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  1. Book ; Online: Manipulation of the cellular microbicidal response and endocytic dynamic by pathogens membrane factors

    Ghigo, Eric / Soubeyran, Philippe / Coiffard, Benjamin

    2015  

    Abstract: Intracellular pathogens, such as bacteria and parasites, have evolved specialized mechanisms to survive and replicate in their host, leading to disorders and diseases. The principle of these mechanisms is to reprogram the microbicidal cell function in ... ...

    Abstract Intracellular pathogens, such as bacteria and parasites, have evolved specialized mechanisms to survive and replicate in their host, leading to disorders and diseases. The principle of these mechanisms is to reprogram the microbicidal cell function in order to disable the host cells defence that aims to control and eliminate foreign invaders. Devoid of their defence, cells become permissive to pathogens invasion. The aim of this Research Topic is to highlight and cover recent understanding of mechanisms and molecules used by pathogens to interfere with the microbicidal function of cells. This Research Topic will focus on the reprogramming of the cellular dynamics, the immune response, the phagolysosome biogenesis and the signal transduction pathways bypathogens. Special attention will be made on non-proteic virulence factors, however this Research Topic is not restricted to non-proteic virulence factors
    Keywords Science (General) ; Infectious and parasitic diseases
    Size 1 electronic resource (81 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020091804
    ISBN 9782889196098 ; 2889196097
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Genomic evolution and adaptation of arthropod-associated Rickettsia.

    El Karkouri, Khalid / Ghigo, Eric / Raoult, Didier / Fournier, Pierre-Edouard

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 3807

    Abstract: Rickettsia species are endosymbionts hosted by arthropods and are known to cause mild to fatal diseases in humans. Here, we analyse the evolution and diversity of 34 Rickettsia species using a pangenomic meta-analysis (80 genomes/41 plasmids). ... ...

    Abstract Rickettsia species are endosymbionts hosted by arthropods and are known to cause mild to fatal diseases in humans. Here, we analyse the evolution and diversity of 34 Rickettsia species using a pangenomic meta-analysis (80 genomes/41 plasmids). Phylogenomic trees showed that Rickettsia spp. diverged into two Spotted Fever groups, a Typhus group, a Canadensis group and a Bellii group, and may have inherited their plasmids from an ancestral plasmid that persisted in some strains or may have been lost by others. The results suggested that the ancestors of Rickettsia spp. might have infected Acari and/or Insecta and probably diverged by persisting inside and/or switching hosts. Pangenomic analysis revealed that the Rickettsia genus evolved through a strong interplay between genome degradation/reduction and/or expansion leading to possible distinct adaptive trajectories. The genus mainly shared evolutionary relationships with α-proteobacteria, and also with γ/β/δ-proteobacteria, cytophagia, actinobacteria, cyanobacteria, chlamydiia and viruses, suggesting lateral exchanges of several critical genes. These evolutionary processes have probably been orchestrated by an abundance of mobile genetic elements, especially in the Spotted Fever and Bellii groups. In this study, we provided a global evolutionary genomic view of the intracellular Rickettsia that may help our understanding of their diversity, adaptation and fitness.
    MeSH term(s) Animals ; Arthropods/genetics ; Evolution, Molecular ; Gammaproteobacteria ; Genomics ; Phylogeny ; Rickettsia/genetics ; Spotted Fever Group Rickettsiosis
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-07725-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Role of the immune system in regeneration and its dynamic interplay with adult stem cells.

    Abnave, Prasad / Ghigo, Eric

    Seminars in cell & developmental biology

    2018  Volume 87, Page(s) 160–168

    Abstract: The immune system plays an indispensable role in the process of tissue regeneration following damage as well as during homeostasis. Inflammation and immune cell recruitment are signs of early onset injury. At the wound site, immune cells not only help to ...

