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Article ; Online: Teleexercise for geriatric patients with failed back surgery syndrome

Reza Alizadeh / Albert Thomas Anastasio / Ardalan Shariat / Mikhail Bethell / Gholamreza Hassanzadeh

Frontiers in Public Health, Vol

2023 Volume 11

Abstract: IntroductionFailed back surgery syndrome (FBSS) is defined as back pain which either persists after attempted surgical intervention or originates after a spine surgery. There is a high risk of perioperative morbidity and a high likelihood of extensive ... ...

Abstract	IntroductionFailed back surgery syndrome (FBSS) is defined as back pain which either persists after attempted surgical intervention or originates after a spine surgery. There is a high risk of perioperative morbidity and a high likelihood of extensive revision surgery in geriatric patients with FBSS or post-laminectomy foraminal stenosis.MethodsThere is a need for less invasive methodologies for the treatment of FBSS, such as patient-tailored exercise training, with attention to the cost and special needs of the geriatric patients with FBSS. This commentary will provide some background regarding teleexercise (utilizing an internet-based platform for the provision of exercise-related care) for FBSS and will propose three exercises which are easy to administer over online-based platforms and can be the subject of future investigation.ResultsGiven the documented benefits of regular rehabilitative exercises for patients with FBSS, the high cost of face-to-face services, and the need for infection mitigation in the wake of the COVID-19 Pandemic, teleexercise may be a practical and cost-beneficial method of exercise delivery, especially for geriatric patients with limitations in mobility and access to care. It should be noted that, prescription of these exercises should be done after face-to-face evaluation by the physician and careful evaluation for any “red flag” symptoms.ConclusionIn this commentary, we will suggest three practical exercise training methodologies and discuss the benefits of teleexercise for geriatric patients with FBSS. Future research should aim to assess the efficacy of these exercises, especially when administered through telehealth platforms.
Keywords	geriatric ; failed back surgery syndrome ; teleexercise ; low back pain ; occupational therapy ; Public aspects of medicine ; RA1-1270
Subject code	796
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correlation of Horizontal Cephalic Index and Cranial Parameters in Iranian Medical Students

Soheila Madadi / Maryam Khanehzad / Fatemeh Tahmasebi / Kyei Gordon / Gholamreza Hassanzadeh

Acta Medica Iranica, Vol 56, Iss

2018 Volume 9

Abstract: Cranial parameters and cephalic indices are used to evaluate the racial and gender differences. The aim of this study was to assess the cephalic indices, to classify the type of cranium and to determine the relationship between the horizontal cephalic ... ...

Abstract	Cranial parameters and cephalic indices are used to evaluate the racial and gender differences. The aim of this study was to assess the cephalic indices, to classify the type of cranium and to determine the relationship between the horizontal cephalic index and cranial parameters among Iranian medical students. This study was done on 200 medical students (100 males and 100 females) with an age range of 18-30-year-old. Head length, head breadth, and auricular height were measured by using a standard spreading caliper. Then cephalic indices were calculated for the classification of cranial type. The linear regression was used for examining the relationship between the horizontal cephalic index and head length, head breadth and auricular height. The results of this study showed that the mean of the horizontal, vertical, and transverse cephalic index in total students were 83.51±6.85, 85.58±5.85 and 102.77±6.35 cm, respectively. According to this result, the predominant head shapes in total students were brachycephalic, hypsicephalic and acrocephalic types. In this study, there was a strongly negative correlation between horizontal cephalic index with head length (r=-0.744, P=0.000), moderate positive correlation between horizontal cephalic index with head breadth (r=0.512, P=0.000) and weakly negative correlation between horizontal cephalic index with auricular height (r=-0.205, P=0.004). The data of the present study can be beneficial in craniofacial reconstruction, clinical diagnosis, and forensic applications.
Keywords	Head length ; Head breadth ; Auricular height ; Cephalic indices ; Medicine (General) ; R5-920
Subject code	001
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Teaching professionalism in cadaver dissection

Mahboobeh Khabaz Mafinejad / Mohammad Taherahmadi / Fariba Asghari / Kobra Mehran Nia / Saeeid Reza Mehrpour / Gholamreza Hassanzadeh / Parisa Farahani / Reza Hosseini Dolama

Journal of Medical Ethics and History of Medicine, Vol

medical students' perspective

2021 Volume 14

Abstract: This study was designed to facilitate freshman medical students’ adaptation to the dissection room and familiarize them with the related ethical codes. Single-group post-test design research was conducted at Tehran University of Medical Sciences in 2018 - ...

