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  1. AU="Ghorbal, Lilia"
  2. AU="Narges Karimi"
  3. AU="Vieira, Carlos Antônio Oliveira"
  4. AU="Babaei, Leila"
  5. AU="Jun, I. J."
  6. AU="Rueda-Molina, C."
  7. AU=Lautz Jaclyn
  8. AU="Lui Wai Man"
  9. AU="Kuohung, Victoria"
  10. AU="Di Donna, Paolo"
  11. AU=aan de Kerk Daan J.
  12. AU="Zieger, Barbara"
  13. AU="Camilo, F"
  14. AU="Iris M. Heid"
  15. AU="Swain, Anne"
  16. AU="Epaminondas, Demetris"
  17. AU="Wu, Anjui"
  18. AU="Nascimento, P H"
  19. AU="Shruti P Gandhi"
  20. AU="Yi-Hsien Wang"
  21. AU="Cialdi, S"
  22. AU="Rabe, Lisa"
  23. AU="Chen, Jinghui"
  24. AU="Callegaro, Giulia"
  25. AU="Chen, Benson"
  26. AU="Paccou, Julien"
  27. AU="Martino, Eliana"
  28. AU="Omar, Sara Ibrahim"
  29. AU="Fernández-Rodrigues, V"
  30. AU="Balasanov, Grigory"

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  1. Artikel: Breast cancer in young women in southern Tunisia: Anatomical study and clinical prognostic factors: About a series of 83 patients.

    Kallel, Mouna / Elloumi, Fatma / Khabir, Abdelmajid / Ghorbal, Lilia / Chaabouni, Souhir / Amouri, Habib / Frikha, Mounir / Daoud, Jamel

    Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

    2015  Band 20, Heft 3, Seite(n) 155–160

    Abstract: Purpose: To define epidemiological, clinical, therapeutic and prognostic factors influencing survival of breast cancer in young women younger than 35 in southern Tunisia.: Material and methods: This is a retrospective study of 83 patients younger ... ...

    Abstract Purpose: To define epidemiological, clinical, therapeutic and prognostic factors influencing survival of breast cancer in young women younger than 35 in southern Tunisia.
    Material and methods: This is a retrospective study of 83 patients younger than 35 years and treated within tumors mammary committee of Sfax.
    Results: The mean age was 31.7 years. T2 stage, high grade with positive node tumors were frequent. Breast surgery was performed for 73 patients. Chemotherapy was neo-adjuvant, adjuvant and palliative for respectively 10, 62 and 13 patients. Radiotherapy was delivered for 65 patients with curative intent and for 8 metastatic patients. Endocrine therapy was adjuvant in 38 patients and palliative in 6 cases. The overall survival (OS) at 5 years was 66.8%. Pejorative prognostic factors in uni-variate analysis were clinical T stage (T3, T4), and the number of involved lymph nodes.
    Conclusion: Despite adequate treatment, the prognosis of breast cancer in young women remains worse. Early diagnosis is necessary to promote outcome.
    Sprache Englisch
    Erscheinungsdatum 2015-03-06
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2188087-6
    ISSN 1507-1367
    ISSN 1507-1367
    DOI 10.1016/j.rpor.2015.01.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Nasopharyngeal cancer (NPC) around the Mediterranean area: standard of care.

    Boussen, Hamouda / Ghorbal, Lilia / Naouel, Lejri / Bouaouina, Noureddine / Gritli, Said / Benna, Farouk / Daoud, Jamel

    Critical reviews in oncology/hematology

    2012  Band 84 Suppl 1, Seite(n) e106–9

    Abstract: Mediterranean area (MA) represents a zone of intermediate incidence (1-5/100,000) for NPC, the highest frequency being observed in North Africa (NA) where it is characterized by a bimodal age repartition due to a first adolescence peak. In MA and NA, NPC ...

