LIVIVO - Search results -

Search results

Result 1 - 10 of total 25

Search options

Article ; Online: T cell exhaustion-a memory locked behind scars.

Yousif, Amir / Ghoneim, Hazem E

2021 Volume 22, Issue 8, Page(s) 938–940

MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/pathology ; Cytokines/biosynthesis ; Hepacivirus/immunology ; Hepatitis C, Chronic/immunology ; Humans ; Immunologic Memory/immunology ; Lymphocyte Depletion ; Lymphocytic Choriomeningitis/immunology ; Lymphocytic choriomeningitis virus/immunology ; Mice ; Receptors, Antigen, T-Cell/immunology
Chemical Substances	Cytokines ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2021-07-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-021-00977-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Gene Regulatory Circuits in Innate and Adaptive Immune Cells.

Saini, Ankita / Ghoneim, Hazem E / Lio, Chan-Wang Jerry / Collins, Patrick L / Oltz, Eugene M

Annual review of immunology

2022 Volume 40, Page(s) 387–411

Abstract: Cell identity and function largely rely on the programming of transcriptomes during development and differentiation. Signature gene expression programs are orchestrated by regulatory circuits consisting ... ...

Abstract	Cell identity and function largely rely on the programming of transcriptomes during development and differentiation. Signature gene expression programs are orchestrated by regulatory circuits consisting of
MeSH term(s)	Animals ; Chromatin ; Gene Expression Regulation ; Gene Regulatory Networks ; Humans ; Promoter Regions, Genetic ; Transcription Factors/genetics
Chemical Substances	Chromatin ; Transcription Factors
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604953-9
ISSN	1545-3278 ; 0732-0582
ISSN (online)	1545-3278
ISSN	0732-0582
DOI	10.1146/annurev-immunol-101320-025949
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Se 849: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Functional T cells are capable of supernumerary cell division and longevity.

Soerens, Andrew G / Künzli, Marco / Quarnstrom, Clare F / Scott, Milcah C / Swanson, Lee / Locquiao, J J / Ghoneim, Hazem E / Zehn, Dietmar / Youngblood, Benjamin / Vezys, Vaiva / Masopust, David

Nature

2023 Volume 614, Issue 7949, Page(s) 762–766

Abstract: Differentiated somatic mammalian cells putatively exhibit species-specific division limits that impede cancer but may constrain ... ...

Abstract	Differentiated somatic mammalian cells putatively exhibit species-specific division limits that impede cancer but may constrain lifespans
MeSH term(s)	Animals ; Mice ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; Cell Differentiation ; Cell Division ; Immunologic Memory ; Longevity/immunology ; Neoplasms/immunology ; Neoplasms/pathology ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; Cellular Senescence/immunology ; Cellular Senescence/physiology ; Lymphocyte Activation ; Immunization, Secondary ; Vaccination ; Adoptive Transfer ; Time Factors ; Infections/immunology ; Chronic Disease ; Epigenesis, Genetic
Chemical Substances	Pdcd1 protein, mouse
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-05626-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease.

Alzheimer's research & therapy

2024 Volume 16, Issue 1, Page(s) 29

Abstract: Alzheimer's disease (AD) is the sixth leading cause of death in the USA. It is established that neuroinflammation contributes to the synaptic loss, neuronal death, and symptomatic decline of AD patients. Accumulating evidence suggests a critical role for ...