Abstract	This study was designed to facilitate freshman medical students’ adaptation to the dissection room and familiarize them with the related ethical codes. Single-group post-test design research was conducted at Tehran University of Medical Sciences in 2018 - 2019. The program began with a brief explanation of the necessity of the subject, and after a documentary film was shown, the principles of professional and ethical behaviors in the dissection room were discussed by a panel of experts. In the end, a valid and reliable evaluation questionnaire (Cronbach's alpha coefficient = 0.89) was distributed among the students. A total of 129 questionnaires were completed and returned. Overall, 94.4% of the students believed that the program provided an excellent opportunity to reflect on professional behaviors during practical anatomy sessions. In addition, 92.8% of the students believed that they would use the ethical points mentioned in the program in the future. Content analysis of the open questions produced three main categories: "motivating learning", "application of theory in practice" and "changing the attitude toward responsibility". The results indicate that adequate preparation for cadaver dissection sessions and learning about professional behavior codes in the first exposure can help medical students to better understand the principles of professional behaviors.
Keywords	Anatomy ; Ethical Codes ; Professionalism ; Cadaver ; Dissection ; History of medicine. Medical expeditions ; R131-687 ; Medical philosophy. Medical ethics ; R723-726
Subject code	170
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Differential expression of gluconeogenic enzymes in early- and late-stage diabetes

Arezoo Afshari / Fouzieh Salimi / Azin Nowrouzi / Masoumeh Babaie Khalili / Salar Bakhtiyari / Gholamreza Hassanzadeh / Maryam Shabani / Ali Ahadi / Masoumeh Farhadiannezhad

Clinical Phytoscience, Vol 7, Iss 1, Pp 1-

the effect of Citrullus colocynthis (L.) Schrad. Seed extract on hyperglycemia and hyperlipidemia in Wistar-Albino rats model

2021 Volume 22

Abstract: Abstract Background The medicinal plant Citrullus colocynthis (L.) Schrad. (C. colocynthis) may benefit patients at different phases of diabetes by attuning to contrasting situations. Our primary objective was to find the mechanism(s) behind the ... ...

Abstract	Abstract Background The medicinal plant Citrullus colocynthis (L.) Schrad. (C. colocynthis) may benefit patients at different phases of diabetes by attuning to contrasting situations. Our primary objective was to find the mechanism(s) behind the antidiabetic/anti-hyperlipidemic effects of C . c olocynthis seed aqueous extract (CCAE) in two different stages of type 2 diabetes (T2D) in rats. Methods Fasting blood sugar (FBS) levels, body weights, and the degree of impaired glucose tolerance (IGT) were measured in healthy nondiabetic control rats (Con), as well as rats with early and late stages of T2D, denoted as ET2D and LT2D, respectively. CCAE was intraperitoneally (IP) injected for 28 days. In the end, the hepatic mRNA expression levels of the following genes were determined by RT-PCR: glucose-6-phosphatase (G6Pase), phosphoenolpyruvate carboxykinase (PEPCK), insulin-dependent sterol regulatory element-binding protein-1c (SREBP-1c), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), peroxisome proliferator-activated receptor alpha (PPARα), and carnitine palmitoyltransferase I (CPT1). The liver was examined by hematoxylin and eosin (H&E) and Oil-Red O staining. CCAE was partially analyzed by HPLC-DAD. Results ET2D and LT2D were characterized by differentially elevated FBS, deteriorated bodyweight, and significant IGT compared to Con. Hepatosteatoses of varying morphologies and higher hepatic expression of G6Pase than PRPCK in ET2D versus the opposite in LT2D further confirmed the divergent nature of metabolic aberrations. At the end of 28 days, the high levels of FBS, alkaline phosphatase (ALP), triglyceride (TG), urea, hepatic protein carbonyl content (PCC), and alanine and aspartate aminotransferases (AST and ALT, respectively) persisted in untreated LT2D. CCAE ameliorated oxidative stress and upregulated PPARα expression in diabetic groups and Con; it downregulated CPT1 expression in the LT2D group. CCAE’s ability to lower FBS and serum and hepatic TG in both ET2D and LT2D indicated its ability to ...
Keywords	Citrullus colocynthis (L.) Schrad ; Early- and late-stage diabetes mellitus ; Hyperglycemia ; Hyperlipidemia ; Gluconeogenesis ; Wistar-albino rats ; Medicine ; R ; Homeopathy ; RX1-681
Subject code	571
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Radioprotective Effect of Combination of Melatonin and Metformin on Rat Duodenum Damage Induced by Ionizing Radiation

