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  1. Article ; Online: Targeting c-Myc with decoy oligodeoxynucleotide-loaded polycationic nanoparticles inhibits cell growth and induces apoptosis in cancer stem-like cells (NTERA-2).

    Ghorbani, Roghayeh / Gharbavi, Mahmoud / Keshavarz, Benyamin / Madanchi, Hamid / Johari, Behrooz

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 623

    Abstract: Background: An increase in cancer stem cell (CSC) populations and their resistance to common treatments could be a result of c-Myc dysregulations in certain cancer cells. In the current study, we investigated anticancer effects of c-Myc decoy ODNs ... ...

    Abstract Background: An increase in cancer stem cell (CSC) populations and their resistance to common treatments could be a result of c-Myc dysregulations in certain cancer cells. In the current study, we investigated anticancer effects of c-Myc decoy ODNs loaded-poly (methacrylic acid-co-diallyl dimethyl ammonium chloride) (PMA-DDA)-coated silica nanoparticles as carriers on cancer-like stem cells (NTERA-2).
    Methods and results: The physicochemical characteristics of the synthesized nanocomposites (SiO
    Conclusions: The conclusion drawn from this study is that c-Myc decoy ODN-loaded SiO
    MeSH term(s) Humans ; Apoptosis/drug effects ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Proto-Oncogene Proteins c-myc/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; Cell Proliferation/drug effects ; Nanoparticles/chemistry ; Cell Line, Tumor ; Nanocomposites/chemistry ; Polyelectrolytes/chemistry ; Oligodeoxyribonucleotides/pharmacology ; Oligodeoxyribonucleotides/chemistry ; Cell Survival/drug effects ; Silicon Dioxide/chemistry ; Polyamines/chemistry ; Polyamines/pharmacology ; Cell Cycle/drug effects
    Chemical Substances Proto-Oncogene Proteins c-myc ; Polyelectrolytes ; Oligodeoxyribonucleotides ; polycations ; Silicon Dioxide (7631-86-9) ; Polyamines ; MYC protein, human
    Language English
    Publishing date 2024-05-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09559-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Targeted anti-tumor synergistic effects of Myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells.

    Ghorbani, Roghayeh / Gharbavi, Mahmoud / Sharafi, Ali / Rismani, Elham / Rezaeejam, Hamed / Mortazavi, Yousef / Johari, Behrooz

    Oncology research

    2023  Volume 32, Issue 1, Page(s) 101–125

    Abstract: In the present study, we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing Myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNCaP prostate cancer cells. Myc decoy ... ...

    Abstract In the present study, we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing Myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNCaP prostate cancer cells. Myc decoy ODNs were designed based on the promoter of
    MeSH term(s) Male ; Humans ; Selenium/pharmacology ; Prostate ; Hemolysis ; Molecular Docking Simulation ; Prostatic Neoplasms/drug therapy ; Chemoradiotherapy ; Nanostructures
    Chemical Substances Selenium (H6241UJ22B)
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1114699-0
    ISSN 1555-3906 ; 0965-0407
    ISSN (online) 1555-3906
    ISSN 0965-0407
    DOI 10.32604/or.2023.044741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3087: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Polydopamine contained hydrogel nanocomposites with combined antimicrobial and antioxidant properties for accelerated wound healing.

    Abdollahi, Mahin / Andalib, Sina / Ghorbani, Roghayeh / Afshar, Davoud / Gholinejad, Mohammad / Abdollahi, Hamed / Akbari, Ali / Nikfarjam, Nasser

    International journal of biological macromolecules

    2024  Volume 268, Issue Pt 1, Page(s) 131700

    Abstract: Overproduction of reactive oxygen species (ROS) in infected wounds induces a tremendous inflammatory reaction to delay wound healing. To address this problem, we designed a multifunctional polyacrylamide/PVA-based hydrogel containing synthesized poly(1- ... ...

    Abstract Overproduction of reactive oxygen species (ROS) in infected wounds induces a tremendous inflammatory reaction to delay wound healing. To address this problem, we designed a multifunctional polyacrylamide/PVA-based hydrogel containing synthesized poly(1-glycidyl-3-butylimidazolium salicylate) (polyGBImSal) and fabricated polydopamine-coated polyphenolic nanosheet (PDA@PNS) for wound dressing. The PDA@PNS particles were designed to induce I) antioxidant and anti-inflammatory features through ROS-scavenging and II) cell adhesive properties by the existing polydopamine into the hydrogels. The poly(ionic liquid)-based polyGBImSal was designed to allocate effective hydrogel antimicrobial activity. The fabricated hydrogel nanocomposites showed excellent properties in the swelling ratio, cell adhesiveness, protein adsorption, and anti-inflammatory, proving their general performance for application in wound healing. Furthermore, these hydrogels showed high antimicrobial activity (over 95 %) against three common wound-infecting pathogenic microbes: Escherichia coli, Staphylococcus aureus, and Candida albicans. The healing process of full-thickness dermal wounds in rats was accelerated by applying hydrogel nanocomposites with 0.5 wt% of PDA@PNS and 28 wt% of polyGBImSal. The wound closure contraction attained full closure, reaching 100 %, after 14 days, contrasted with the control group employing commercial wound dressing (Tegaderm), which achieved a closure rate of 68 % within the equivalent timeframe. These results make these hydrogel nanocomposites promising candidates for multifunctional wound dressing applications.
    Language English
    Publishing date 2024-04-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2374: Show issues Location:
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  4. Article ; Online: Developing techniques for cause-responsibility analysis of occupational accidents.

    Jabbari, Mousa / Ghorbani, Roghayeh

    Accident; analysis and prevention

    2016  Volume 96, Page(s) 101–107

    Abstract: The aim of this study was to specify the causes of occupational accidents, determine social responsibility and the role of groups involved in work-related accidents. This study develops occupational accidents causes tree, occupational accidents ... ...

    Abstract The aim of this study was to specify the causes of occupational accidents, determine social responsibility and the role of groups involved in work-related accidents. This study develops occupational accidents causes tree, occupational accidents responsibility tree, and occupational accidents component-responsibility analysis worksheet; based on these methods, it develops cause-responsibility analysis (CRA) techniques, and for testing them, analyzes 100 fatal/disabling occupational accidents in the construction setting that were randomly selected from all the work-related accidents in Tehran, Iran, over a 5-year period (2010-2014). The main result of this study involves two techniques for CRA: occupational accidents tree analysis (OATA) and occupational accidents components analysis (OACA), used in parallel for determination of responsible groups and responsibilities rate. From the results, we find that the management group of construction projects has 74.65% responsibility of work-related accidents. The developed techniques are purposeful for occupational accidents investigation/analysis, especially for the determination of detailed list of tasks, responsibilities, and their rates. Therefore, it is useful for preventing work-related accidents by focusing on the responsible group's duties.
    MeSH term(s) Accidents, Occupational/classification ; Accidents, Occupational/prevention & control ; Humans ; Industry ; Iran ; Occupational Health
    Language English
    Publishing date 2016-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 210223-7
    ISSN 1879-2057 ; 0001-4575
    ISSN (online) 1879-2057
    ISSN 0001-4575
    DOI 10.1016/j.aap.2016.07.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2461: Show issues Location:
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