Abstract	Alzheimer's disease (AD) is the sixth leading cause of death in the USA. It is established that neuroinflammation contributes to the synaptic loss, neuronal death, and symptomatic decline of AD patients. Accumulating evidence suggests a critical role for microglia, innate immune phagocytes of the brain. For instance, microglia release pro-inflammatory products such as IL-1β which is highly implicated in AD pathobiology. The mechanisms underlying the transition of microglia to proinflammatory promoters of AD remain largely unknown. To address this gap, we performed reduced representation bisulfite sequencing (RRBS) to profile global DNA methylation changes in human AD brains compared to no disease controls. We identified differential DNA methylation of CASPASE-4 (CASP4), which when expressed promotes the generation of IL-1β and is predominantly expressed in immune cells. DNA upstream of the CASP4 transcription start site was hypomethylated in human AD brains, which was correlated with increased expression of CASP4. Furthermore, microglia from a mouse model of AD (5xFAD) express increased levels of CASP4 compared to wild-type (WT) mice. To study the role of CASP4 in AD, we developed a novel mouse model of AD lacking the mouse ortholog of CASP4 and CASP11, which is encoded by mouse Caspase-4 (5xFAD/Casp4
MeSH term(s)	Animals ; Humans ; Mice ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Disease Models, Animal ; DNA Methylation ; Inflammation/pathology ; Mice, Transgenic ; Microglia/metabolism ; Caspases, Initiator/metabolism
Chemical Substances	Amyloid beta-Peptides ; Casp4 protein, mouse (EC 3.4.22.-) ; Caspases, Initiator (EC 3.4.22.-)
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2506521-X
ISSN	1758-9193 ; 1758-9193
ISSN (online)	1758-9193
ISSN	1758-9193
DOI	10.1186/s13195-024-01390-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Epigenetic remodeling by vitamin C potentiates plasma cell differentiation.

Chen, Heng-Yi / Almonte-Loya, Ana / Lay, Fang-Yun / Hsu, Michael / Johnson, Eric / González-Avalos, Edahí / Yin, Jieyun / Bruno, Richard S / Ma, Qin / Ghoneim, Hazem E / Wozniak, Daniel J / Harrison, Fiona E / Lio, Chan-Wang Jerry

eLife

2022 Volume 11

Abstract: Ascorbate (vitamin C) is an essential micronutrient in humans. The severe chronic deficiency of ascorbate, termed scurvy, has long been associated with increased susceptibility to infections. How ascorbate affects the immune system at the cellular and ... ...

Abstract	Ascorbate (vitamin C) is an essential micronutrient in humans. The severe chronic deficiency of ascorbate, termed scurvy, has long been associated with increased susceptibility to infections. How ascorbate affects the immune system at the cellular and molecular levels remained unclear. From a micronutrient analysis, we identified ascorbate as a potent enhancer for antibody response by facilitating the IL-21/STAT3-dependent plasma cell differentiation in mouse and human B cells. The effect of ascorbate is unique as other antioxidants failed to promote plasma cell differentiation. Ascorbate is especially critical during early B cell activation by poising the cells to plasma cell lineage without affecting the proximal IL-21/STAT3 signaling and the overall transcriptome. As a cofactor for epigenetic enzymes, ascorbate facilitates TET2/3-mediated DNA modification and demethylation of multiple elements at the
MeSH term(s)	Animals ; Ascorbic Acid/pharmacology ; Cell Differentiation ; Epigenesis, Genetic ; Epigenomics ; Humans ; Mice ; Vitamins
Chemical Substances	Vitamins ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2022-09-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.73754
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy.

Saadey, Abbey A / Yousif, Amir / Osborne, Nicole / Shahinfar, Roya / Chen, Yu-Lin / Laster, Brooke / Rajeev, Meera / Bauman, Parker / Webb, Amy / Ghoneim, Hazem E

Nature immunology

2022 Volume 24, Issue 2, Page(s) 280–294

Abstract: T cell dysfunctionality prevents the clearance of chronic infections and cancer. Furthermore, epigenetic programming in dysfunctional ... ...

Abstract	T cell dysfunctionality prevents the clearance of chronic infections and cancer. Furthermore, epigenetic programming in dysfunctional CD8
MeSH term(s)	Humans ; CD8-Positive T-Lymphocytes ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy ; Signal Transduction ; Virus Diseases ; Transforming Growth Factor beta1/metabolism ; Bone Morphogenetic Proteins/metabolism
Chemical Substances	Immune Checkpoint Inhibitors ; Transforming Growth Factor beta1 ; Bone Morphogenetic Proteins
Language	English
Publishing date	2022-12-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-022-01384-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Influenza A virus directly modulates mouse eosinophil responses.

