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  1. Book ; Online: Biomarkers in Neurodegenerative Diseases 2.0

    Ghosh, Arnab

    2023  

    Keywords Medicine ;   ; neurodegenerative disease ; biomarker ; diagnosis ; prognosis ; treatment management ; proteomics ; sequencing ; immunology ; mass spectrometry
    Language English
    Size 1 electronic resource (206 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030378236
    ISBN 9783036557328 ; 3036557326
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Biomarkers in Neurodegenerative Diseases

    Ghosh, Arnab

    2022  

    Keywords Medicine ; Alzheimer's disease ; amyloid beta ; hippocampus ; Kir channels ; K+ channels ; glioblastoma multiforme ; low-grade glioma ; astrocytoma ; recurrence ; multifocal growth ; mRNA expression ; MPS1 ; TTK ; therapy ; EDTA chelation therapy ; neurodegenerative diseases ; metal detoxification ; reactive oxygen species (ROS) ; neuroinflammation ; neurodegeneration ; cognitive dysfunction ; neurofibrillary tangles ; diagnosis methods ; biomarkers ; perinatal stress ; NURR1 ; inflammation ; late-onset diseases ; early life ; artificial neural network ; deep learning ; Parkinson's disease ; atypical parkinsonian syndrome ; dopamine transporter SPECT ; β-Amyloid ; calpain ; Collapsin Response Mediator Protein-2 ; human-neuroblastoma SH-SY5Y cells ; Somatostatin-14 ; somatostatin receptor ; brain injury ; quinpirole ; dopamine D2 receptors ; glial cell ; autophagy ; mitophagy ; multiple sclerosis ; biomarker ; neurons ; astrocytes ; Alzheimer's and Parkinson's diseases ; fluid and imaging biomarkers ; amyloid-β and tau ; miRNA ; extracellular vesicles ; exosomes and ectosomes ; PET ; radiotracers ; radiolabeled molecules ; n/a
    Language English
    Size 1 electronic resource (190 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030379908
    ISBN 9783036557304 ; 303655730X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Biomarkers in Neurodegenerative Diseases.

    Ghosh, Arnab

    Biomedicines

    2022  Volume 10, Issue 2

    Abstract: An increasing number of people are affected by various neurodegenerative diseases each year, impacting the quality of life of millions of people worldwide [ ... ]. ...

    Abstract An increasing number of people are affected by various neurodegenerative diseases each year, impacting the quality of life of millions of people worldwide [...].
    Language English
    Publishing date 2022-01-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10020215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Quantum Advantage of Thermal Machines with Bose and Fermi Gases.

    Sur, Saikat / Ghosh, Arnab

    Entropy (Basel, Switzerland)

    2023  Volume 25, Issue 2

    Abstract: In this article, we show that a quantum gas, a collection of massive, non-interacting, indistinguishable quantum particles, can be realized as a thermodynamic machine as an artifact of energy quantization and, hence, bears no classical analog. Such a ... ...

    Abstract In this article, we show that a quantum gas, a collection of massive, non-interacting, indistinguishable quantum particles, can be realized as a thermodynamic machine as an artifact of energy quantization and, hence, bears no classical analog. Such a thermodynamic machine depends on the statistics of the particles, the chemical potential, and the spatial dimension of the system. Our detailed analysis demonstrates the fundamental features of quantum Stirling cycles, from the viewpoint of particle statistics and system dimensions, that helps us to realize desired quantum heat engines and refrigerators by exploiting the role of quantum statistical mechanics. In particular, a clear distinction between the behavior of a Fermi gas and a Bose gas is observed in one dimension, rather than in higher dimensions, solely due to the innate differences in their particle statistics indicating the conspicuous role of a quantum thermodynamic signature in lower dimensions.
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e25020372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hsp90 in Human Diseases: Molecular Mechanisms to Therapeutic Approaches.