    Abstract The immune system plays an indispensable role in the process of tissue regeneration following damage as well as during homeostasis. Inflammation and immune cell recruitment are signs of early onset injury. At the wound site, immune cells not only help to clear debris but also secrete numerous signalling molecules that induce appropriate cell proliferation and differentiation programmes essential for successful regeneration. However, the immune system does not always perform a complementary role in regeneration and several reports have suggested that increased inflammation can inhibit the regeneration process. Successful regeneration requires a balanced immune cell response, with the recruitment of accurately polarised immune cells in an appropriate quantity. The regulatory interactions of the immune system with regeneration are not unidirectional. Stem cells, as key players in regeneration, can also modulate the immune system in several ways to facilitate regeneration. In this review, we will focus on recent research demonstrating the key role of immune system in the regeneration process as well as the immunomodulatory effects of stem cells. Finally, we propose that research investigating the interplay between the immune system and stem cells within highly regenerating animals can benefit the identification of the key interactions and molecules required for successful regeneration.
    MeSH term(s) Adult Stem Cells/immunology ; Animals ; Humans ; Immune System/immunology ; Regeneration/immunology ; Regeneration/physiology
    Language English
    Publishing date 2018-04-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2018.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2918: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Chryseobacterium schmidteae sp. nov. a novel bacterial species isolated from planarian Schmidtea mediterranea.

    Kangale, Luis Johnson / Raoult, Didier / Ghigo, Eric / Fournier, Pierre-Edouard

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 11002

    Abstract: Marseille- ... ...

    Abstract Marseille-P9602
    MeSH term(s) Chryseobacterium ; Mediterranea ; Phylogeny ; RNA, Ribosomal, 16S
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-05-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-90562-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Publisher Correction: Chryseobacterium schmidteae sp. nov. a novel bacterial species isolated from planarian Schmidtea mediterranea.

    Kangale, Luis Johnson / Raoult, Didier / Ghigo, Eric / Fournier, Pierre-Edouard

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 17724

    Language English
    Publishing date 2021-08-31
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-97051-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Culturomics revealed the bacterial constituents of the microbiota of a 10-year-old laboratory culture of planarian species S. mediterranea.

    Kangale, Luis Johnson / Raoult, Didier / Fournier, Pierre-Edouard / Ghigo, Eric

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 24311

    Abstract: The planarian species Schmidtea mediterranea is a flatworm living in freshwater that is used in the research laboratory as a model to study developmental and regeneration mechanisms, as well as antibacterial mechanisms. However, the cultivable microbial ... ...

    Abstract The planarian species Schmidtea mediterranea is a flatworm living in freshwater that is used in the research laboratory as a model to study developmental and regeneration mechanisms, as well as antibacterial mechanisms. However, the cultivable microbial repertoire of the microbes comprising its microbiota remains unknown. Here, we characterized the bacterial constituents of a 10-year-old laboratory culture of planarian species S. mediterranea via culturomics analysis. We isolated 40 cultivable bacterial species, including 1 unidentifiable species. The predominant phylum is Proteobacteria, and the most common genus is Pseudomonas. We discovered that parts of the bacterial flora of the planarian S. mediterranea can be classified as fish pathogens and opportunistic human pathogens.
    MeSH term(s) Animals ; Bacteria/classification ; Bacteria/genetics ; Bacteria/growth & development ; Bacteria/isolation & purification ; Culture Techniques ; Laboratories/statistics & numerical data ; Microbiota ; Planarians/microbiology ; RNA, Ribosomal, 16S/genetics ; Regeneration ; Specimen Handling
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-12-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-03719-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A dilemma for viruses and giant viruses: which endocytic pathway to use to enter cells?

    Ghigo, Eric

    Intervirology

    2010  Volume 53, Issue 5, Page(s) 274–283

    Abstract: Viruses must enter host cells to deliver their genetic material and accessory proteins. Endocytosis offers to viruses the opportunity to enter host cells. However, endocytosis is a complex phenomenon that includes different mechanisms, clathrin-mediated ... ...

    Abstract Viruses must enter host cells to deliver their genetic material and accessory proteins. Endocytosis offers to viruses the opportunity to enter host cells. However, endocytosis is a complex phenomenon that includes different mechanisms, clathrin-mediated endocytosis, caveolin-mediated endocytosis, macropinocytosis, and phagocytosis. Here, I describe the ways used by different viruses to exploit these endocytic pathways.
    MeSH term(s) Endocytosis ; Models, Biological ; Virus Internalization ; Virus Physiological Phenomena
    Language English
    Publishing date 2010
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 184545-7
    ISSN 1423-0100 ; 0300-5526
    ISSN (online) 1423-0100
    ISSN 0300-5526
    DOI 10.1159/000312912
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1040: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Trained Immunity Carried by Non-immune Cells.