LeMessurier, Kim S / Rooney, Robert / Ghoneim, Hazem E / Liu, Baoming / Li, Kui / Smallwood, Heather S / Samarasinghe, Amali E

Journal of leukocyte biology

2020 Volume 108, Issue 1, Page(s) 151–168

Abstract: Allergic asthma and influenza are common respiratory diseases with a high probability of co-occurrence. During the 2009 influenza pandemic, hospitalized patients with influenza experienced lower morbidity if asthma was an underlying condition. We have ... ...

Abstract	Allergic asthma and influenza are common respiratory diseases with a high probability of co-occurrence. During the 2009 influenza pandemic, hospitalized patients with influenza experienced lower morbidity if asthma was an underlying condition. We have previously demonstrated that acute allergic asthma protects mice from severe influenza and have implicated eosinophils in the airways of mice with allergic asthma as participants in the antiviral response. However, very little is known about how eosinophils respond to direct exposure to influenza A virus (IAV) or the microenvironment in which the viral burden is high. We hypothesized that eosinophils would dynamically respond to the presence of IAV through phenotypic, transcriptomic, and physiologic changes. Using our mouse model of acute fungal asthma and influenza, we showed that eosinophils in lymphoid tissues were responsive to IAV infection in the lungs and altered surface expression of various markers necessary for cell activation in a niche-specific manner. Siglec-F expression was altered in a subset of eosinophils after virus exposure, and those expressing high Siglec-F were more active (IL-5Rα
MeSH term(s)	Animals ; Antigens, Differentiation, Myelomonocytic/metabolism ; Antigens, Viral/immunology ; Asthma/immunology ; Asthma/pathology ; Asthma/virology ; Bone Marrow Cells/pathology ; CD8-Positive T-Lymphocytes/immunology ; Cell Respiration/genetics ; Chickens ; DNA Demethylation ; Dogs ; Eosinophils/immunology ; Eosinophils/metabolism ; Epigenesis, Genetic ; Female ; Influenza A virus/immunology ; Interleukin-5 Receptor alpha Subunit/metabolism ; Lung/pathology ; Lung/virology ; Madin Darby Canine Kidney Cells ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Orthomyxoviridae Infections/genetics ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/virology ; Phenotype ; T-Box Domain Proteins/metabolism ; Transcriptome/genetics ; Up-Regulation
Chemical Substances	Antigens, Differentiation, Myelomonocytic ; Antigens, Viral ; Interleukin-5 Receptor alpha Subunit ; Siglecf protein, mouse ; T-Box Domain Proteins ; T-box transcription factor TBX21
Language	English
Publishing date	2020-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1002/JLB.4MA0320-343R
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 603: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Cell-Intrinsic Barriers of T Cell-Based Immunotherapy.

Ghoneim, Hazem E / Zamora, Anthony E / Thomas, Paul G / Youngblood, Ben A

Trends in molecular medicine

2016 Volume 22, Issue 12, Page(s) 1000–1011

Abstract: Prolonged exposure of ... ...

Abstract	Prolonged exposure of CD8
MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/transplantation ; DNA Methylation ; Epigenesis, Genetic ; Genetic Engineering/methods ; Humans ; Immunotherapy/methods ; Immunotherapy, Adoptive/methods ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/therapy ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/transplantation
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2016-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2036490-8
ISSN	1471-499X ; 1471-4914
ISSN (online)	1471-499X
ISSN	1471-4914
DOI	10.1016/j.molmed.2016.10.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4345: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Generating long-lived CD8(+) T-cell memory: Insights from epigenetic programs.

Dogra, Pranay / Ghoneim, Hazem E / Abdelsamed, Hossam A / Youngblood, Ben

European journal of immunology

2016 Volume 46, Issue 7, Page(s) 1548–1562

Abstract: T-cell-based immunological memory has the potential to provide the host with life-long protection against pathogen reexposure and thus offers tremendous promise for the design of vaccines targeting chronic infections or cancer. In order to exploit this ... ...