Masoud Najafi / Mohsen Cheki / Gholamreza Hassanzadeh / Peyman Amini / Dheyauldeen Shabeeb / Ahmed Eleojo Musa

Advanced Biomedical Research, Vol 8, Iss 1, Pp 51-

A Histological Study

2019 Volume 51

Abstract: Background: Radiation toxicity is one of the major concerns for patients with gastrointestinal cancers that undergo radiotherapy. Duodenum is one of the most radiosensitive parts of gastrointestinal system that may be exposed to a high dose of radiation ... ...

Abstract	Background: Radiation toxicity is one of the major concerns for patients with gastrointestinal cancers that undergo radiotherapy. Duodenum is one of the most radiosensitive parts of gastrointestinal system that may be exposed to a high dose of radiation during radiotherapy for some cancers. The development or identification of appropriate radioprotectors with less toxicity is an interesting aim in radiobiology for clinical radiotherapy applications. In the present study, we aimed to evaluate the radioprotective effect of melatonin and metformin combination in rat's duodenum. In addition, we compared our results with the radioprotective effect of melatonin, when administered alone. Materials and Methods: Thirty male rats were divided into six groups: control, melatonin treatment, melatonin plus metformin treatment, whole-body irradiation, irradiation with melatonin treatment, and irradiation with melatonin plus metformin treatment. Irradiation was performed with 10 Gy cobalt-60 gamma rays, while 100 mg/kg of melatonin and metformin were administered 24 h before to 72 h after irradiation. After 3.5 days, their duodenum tissues were removed for histopathological evaluation. Results: Irradiation of rats led to mild-to-moderate mucositis signs, infiltration of inflammatory cells, necrosis, and damage to Brunner's glands and reduction of goblet cells. Melatonin was able to alleviate these damages, while melatonin plus metformin could reduce some radiation toxicity signs. Conclusion: Administration of melatonin plus metformin could reduce mucositis in duodenum. However, the administration of melatonin is more effective for mitigation of duodenal injury compared with melatonin plus metformin.
Keywords	Duodenum ; melatonin ; metformin ; radiation ; radioprotection ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Associated functional motor recovery induced by Intracerebroventricular (ICV) microinjection of Wharton’s jelly mesenchymal stem cells following brain ischemia/reperfusion injury in rat

Tahereh Alizamir / Mohammad Akbari / Tahmineh Mokhtari / Mojtaba khaksarian / Gholamreza Hassanzadeh

Journal of Contemporary Medical Sciences, Vol 3, Iss

Decreased dark neurons and Bax gene expression in the cerebral corte

2017 Volume 12

Abstract: Objectives Stroke is a situation caused activation of some events leading to neuronal damage and death. The proteins of Bcl-2-family are important in regulation of cell death and life. Bax, as a Bcl-2-interacting protein, is a member of this family which ...

Abstract	Objectives Stroke is a situation caused activation of some events leading to neuronal damage and death. The proteins of Bcl-2-family are important in regulation of cell death and life. Bax, as a Bcl-2-interacting protein, is a member of this family which promotes apoptosis and cell death. Some therapeutic approaches have been introduced for the treatment of ischemic brain injury. Neuroprotection is one of the approaches for diminishing neurological deficits. We investigated the effects of intracerebroventricular (ICV) injection of Wharton’s jelly mesenchymal stem cells (WJ-MSCs) on the cortex of the brain in ischemic rats. Methods In this study, we occlude the middle cerebral artery (MCA) for induction of ischemic stroke in the brain. Rats were classified in four groups of Co, Sh, MCAo and MCAo + WJ-MSCs. Single dose of intraventricular microinjection of WJ-MSCs was injected by a Hamilton syringe. For detecting behavioral outcomes in the rats, Neurological examination was carried out. After 21 days, the animals were sacrificed and their brain tissues were removed for histopathological and molecular analysis. Results ICV microinjection of WJ-MSCs significantly prevented apoptosis and cell death compared with MCAo group. A significant reduction in the level of Bax gene expression was observed in the MCAo + WJ-MSCs as group compared with Co, Sh and MCAo groups (P < 0.05). H&E staining showed considerable reduction of dark neurons in MCAo + WJ-MSCs group rather than Co, Sh and MCAo groups (P < 0.05). Conclusions The results of the current study suggest that ICV microinjection of WJ-MSCs had neuroprotective effects on the brain cortex of ischemic rats by reduction of the Bax gene expression level and the number of dark neurons. Keywords Wharton’s jelly mesenchymal stem cells, Bax, dark neurons, cortex, stroke
Keywords	Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	Nab'a Al-Hayat Foundation for Medical Sciences and Health Care - Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Anti-oxidative and neuroprotective effects of flaxseed on experimental unilateral spinal cord injury in rat