    Hamada, Attoumani / Torre, Cédric / Drancourt, Michel / Ghigo, Eric

    Frontiers in microbiology

    2019  Volume 9, Page(s) 3225

    Abstract: Trained immunity" is a term proposed by Netea to describe the ability of an organism to develop an exacerbated immunological response to protect against a second infection independent of the adaptative immunity. This immunological memory can last from 1 ...

    Abstract "Trained immunity" is a term proposed by Netea to describe the ability of an organism to develop an exacerbated immunological response to protect against a second infection independent of the adaptative immunity. This immunological memory can last from 1 week to several months and is only described in innate immune cells such as monocytes, macrophages, and natural killer cells. Paradoxically, the lifespan of these cells in the blood is shorter than the duration of trained immunity. This observation suggested that trained immunity could be carried by long lifespan cells such as stem cells and non-immune cells like fibroblasts. It is now evident that in addition to performing their putative function in the development and maintenance of tissue homeostasis, non-immune cells also play an important role in the response to pathogens by producing anti-microbial factors, with long-term inflammation suggesting that non-immune cells can be trained to confer long-lasting immunological memory. This review provides a summary of the current relevant knowledge about the cells which possess immunological memory and discusses the possibility that non-immune cells may carry immunological memory and mechanisms that might be involved.
    Language English
    Publishing date 2019-01-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2018.03225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Modèles alternatifs (6) - La planaire, un modèle animal original pour la toxicologie.

    Poirier, Laetitia / Ghigo, Éric / Daudé, David / Chabrière, Éric

    Medecine sciences : M/S

    2019  Volume 35, Issue 6-7, Page(s) 544–548

    Abstract: Since a few decades, a new invertebrate animal model has emerged in toxicology studies: the planarian. This non-parasitic flatworm, from phylum Platyhelminthes, has an amazing regenerative capacity and has been described as "immortal under the edge of ... ...

    Title translation Planarian, an emerging animal model for toxicology studies.
    Abstract Since a few decades, a new invertebrate animal model has emerged in toxicology studies: the planarian. This non-parasitic flatworm, from phylum Platyhelminthes, has an amazing regenerative capacity and has been described as "immortal under the edge of the knife" in 1814 by Dalyell. This formidable capacity is due to the abundance of stem cells called neoblasts, allowing for a tiny fragment equivalent to 1/279
    MeSH term(s) Animals ; Disease Models, Animal ; Insecticides/toxicity ; Metals/toxicity ; Models, Animal ; Neurotoxicity Syndromes/pathology ; Organometallic Compounds/toxicity ; Planarians/physiology ; Toxicity Tests/methods ; Toxicity Tests/trends ; Toxicology/methods ; Toxicology/trends
    Chemical Substances Insecticides ; Metals ; Organometallic Compounds
    Language French
    Publishing date 2019-07-05
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2019110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2872: Show issues Location:
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  10. Article ; Online: Pedobacter schmidteae sp. nov., a new bacterium isolated from the microbiota of the planarian Schmidtea mediterranea.

    Kangale, Luis Johnson / Raoult, Didier / Ghigo, Eric / Fournier, Pierre-Edouard

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 6113

    Abstract: Pedobacter schmidteae sp. nov. strain ... ...

    Abstract Pedobacter schmidteae sp. nov. strain EG
    MeSH term(s) Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Catalase/genetics ; Catalase/metabolism ; Genome, Bacterial ; Microbiota ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Pedobacter/genetics ; Pedobacter/metabolism ; Pedobacter/pathogenicity ; Planarians/microbiology ; RNA, Ribosomal, 16S/genetics ; Sequence Homology
    Chemical Substances Bacterial Proteins ; RNA, Ribosomal, 16S ; Oxidoreductases (EC 1.-) ; Catalase (EC 1.11.1.6)
    Language English
    Publishing date 2020-04-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-62985-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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