    Abstract Mediterranean area (MA) represents a zone of intermediate incidence (1-5/100,000) for NPC, the highest frequency being observed in North Africa (NA) where it is characterized by a bimodal age repartition due to a first adolescence peak. In MA and NA, NPC remain diagnosed at advanced stages which impact poorly on overall and disease-free survival. It's therapy in MA followed the progresses and standardisation of protocols, based on concomitant chemoradiotherapy (CCRT) alone or preceded by induction chemotherapy (ICT) in advanced (N2-3, T3-4) stages, while localized cases are managed irradiation alone. NPC overall an disease-free survival improved, due to the use of combined chemo and radiotherapy.
    Mesh-Begriff(e) Antineoplastic Agents/therapeutic use ; Chemoradiotherapy/methods ; Humans ; Mediterranean Region/epidemiology ; Nasopharyngeal Neoplasms/drug therapy ; Nasopharyngeal Neoplasms/epidemiology ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/radiotherapy ; Nasopharynx/drug effects ; Nasopharynx/pathology ; Nasopharynx/radiation effects ; Standard of Care
    Chemische Substanzen Antineoplastic Agents
    Sprache Englisch
    Erscheinungsdatum 2012-12
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2010.09.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Conference abstracts of the of the 4th Congress of Tunisian Society of Oncology Radiotherapy (STOR). November 2018.

    Ghorbel, Asma / Baccouche, Atika / Nasr, Chiraz / Noubigh, Fida / Noubbigh, Ghaiet El Fida / Chabchoub, Imène / Daoud, Jamel / Ben Zid, Khadija / Mahjoubi, Khalil / Farhat, Laila / Ghorbal, Lilia / Kochbati, Lotfi / Kallel, Mouna / Besbes, Mounir / Bouzid, Nadia / Fourati, Najla / Bouaouina, Noureddine / Abidi, Rim / Moujahed, Rim /
    Tbessi, Sabrine / Solti, Said / Gamra, Sana / Mnejja, Wafa / Siala, Wicem / Belkacimie, Yazid / Fessi, Zied

    La Tunisie medicale

    2019  Band 96, Heft 12, Seite(n) 893–910

    Mesh-Begriff(e) Breast Neoplasms/pathology ; Breast Neoplasms/radiotherapy ; Congresses as Topic ; Female ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/radiotherapy ; Humans ; Male ; Organs at Risk ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; Radiation Oncology/methods ; Radiation Oncology/organization & administration ; Radiation Oncology/standards ; Radiation Oncology/trends ; Radiotherapy/classification ; Radiotherapy/methods ; Societies, Medical/organization & administration ; Tunisia
    Sprache Englisch
    Erscheinungsdatum 2019-05-25
    Erscheinungsland Tunisia
    Dokumenttyp Congress
    ZDB-ID 128627-4
    ISSN 0041-4131
    ISSN 0041-4131
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Les esthésioneuroblastomes.

    Elloumi, Fatma / Boujelbene, Noureddine / Ghorbal, Lilia / Boujelbene, Nadia / Khanfir, Khaouthar / Mirimanoff, René-Olivier / Daoud, Jamel

    Bulletin du cancer

    2012  Band 99, Heft 12, Seite(n) 1197–1207

    Abstract: Esthesioneuroblastoma is an uncommon malignancy originating from olfactive epithelium. Men are more frequently affected than women. Nasal symptoms are the most common revealing signs. Immunohistochemistry helps diagnosis. There is no randomized trial ... ...

