keywords	chloroform ; Diospyros lotus ; inhibitory concentration 50 ; molecular models ; phosphodiesterase I ; roots ; thiourea ; urease
Language	English
Dates of publication	2017-0519
Size	p. 1214-1218.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2016.1226832
Database	NAL-Catalogue (AGRICOLA)

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Article: Bioassay-guided isolation of novel and selective urease inhibitors from Diospyros lotus

Rauf, Abdur / Ajmal Khan / Bina S. Siddiqui / Farhan A. Khan / Ghias Uddin / Sher Bahadar Khan / Syed Majid Bukhari / Umar Farooq

Chinese journal of natural medicines. 2017 Nov., v. 15, no. 11

2017

Abstract: Two new dimeric naphthoquinones, 5′,8′-dihydroxy-6,6′-dimethyl-7,3′-binaphthyl-1,4,1′,4′-tetraone (1; Di-naphthodiospyrol D) and 5′,8′-dihydroxy-5,8-dimethoxy-6,6′-dimethyl-7,3′-binaphthyl-1,4,1′,4′-tetraone (2; Di-naphthodiospyrol E), along with known ... ...

Abstract	Two new dimeric naphthoquinones, 5′,8′-dihydroxy-6,6′-dimethyl-7,3′-binaphthyl-1,4,1′,4′-tetraone (1; Di-naphthodiospyrol D) and 5′,8′-dihydroxy-5,8-dimethoxy-6,6′-dimethyl-7,3′-binaphthyl-1,4,1′,4′-tetraone (2; Di-naphthodiospyrol E), along with known naphthoquinones diospyrin (3) and 8-hydroxy diospyrin (4) were isolated from the chloroform fraction of extract of Diospyros lotus roots. Their structures were elucidated by advanced spectroscopic analyses, including HSQC, HMBC, NOESY, and J-resolved NMR experiments. The fractions and compounds 1−4 were evaluated for urease activity and phosphodiesterase-I, carbonic anhydrase-II and α-chymotrypsin enzyme inhibitory activities. Compounds 1 and 2 and their corresponding fractions showed significant and selective inhibitory effects on urease activities. The IC50 values of 1 and 2 were 260.4 ± 6.37 and 381.4 ± 4.80 μmol·L−1, respectively, using thiourea (IC50 = 21 ± 0.11 μmol·L−1) as the standard inhibitor. This was the first report demonstrating that the naphthoquinones class showed urease inhibition.
Keywords	chloroform ; chymotrypsin ; Diospyros lotus ; enzyme activity ; enzyme inhibition ; inhibitory concentration 50 ; naphthoquinones ; nuclear magnetic resonance spectroscopy ; Oriental traditional medicine ; phosphodiesterase I ; roots ; spectral analysis ; thiourea ; urease ; urease inhibitors
Language	English
Dates of publication	2017-11
Size	p. 865-870.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(18)30021-9
Database	NAL-Catalogue (AGRICOLA)

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