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Article ; Online: Visceral Adipose Tissue Molecular Networks and Regulatory microRNA in Pediatric Obesity: An In Silico Approach.

Roy, Dipayan / Modi, Anupama / Ghosh, Ritwik / Ghosh, Raghumoy / Benito-León, Julián

International journal of molecular sciences

2022 Volume 23, Issue 19

Abstract: Childhood obesity carries an increased risk of metabolic complications, sleep disturbances, and cancer. Visceral adiposity is independently associated with inflammation and insulin resistance in obese children. However, the underlying pathogenic ... ...

Abstract	Childhood obesity carries an increased risk of metabolic complications, sleep disturbances, and cancer. Visceral adiposity is independently associated with inflammation and insulin resistance in obese children. However, the underlying pathogenic mechanisms are still unclear. We aimed to detect the gene expression pattern and its regulatory network in the visceral adipose tissue of obese pediatric individuals. Using differentially-expressed genes (DEGs) identified from two publicly available datasets, GSE9624 and GSE88837, we performed functional enrichment, protein-protein interaction, and network analyses to identify pathways, targeting transcription factors (TFs), microRNA (miRNA), and regulatory networks. There were 184 overlapping DEGs with six significant clusters and 19 candidate hub genes. Furthermore, 24 TFs targeted these hub genes. The genes were regulated by miR-16-5p, miR-124-3p, miR-103a-3p, and miR-107, the top miRNA, according to a maximum number of miRNA-mRNA interaction pairs. The miRNA were significantly enriched in several pathways, including lipid metabolism, immune response, vascular inflammation, and brain development, and were associated with prediabetes, diabetic nephropathy, depression, solid tumors, and multiple sclerosis. The genes and miRNA detected in this study involve pathways and diseases related to obesity and obesity-associated complications. The results emphasize the importance of the TGF-β signaling pathway and its regulatory molecules, the immune system, and the adipocytic apoptotic pathway in pediatric obesity. The networks associated with this condition and the molecular mechanisms through which the potential regulators contribute to pathogenesis are open to investigation.
MeSH term(s)	Child ; Gene Regulatory Networks ; Humans ; Inflammation ; Intra-Abdominal Fat/metabolism ; MicroRNAs/metabolism ; Pediatric Obesity/genetics ; RNA, Messenger/genetics ; Transcription Factors/metabolism ; Transforming Growth Factor beta/genetics
Chemical Substances	MicroRNAs ; RNA, Messenger ; Transcription Factors ; Transforming Growth Factor beta
Language	English
Publishing date	2022-09-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231911036
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland.

Elazary, Yotam / Cheow, Kathleen / Cheng, Ruey-Kuang / Ghosh, Raghumoy / Shainer, Inbal / Wexler, Yair / Crasta, Karen / Gothilf, Yoav / Jesuthasan, Suresh J

Journal of pineal research

2023 Volume 74, Issue 3, Page(s) e12854

Abstract: Photoreceptors in the vertebrate eye are dependent on the retinal pigmented epithelium for a variety of functions including retinal re-isomerization and waste disposal. The light-sensitive pineal gland of fish, birds, and amphibians is evolutionarily ... ...

