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  1. Article ; Online: Oral manifestations associated with inherited hyperhomocysteinemia: A first case description.

    Husseini, Bachar / Nehme, Edgard / Senni, Karim / Ghorra, Claude Sader / Younes, Khalil / Roffino, Sandrine / Ghorra, Pierre / Changotade, Sylvie / Younes, Ronald

    Oral surgery, oral medicine, oral pathology and oral radiology

    2021  Volume 133, Issue 5, Page(s) e105–e112

    Abstract: Hyperhomocysteinemia is a rare disease caused by nutritional deficiencies or genetic impairment of cysteine metabolism. To date, no oral manifestations of hyperhomocysteinemia have been described in humans. Therefore, to our knowledge, the present case ... ...

    Abstract Hyperhomocysteinemia is a rare disease caused by nutritional deficiencies or genetic impairment of cysteine metabolism. To date, no oral manifestations of hyperhomocysteinemia have been described in humans. Therefore, to our knowledge, the present case report is the first description of a hyperhomocysteinemic patient showing oral tissue alterations leading to both early tooth loss and failed implant osseointegration. The patient presented with a methylenetetrahydrofolate reductase gene mutation (677T polymorphism) leading to mild hyperhomocysteinemia. The radiologic analysis showed hyperdense lesions scattered in the maxillae. The histologic observations indicated alterations in both collagen and elastic networks in the gingiva and dermis. Interestingly, the presence of ectopic mineralized inclusions was noted in both periodontal ligament and gingiva. Strong osteoclastic activity was associated with abnormal calcification of trabecular spaces. Uneven oral tissue remodeling due to high tissue levels of homocysteine could explain the pathologic manifestations observed in this case.
    MeSH term(s) Humans ; Hyperhomocysteinemia/complications ; Hyperhomocysteinemia/genetics ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Polymorphism, Genetic
    Chemical Substances Methylenetetrahydrofolate Reductase (NADPH2) (EC 1.5.1.20)
    Language English
    Publishing date 2021-09-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2021.09.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.121: Show issues Location:
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  2. Article ; Online: Added Value of Anti-CD74 Autoantibodies in Axial SpondyloArthritis in a Population With Low HLA-B27 Prevalence.

    Ziade, Nelly R / Mallak, Iyad / Merheb, Georges / Ghorra, Pierre / Baerlecken, Niklas / Witte, Torsten / Baraliakos, Xenofon

    Frontiers in immunology

    2019  Volume 10, Page(s) 574

    Abstract: Axial spondyloarthritis (axSpA) is often diagnosed late due to the non-specific nature of its main symptom [chronic back pain (CBP)] and to the paucity of diagnostic markers, particularly in regions with low HLA-B27 prevalence, such as the Middle-East. ... ...