Morteza Gholaminejhad / Somayeh Arabzadeh / Mohammad Akbari / Yousef Mohamadi / Gholamreza Hassanzadeh

Journal of Contemporary Medical Sciences, Vol 3, Iss 10, Pp 213-

2017 Volume 217

Abstract: Objectives Investigation of anti-oxidative and neuroprotective effects of flaxseed on rats with unilateral SCI. Methods 30 male Wistar rats were randomly assigned to five groups: control (Ctrl), laminectomy, flaxseed, spinal cord injured (SCI) and SCI + ... ...

Abstract	Objectives Investigation of anti-oxidative and neuroprotective effects of flaxseed on rats with unilateral SCI. Methods 30 male Wistar rats were randomly assigned to five groups: control (Ctrl), laminectomy, flaxseed, spinal cord injured (SCI) and SCI + flaxseed (treatment) groups. SCI model was induced by placing a 50 g weight for 5 min on to a 2.2 mm × 2.5 mm platform applied to the dura at vertebral level T10. After 4 weeks, the blood of rats in different groups was collected and the influence of flaxseed on antioxidant enzymes and oxidative stress marker level, histologic alterations and locomotion score were assessed. Results Our results showed that in the SCI group, the mean level of Superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were significantly decreased (P < 0.01), whereas the mean malondialdehyde (MDA) content was significantly increased (P < 0.001) in comparison to the laminectomy group. Furthermore, the mean levels of SOD, GPx and CAT in the treatment group was higher than the SCI group (P < 0.001), while, the mean MDA content in the treatment group was significantly less than the SCI group (P < 0.001). In addition, comparison between SCI and treatment groups determined a significant decrease in tissue degeneration and volume of cavities in the treatment group. However, Basso, Beattie and Bresnahan (BBB) scores were significantly increased in flaxseed-treated rats on days 14 (P < 0.05), 21 and 28 (P < 0.01) after surgery compared with the SCI group. Conclusions Our study for the first time showed the anti-oxidative and neuroprotective effects of flaxseed on experimental unilateral spinal cord injury in rat. Keywords spinal cord injury, flaxseed, oxidative stress, neuroprotective, anti-oxidative
Keywords	Medicine (General) ; R5-920
Subject code	630
Language	English
Publishing date	2017-06-01T00:00:00Z
Publisher	Nab'a Al-Hayat Foundation for Medical Sciences and Health Care - Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The effects of maternal separation stress experienced by parents on male reproductive potential in the next generation

Kajal Khodamoradi / Zahra Khosravizadeh / Hossein Amini-Khoei / Seyed Reza Hosseini / Ahmad Reza Dehpour / Gholamreza Hassanzadeh

Heliyon, Vol 6, Iss 9, Pp e04807- (2020)

2020

Abstract: There is little information available about the effects of early-life parental stress on the reproductive potential of the next generation. The aim of this study is to examine the reproductive potential of male mice whose parents experienced maternal ... ...

Abstract	There is little information available about the effects of early-life parental stress on the reproductive potential of the next generation. The aim of this study is to examine the reproductive potential of male mice whose parents experienced maternal separation stress. In the present study, male first-generation offspring from parents were undergone of maternal separation (MS) were examined. Sperm characteristics, histological changes in testis, reactive oxygen species (ROS) production, expression of apoptotic and inflammatory genes and proteins were assessed. Findings showed that MS experienced by parents significantly decreased the morphology and viability of spermatozoa. Furthermore, significant changes in testicular tissue histology were observed. Increased production of ROS, decreased glutathione peroxidase (GPX) and adenosine triphosphate (ATP) concentrations, and affected the expression of genes and cytokines involved in inflammation. Finally, the mean percentage of caspase-1 and NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) positive cells was significantly higher in first-generation group. MS experienced by parents may negatively affect the reproduction of first generation offspring.
Keywords	Cell biology ; Immunology ; Biochemistry ; Molecular biology ; Developmental biology ; Pathophysiology ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	580
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Wharton’ jelly mesenchymal stem cells and insulin effect on BDNF expression in CA1 and CA3 regions of rats’ hippocampus after chronic hypoxia