Abstract	Photoreceptors in the vertebrate eye are dependent on the retinal pigmented epithelium for a variety of functions including retinal re-isomerization and waste disposal. The light-sensitive pineal gland of fish, birds, and amphibians is evolutionarily related to the eye but lacks a pigmented epithelium. Thus, it is unclear how these functions are performed. Here, we ask whether a subpopulation of zebrafish pineal cells, which express glial markers and visual cycle genes, is involved in maintaining photoreceptors. Selective ablation of these cells leads to a loss of pineal photoreceptors. Moreover, these cells internalize exorhodopsin that is secreted by pineal rod-like photoreceptors, and in turn release CD63-positive extracellular vesicles (EVs) that are taken up by pdgfrb-positive phagocytic cells in the forebrain meninges. These results identify a subpopulation of glial cells that is critical for pineal photoreceptor survival and indicate the existence of cells in the forebrain meninges that receive EVs released by these pineal cells and potentially function in waste disposal.
MeSH term(s)	Animals ; Extracellular Vesicles/genetics ; Extracellular Vesicles/metabolism ; Gene Expression ; Melatonin ; Meninges/cytology ; Meninges/physiology ; Neuroglia/cytology ; Neuroglia/metabolism ; Photoreceptor Cells/cytology ; Photoreceptor Cells/metabolism ; Photoreceptor Cells, Vertebrate/metabolism ; Photoreceptor Cells, Vertebrate/physiology ; Pineal Gland/cytology ; Pineal Gland/metabolism ; Rhodopsin/metabolism ; Tetraspanin 30/metabolism ; Visual Perception/genetics ; Visual Perception/physiology ; Zebrafish/genetics ; Zebrafish/metabolism
Chemical Substances	exorhodopsin ; Melatonin (JL5DK93RCL) ; Rhodopsin (9009-81-8) ; Tetraspanin 30 ; exorh protein, zebrafish
Language	English
Publishing date	2023-02-04
Publishing country	England
Document type	Journal Article
ZDB-ID	632697-3
ISSN	1600-079X ; 0742-3098
ISSN (online)	1600-079X
ISSN	0742-3098
DOI	10.1111/jpi.12854
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Article: Association Between Circulating Plasmacytoid Dendritic Cell Percentage and Blood Lead Levels in Children

Ghosh, Raghumoy / Goyal, Taru / Mitra, Prasenjit / Malavika, L. / Sharma, Shailja / Sharma, Praveen

Biological trace element research. 2021 July, v. 199, no. 7

2021

Abstract: Lead (Pb) exposure is known to cause T helper 1 (Th1) to T helper 2 (Th2) shift in the immune response. The mechanism responsible for these effects is unclear. Plasmacytoid dendritic cells (pDCs) are known as the principal secretor of type 1 interferons ( ...

Abstract	Lead (Pb) exposure is known to cause T helper 1 (Th1) to T helper 2 (Th2) shift in the immune response. The mechanism responsible for these effects is unclear. Plasmacytoid dendritic cells (pDCs) are known as the principal secretor of type 1 interferons (IFNs), which have a stimulatory effect on Th1 differentiation. However, no previous study has explored the effect of Pb on pDCs. Thus, the present study was conducted to explore the correlation between circulating pDC count, serum IFNα (pan) levels, and blood lead levels (BLLs) in children environmentally exposed to Pb. A total of 82 school-going children were recruited from government and private schools in Jodhpur. BLL, pDC percentages, and serum IFNα (pan) levels were estimated by atomic absorption spectrometry, flow cytometry, and ELISA, respectively, in 82 samples. The participants were divided as per BLL quartiles into 4 groups: (A) BLL < 3 μg/dL (n = 21), (B) BLL = 3–4.08 μg/dL (n = 20), (C) BLL = 4.08–6.17 μg/dL (n = 20), and (D) BLL > 6.17 μg/dL (n = 21). Only in category D, pDC percentages showed a significant positive correlation with BLL (Spearman’s R = 0.5). Therefore, this preliminary data suggests that BLL might modulate pDC levels in a dose-dependent manner.
Keywords	CD4-positive T-lymphocytes ; atomic absorption spectrometry ; blood serum ; dendritic cells ; dose response ; flow cytometry ; immune response ; lead ; research ; trace elements
Language	English
Dates of publication	2021-07
Size	p. 2508-2513.
Publishing place	Springer US
Document type	Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-020-02383-6
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: T helper cells in depression: central role of Th17 cells.

Ghosh, Raghumoy / Mitra, Prasenjit / Kumar, P V S N Kiran / Goyal, Taru / Sharma, Praveen

Critical reviews in clinical laboratory sciences

2021 Volume 59, Issue 1, Page(s) 19–39

Abstract: Depression is one of the most common neuropsychiatric disorders in the world. While conventional pharmaceutical therapy targets monoaminergic pathway dysfunction, it has not been totally successful in terms of positive outcomes, remission, and preventing ...