Abstract	T-cell-based immunological memory has the potential to provide the host with life-long protection against pathogen reexposure and thus offers tremendous promise for the design of vaccines targeting chronic infections or cancer. In order to exploit this potential in the design of new vaccines, it is necessary to understand how and when memory T cells acquire their poised effector potential, and moreover, how they maintain these properties during homeostatic proliferation. To gain insight into the persistent nature of memory T-cell functions, investigators have turned their attention to epigenetic mechanisms. Recent efforts have revealed that many of the properties acquired among memory T cells are coupled to stable changes in DNA methylation and histone modifications. Furthermore, it has recently been reported that the delineating features among memory T cells subsets are also linked to distinct epigenetic events, such as permissive and repressive histone modifications and DNA methylation programs, providing exciting new hypotheses regarding their cellular ancestry. Here, we review recent studies focused on epigenetic programs acquired during effector and memory T-cell differentiation and discuss how these data may shed new light on the developmental path for generating long-lived CD8(+) T-cell memory.
MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Cellular Reprogramming/genetics ; Cellular Reprogramming/immunology ; DNA Methylation ; Epigenesis, Genetic ; Gene Expression Regulation ; Histones/metabolism ; Humans ; Immunologic Memory/genetics ; Lymphocyte Activation/genetics ; Lymphocyte Activation/immunology ; Transcription, Genetic
Chemical Substances	Histones
Language	English
Publishing date	2016-07
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.201545550
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 489: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 85: Show issues

Order via subito

Details ▾

Article ; Online: Adjunctive corticosteroid therapy improves lung immunopathology and survival during severe secondary pneumococcal pneumonia in mice.

Ghoneim, Hazem E / McCullers, Jonathan A

The Journal of infectious diseases

2014 Volume 209, Issue 9, Page(s) 1459–1468

Abstract: Secondary bacterial pneumonia is a significant cause of morbidity and mortality during influenza, despite routine use of standard antibiotics. Antibiotic-induced immunopathology associated with bacterial cell wall lysis has been suggested to contribute ... ...

Abstract	Secondary bacterial pneumonia is a significant cause of morbidity and mortality during influenza, despite routine use of standard antibiotics. Antibiotic-induced immunopathology associated with bacterial cell wall lysis has been suggested to contribute to these poor outcomes. Using Streptococcus pneumoniae in a well-established murine model of secondary bacterial pneumonia (SBP) following influenza, we stratified disease severity based on pneumococcal load in the lungs via in vivo bioluminescence imaging. Ampicillin treatment cured mice with mild pneumonia but was ineffective against severely pneumonic mice, despite effective bacterial killing. Adjunctive dexamethasone therapy improved ampicillin-induced immunopathology and improved outcomes in mice with severe SBP. However, early dexamethasone therapy during primary influenza infection impaired lung adaptive immunity as manifest by increased viral titers, with an associated loss of its protective functions in SBP. These data support adjunctive clinical use of corticosteroids in severe cases of community-acquired pneumonia.
MeSH term(s)	Adaptive Immunity/drug effects ; Ampicillin/pharmacology ; Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Dexamethasone/pharmacology ; Disease Models, Animal ; Dogs ; Female ; Influenza A Virus, H1N1 Subtype/growth & development ; Kaplan-Meier Estimate ; Lung/drug effects ; Lung/immunology ; Lung/pathology ; Madin Darby Canine Kidney Cells ; Mice ; Mice, Inbred BALB C ; Pneumonia, Pneumococcal/drug therapy ; Pneumonia, Pneumococcal/immunology ; Pneumonia, Pneumococcal/pathology
Chemical Substances	Anti-Bacterial Agents ; Anti-Inflammatory Agents ; Ampicillin (7C782967RD) ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2014-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jit653
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh II Zs.50: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 445: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito