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Article ; Online: Optimization of intraperitoneal aerosolized drug delivery using computational fluid dynamics (CFD) modeling.

Rahimi-Gorji, Mohammad / Debbaut, Charlotte / Ghorbaniasl, Ghader / Cosyns, Sarah / Willaert, Wouter / Ceelen, Wim

2022 Volume 12, Issue 1, Page(s) 6305

Abstract: Intraperitoneal (IP) aerosolized anticancer drug delivery was recently introduced in the treatment of patients with peritoneal metastases. However, little is known on the effect of treatment parameters on the spatial distribution of the aerosol droplets ... ...

Abstract	Intraperitoneal (IP) aerosolized anticancer drug delivery was recently introduced in the treatment of patients with peritoneal metastases. However, little is known on the effect of treatment parameters on the spatial distribution of the aerosol droplets in the peritoneal cavity. Here, computational fluid dynamics (CFD) modeling was used in conjunction with experimental validation in order to investigate the effect of droplet size, liquid flow rate and viscosity, and the addition of an electrostatic field on the homogeneity of IP aerosol. We found that spatial distribution is optimal with small droplet sizes (1-5 µm). Using the current clinically used technology (droplet size of 30 µm), the optimal spatial distribution of aerosol is obtained with a liquid flow rate of 0.6 mL s
MeSH term(s)	Aerosols ; Drug Delivery Systems/methods ; Humans ; Hydrodynamics ; Peritoneum ; Static Electricity
Chemical Substances	Aerosols
Language	English
Publishing date	2022-04-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-10369-8
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Article ; Online: Fast computation of time-dependent acoustic fields.

Carley, Michael / Ghorbaniasl, Ghader

The Journal of the Acoustical Society of America

2016 Volume 140, Issue 5, Page(s) 3963

Abstract: A method for the fast evaluation of time-dependent acoustic fields from complex sources is presented. The technique is based on a fast integration method for the boundary integral arising in a Kirchhoff formulation and requires a small, and roughly ... ...

Abstract	A method for the fast evaluation of time-dependent acoustic fields from complex sources is presented. The technique is based on a fast integration method for the boundary integral arising in a Kirchhoff formulation and requires a small, and roughly constant, computation time to compute a transient signal, at the expense of a pre-processing stage. In the calculations in this paper, based on test cases for a single rotor, a counter-rotating open rotor, and a broadband volume source, it is found that transient field calculations require an order of magnitude less computational time for the field from an array of 16 384 sources, a computational advantage that increases with source number.
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/1.4968018
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Article ; Online: A hybrid computational aeroacoustic methodology for broadband noise prediction.

Ricks, Nathan / Nixarlidis, Christos A / Kalfas, Anestis I / Ghorbaniasl, Ghader

The Journal of the Acoustical Society of America

2019 Volume 146, Issue 2, Page(s) 1438

Abstract: Current hybrid computational aeroacoustic methodologies for broadband noise prediction rely on large eddy simulation (LES) for noise source computation, and integral methods for noise propagation. In this paper, LES of a benchmark controlled-diffusion ... ...

Abstract	Current hybrid computational aeroacoustic methodologies for broadband noise prediction rely on large eddy simulation (LES) for noise source computation, and integral methods for noise propagation. In this paper, LES of a benchmark controlled-diffusion airfoil was conducted, utilizing the rotation rate based Smagorinsky model (RoSM). The RoSM is seen to provide flow results of equal or improved accuracy as compared to the dynamic Smagorinsky model, with 35% less computational cost, with computational benefits of the RoSM increasing with mesh size. Current integral methods for noise propagation, including Formulation 1A of Farassat, require numerical differentiation of highly turbulent input flow data coming from LES, introducing numerical inaccuracies. Here, Formulation 1 of Farassat is modified to entirely avoid the numerical differentiation of flow field data. The ability of the methodology for broadband noise prediction is demonstrated, with the prediction at high frequencies being considerably closer to experimental data than Formulation 1A. For low discrete frequency noise prediction, Formulation 1A is still recommended. The use of two innovative approaches in conjunction for broadband noise prediction is seen to be efficient and easy to implement, without compromising on accuracy.
Language	English
Publishing date	2019-08-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/1.5123142
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Article: A time-domain method for prediction of noise radiated from supersonic rotating sources in a moving medium.