    Titelübersetzung Esthesioneuroblastoma.
    Abstract Esthesioneuroblastoma is an uncommon malignancy originating from olfactive epithelium. Men are more frequently affected than women. Nasal symptoms are the most common revealing signs. Immunohistochemistry helps diagnosis. There is no randomized trial evaluating treatment due to the low incidence of this tumor. Radiotherapy and surgery are the standard of care. Radiotherapy is benefic even in early stage disease. Chemotherapy is indicated in case of locally advanced or metastatic disease.
    Mesh-Begriff(e) Antineoplastic Agents/therapeutic use ; Esthesioneuroblastoma, Olfactory/diagnosis ; Esthesioneuroblastoma, Olfactory/pathology ; Esthesioneuroblastoma, Olfactory/secondary ; Esthesioneuroblastoma, Olfactory/therapy ; Female ; Humans ; Male ; Nasal Cavity/pathology ; Nose Neoplasms/diagnosis ; Nose Neoplasms/pathology ; Nose Neoplasms/therapy ; Prognosis ; Radiotherapy/methods ; Rare Diseases/diagnosis ; Rare Diseases/pathology ; Rare Diseases/therapy
    Chemische Substanzen Antineoplastic Agents
    Sprache Französisch
    Erscheinungsdatum 2012-12
    Erscheinungsland France
    Dokumenttyp English Abstract ; Journal Article ; Review
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1684/bdc.2012.1642
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Impact of breast cancer stage, time from diagnosis and chemotherapy on plasma and cellular biomarkers of hypercoagulability.

    Chaari, Mourad / Ayadi, Ines / Rousseau, Aurelie / Lefkou, Eleftheria / Van Dreden, Patrick / Sidibe, Fatoumata / Ketatni, Hela / Galea, Vassiliki / Khaterchi, Amir / Bouzguenda, Racem / Frikha, Mounir / Ghorbal, Lilia / Daoud, Jamel / Kallel, Choumous / Quinn, Martin / Gligorov, Joseph / Lotz, Jean Pierre / Hatmi, Mohamed / Elalamy, Ismail /
    Gerotziafas, Grigoris T

    BMC cancer

    2014  Band 14, Seite(n) 991

    Abstract: Background: In breast cancer patients routine thromboprophylaxis is not recommended but individualized risk assessment is encouraged. The incorporation of hypercoagulability biomarkers could increase the sensitivity of risk assessment models (RAM) to ... ...

    Abstract Background: In breast cancer patients routine thromboprophylaxis is not recommended but individualized risk assessment is encouraged. The incorporation of hypercoagulability biomarkers could increase the sensitivity of risk assessment models (RAM) to identify patients at VTE risk. To this aim we investigated the impact of cancer-related characteristics on hypercoagulability biomarkers.
    Methods: Thrombin generation (TG) assessed with the Thrombogramme-Thrombinoscope®, levels of platelet derived microparticles (Pd-MP) assessed with flow cytometry, procoagulant phospholid dependent clotting time (PPL-ct) measured with a clotting assay and D-Dimers (were assessed in a cohort of 62 women with breast cancer and in 30 age matched healthy women.
    Results: Patients showed significantly higher TG, Pd-MP, D-Dimers levels and shortened PPL-ct compared to the controls. The PPL-ct was inversely correlated with the levels of Pd-MP, which were increased in 97% of patients. TG and D-Dimers were increased in 76% and 59% of patients respectively. In any stage of the disease TG was significantly increased as compared to the controls. There was no significant difference of TG in patients with local, regional of metastatic stage. There was no significant difference in Pd-MP or Pd-MP/PS+ between the subgroups of patients with local or regional stage of cancer. Patients with metastatic disease had significantly higher levels of Pd-MP and Pd-MP/PS+ compared to those with regional stage. The D-Dimers increased in patients with metastatic stage. In patients on chemotherapy with less than 6 months since diagnosis TG was significantly higher compared to those on chemotherapy who diagnosed in interval > 6 months. Patients with metastatic disease had significantly higher levels of Pd-MP and D-Dimers compared to those with non-metastatic disease.
    Conclusion: In breast cancer patients the stage, the time elapsed since the diagnosis and the administration of chemotherapy are determinants of cellular and plasma hypercoagulability. The levels and the procoagulant activity of Pd-MP are interconnected with the biological activity and the overall burden of cancer. TG reflects the procoagulant properties of both breast cancer and chemotherapy in the initial period of cancer diagnosis. Thus the weighted incorporation of the biomarkers of cellular and plasma hypercoagulabilty in RAM for VTE might improve their predictive value.
    Mesh-Begriff(e) Adult ; Aged ; Biomarkers/blood ; Biomarkers/metabolism ; Blood Coagulation Tests ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Female ; Fibrin Fibrinogen Degradation Products/metabolism ; Humans ; Middle Aged ; Risk Factors ; Thrombin/metabolism ; Thrombophilia/blood ; Thrombophilia/metabolism
    Chemische Substanzen Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D ; Thrombin (EC 3.4.21.5)
    Sprache Englisch
    Erscheinungsdatum 2014-12-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 1471-2407
    ISSN (online) 1471-2407
    DOI 10.1186/1471-2407-14-991
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Reappraisal of clinical outcome in adult medulloblastomas with emphasis on patterns of relapse.

