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  1. Book ; Online ; E-Book: Plasma cell dyscrasias

    Roccaro, Aldo M. / Ghobrial, Irene M.

    (Cancer treatment and research)

    2017  

    Author's details Aldo M. Roccaro, Irene M. Ghobrial editors
    Series title Cancer treatment and research
    Keywords Bone marrow microenvironment ; Genetics ; Multiple Myeloma ; Plasma cell dyscrasias ; Therapies
    Language English
    Size 1 Online-Ressource (vi, 361 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019381187
    ISBN 978-3-319-40320-5 ; 9783319403182 ; 3-319-40320-6 ; 3319403184
    DOI 10.1007/978-3-319-40320-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Early Detection of Precursor Diseases of Multiple Myeloma.

    O'Donnell, Elizabeth K / Borden, Brittany A / Ghobrial, Irene M

    Hematology/oncology clinics of North America

    2024  

    Abstract: Precursor diseases of multiple myeloma (MM) are monoclonal gammopathy of uncertain significance and smoldering MM. While it is well known that a percentage of those affected by these conditions will progress to MM, it is difficult to predict who will ... ...

    Abstract Precursor diseases of multiple myeloma (MM) are monoclonal gammopathy of uncertain significance and smoldering MM. While it is well known that a percentage of those affected by these conditions will progress to MM, it is difficult to predict who will progress and when, and guidelines for screening for these conditions are lacking. Moreover, there are various models for risk stratification, though there are ongoing efforts to improve these models in order to predict who may benefit from treatment. Finally, there are various clinical trials, both past and ongoing, expanding the scope of possible treatment options for precursor diseases.
    Language English
    Publishing date 2024-05-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2024.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Monoclonal B-cell lymphocytosis, monoclonal gammopathy of undetermined significance, and T-cell clones of uncertain significance: are these premalignant conditions sharing a common identity?

    Semenzato, Gianpietro / Ghobrial, Irene M / Ghia, Paolo

    The Lancet. Haematology

    2023  Volume 10, Issue 7, Page(s) e549–e556

    Abstract: Monoclonal B-cell lymphocytosis, monoclonal gammopathy of undetermined significance, and T-cell clones of uncertain significance are three premalignant conditions characterised by the presence of small clonal cell expansions in individuals without ... ...

    Abstract Monoclonal B-cell lymphocytosis, monoclonal gammopathy of undetermined significance, and T-cell clones of uncertain significance are three premalignant conditions characterised by the presence of small clonal cell expansions in individuals without symptoms or signs that distinguish the related overt malignancies (chronic lymphocytic leukaemia, multiple myeloma, and T-cell large granular lymphocytic leukaemia). As most individuals with these precursor states never progress to malignancies, considerable interest has arisen in comprehending the steps involved in the progression to malignancy, providing more accurate models to investigate potential mechanisms of early blood cancer identification, prevention, and, possibly, intervention. Single-cell technologies and recent progress in high-throughput sequencing and multiomics approaches have contributed to a better definition of the pathophysiological mechanisms of these premalignant conditions, moving our knowledge in the field forward. In this Viewpoint, we analyse the seemingly shared biological trajectories in these precursor haematological malignancies in search of common pathogenetic events. In particular, we address the issue of interactions between expanding clones and their immune ecosystem, offering new clues that might prompt innovative ideas and inspire further investigations to understand the cellular and molecular dynamics entailing progression into overt malignant disease. The relationships between the non-leukaemic microenvironmental cells and the leukaemic counterpart, and the primary drivers of their initial clonal expansion, represent shared biologies that suggest a common identity among the premalignant conditions considered in this Viewpoint.
    MeSH term(s) Humans ; Monoclonal Gammopathy of Undetermined Significance ; Lymphocytosis ; Ecosystem ; T-Lymphocytes ; Precancerous Conditions/pathology ; Multiple Myeloma/diagnosis ; Hematologic Neoplasms
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(23)00086-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Bortezomib in the treatment of multiple myeloma

    Ghobrial, Irene M. / Richardson, Paul G. / Anderson, Kenneth C.

    (Milestones in drug therapy)

    2011  

    Author's details Irene M. Ghobrial ; Paul G. Richardson ; Kenneth C. Anderson, ed
    Series title Milestones in drug therapy
    Language English
    Size VIII, 179 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Basel
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT016593132
    ISBN 978-3-7643-8947-5 ; 3-7643-8947-8 ; 9783764389482 ; 3764389486
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 5809 order for loan Magazin

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  5. Article ; Online: Clinical Controversies in the Management of Smoldering Multiple Myeloma.

    Lomas, Oliver C / Ghobrial, Irene M

    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

    2020  Volume 40, Page(s) 1–6

    Abstract: Forty years ago this year, smoldering multiple myeloma was defined as a clinical entity that identifies a group of patients with a substantial burden of disease but with a relatively indolent natural history compared with symptomatic disease. Since then, ...