Huang, Zhongjie / Siozos-Rousoulis, Leonidas / De Troyer, Tim / Ghorbaniasl, Ghader

Proceedings. Mathematical, physical, and engineering sciences

2018 Volume 474, Issue 2210, Page(s) 20170089

Abstract: This paper presents a time-domain method for noise prediction of supersonic rotating sources in a moving medium. The proposed approach can be interpreted as an extensive time-domain solution for the convected permeable Ffowcs Williams and Hawkings ... ...

Abstract	This paper presents a time-domain method for noise prediction of supersonic rotating sources in a moving medium. The proposed approach can be interpreted as an extensive time-domain solution for the convected permeable Ffowcs Williams and Hawkings equation, which is capable of avoiding the Doppler singularity. The solution requires special treatment for construction of the emission surface. The derived formula can explicitly and efficiently account for subsonic uniform constant flow effects on radiated noise. Implementation of the methodology is realized through the Isom thickness noise case and high-speed impulsive noise prediction from helicopter rotors.
Language	English
Publishing date	2018-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	209241-4
ISSN	1471-2946 ; 1364-5021 ; 0962-8444 ; 0080-4630 ; 0950-1207
ISSN (online)	1471-2946
ISSN	1364-5021 ; 0962-8444 ; 0080-4630 ; 0950-1207
DOI	10.1098/rspa.2017.0089
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Article: A time-domain Kirchhoff formula for the convective acoustic wave equation.

Ghorbaniasl, Ghader / Siozos-Rousoulis, Leonidas / Lacor, Chris

Proceedings. Mathematical, physical, and engineering sciences

2016 Volume 472, Issue 2187, Page(s) 20150689

Abstract: Kirchhoff's integral method allows propagated sound to be predicted, based on the pressure and its derivatives in time and space obtained on a data surface located in the linear flow region. Kirchhoff's formula for noise prediction from high-speed rotors ...

Abstract	Kirchhoff's integral method allows propagated sound to be predicted, based on the pressure and its derivatives in time and space obtained on a data surface located in the linear flow region. Kirchhoff's formula for noise prediction from high-speed rotors and propellers suffers from the limitation of the observer located in uniform flow, thus requiring an extension to arbitrarily moving media. This paper presents a Kirchhoff formulation for moving surfaces in a uniform moving medium of arbitrary configuration. First, the convective wave equation is derived in a moving frame, based on the generalized functions theory. The Kirchhoff formula is then obtained for moving surfaces in the time domain. The formula has a similar form to the Kirchhoff formulation for moving surfaces of Farassat and Myers, with the presence of additional terms owing to the moving medium effect. The equation explicitly accounts for the influence of mean flow and angle of attack on the radiated noise. The formula is verified by analytical cases of a monopole source located in a moving medium.
Language	English
Publishing date	2016-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	209241-4
ISSN	1471-2946 ; 1364-5021 ; 0962-8444 ; 0080-4630 ; 0950-1207
ISSN (online)	1471-2946
ISSN	1364-5021 ; 0962-8444 ; 0080-4630 ; 0950-1207
DOI	10.1098/rspa.2015.0689
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Article ; Online: A survey on the applications of implantable micropump systems in drug delivery.

Mahnama, Ali / Nourbakhsh, Ahmad / Ghorbaniasl, Ghader

Current drug delivery

2014 Volume 11, Issue 1, Page(s) 123–131

Abstract: Systemic drug delivery is the most prevalent form of the drug administration; but it is not possible to extend this approach to all of diseases. In the traditional approaches of drug delivery, the drug spreads through whole of body and this could cause ... ...

Abstract	Systemic drug delivery is the most prevalent form of the drug administration; but it is not possible to extend this approach to all of diseases. In the traditional approaches of drug delivery, the drug spreads through whole of body and this could cause severe side effects in the healthy parts. In addition, in some parts of our body like the eye, ear and brain, there are biological barriers against drug penetration which made drug delivery to these organs as a challenging work. Micropumps are one of the MEMS based devices with great capabilities in controlled drug administration. The most prevalent application of micropumps in drug delivery is known as continuous subcutaneous insulin infusion (CSII) for diabetic patients; but our study showed that there are some other ongoing investigations to extend application of micropumps in new treatment methods for some incurred diseases.
MeSH term(s)	Administration, Metronomic ; Administration, Ophthalmic ; Animals ; Diabetes Mellitus/blood ; Diabetes Mellitus/drug therapy ; Drug Delivery Systems/instrumentation ; Equipment Design ; Humans ; Hypoglycemic Agents/administration & dosage ; Infusion Pumps, Implantable ; Insulin/administration & dosage ; Insulin Infusion Systems ; Miniaturization
Chemical Substances	Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2014-02-11
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2185284-4
ISSN	1875-5704 ; 1567-2018
ISSN (online)	1875-5704
ISSN	1567-2018
DOI	10.2174/156720181101140212165729
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Article ; Online: Exploring high pressure nebulization of Pluronic F127 hydrogels for intraperitoneal drug delivery.