    Chargari, Cyrus / Feuvret, Loïc / Levy, Antonin / Lamproglou, Ionnis / Assouline, Avi / Hemery, Charles / Ghorbal, Lilia / Lopez, Stephane / Tep, Bernadette / G, Gilbert Boisserie / Lang, Philippe / Laigle-Donadey, Florence / Cornu, Philippe / Mazeron, Jean-Jacques / Simon, Jean-Marc

    British journal of neurosurgery

    2010  Band 24, Heft 4, Seite(n) 460–467

    Abstract: Background: Clinical outcome and prognostic factors were assessed in adult medulloblastoma patients, with emphasis on patterns of relapse.: Patients and methods: Records of 36 consecutive adult patients with medulloblastoma were reviewed. Patients ... ...

    Abstract Background: Clinical outcome and prognostic factors were assessed in adult medulloblastoma patients, with emphasis on patterns of relapse.
    Patients and methods: Records of 36 consecutive adult patients with medulloblastoma were reviewed. Patients were classified into 2 prognostic groups according to the extent of disease and quality of surgical excision based on the early postoperative magnetic resonance imaging (MRI) findings. Standard-risk (SR) patients (n = 11) received postoperative craniospinal radiation therapy (RT) only, 36 Gy, 1.8 Gy per daily fraction, with a 18 Gy boost to the posterior cerebral fossa (PCF). High-risk (HR) patients (n = 25) received additional adjuvant chemotherapy.
    Results: With a median follow-up of 46 months (range 5-155), 19 patients experienced tumour relapse. Sites of relapse(s) included tumour bed in 6 patients, resulting in a PCF control of 83.4%. Three-year overall survival (OS) and progression-free survival (PFS) were 67.3% and 57.4%, respectively. The comparison of the HR and SR populations demonstrated significant differences in OS (p = 0.005) and PFS (p = 0.001). Quality of surgical excision and extent of disease beyond the PCF were predictive factors for OS (p = 0.04, p = 0.001, respectively) and PFS (p = 0.004, and p = 0.02, respectively).
    Conclusion: The quality of resection was a significant prognostic factor, suggesting that surgery should be as extensive as possible. Systematic postoperative MRI allowed accurate selection of SR patients for whom RT alone was enough to obtain high local control. Every effort should be made to avoid RT disruption. Increased delay led to worse outcome.
    Mesh-Begriff(e) Adolescent ; Adult ; Cerebellar Neoplasms/mortality ; Cerebellar Neoplasms/pathology ; Cerebellar Neoplasms/therapy ; Chemotherapy, Adjuvant/methods ; Disease-Free Survival ; Female ; Humans ; Magnetic Resonance Angiography ; Male ; Medulloblastoma/mortality ; Medulloblastoma/pathology ; Medulloblastoma/therapy ; Middle Aged ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/pathology ; Outcome Assessment (Health Care) ; Prognosis ; Radiotherapy, Adjuvant/methods ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2010-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.3109/02688691003739881
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Poster abstracts of the 4th Congress of Tunisian Society of Oncology Radiotherapy (STOR). November 2018.