    Abstract Forty years ago this year, smoldering multiple myeloma was defined as a clinical entity that identifies a group of patients with a substantial burden of disease but with a relatively indolent natural history compared with symptomatic disease. Since then, there has been a revolution in the therapeutic options for multiple myeloma. The aim of this article is to describe recent advances in the identification of those patients who are at the highest risk of progression and whether they may benefit from therapy. Treatment of smoldering myeloma is an area of active debate and we present contrasting interpretations of the available trial data. We conclude by identifying the priorities for research that will help to clarify the management of this condition, which can be challenging for physicians and patients alike.
    MeSH term(s) Humans ; Smoldering Multiple Myeloma/therapy
    Language English
    Publishing date 2020-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2431126-1
    ISSN 1548-8756 ; 1548-8748
    ISSN (online) 1548-8756
    ISSN 1548-8748
    DOI 10.1200/EDBK_278911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intensification and consolidation therapy in multiple myeloma in the current era.

    Nadeem, Omar / Ghobrial, Irene M

    The Lancet. Haematology

    2020  Volume 7, Issue 6, Page(s) e427–e429

    MeSH term(s) Bortezomib ; Consolidation Chemotherapy ; Humans ; Lenalidomide ; Multiple Myeloma
    Chemical Substances Bortezomib (69G8BD63PP) ; Lenalidomide (F0P408N6V4)
    Language English
    Publishing date 2020-04-30
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(20)30110-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Immunotherapy for hematological malignancies.

    Dong, Shuai / Ghobrial, Irene M

    Journal of life sciences (Westlake Village, Calif.)

    2019  Volume 1, Issue 1, Page(s) 46–52

    Abstract: Tumor immune tolerance remains a major barrier for effective anti-cancer therapy. A growing number of pathways whereby solid tumors escape immune surveillance have been characterized (1). This progress led us to revisit the "hallmarks of cancer" and ... ...

    Abstract Tumor immune tolerance remains a major barrier for effective anti-cancer therapy. A growing number of pathways whereby solid tumors escape immune surveillance have been characterized (1). This progress led us to revisit the "hallmarks of cancer" and brought forward many promising immunotherapies. Every growing bodies of research have brought forward many exciting treatment strategies for hematological cancers like chimeric antigen receptor T cells (CAR-T cells) and immune checkpoint inhibitors. Given the distinct characteristics of the different cancers, some benefited profoundly from such therapies while some remain challenging for scientists and physicians. Here, we discuss the unique aspect of hematological malignancies, and briefly review the history, existing and future of immunotherapies for this group of cancer.
    Language English
    Publishing date 2019-08-21
    Publishing country United States
    Document type Journal Article
    ISSN 2688-1020
    ISSN (online) 2688-1020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Autologous graft versus myeloma: it's not a myth.

    Dong, Shuai / Ghobrial, Irene M

    The Journal of clinical investigation

    2018  Volume 129, Issue 1, Page(s) 48–50

    Abstract: Graft-versus-tumor (GVT) effects have been thought to mostly result from allogeneic transplants; however, there is a growing body of research that supports a possible autologous GVT effect. In early clinical studies, a positive correlation between ... ...

    Abstract Graft-versus-tumor (GVT) effects have been thought to mostly result from allogeneic transplants; however, there is a growing body of research that supports a possible autologous GVT effect. In early clinical studies, a positive correlation between lymphocyte count recovery after autologous transplantation and overall survival has been observed. However, mechanistic studies to identify the mediators of autologous GVT responses have been lacking. In this issue of the JCI, Vuckovic et al. observed a T cell-dependent autologous GVT effect in the Vk*MYC myeloma model. Moreover, the authors showed that CD8+ T cells mediate myeloma control through IFN-γ secretion, which could be further augmented with a CD137 agonist, suggesting a therapeutic approach for enhancing autologous GVT.
    MeSH term(s) Animals ; Bone Marrow Transplantation ; Graft vs Host Disease ; Graft vs Tumor Effect ; Hematopoietic Stem Cell Transplantation ; Mice ; Multiple Myeloma ; Transplantation, Autologous
    Language English
    Publishing date 2018-11-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI125431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Update on Waldenström's macroglobulinemia.

    Ghobrial, Irene M

    Clinical advances in hematology & oncology : H&O

    2013  Volume 11, Issue 4, Page(s) 244–246

    MeSH term(s) Humans ; Waldenstrom Macroglobulinemia/diagnosis ; Waldenstrom Macroglobulinemia/drug therapy ; Waldenstrom Macroglobulinemia/etiology
    Language English
    Publishing date 2013-04
    Publishing country United States
    Document type Interview
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Choice of therapy for patients with Waldenstrom macroglobulinemia.

    Ghobrial, Irene M

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2013  Volume 31, Issue 3, Page(s) 291–293

    MeSH term(s) Clinical Trials as Topic ; Humans ; Waldenstrom Macroglobulinemia/drug therapy
    Language English
    Publishing date 2013-01-20
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2012.46.6177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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