Braet, Helena / Rahimi-Gorji, Mohammad / Debbaut, Charlotte / Ghorbaniasl, Ghader / Van Walleghem, Thibault / Cornelis, Senne / Cosyns, Sarah / Vervaet, Chris / Willaert, Wouter / Ceelen, Wim / De Smedt, Stefaan C / Remaut, Katrien

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

2021 Volume 169, Page(s) 134–143

Abstract: Peritoneal metastasis is an advanced cancer type which can be treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC). Here, chemotherapeutics are nebulized under high pressure in the intraperitoneal (IP) cavity to obtain a better ... ...

Abstract	Peritoneal metastasis is an advanced cancer type which can be treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC). Here, chemotherapeutics are nebulized under high pressure in the intraperitoneal (IP) cavity to obtain a better biodistribution and tumor penetration. To prevent the fast leakage of chemotherapeutics from the IP cavity, however, nebulization of controlled release formulations is of interest. In this study, the potential of the thermosensitive hydrogel Pluronic F127 to be applied by high pressure nebulization is evaluated. Therefore, aerosol formation is experimentally examined by laser diffraction and theoretically simulated by computational fluid dynamics (CFD) modelling. Furthermore, Pluronic F127 hydrogels are subjected to rheological characterization after which the release of fluorescent model nanoparticles from the hydrogels is determined. A delicate equilibrium is observed between controlled release properties and suitability for aerosolization, where denser hydrogels (20% and 25% w/v Pluronic F127) are able to sustain nanoparticle release up to 30 h, but cannot effectively be nebulized and vice versa. This is demonstrated by a growing aerosol droplet size and exponentially decreasing aerosol cone angle when Pluronic F127 concentration and viscosity increase. Novel nozzle designs or alternative controlled release formulations could move intraperitoneal drug delivery by high pressure nebulization forward.
MeSH term(s)	Aerosolized Particles and Droplets/pharmacology ; Antineoplastic Agents/pharmacology ; Delayed-Action Preparations/pharmacology ; Drug Compounding/methods ; Excipients/pharmacology ; Humans ; Hydrodynamics ; Hydrogels/pharmacology ; Nanoparticles/therapeutic use ; Nebulizers and Vaporizers ; Peritoneal Absorption/drug effects ; Peritoneal Neoplasms/secondary ; Peritoneal Neoplasms/therapy ; Poloxamer/pharmacology ; Tissue Distribution
Chemical Substances	Aerosolized Particles and Droplets ; Antineoplastic Agents ; Delayed-Action Preparations ; Excipients ; Hydrogels ; Poloxamer (106392-12-5)
Language	English
Publishing date	2021-10-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1065368-5
ISSN	1873-3441 ; 0939-6411
ISSN (online)	1873-3441
ISSN	0939-6411
DOI	10.1016/j.ejpb.2021.10.001
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Article ; Online: Semi-analytical solution for the in-vitro sedimentation, diffusion and dosimetry model: surveying the impact of the Peclet number.

Mahnama, Ali / Ghorbaniasl, Ghader / Allaei, S Mehdi Vaez / Nourbakhsh, Ahmad

Colloids and surfaces. B, Biointerfaces

2014 Volume 122, Page(s) 324–331

Abstract: Reducing size of the particles to the nanoscale range gives them new physicochemical properties. Several experiments have shown cytotoxic effects for different kinds of engineered nanoparticles (ENP). In-vitro cell culture assays are widely utilized by ... ...