    Kallel, Adel / Khanfir, Afef / Jmal, Aida / Essadok, Ali / Khalfallah, Ali / Boussarsar, Amal / Chamsi, Amal / Yousfi, Amani / Mezlini, Amel / Hdiji, Anis / Moalla, Anis / Mtibaa, Anis / Belaïd, Asma / Ghorbel, Asma / Hadhri, Asma / Hamdoun, Awatef / Oualha, Azhar / Keskes, Aïcha / Graja Ben Cheikha, Besma /
    Daoud, Bilel / Hammemi, Bouthaina / Zaidi, Chaker / Ben Ammar, Chiraz / Nasr, Chiraz / Yazid, Dalia / Daoud, Jamel / Zaidi, Emna / Dhouib, Fatma / Elloumi, Fatma / Noubbigh, Ghaiet El Fida / Jaffel, Hager / Abdelhédi, Hajer / Kammoun, Hajer / Ouaz, Hamza / Bensalah, Hanène / Njeh, Hanène / Daoud, Hend / Abdelatif, Imen / Chabchoub, Imène / Chaffai, Ines / Werda, Ines / Saidani, Intidhar / Naceur, Islem / Yahiaoui, Jamel / Chaabène, Kais / Khabir, Abdelmajid / Ben Zid, Khadija / Meddeb, Khadija / Ben Fradj, Khalil / Mahjoubi, Khalil / Meddeb, Khedija / Ben Mahfoudh, Kheireddine / Farhat, Leila / Ghorbal, Lilia / Mrissa, Linda / Ben Salem, Lotfi / Kochbati, Lotfi / Jebsi, Manel / Bohli, Mariem / Bouhamed, Maroua / Mahdouani, Marouen / Fourati, Mohamed / Morroka, K / Ben Rejeb, Mouna / Kallel, Mouna / Besbes, Mounir / Toumi, Nabil / Neifar, Nada / Bouzid, Nadia / Nsiri, Nadia / Tounsi, Nadra / Fourati, Najla / Gouiaa, Naourez / Absi, Narjes / Chaari, Narjes / Fourati, Nejla / Bouaouina, Noureddine / Toumi, Nozha / Kammoun, Omar / Nouri, Omar / Braikia, Radhouane / Mzali, Rafik / Ben Amor, Raouia / Abidi, Rim / Moujahed, Rim / Trigui, Rim / Meftah, Sabrine / Tbessi, Sabrine / Boughanmi, Safa / Yahyaoui, Safia / Gritli, Said / Soltani, Said / Tebra, Sameh / Tebra Mrad, Sameh / Kannoun Belajouza, Samia / Kanoun, Samia / Gamra, Sana / Saghaier, Sarra / Zaraa, Semia / Zouari, Sirine / Kdous, Skander / Haddar, Sondes / Ben Dhia, Syrine / Sghaier, Syrine / Boudawara, Taheya / Sahnoun, Tarak / Salem Zrafi, Wael / Mnejja, Wafa / Ben Kridis, Wala / Gargouri, Walid / Siala, Wicem / Abid, Wiem / Boudawara, Zaher / Fessi, Zied

    La Tunisie medicale

    2019  Band 96, Heft 12, Seite(n) 911–931

    Mesh-Begriff(e) Congresses as Topic ; Female ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/radiotherapy ; Humans ; Male ; Medical Oncology/methods ; Medical Oncology/organization & administration ; Medical Oncology/trends ; Organs at Risk ; Radiation Oncology/methods ; Radiation Oncology/organization & administration ; Radiation Oncology/standards ; Radiation Oncology/trends ; Radiotherapy Dosage ; Societies, Medical/organization & administration ; Societies, Medical/standards ; Tunisia
    Sprache Englisch
    Erscheinungsdatum 2019-05-27
    Erscheinungsland Tunisia
    Dokumenttyp Congress
    ZDB-ID 128627-4
    ISSN 0041-4131
    ISSN 0041-4131
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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