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  1. Article: Flavonoids: A treasure house of prospective pharmacological potentials.

    Hasnat, Hasin / Shompa, Suriya Akter / Islam, Md Mirazul / Alam, Safaet / Richi, Fahmida Tasnim / Emon, Nazim Uddin / Ashrafi, Sania / Ahmed, Nazim Uddin / Chowdhury, Md Nafees Rahman / Fatema, Nour / Hossain, Md Sakhawat / Ghosh, Avoy / Ahmed, Firoj

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27533

    Abstract: Flavonoids are organic compounds characterized by a range of phenolic structures, which are abundantly present in various natural sources such as fruits, vegetables, cereals, bark, roots, stems, flowers, tea, and wine. The health advantages of these ... ...

    Abstract Flavonoids are organic compounds characterized by a range of phenolic structures, which are abundantly present in various natural sources such as fruits, vegetables, cereals, bark, roots, stems, flowers, tea, and wine. The health advantages of these natural substances are renowned, and initiatives are being taken to extract the flavonoids. Apigenin, galangin, hesperetin, kaempferol, myricetin, naringenin, and quercetin are the seven most common compounds belonging to this class. A thorough analysis of bibliographic records from reliable sources including Google Scholar, Web of Science, PubMed, ScienceDirect, MEDLINE, and others was done to learn more about the biological activities of these flavonoids. These flavonoids appear to have promising anti-diabetic, anti-inflammatory, antibacterial, antioxidant, antiviral, cytotoxic, and lipid-lowering activities, according to evidence from
    Language English
    Publishing date 2024-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Indole alkaloids from marine resources: Understandings from therapeutic point of view to treat cancers.

    Islam, Fahadul / Dehbia, Zerrouki / Zehravi, Mehrukh / Das, Rajib / Sivakumar, M / Krishnan, Karthickeyan / Billah, Abdul Ajeed Mohathasim / Bose, Bharadhan / Ghosh, Avoy / Paul, Shyamjit / Nainu, Firzan / Ahmad, Irfan / Emran, Talha Bin

    Chemico-biological interactions

    2023  Volume 383, Page(s) 110682

    Abstract: Cancer is the leading cause of mortality all over the world. Scientific investigation has demonstrated that disruptions in the process of autophagy are frequently interrelated with the emergence of cancer. Hence, scientists are seeking permanent ... ...

    Abstract Cancer is the leading cause of mortality all over the world. Scientific investigation has demonstrated that disruptions in the process of autophagy are frequently interrelated with the emergence of cancer. Hence, scientists are seeking permanent solutions to counter the deadly disease. Indole alkaloids have been extensively studied and are acknowledged to exhibit several bioactivities. The current state of disease necessitates novel pharmacophores development. In recent decades, indole alkaloids have become increasingly significant in cancer treatment and are also used as adjuvants. A substantial amount of pharmacologically active molecules come from indole alkaloids, which are widely distributed in nature. Indole alkaloids derived from marine organisms show immense potential for therapeutic applications and seem highly effective in cancer treatment. A couple of experiments have been conducted preclinically to investigate the possibility of indole alkaloids in cancer treatment. Marine-derived indole alkaloids possess the ability to exhibit anticancer properties through diverse antiproliferative mechanisms. Certain indole alkaloids, including vincristine and vinblastine, were verified in clinical trials or are presently undergoing clinical assessments for preventing and treating cancer. Indole alkaloids from marine resources hold a significant functionality in identifying new antitumor agents. The current literature highlights recent advancements in indole alkaloids that appear to be anticancer agents and the underlying mechanisms.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Autophagy ; Indole Alkaloids ; Pharmacophore
    Chemical Substances Indole Alkaloids
    Language English
    Publishing date 2023-08-28
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 218799-1
    ISSN 1872-7786 ; 0009-2797
    ISSN (online) 1872-7786
    ISSN 0009-2797
    DOI 10.1016/j.cbi.2023.110682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Hormonal Therapy for Gynecological Cancers: How Far Has Science Progressed toward Clinical Applications?

    Mitra, Saikat / Lami, Mashia Subha / Ghosh, Avoy / Das, Rajib / Tallei, Trina Ekawati / Fatimawali / Islam, Fahadul / Dhama, Kuldeep / Begum, M Yasmin / Aldahish, Afaf / Chidambaram, Kumarappan / Emran, Talha Bin

    Cancers

    2022  Volume 14, Issue 3

    Abstract: In recent years, hormone therapy has been shown to be a remarkable treatment option for cancer. Hormone treatment for gynecological cancers involves the use of medications that reduce the level of hormones or inhibit their biological activity, thereby ... ...

    Abstract In recent years, hormone therapy has been shown to be a remarkable treatment option for cancer. Hormone treatment for gynecological cancers involves the use of medications that reduce the level of hormones or inhibit their biological activity, thereby stopping or slowing cancer growth. Hormone treatment works by preventing hormones from causing cancer cells to multiply. Aromatase inhibitors, anti-estrogens, progestin, estrogen receptor (ER) antagonists, GnRH agonists, and progestogen are effectively used as therapeutics for vulvar cancer, cervical cancer, vaginal cancer, uterine cancer, and ovarian cancer. Hormone replacement therapy has a high success rate. In particular, progestogen and estrogen replacement are associated with a decreased incidence of gynecological cancers in women infected with human papillomavirus (HPV). The activation of estrogen via the transcriptional functionality of ERα may either be promoted or decreased by gene products of HPV. Hormonal treatment is frequently administered to patients with hormone-sensitive recurring or metastatic gynecologic malignancies, although response rates and therapeutic outcomes are inconsistent. Therefore, this review outlines the use of hormonal therapy for gynecological cancers and identifies the current knowledge gaps.
    Language English
    Publishing date 2022-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14030759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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