Abstract	Reducing size of the particles to the nanoscale range gives them new physicochemical properties. Several experiments have shown cytotoxic effects for different kinds of engineered nanoparticles (ENP). In-vitro cell culture assays are widely utilized by researchers to evaluate cytotoxic effects of the ENPs. The present paper deals with the "In vitro Sedimentation, Diffusion and Dosimetry (ISDD)" model. This mathematical model uses an advection-diffusion equation with specific assumptions and coefficients to estimate the dose of the particles delivered to the cells monolayer in the culture medium. In the present work, utilizing the generalized integral transform technique (GITT), a semi-analytical solution is developed for the ISDD model. The parameters affecting the ISDD predictions are integrated into two dimensionless numbers, Pe and τ. The Pe number shows the ratio of the convective to the diffusive mass transport rates and τ is a dimensionless time parameter. The quality of the results for an extensive range of Pe and τ numbers is surveyed through application of the developed formula to two series of test cases. A comparison of the results with those obtained from numerical methods shows deviations in the numerical results at high Pe numbers. Applying the developed formula, ISDD predictions for a wide practical range of Pe and τ numbers are calculated and plotted in two- and three-dimensional plots. The curves and formula obtained in this study facilitate the achievement of ISDD predictions with higher accuracies and capabilities for verification of the results.
MeSH term(s)	Diffusion ; Dose-Response Relationship, Drug ; In Vitro Techniques ; Models, Theoretical ; Nanoparticles
Language	English
Publishing date	2014-10-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2014.06.063
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Article ; Online: Intraperitoneal aerosolized drug delivery: Technology, recent developments, and future outlook.

Rahimi-Gorji, Mohammad / Van de Sande, Leen / Debbaut, Charlotte / Ghorbaniasl, Ghader / Braet, Helena / Cosyns, Sarah / Remaut, Katrien / Willaert, Wouter / Ceelen, Wim

Advanced drug delivery reviews

2020 Volume 160, Page(s) 105–114

Abstract: Current therapies for patients with peritoneal metastases (PM) are only moderately effective. Recently, a novel locoregional treatment method for PM was introduced, consisting of a combination of laparoscopy with intraperitoneal (IP) delivery of ... ...

Abstract	Current therapies for patients with peritoneal metastases (PM) are only moderately effective. Recently, a novel locoregional treatment method for PM was introduced, consisting of a combination of laparoscopy with intraperitoneal (IP) delivery of anticancer agents as an aerosol. This 'pressurized intraperitoneal aerosol chemotherapy' (PIPAC) may enhance tissue drug penetration by the elevated IP pressure during CO
Language	English
Publishing date	2020-10-24
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	639113-8
ISSN	1872-8294 ; 0169-409X
ISSN (online)	1872-8294
ISSN	0169-409X
DOI	10.1016/j.addr.2020.10.015
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Article ; Online: Electrostatic Intraperitoneal Aerosol Delivery of Nanoparticles: Proof of Concept and Preclinical Validation.

Van de Sande, Leen / Rahimi-Gorji, Mohammad / Giordano, Silvia / Davoli, Enrico / Matteo, Cristina / Detlefsen, Sönke / D'Herde, Katharina / Braet, Helena / Shariati, Molood / Remaut, Katrien / Xie, Feifan / Debbaut, Charlotte / Ghorbaniasl, Ghader / Cosyns, Sarah / Willaert, Wouter / Ceelen, Wim

Advanced healthcare materials

2020 Volume 9, Issue 16, Page(s) e2000655

Abstract: There is an increasing interest in intraperitoneal delivery of chemotherapy as an aerosol in patients with peritoneal metastasis. The currently used technology is hampered by inhomogenous drug delivery throughout the peritoneal cavity because of gravity, ...

Abstract	There is an increasing interest in intraperitoneal delivery of chemotherapy as an aerosol in patients with peritoneal metastasis. The currently used technology is hampered by inhomogenous drug delivery throughout the peritoneal cavity because of gravity, drag, and inertial impaction. Addition of an electrical force to aerosol particles, exerted by an electrostatic field, can improve spatial aerosol homogeneity and enhance tissue penetration. A computational fluid dynamics model shows that electrostatic precipitation (EP) results in a significantly improved aerosol distribution. Fluorescent nanoparticles (NPs) remain stable after nebulization in vitro, while EP significantly improves spatial homogeneity of NP distribution. Next, pressurized intraperitoneal chemotherapy with and without EP using NP albumin bound paclitaxel (Nab-PTX) in a novel rat model is examined. EP does not worsen the effects of CO
MeSH term(s)	Aerosols ; Animals ; Drug Delivery Systems ; Humans ; Nanoparticles ; Peritoneum ; Rats ; Static Electricity
Chemical Substances	Aerosols
Language	English
Publishing date	2020-06-16
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202000655
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