Simin Mahakizadeh / Mohammad Akbari / Mohammad Sharifzadeh / Tayebeh Rastegar / Farid Abolhassani / Gholamreza Hassanzadeh

Journal of Contemporary Medical Sciences, Vol 4, Iss 2, Pp 63-

2018 Volume 69

Abstract: Objectives Brain is vulnerable to deprivation of oxygen supply during hypoxia, and therefore undergoes neurodegeneration and cognitive dysfunction. Regarded to Regenerative capacities of Wharton’s jelly mesenchymal stem cells (MSCs) and insulin at the ... ...

Abstract	Objectives Brain is vulnerable to deprivation of oxygen supply during hypoxia, and therefore undergoes neurodegeneration and cognitive dysfunction. Regarded to Regenerative capacities of Wharton’s jelly mesenchymal stem cells (MSCs) and insulin at the site of injury, we were aimed to evaluate the effect of Wharton’s jelly MSCs and insulin on degenerative consequences induced by chronic hypoxia. Methods 36 male rats were randomly divided into six groups: Control (C), Sham1-saline (Sh1), Sham2-surgery (Sh2), Hypoxia (H), Hypoxia + Insulin (HI), Hypoxia + MSCs (HCs). Animals were exposed to hypoxic chamber (8% O2, 92% N2) for 30 days (4 hours/day) in H, HI and HCs groups. Intranasal insulin and stereotaxical MSCs in HI and HCs were used, respectively. Spatial learning and memory were analyzed using the Morris water maze task. Brain-derived neurotrophic factor (BDNF) gene expression was studied in the hippocampus by real time-PCR. Results BDNF had the significant depletion in HI group and magnification in HI and HCs groups comparing with C and Sh groups (P < 0.05). Insulin and MSCs improve hypoxia’s signs such as BDNF gene expression fallen and memory impairment. Conclusion In conclusion, we indicated that use of insulin hormone and MSCs as neuroprotective and stimulating factors for neurogenesis, could be beneficial in neurodegenerative damage induced by hypoxia.
Keywords	Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	Nab'a Al-Hayat Foundation for Medical Sciences and Health Care - Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Team-Based Learning A New Strategy in Integrated Medical Curriculum

GHolamreza Hassanzadeh / Farid Abolhasani / Azim Mirzazadeh / Maryam Alizadeh

مجله ایرانی آموزش در علوم پزشکی, Vol 13, Iss 7, Pp 601-

The experience of School of Medicine, Tehran University of Medical Sciences

2013 Volume 610

Abstract: Introduction: Revising medical curricula & establishing reformed programs result in refined educational methods which are accompanied by development of active & student-based teaching methods such as Team Based Learning (TBL). This paper describes an ... ...

Abstract	Introduction: Revising medical curricula & establishing reformed programs result in refined educational methods which are accompanied by development of active & student-based teaching methods such as Team Based Learning (TBL). This paper describes an experience of implementation and evaluation findings of TBL according to medical students’ viewpoints. Methods: This action research was planned for a census sample (n=187) basic science students of Tehran University of Medical Sciences with the new curriculum. After briefing the students about TBL and forming teams we did TBL in the following steps: Individual Readiness Assurance Test (IRAT), Team Readiness Assurance Test(TRAT), appeal, Team Application(TAP), and peer assessment in 15% of each program block. Data gathered by observation recording sheets, and a researcher-made questionnaire, and analyzed using descriptive statistics. Results: A major part of the students (63.8% ) have admitted TBL as a deep learning approach. Students believed that TRATs were useful (46.2%), team application was a learning facilitator in TBL classes (51.7%) and the class management was suitable (60.5%). The observational data showed that the students changed their seats in order to take part in group discussions. They were listening carefully, asking questions and giving reference to support their claims. Some were against this method because it increased their study workload. Conclusion: It seems TBL has a positive effect on deep learning and facilitates learning. The results indicate that TBL results in cooperative & active learning, and it improves class activity and may be, because of the developed interaction between students, it can promote communication skills. We recommend the use of TBL as a teaching method, beside other teaching methods, in medical sciences education.
Keywords	team based learning ; small group teaching ; medical education ; students ; collaborative learning ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	370
Language	Persian
Publishing date	2013-10-01T00:00:00Z
Publisher	Isfahan University of Medical Sciences, Medical Education Development Center
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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