Abstract	Depression is one of the most common neuropsychiatric disorders in the world. While conventional pharmaceutical therapy targets monoaminergic pathway dysfunction, it has not been totally successful in terms of positive outcomes, remission, and preventing relapses. There is an increasing amount of evidence that neuroinflammation may play a significant part in the pathophysiology of depression. Among the key components of the neuroinflammatory pathways already known to be active are the T helper (Th) cells, especially Th17 cells. While various preclinical and clinical studies have reported increased levels of Th17 cells in both serum and brain tissue of laboratory model animals, contradictory results have argued against a pertinent role of Th17 cells in depression. Recent studies have also revealed a role for more pathogenic and inflammatory subsets of Th17 in depression, as well as IL-17A and Th17 cells in non-responsiveness to conventional antidepressant therapy. Despite recent advances, there is still a significant knowledge gap concerning the exact mechanism by which Th17 cells influence neuroinflammation in depression. This review first provides a short introduction to the major findings that led to the discovery of the role of Th cells in depression. The major subsets of Th cells known to be involved in neuroimmunology of depression, such as Th1, Th17, and T regulatory cells, are subsequently described, with an in-depth discussion on current knowledge about Th17 cells in depression.
MeSH term(s)	Animals ; Depression ; Humans ; Neuroinflammatory Diseases ; T-Lymphocytes, Regulatory ; Th17 Cells
Language	English
Publishing date	2021-09-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	280641-1
ISSN	1549-781X ; 1040-8363 ; 0590-8191
ISSN (online)	1549-781X
ISSN	1040-8363 ; 0590-8191
DOI	10.1080/10408363.2021.1965535
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Zs.A 771: Show issues

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Article ; Online: Association of microRNA expression with changes in immune markers in workers with cadmium exposure.

Goyal, Taru / Mitra, Prasenjit / Singh, Preeti / Ghosh, Raghumoy / Sharma, Shailja / Sharma, Praveen

Chemosphere

2021 Volume 274, Page(s) 129615

Abstract: Human exposure to cadmium (Cd) is known to produce severe health effects. Recently, molecular mechanism of Cd toxicity has revealed the role of Cd in causing epigenetic alterations. miRNAs are small, non-coding RNAs which are involved in translational ... ...

Abstract	Human exposure to cadmium (Cd) is known to produce severe health effects. Recently, molecular mechanism of Cd toxicity has revealed the role of Cd in causing epigenetic alterations. miRNAs are small, non-coding RNAs which are involved in translational repression of genes. Therefore, the aim of the present study was to evaluate the alterations in expression of miRNAs associated with inflammation, carcinogenesis and, further, study their possible correlation with immune profile, in occupationally Cd exposed workers of Jodhpur. 106 workers from metal handicraft and welding factories were recruited as subjects, while, 80 apparently healthy non-exposed individuals served as control for this study. Blood Cd levels (BCd) were determined by Graphite Furnace Atomic Absorption Spectroscopy (GFAAS). Lymphocyte cell subset were measured by flow cytometry, serum interleukins were assessed by ELISA and miRNA expression was determined by Real Time Polymerase Chain Reaction (RT-PCR). BCd levels were significantly higher in the exposed individuals when compared to the non-exposed, with welders reporting the highest amongst all. Among the lymphocyte subset, exposed group showed significantly higher percentage of Th17 and lower percentage of Treg population. Cytokine profile expressed by exposed workers were predominantly pro-inflammatory in nature. Among, the studied miRNAs, miR-221 was significantly higher in exposed group with a fold change of 3.05. Additionally, miR-221 and miR-155 showed significant positive correlation with Th17 cell %. Regression analysis showed duration of exposure and IL-17 to have significant effect on miR-221 in exposed group. In conclusion, miR-221 was significantly upregulated in exposed and was correlated with immune alteration making it a potential candidate for further exploration of mechanism underlying Cd toxicity.
MeSH term(s)	Biomarkers ; Cadmium/toxicity ; Humans ; Inflammation ; MicroRNAs/genetics ; Occupational Exposure/adverse effects
Chemical Substances	Biomarkers ; MicroRNAs ; Cadmium (00BH33GNGH)
Language	English
Publishing date	2021-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2021.129615
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Article: Inflammation, Immunity and Immunogenetics in COVID-19: A Narrative Review.