    Sumi, Mamta P / Ghosh, Arnab

    Cells

    2022  Volume 11, Issue 6

    Abstract: The maturation of hemeprotein dictates that they incorporate heme and become active, but knowledge of this essential cellular process remains incomplete. Studies on chaperon Hsp90 has revealed that it drives functional heme maturation of inducible nitric ...

    Abstract The maturation of hemeprotein dictates that they incorporate heme and become active, but knowledge of this essential cellular process remains incomplete. Studies on chaperon Hsp90 has revealed that it drives functional heme maturation of inducible nitric oxide synthase (iNOS), soluble guanylate cyclase (sGC) hemoglobin (Hb) and myoglobin (Mb) along with other proteins including GAPDH, while globin heme maturations also need an active sGC. In all these cases, Hsp90 interacts with the heme-free or apo-protein and then drives the heme maturation by an ATP dependent process before dissociating from the heme-replete proteins, suggesting that it is a key player in such heme-insertion processes. As the studies on globin maturation also need an active sGC, it connects the globin maturation to the NO-sGC (Nitric oxide-sGC) signal pathway, thereby constituting a novel NO-sGC-Globin axis. Since many aggressive cancer cells make Hbβ/Mb to survive, the dependence of the globin maturation of cancer cells places the NO-sGC signal pathway in a new light for therapeutic intervention. Given the ATPase function of Hsp90 in heme-maturation of client hemeproteins, Hsp90 inhibitors often cause serious side effects and this can encourage the alternate use of sGC activators/stimulators in combination with specific Hsp90 inhibitors for better therapeutic intervention.
    MeSH term(s) HSP90 Heat-Shock Proteins/metabolism ; Heme/metabolism ; Humans ; Molecular Chaperones/metabolism ; Myoglobin/metabolism ; Nitric Oxide/metabolism ; Soluble Guanylyl Cyclase/metabolism
    Chemical Substances HSP90 Heat-Shock Proteins ; Molecular Chaperones ; Myoglobin ; Nitric Oxide (31C4KY9ESH) ; Heme (42VZT0U6YR) ; Soluble Guanylyl Cyclase (EC 4.6.1.2)
    Language English
    Publishing date 2022-03-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11060976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Clinicians Who Practice Primarily in Nursing Homes and the Quality of End-of-Life Care Among Residents.

    Ghosh, Arnab K / Unruh, Mark Aaron / Yun, Hyunkyung / Jung, Hye-Young

    JAMA network open

    2024  Volume 7, Issue 3, Page(s) e242546

    Abstract: Importance: Clinician specialization in the care of nursing home (NH) residents or patients in skilled nursing facilities (SNFs) has become increasingly common. It is not known whether clinicians focused on NH care, often referred to as SNFists (ie, ... ...

    Abstract Importance: Clinician specialization in the care of nursing home (NH) residents or patients in skilled nursing facilities (SNFs) has become increasingly common. It is not known whether clinicians focused on NH care, often referred to as SNFists (ie, physicians, nurse practitioners, and physician assistants concentrating their practice in the NH or SNF setting), are associated with a reduced likelihood of burdensome transitions in the last 90 days of life for residents, which are a marker of poor-quality end-of-life (EOL) care.
    Objective: To quantify the association between receipt of care from an SNFist and quality of EOL care for NH residents.
    Design, setting, and participants: This cohort study analyzed Medicare fee-for-service claims for a nationally representative 20% sample of beneficiaries to examine burdensome transitions among NH decedents at the EOL from January 1, 2013, through December 31, 2019. Statistical analyses were conducted from December 2022 to June 2023.
    Exposure: Receipt of care from an SNFist, defined as physicians and advanced practitioners who provided 80% or more of their evaluation and management visits in NHs annually.
    Main outcomes and measures: This study used augmented inverse probability weighting in analyses of Medicare fee-for-service claims for a nationally representative 20% sample of beneficiaries. Main outcomes included 4 measures of burdensome transitions: (1) hospital transfer in the last 3 days of life; (2) lack of continuity in NHs after hospitalization in the last 90 days of life; (3) multiple hospitalizations in the last 90 days of life for any reason or any hospitalization for pneumonia, urinary tract infection, dehydration, or sepsis; and (4) any hospitalization in the last 90 days of life for an ambulatory care-sensitive condition.
    Results: Of the 2 091 954 NH decedents studied (mean [SD] age, 85.4 [8.5] years; 1 470 724 women [70.3%]), 953 722 (45.6%) received care from SNFists and 1 138 232 (54.4%) received care from non-SNFists; 422 575 of all decedents (20.2%) experienced a burdensome transition at the EOL. Receipt of care by an SNFist was associated with a reduced risk of (1) hospital transfer in the last 3 days of life (-1.6% [95% CI, -2.5% to -0.8%]), (2) lack of continuity in NHs after hospitalization (-4.8% [95% CI, -6.7% to -3.0%]), and (3) decedents experiencing multiple hospitalizations for any reason or any hospitalization for pneumonia, urinary tract infection, dehydration, or sepsis (-5.8% [95% CI, -10.1% to -1.7%]). There was not a statistically significant association with the risk of hospitalization for an ambulatory care-sensitive condition in the last 90 days of life (0.0% [95% CI, -14.7% to 131.7%]).
    Conclusions and relevance: This study suggests that SNFists may be an important resource to improve the quality of EOL care for NH residents.
    MeSH term(s) Humans ; Female ; Aged ; United States ; Aged, 80 and over ; Cohort Studies ; Dehydration ; Medicare ; Terminal Care ; Nursing Homes ; Pneumonia/epidemiology ; Pneumonia/therapy ; Urinary Tract Infections ; Sepsis
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2024.2546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Top-ranked cycle flux network analysis of molecular photocells.

    Gupt, Nikhil / Ghosh, Shuvadip / Ghosh, Arnab

    Physical review. E

    2023  Volume 108, Issue 3-1, Page(s) 34305

    Abstract: We introduce a top-ranked cycle flux ranking scheme of network analysis to assess the performance of molecular junction solar cells. By mapping the Lindblad master equation to the quantum-transition network, we propose a microscopic Hamiltonian ... ...

    Abstract We introduce a top-ranked cycle flux ranking scheme of network analysis to assess the performance of molecular junction solar cells. By mapping the Lindblad master equation to the quantum-transition network, we propose a microscopic Hamiltonian description underpinning the rate equations commonly used to characterize molecular photocells. Our approach elucidates the paramount significance of edge flux and unveils two pertinent electron transfer pathways that play equally important roles in robust photocurrent generation. Furthermore, we demonstrate that nonradiative loss processes impede the maximum power efficiency of photocells, which may otherwise be above the Curzon-Ahlborn limit. These findings shed light on the intricate functionalities that govern molecular photovoltaics and offer a comprehensive approach to address them in a systematic way.
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.108.034305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Design and implementation of optimized virtual oscillatory controllers for grid-forming inverters.

    Gurugubelli, Vikash / Ghosh, Arnab / Panda, Anup Kumar

    ISA transactions

    2023  Volume 139, Page(s) 685–712

    Abstract: The percentage of renewable power in conventional power generation is gradually growing due to developments in power electronic converters (PECs). Renewable energy sources (RESs) can be integrated into the main grid through PECs, which are the most ... ...

    Abstract The percentage of renewable power in conventional power generation is gradually growing due to developments in power electronic converters (PECs). Renewable energy sources (RESs) can be integrated into the main grid through PECs, which are the most prevalent method to accomplish this. Virtual oscillator control (VOC) is a well-known time-domain method to regulate grid-forming inverters. VOC objective is to model the nonlinear dynamics of deadzone oscillator in a system of voltage source inverters to give a steady AC microgrid (MG). VOC is a self-synchronizing control method that just involves the current feedback signal. In contrast, classical droop and virtual synchronous machine (VSM) controllers both require the use of low pass filters to calculate real and reactive powers. The selection of control parameters in deadzone VOC is difficult and time-consuming. The VOC parameters are designed using different optimization techniques such as Particle Swarm Optimization (PSO), Sine Cosine Algorithm (SCA), modified Sine Cosine Algorithm (mSCA), African Vulture Optimization Algorithm (AVOA), and Artificial Jellyfish Search Optimization (AJSO). MATLAB and a real-time digital simulator (Opal RT-OP5142) were used to examine the system's performance with aforesaid controllers (droop, VSM, conventional VOC, VOC-PSO, VOC-SCA, VOC-mSCA, VOC-AVOA, and VOC-AJSO). In comparison to all control methods, the proposed VOC-AJSO provides faster synchronization. The effectiveness of the suggested VOC-AJSO control approach is proved by the hardware results.
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2012746-7
    ISSN 1879-2022 ; 0019-0578
    ISSN (online) 1879-2022
    ISSN 0019-0578
    DOI 10.1016/j.isatra.2023.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A spectroscopic overview of the differences between the absorbing states and the emitting states in semiconductor perovskite nanocrystals.

    Ghosh, Arnab / Strandell, Dallas P / Kambhampati, Patanjali

    Nanoscale

    2023  Volume 15, Issue 6, Page(s) 2470–2487

    Abstract: Semiconductor perovskites have been under intense investigation for their promise in optoelectronic applications and their novel and unique physical properties. There have been a variety of material implementations of perovskites from thin films to ... ...

    Abstract Semiconductor perovskites have been under intense investigation for their promise in optoelectronic applications and their novel and unique physical properties. There have been a variety of material implementations of perovskites from thin films to single crystals to nanocrystals. The nanocrystal form, in particular, is attractive as it enables solution processing and also spectroscopically probes both absorptive and emissive transitions. Broadly, the literature is comprised of experiments of either form, but the experiments are rarely performed in concert and are not discussed in a unified picture. For example, absorptive experiments are typically transient absorption measurements, which aim to measure carrier kinetics and dynamics. In contrast, the emissive experiments largely focus on excitonic fine structures and coupling to phonons. The time resolved emission experiments report on excited state lifetimes and their dependence on temperature. There are broad differences in the spectroscopy techniques and the questions asked in both classes of experiments. Yet there is one measure in common that suggests there are mysteries in our understanding of how the absorbing and emitting states are connected. The linewidth of emission spectra is always larger than the linewidth of absorption spectra. The question of the physics underlying linewidths is complex and is one of the central issues in perovskite nanocrystals. So why are the absorptive and emissive linewidths different? At present even this simple question has no clear answer. The more complex questions of the structure and dynamics of absorptive and emissive states are even more ambiguous. Hence there is a need to connect these experiments and the relevant states. Here, we provide an overview of the salient absorptive and emissive spectroscopy techniques in an effort to begin connecting these two disparate areas of inquiry.
    Language English
    Publishing date 2023-02-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d2nr05698d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Two-Dimensional Electronic Spectroscopy Reveals Dynamics within the Bright Fine Structure of CdSe Quantum Dots.

    Brosseau, Patrick / Jasrasaria, Dipti / Ghosh, Arnab / Seiler, Helene / Palato, Samuel / Kambhampati, Patanjali

    The journal of physical chemistry letters

    2024  Volume 15, Issue 6, Page(s) 1702–1707

    Abstract: Semiconductor quantum dots are characterized by a discrete excitonic structure featuring coarse as well as fine structure. The lowest fine structure states have splittings into bright-dark states which are now well confirmed by single dot spectroscopy. ... ...

    Abstract Semiconductor quantum dots are characterized by a discrete excitonic structure featuring coarse as well as fine structure. The lowest fine structure states have splittings into bright-dark states which are now well confirmed by single dot spectroscopy. In contrast, the splitting of the lowest coarse exciton into bright-bright fine structure states has not been observed nor the dynamics between these states. Here, we use the unique combination of time and energy resolution of two-dimensional electronic spectroscopy to directly observe the fine structure splittings into a bright-bright doublet. These splittings are strongly size dependent, with population relaxation on the <100 fs time scale.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c03378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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