    Abstract Axial spondyloarthritis (axSpA) is often diagnosed late due to the non-specific nature of its main symptom [chronic back pain (CBP)] and to the paucity of diagnostic markers, particularly in regions with low HLA-B27 prevalence, such as the Middle-East. We tested the performance of IgG4 and IgA anti-CD74 antibodies as an early diagnostic marker for axSpA, compared with the performance of HLA-B27, in Lebanon. Sera of axSpA patients diagnosed by the rheumatologist and also fulfilling the imaging arm of the ASAS criteria (patients) and of blood donors (BD) (controls) were analyzed for HLA-B27, IgG4 and IgA anti-CD74, blinded to clinical characteristics. Receiver Operating Characteristic curves were constructed to identify an optimal cut-off point for anti-CD74 antibodies. Diagnostic properties were calculated (sensitivity, specificity, positive, and positive predictive values (PPV, NPV), Likelihood ratios) for each marker. Forty-nine axSpA patients and 102 BD were included in the final analysis. IgA anti-CD74 correlated poorly with axSpA (Area Under the Curve (AUC) 0.657), whereas IgG4 anti-CD74 had a good discriminative value (AUC 0.837). Respectively, for HLA-B27, IgG4 anti-CD74, and the combination of both, we found a sensitivity of 33-92-33%, specificity of 96-79-98%, PPV 80-68-89%, NPV 75-95-75%, and LR+ 8.2-4.4-16.5. IgG4 anti-CD 74 were positive in 88% of HLA-B27 negative axSpA patients, and correlated with BASDAI. In this first study in a population with low HLA-B27 prevalence, IgG4 anti-CD74 antibodies combined with HLA-B27 showed higher diagnostic value than HLA-B27 alone for early axSpA. IgG4 anti-CD74 should be considered for further evaluation as an early axSpA diagnostic marker in future dedicated research, particularly in patients with CBP.
    MeSH term(s) Adult ; Antigens, Differentiation, B-Lymphocyte/immunology ; Autoantibodies/blood ; Female ; HLA-B27 Antigen/analysis ; Histocompatibility Antigens Class II/immunology ; Humans ; Immunoglobulin G/analysis ; Male ; Prevalence ; Spondylarthritis/immunology
    Chemical Substances Antigens, Differentiation, B-Lymphocyte ; Autoantibodies ; HLA-B27 Antigen ; Histocompatibility Antigens Class II ; Immunoglobulin G ; invariant chain
    Language English
    Publishing date 2019-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Seroprevalence of West Nile virus in blood donors at Hôtel Dieu de France, Beirut, Lebanon.

    Gallian, Pierre / de Micco, Philippe / Ghorra, Pierre

    Transfusion

    2010  Volume 50, Issue 5, Page(s) 1156–1158

    MeSH term(s) Adolescent ; Adult ; Blood Donors ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Lebanon ; Male ; Middle Aged ; Seroepidemiologic Studies ; West Nile virus/isolation & purification
    Language English
    Publishing date 2010-05
    Publishing country United States
    Document type Letter
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/j.1537-2995.2010.02597.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 284: Show issues Location:
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  4. Article ; Online: HLA-B27 prevalence in axial spondyloarthritis patients and in blood donors in a Lebanese population: Results from a nationwide study.

    Ziade, Nelly / Abi Karam, Ghada / Merheb, Georges / Mallak, Iyad / Irani, Laure / Alam, Elie / Messaykeh, Jamil / Menassa, Jeanine / Mroue', Kamel / Uthman, Imad / Masri, Abdel Fattah / Ghorra, Pierre / Witte, Torsten / Baraliakos, Xenofon

    International journal of rheumatic diseases

    2019  Volume 22, Issue 4, Page(s) 708–714

    Abstract: Aim: To calculate the prevalence of human leukocyte antigen (HLA)-B27 in axial spondyloarthritis patients (axSpA) compared to blood donors (BD) in Lebanon, to identify the clinical and radiological findings associated with HLA-B27 and to estimate the ... ...

    Abstract Aim: To calculate the prevalence of human leukocyte antigen (HLA)-B27 in axial spondyloarthritis patients (axSpA) compared to blood donors (BD) in Lebanon, to identify the clinical and radiological findings associated with HLA-B27 and to estimate the proportion of patients fulfilling the clinical arm of the Assessment of the Spondyloarthritis International Association (ASAS) criteria.
    Method: Consecutive Lebanese adult axSpA patients fulfilling the ASAS classification criteria were included from 12 rheumatology clinics across Lebanon. BD served as controls. A binary logistic regression was used to study the association between HLA-B27 and the disease features.
    Results: A total of 247 individuals were included (141 axSpA patients and 106 BD). The prevalence of HLA-B27 was 3.8% in BD and 41.1% in axSpA. Overall, 39.7% of the axSpA patients fulfilled the clinical arm of the ASAS classification criteria. Sensitivity of HLA-B27 for axSpA was 41.1%, specificity was 96.2%, positive predictive value was 93.6%, and negative predictive value was 55.13%. Positive likelihood ratio (LR) was 10.9 and negative LR was 1.63. We found a positive association of HLA-B27 with family history of SpA and psoriasis.
    Conclusion: Our study confirmed a low prevalence of HLA-B27 in axSpA patients and BD in this Lebanese population, However, we found a high specificity and positive LR, as well as the same number of axSpA patients fulfilling the clinical arm of the ASAS criteria as in European studies. HLA-B27 is therefore valuable for identification of axSpA in Lebanese patients despite the overall low prevalence in this population. Our results may guide future evaluations the role of HLA-B27 in planning local referral strategies.
    MeSH term(s) Adult ; Blood Donors ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; HLA-B27 Antigen/genetics ; HLA-B27 Antigen/immunology ; Humans ; Lebanon/epidemiology ; Male ; Middle Aged ; Molecular Epidemiology ; Phenotype ; Prevalence ; Risk Factors ; Spondylarthritis/diagnosis ; Spondylarthritis/epidemiology ; Spondylarthritis/genetics ; Spondylarthritis/immunology ; Young Adult
    Chemical Substances HLA-B27 Antigen
    Language English
    Publishing date 2019-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.13487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6098: Show issues Location:
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  5. Article ; Online: Effects of clopidogrel on soluble CD40 ligand and on high-sensitivity C-reactive protein in patients with stable coronary artery disease.

    Azar, Rabih R / Kassab, Roland / Zoghbi, Antoine / Aboujaoudé, Simon / El-Osta, Hazem / Ghorra, Pierre / Germanos, Mirna / Salamé, Elie

    American heart journal

    2006  Volume 151, Issue 2, Page(s) 521.e1–521.e4

    Abstract: Background: Antiplatelet therapy with clopidogrel decreases ischemic complication especially in patients with acute coronary syndromes or after percutaneous coronary interventions. Our study was designed to test the effects of clopidogrel on soluble ... ...

    Abstract Background: Antiplatelet therapy with clopidogrel decreases ischemic complication especially in patients with acute coronary syndromes or after percutaneous coronary interventions. Our study was designed to test the effects of clopidogrel on soluble CD40 ligand (sCD40l) and on high-sensitivity C-reactive protein (hs-CRP) in patients with stable coronary artery disease (CAD).
    Methods: This is a randomized, double-blind, placebo-controlled study. A total of 73 patients with stable CAD for > 6 months were randomized to receive either clopidogrel (loading dose 300 mg followed by 75 mg/d) for 8 weeks or placebo. Soluble CD40 ligand and hs-CRP were measured at baseline and at completion of the study.
    Results: All patients were on aspirin therapy, and 74% were on statins. Median and interquartile ranges (IQR) of sCD40l decreased from 64 pg/mL (43-99) at baseline to 53 pg/mL (35-77) at 8 weeks (P = .03) in the clopidogrel group and remained unchanged in the placebo group (59 pg/mL, IQR 35-77 vs 55 pg/mL, IQR 35-78) (P = non significant). Levels of hs-CRP were not affected by therapy and remained unchanged in both groups.
    Conclusions: In patients with stable CAD, clopidogrel inhibits the release of sCD40l by platelets, which may contribute to the clinical benefit provided by this drug. This, however, does not translate in a reduction of subclinical inflammation, as measured by hs-CRP.
    MeSH term(s) Aged ; Biomarkers/blood ; C-Reactive Protein/analysis ; CD40 Ligand/blood ; Coronary Artery Disease/blood ; Coronary Artery Disease/drug therapy ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/therapeutic use ; Ticlopidine/analogs & derivatives ; Ticlopidine/therapeutic use
    Chemical Substances Biomarkers ; Platelet Aggregation Inhibitors ; CD40 Ligand (147205-72-9) ; C-Reactive Protein (9007-41-4) ; clopidogrel (A74586SNO7) ; Ticlopidine (OM90ZUW7M1)
    Language English
    Publishing date 2006-02
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2005.10.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.15: Show issues Location:
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