Lingeswaran, Malavika / Goyal, Taru / Ghosh, Raghumoy / Suri, Smriti / Mitra, Prasenjit / Misra, Sanjeev / Sharma, Praveen

Indian journal of clinical biochemistry : IJCB

2020 Volume 35, Issue 3, Page(s) 260–273

Abstract: The novel Coronavirus Disease 2019 (COVID-19), that began in Wuhan Province, China was labelled as an International Public Health Emergency on January 30, 2020 and later was declared a pandemic by the World Health Organisation (WHO) on March 11, 2020. ... ...

Abstract	The novel Coronavirus Disease 2019 (COVID-19), that began in Wuhan Province, China was labelled as an International Public Health Emergency on January 30, 2020 and later was declared a pandemic by the World Health Organisation (WHO) on March 11, 2020. The causative agent, SARS-CoV-2 was the third coronavirus responsible for causing major disease outbreaks in human population after Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) caused by SARS-CoV and MERS-CoV respectively. The patients of COVID-19 present with a clinical feature resembling mild form of viral pneumonia which in certain cases progress to a severe form characterised by adult respiratory distress syndrome (ARDS) and/or multiorgan failure leading to death. The transition from mild to severe form of COVID-19 is affected by a lot of factors like age, co-morbidities etc. In the absence of an absolute cure, it is essential to explore the molecular pathogenesis of the disease to identify people at risk of developing severity so that alternative treatment modalities may be planned. The aim of this review is to provide an update on the general characteristics of SARS-CoV-2 and highlight the inflammatory changes and immune dysregulation that may help in identification of molecular predictors of disease severity.
Keywords	covid19
Language	English
Publishing date	2020-06-06
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	1033583-3
ISSN	0974-0422 ; 0970-1915
ISSN (online)	0974-0422
ISSN	0970-1915
DOI	10.1007/s12291-020-00897-3
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Article ; Online: Association Between Circulating Plasmacytoid Dendritic Cell Percentage and Blood Lead Levels in Children.

Ghosh, Raghumoy / Goyal, Taru / Mitra, Prasenjit / Malavika, L / Sharma, Shailja / Sharma, Praveen

Biological trace element research

2020 Volume 199, Issue 7, Page(s) 2508–2513

Abstract	Lead (Pb) exposure is known to cause T helper 1 (Th1) to T helper 2 (Th2) shift in the immune response. The mechanism responsible for these effects is unclear. Plasmacytoid dendritic cells (pDCs) are known as the principal secretor of type 1 interferons (IFNs), which have a stimulatory effect on Th1 differentiation. However, no previous study has explored the effect of Pb on pDCs. Thus, the present study was conducted to explore the correlation between circulating pDC count, serum IFNα (pan) levels, and blood lead levels (BLLs) in children environmentally exposed to Pb. A total of 82 school-going children were recruited from government and private schools in Jodhpur. BLL, pDC percentages, and serum IFNα (pan) levels were estimated by atomic absorption spectrometry, flow cytometry, and ELISA, respectively, in 82 samples. The participants were divided as per BLL quartiles into 4 groups: (A) BLL < 3 μg/dL (n = 21), (B) BLL = 3-4.08 μg/dL (n = 20), (C) BLL = 4.08-6.17 μg/dL (n = 20), and (D) BLL > 6.17 μg/dL (n = 21). Only in category D, pDC percentages showed a significant positive correlation with BLL (Spearman's R = 0.5). Therefore, this preliminary data suggests that BLL might modulate pDC levels in a dose-dependent manner.
MeSH term(s)	Child ; Dendritic Cells/chemistry ; Environmental Exposure ; Humans ; Lead/analysis
Chemical Substances	Lead (2P299V784P)
Language	English
Publishing date	2020-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-020-02383-6
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Article ; Online: Alterations in Th17 and Treg Lymphocyte Subset in Workers Occupationally Exposed to Lead.

Goyal, Taru / Mitra, Prasenjit / Singh, Preeti / Ghosh, Raghumoy / Lingeswaran, Malavika / Sharma, Shailja / Sharma, Praveen

Biological trace element research

2020 Volume 199, Issue 5, Page(s) 1693–1700

Abstract: Occupational exposure to lead (Pb) may have a deleterious effect on health of the workers. Among the various physiological systems, the immune system is one of the most susceptible targets of lead. Previous studies have been inconclusive in establishing ... ...

Abstract	Occupational exposure to lead (Pb) may have a deleterious effect on health of the workers. Among the various physiological systems, the immune system is one of the most susceptible targets of lead. Previous studies have been inconclusive in establishing the effect of Pb on the immune system. With this background, the aim of our study was to determine the effect of occupational Pb exposure on workers' immune parameters. A total of 110 individuals who were occupationally exposed to Pb and 97 apparently healthy non-exposed individuals were recruited in this study. Blood lead levels (BLL) were determined by atomic absorption spectrophotometry (AAS). Lymphocyte subsets (Th1, Th17, and Tregs) were analyzed using flow cytometry, and the cytokine levels (IL-2, IL-4, IL-6, IL-10, IL-17, and TNF-α) were determined by ELISA. BLL were found to be significantly higher in the exposed group than non-exposed. A significant increase of CD8 cells (%) was observed in the lead-exposed group, while CD4 cells (%), although higher in the exposed group did not differ significantly. Among the T lymphocyte subsets, proportion of Th1 and Tregs was found to be lower in the exposed group with a significant increase in Th17 (%). Additionally, the levels of estimated cytokines suggested a predominant pro-inflammatory response in Pb-exposed workers with significant increase in IL-4, IL-6, and TNF-α, and a significant decrease in IL-2 and IL-10. IL-17 levels did not show any significant difference between the two groups. Increased Th17/Tregs ratio in the exposed group is also suggestive of an increased pro-inflammatory immune response in the exposed group. In conclusion, Pb exposure may induce functional alteration in the immune cells, which may predispose to other abnormalities.
MeSH term(s)	Cytokines ; Humans ; Lead/toxicity ; T-Lymphocyte Subsets ; T-Lymphocytes, Regulatory ; Th1 Cells ; Th17 Cells
Chemical Substances	Cytokines ; Lead (2P299V784P)
Language	English
Publishing date	2020-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-020-02294-6
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Article ; Online: Association of circulating BDNF levels with BDNF rs6265 polymorphism in schizophrenia.

Kumar, Pvsn Kiran / Mitra, Prasenjit / Ghosh, Raghumoy / Sharma, Shailja / Nebhinani, Naresh / Sharma, Praveen

Behavioural brain research

2020 Volume 394, Page(s) 112832

Abstract: Schizophrenia is a severe neuropsychiatric disorder affecting 1% of the world population. Disturbances in neuronal development and synaptic connections are important factors in the pathogenesis of schizophrenia. Brain derived neurotrophic factor (BDNF), ... ...

Abstract	Schizophrenia is a severe neuropsychiatric disorder affecting 1% of the world population. Disturbances in neuronal development and synaptic connections are important factors in the pathogenesis of schizophrenia. Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays a critical role in the development of neurons. Among several polymorphisms reported in BDNF, the rs6265 polymorphism is known to be associated with many neuropsychiatric diseases. This study was aimed to determine the effect of BDNF rs6265 functional polymorphism on serum BDNF concentration in patients with schizophrenia. In total, 50 schizophrenia patients and 50 controls were recruited after obtaining written informed consent. Serum BDNF levels were estimated using the ELISA method and BDNF rs6265 polymorphism was genotyped using T-ARMS PCR. Serum BDNF levels were decreased significantly in schizophrenia patients when compared to the healthy controls (p < 0.0001). Further, the rs6265 polymorphism was also not associated with the schizophrenia (p = 0.41). Intragroup analysis between different genotypes revealed no association between the serum BDNF levels and rs6265 polymorphism. Our results suggest that the functional polymorphism rs6265 is not associated with serum BDNF levels, which is in line with previous findings, which indicates that serum BDNF levels depend more on diagnostic effect than genetic effect. Replication studies on a larger study population are needed.
MeSH term(s)	Adult ; Brain-Derived Neurotrophic Factor/blood ; Brain-Derived Neurotrophic Factor/genetics ; Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Polymorphism, Single Nucleotide ; Schizophrenia/blood ; Schizophrenia/genetics
Chemical Substances	Brain-Derived Neurotrophic Factor ; BDNF protein, human (7171WSG8A2)
Language	English
Publishing date	2020-07-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2020.112832
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Article ; Online: Circulating T helper 17 and IFN-γ positive Th17 cells in Major Depressive Disorder.

Ghosh, Raghumoy / Kumar, Pvsn Kiran / Mitra, Prasenjit / Purohit, Purvi / Nebhinani, Naresh / Sharma, Praveen

Behavioural brain research

2020 Volume 394, Page(s) 112811

Abstract: Introduction: Animal models of depression have reported elevated levels of T helper 17 (Th17) and T helper 1 (Th1) cells along with a decrease in T regulatory (Treg) cell percentage. However, there is ambiguity in the results of clinical studies ... ...

Abstract	Introduction: Animal models of depression have reported elevated levels of T helper 17 (Th17) and T helper 1 (Th1) cells along with a decrease in T regulatory (Treg) cell percentage. However, there is ambiguity in the results of clinical studies investigating Th17 cells in Major Depressive Disorder (MDD). No studies have investigated the role of Interferon gamma positive Th17 cells (IFNγ+ Th17) in MDD yet. Methods: The study population included 53 patients of first episode, drug naïve MDD patients, and 53 non-psychiatric healthy volunteers as healthy controls. Th17, Th1, IFNγ+ Th17 and Treg cell percentages were assessed by flow cytometry. Results: The mean (±SD) percentage of Th17 cells in cases (1.87 ± 1.03) was significantly higher than the mean in controls (1.1 ± 0.94) (p < 0.001). There was no significant difference in the Treg percentages between the cases (2.1 ± 2.0) and controls (2.23 ± 0.95). The Th17:Treg ratio was significantly higher in cases (5.41 ± 10.84) compared to the controls (0.69 ± 0.89) (p < 0.05). Further analysis of data has also revealed that IFNγ+ Th17 subsets secreted more IL-17 in cases (515.7 ± 423.4) compared to controls (509.6 ± 337.4). Intracellular IL-17 levels in this subset also showed a weak though insignificant positive correlation with HDRS scores in the cases. Conclusion: Elevated circulating Th17 cell percentage and Th17:Treg ratio in MDD cases thus add to the evidence suggesting Th17 mediated pro-inflammatory state in MDD. The study also provides preliminary findings of the more pathogenic IFNγ+ Th17 cell subset in MDD.
MeSH term(s)	Adolescent ; Adult ; Cross-Sectional Studies ; Depressive Disorder, Major/blood ; Depressive Disorder, Major/immunology ; Female ; Humans ; Interferon-gamma/blood ; Interferon-gamma/immunology ; Male ; Middle Aged ; Th17 Cells/immunology ; Young Adult
Chemical Substances	Interferon-gamma (82115-62-6)
Language	English
Publishing date	2020-07-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2020.112811
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